Frontiers in Immunology

Editorial

Published on 15 Dec 2025

Editorial: Exploring immune-stromal cell dynamics: pathways and therapeutic implications

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Stacy Ryu
Stephen B Gauld
Matthew M Staron
Ian D Odell
Jenna L Cash
Timothy RDJ Radstake

Frontiers in Immunology

doi 10.3389/fimmu.2025.1744273

1,131 views

Review

Published on 15 Dec 2025

Macrophages: friend or foe in diabetes pathogenesis and therapy

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Rachel N. Grimes
Marco Orecchioni
Estefania Quesada-Masachs

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625391

2,418 views

Correction

Published on 15 Dec 2025

Correction: A multi-omics approach combining causal inference and in vivo validation identifies key protein drivers of alcohol-associated liver disease

in Inflammation

Qingyi Zhou
Xuan Ma
Qianqian Cui
Lei Zhang
Chao Yao
Zilu Zhang
Xiaoli Wang
Liang Chu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1763736

900 views

Review

Published on 15 Dec 2025

Co-occurrence of autoimmune diseases and metabolic disorders in familial mediterranean fever patients: review of literature and case reports

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Ahlam Chaaban
Nohad Baalbaki
Ralph Narch
Eliana Eldawra
Philippe Hussein Kobeissy
José-Noel Ibrahim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726664

1,906 views

Review

Published on 15 Dec 2025

Leveraging beneficial microbiome-immune interactions via probiotic use in cancer immunotherapy

in Cancer Immunity and Immunotherapy

Chinmay T. Jani
Kyle Edwards
Charmi Bhanushali
Xena Zheng
Ana S. Salazar
Gilberto Lopes
Dionysios C. Watson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713382

3,624 views

Original Research

Published on 15 Dec 2025

Epitope-level analysis of cross-reactive human HLA antibodies against genetically modified swine leukocyte antigens in xenotransplantation

in Alloimmunity and Transplantation

Sang-Ik Cho
Ji-Jing Yan
Beom Seok Kim
Nayoung Ko
Joohyun Shim
Hyunil Kim
Eun-Jee Oh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712793

1,723 views

Review

Published on 15 Dec 2025

Frontiers in thoracic oncology: new breakthroughs in molecular targets and immunotherapy

in Inflammation

Yujing Yang
Dan Pu
Xuehan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721638

1,270 views

Review

Published on 15 Dec 2025

Immunobiology of pulmonary fibrosis

in Molecular Innate Immunity

Samik Bindu
Hadida Yasmin
Uttam Barman
Subhradip Pandit
Khaled Masmoudi
Uday Kishore

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708716

2,227 views

Original Research

Published on 15 Dec 2025

Regulation of neutrophil extracellular trap formation by c-di-GMP in Pseudomonas aeruginosa-induced pleural infection

in Microbial Immunology

Cao Qing
WenHui Huang
Lilu Shi
Jing Luo
Shaochu Zheng
Jinliang Kong
Ke Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610266

1,335 views

Original Research

Published on 12 Dec 2025

Deep learning-aided inter-species-comparison reveals shared and distinct molecular patterns in cynomolgus monkey and humans following non-specific T cell activation

in Systems Immunology

Vincent D. Friedrich
Kari Neier
Kristina Müller
Birgit Fogal
Zuzana Loncova
Michael Rade
Muhammad Shoaib
Ulrike Köhl
Kathleen Hoyt
Parimal Pande

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603716

3,089 views

Original Research

Published on 12 Dec 2025

A trans-activating transduction peptide fused nanobody targeting viral nonstructural protein NS4B inhibits bovine viral diarrhea virus replication

in Vaccines and Molecular Therapeutics

Bao Zhao
Zehao Lv
Wenqi Fan
Ying Zhang
Shuang Wei
Junyang Fang
Ni Huang
Xiwen Chen
Lizhen Wang
Xuefeng Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712683

1,155 views

Original Research

Published on 12 Dec 2025

Integrated analysis of the relationship between metabolic pathways and immune infiltration in rheumatoid arthritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Chaofeng Zhang
Zhongyi You
Zhiqun Pan
Yuming Huang
Zhiming Zhang
Qi Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679356

1,367 views

Review

Published on 12 Dec 2025

Macrophage polarization: molecular mechanisms, disease implications, and targeted therapeutic strategies

in Inflammation

Yanan Ji
Xia Li
Xinlei Yao
Jiacheng Sun
Jia Yi
Yuntian Shen
Bingqian Chen
Hualin Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1732718

4,498 views
2 citations

Review

Published on 12 Dec 2025

GPR35-mediated metabolic reprogramming promotes tumorigenesis in digestive cancers

in Cancer Immunity and Immunotherapy

Fang Wang
Xin-Xin Ding
Tao-Hong Su
Jing Cao
Feng-Qin Li
Zi-Shu Dong
Xin-Zhi Guo
Yan Zhang
Yang Chen
Dong-Hua Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668471

1,573 views

Original Research

Published on 12 Dec 2025

TMEM106A mediates atherosclerosis progression through macrophage-centered immune responses and chemokine signaling

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Menglong Gao
Xingbang Liu
Zhen Fang
Jia Lun
Qingyun Zhang
Yunbo Zhao
Yin Huang
Zhenhua Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681645

1,416 views

Original Research

Published on 12 Dec 2025

2B4 co-stimulation and dasatinib modulation enhance anti-CD19 CAR-NK-92 cell cytotoxicity

in NK and Innate Lymphoid Cell Biology

Matheus Henrique dos Santos
Júlia Teixeira Cottas de Azevedo
Mara Elisama da Silva Januário
Dayane de Fátima Schmidt
Mariane Cariati Tirapelle
Alison Felipe Bordini Biggi
Sima Ebrahimabadi
Renata Nacasaki Silvestre
Dimas Tadeu Covas
Rodrigo T. Calado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675877

