Frontiers in Immunology

Original Research

Published on 16 Dec 2025

βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism

in Inflammation

Hao Wang
Damon J. Tumes
Simon Keam
Jia Wen Lim
Quynh Anh Nguyen
Ross Vlahos
Jonathan McQualter
Adam Quek
Carly Whyte
Harshita Pant

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733060

1,430 views

Case Report

Published on 16 Dec 2025

Adult-onset Still’s disease presenting with aseptic meningitis: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Xiao-Fen Li
Amy Ker
Hong-Li Liao
Yuan Liu
James Cheng-Chung Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660434

1,511 views

Original Research

Published on 16 Dec 2025

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

in Immunological Tolerance and Regulation

Elisa Talker
Tanja Gerlza
Philippe Stas
Christina Trojacher
Tiziana Adage
Andreas J. Kungl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679409

1,188 views

Review

Published on 16 Dec 2025

Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Feng-Xian Ni
Hui-Xian Wang
Jie Hu
Pei-Sheng Chen
Hua-Jing Huang
Hui-Hui Chen
Dong-Hui Huang
Ze-Bo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686175

1,843 views

Review

Published on 16 Dec 2025

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

in T Cell Biology

Yuehong Hu
Qihan Zhao
Haoran Dai
Yadi Wu
Xinyue Tang
Naiqian Zhang
Hanxue Jiang
Hongliang Rui
Baoli Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687755

2,897 views

Perspective

Published on 16 Dec 2025

Vaccination in the post-COVID era: lessons to be learned in Latin America

in Vaccines and Molecular Therapeutics

Luis Del Carpio-Orantes
Gabriela Zambrano-Sánchez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726836

1,339 views

Original Research

Published on 16 Dec 2025

Eubacterium limosum modulates gut microbiota and produces anti-inflammatory metabolites to alleviate DSS-induced colitis

in Inflammation

Yao Lu
Huijing Tang
Qianhua Fan
Ruiting Lan
Xiaoying Lin
Shuwei Zhang
Liyun Liu
Jianguo Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728808

1,724 views

Mini Review

Accepted on 15 Dec 2025

Hemophagocytic Lymphohistiocytosis Induced by Immune Checkpoint Inhibitors: Observations and Proposed Clinical Management

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Bianca Arianna Facchini
Benjamin Switzer
Marc S Ernstoff
Igor Puzanov
Paolo Antonio Ascierto

Frontiers in Immunology

359 views

Original Research

Published on 15 Dec 2025

EGR3 as a dual tumor-immune regulator: a machine learning-driven prognostic target for cold breast cancer

in Cancer Immunity and Immunotherapy

Qianxue Wu
Daqiang Song
Jian Yue
Benhua Li
Junge Gong
Xiang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627133

1,584 views

Original Research

Published on 15 Dec 2025

CCL18: a potential immunosuppressive biomarker for prognosis in ABC diffuse large B-cell lymphoma

in Cancer Immunity and Immunotherapy

Marta Rodríguez
Francisco Rojas-Vega
Jesus Frutos Díaz-Alejo
Ignacio Mahillo-Fernández
Cristina Serrano
Alberto López
Teresa Morales-Ruiz
Teresa Roldan-Arjona
Joaquín Sánchez-García
Ana Río-Machín

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693730

2,043 views

Original Research

Published on 15 Dec 2025

Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation

in Cancer Immunity and Immunotherapy

Paola Tieppo
Hussein Shehade
Chiara Martinoli
Marjorie Mercier
David Carbonez
Nicolas Rosewick
Sophie Jung
Anais Vezzu
Boris Pirlot
Noemie Wald

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702402

1,626 views

Original Research

Published on 15 Dec 2025

Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy

in Nutritional Immunology

Yan Song
Rui Lin
Yifeng Fu
Anna Wang
Hu Yang
Wentian Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727993

1,732 views
1 citation

Review

Published on 15 Dec 2025

Acoustic immune reprogramming: a novel paradigm for spatiotemporally controlled immune regulation using ultrasound-responsive nanoplatforms

in Systems Immunology

Tianyi Chen
Junli Chen
Mingkai Chen
Ruixiao Song
Mingsi Wang
Xiaolong Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715455

1,596 views

Original Research

Published on 15 Dec 2025

Identification and validation of core biomarkers for sepsis: a comprehensive analysis using bioinformatics and machine learning

in Inflammation

Haili Li
Sishi Jiang
Zhibin Chen
Yandong Yao
Muhu Chen
Yingchun Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700704

1,461 views

Original Research

Published on 15 Dec 2025

Age-dependent diagnostic and treatment response prediction of TBII and TSI in Graves’ orbitopathy: integration with orbital MRI biomarkers

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Cheng Song
Xiao Wang
Qintao Ma
Genfeng Yu
Yan Zhu
Zimeng Huang
Tian Chen
Kai Huang
Yuanping Hai
Haixiong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657160

1,307 views

Original Research

Published on 15 Dec 2025

A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism

in Comparative Immunology

Alexandre Menezes
Ana Beatriz Walter-Nuno
Emylle Costa-Bartuli
Daniel Moreira
Tatiana El-Bacha
Ana Paula Méndez
Anderson Amarante
Nathan Kistenmacker
Pâmela Huaman
Mileane Busch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704301

1,820 views

Editorial

Published on 15 Dec 2025

Editorial: Exploring the role of immune cells and cell therapy in liver cancer

in Cancer Immunity and Immunotherapy

Wencheng Zhang
Yan-Ru Lou
Yue Wang
Xicheng Wang
Zhiying He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1752606

1,111 views

Correction

Published on 15 Dec 2025

Correction: Association of clinical features and myositis-specific antibodies in idiopathic inflammatory myopathy: a retrospective study from southern China

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Can Li
Yushi Zheng
Yu Zhang
Yujin Ye
Hui Zhang
Niansheng Yang
Shuang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1743471

848 views

Review

Published on 15 Dec 2025

Exploring gut microbiota and spinal cord injury: pathogenesis, treatment strategies and prospects

in Microbial Immunology

Qin Chen
Mingliang Zhong
Ye Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693883

1,550 views

Review

Published on 15 Dec 2025

Heat shock proteins in osteoarthritis: molecular mechanisms, pathogenic roles, and therapeutic opportunities

in Inflammation

Bin Zhao
Zhijun Deng
Zhijun Yang
Fengyun Yang
Wenlong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688250

1,958 views
1 citation

Mini Review

Published on 15 Dec 2025

Nanovaccines in gastrointestinal cancers

in Cancer Immunity and Immunotherapy

YuHan Wang
Peng Huang
Chun Li
ShengJin Tu
Hua Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680053

1,622 views

Original Research

Published on 15 Dec 2025

How conformational changes near the F pocket of MHC class I proteins mediate chaperone assisted peptide loading

in Antigen Presenting Cell Biology

Simone Göppert
Sebastian Springer
Martin Zacharias

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689803

1,250 views

Review

Published on 15 Dec 2025

Anti-inflammatory effects of natural polysaccharides: molecular mechanisms and nanotherapeutic applications

in Inflammation

Jihao Yang
Kai Xiong
Tengzhen Li
Morang Zhang
Zhangyun Li
Zhili Wen
Yuchuan Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723346

1,708 views

Review

Published on 15 Dec 2025

Remote patient monitoring in autoimmune related interstitial lung diseases: a narrative review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Malik A. Althobiani
Maryam Almoagal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643176

1,243 views

49,865 articles

articles

βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism

Adult-onset Still’s disease presenting with aseptic meningitis: a case report

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

Vaccination in the post-COVID era: lessons to be learned in Latin America

Eubacterium limosum modulates gut microbiota and produces anti-inflammatory metabolites to alleviate DSS-induced colitis

Hemophagocytic Lymphohistiocytosis Induced by Immune Checkpoint Inhibitors: Observations and Proposed Clinical Management

EGR3 as a dual tumor-immune regulator: a machine learning-driven prognostic target for cold breast cancer

CCL18: a potential immunosuppressive biomarker for prognosis in ABC diffuse large B-cell lymphoma

Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation

Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy

Acoustic immune reprogramming: a novel paradigm for spatiotemporally controlled immune regulation using ultrasound-responsive nanoplatforms

Identification and validation of core biomarkers for sepsis: a comprehensive analysis using bioinformatics and machine learning

Age-dependent diagnostic and treatment response prediction of TBII and TSI in Graves’ orbitopathy: integration with orbital MRI biomarkers

A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism

Editorial: Exploring the role of immune cells and cell therapy in liver cancer

Correction: Association of clinical features and myositis-specific antibodies in idiopathic inflammatory myopathy: a retrospective study from southern China

Exploring gut microbiota and spinal cord injury: pathogenesis, treatment strategies and prospects

Heat shock proteins in osteoarthritis: molecular mechanisms, pathogenic roles, and therapeutic opportunities

Nanovaccines in gastrointestinal cancers

How conformational changes near the F pocket of MHC class I proteins mediate chaperone assisted peptide loading

Anti-inflammatory effects of natural polysaccharides: molecular mechanisms and nanotherapeutic applications

Remote patient monitoring in autoimmune related interstitial lung diseases: a narrative review