2,324 views
1 citation

Original Research

Published on 12 Dec 2025

Prediction of first-line immunotherapy response in patients with extensive-stage small cell lung cancer using a clinical-radiomics combined model

in Cancer Immunity and Immunotherapy

Jing Fan
Xingyi Li
Jiamao Lin
Xiaopeng Song
Chenran Zhao
Fang Zhao
Zhenxiang Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688012

1,754 views

Original Research

Published on 12 Dec 2025

Single-cell and bulk transcriptomics reveal a CD8+ T-cell gene signature predicting prognosis in diffuse large B-cell lymphoma

in Cancer Immunity and Immunotherapy

Hengqi Liu
Yingfang Feng
Zhengzi Qian
Zheng Song
Ning Zhang
Jingwei Yu
Xia Liu
Lihua Qiu
Shiyong Zhou
Wenchen Gong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685541

2,738 views

Mini Review

Published on 12 Dec 2025

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease

in T Cell Biology

Feven Getachew
Junhui Hu
Mehdi Benamar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729690

2,523 views

Original Research

Published on 12 Dec 2025

Mono-WNV and combined WNV/TBEV inactivated vaccine efficacy against a wide range of WNV and TBEV strains

in Vaccines and Molecular Therapeutics

Ksenia Tuchynskaya
Mikhail Vorovitch
Yuriy Kruglov
Guzal Mostipanova
Ivan Kholodilov
Alla Ivanova
Victoria Kuchina
Anastasia Rogova
Galina Karganova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715371

940 views

Brief Research Report

Published on 12 Dec 2025

Clinical correlation of anti-desmoglein antibody dynamics in pemphigus treated with rituximab

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Vishvan Naidu
Harshita A. Jain
Ali Yalcinkaya
Yathavi Charavanamuttu
Dhruva Biswas
Nadira Ali
John B. Mee
Jitesh Chauhan
Kristina Semkova
Emma C. Benton

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713987

2,308 views

Conceptual Analysis

Published on 12 Dec 2025

Conceptual quantitative systems pharmacology framework for supporting clinical trial design in organ-specific autoimmune and rare diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Zhengwu Sun
Yalin Xi
Xiaoyan Lan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714438

1,167 views

Original Research

Published on 12 Dec 2025

Deep learning, deeper relief: pipeline toward tailored analgesia for experimental animal models

in Mucosal Immunity

Luisa Barleben
Mareike Simon
Lisa Drees
Franziska Flohr
Christoph Jochum
Michela Di Virgilio
Frank Tacke
Sonja Bröer
Jana Wolf
Marina Kolesnichenko

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639881

1,098 views

Original Research

Published on 12 Dec 2025

Long-term compromised immune regulation after rituximab induction in blood group incompatible (ABOi) living-donor renal transplantation – 5 year results of a prospective pilot study

in Alloimmunity and Transplantation

Rolf Weimer
Hristos Karakizlis
Fabrice Renner
Hartmut Dietrich
Volker Daniel
Caner Süsal
Christian Schüttler
Daniel Kämper
Dominik Leicht
Michael Wörlen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706158

1,316 views

49,864 articles

articles

Editorial: Exploring immune-stromal cell dynamics: pathways and therapeutic implications

Macrophages: friend or foe in diabetes pathogenesis and therapy

Correction: A multi-omics approach combining causal inference and in vivo validation identifies key protein drivers of alcohol-associated liver disease

Co-occurrence of autoimmune diseases and metabolic disorders in familial mediterranean fever patients: review of literature and case reports

Leveraging beneficial microbiome-immune interactions via probiotic use in cancer immunotherapy

Epitope-level analysis of cross-reactive human HLA antibodies against genetically modified swine leukocyte antigens in xenotransplantation

Frontiers in thoracic oncology: new breakthroughs in molecular targets and immunotherapy

Immunobiology of pulmonary fibrosis

Regulation of neutrophil extracellular trap formation by c-di-GMP in Pseudomonas aeruginosa-induced pleural infection

Deep learning-aided inter-species-comparison reveals shared and distinct molecular patterns in cynomolgus monkey and humans following non-specific T cell activation

A trans-activating transduction peptide fused nanobody targeting viral nonstructural protein NS4B inhibits bovine viral diarrhea virus replication

Integrated analysis of the relationship between metabolic pathways and immune infiltration in rheumatoid arthritis

Macrophage polarization: molecular mechanisms, disease implications, and targeted therapeutic strategies

GPR35-mediated metabolic reprogramming promotes tumorigenesis in digestive cancers

TMEM106A mediates atherosclerosis progression through macrophage-centered immune responses and chemokine signaling

2B4 co-stimulation and dasatinib modulation enhance anti-CD19 CAR-NK-92 cell cytotoxicity

Prediction of first-line immunotherapy response in patients with extensive-stage small cell lung cancer using a clinical-radiomics combined model

Single-cell and bulk transcriptomics reveal a CD8+ T-cell gene signature predicting prognosis in diffuse large B-cell lymphoma

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease

Mono-WNV and combined WNV/TBEV inactivated vaccine efficacy against a wide range of WNV and TBEV strains

Clinical correlation of anti-desmoglein antibody dynamics in pemphigus treated with rituximab

Conceptual quantitative systems pharmacology framework for supporting clinical trial design in organ-specific autoimmune and rare diseases

Deep learning, deeper relief: pipeline toward tailored analgesia for experimental animal models

Long-term compromised immune regulation after rituximab induction in blood group incompatible (ABOi) living-donor renal transplantation – 5 year results of a prospective pilot study