Frontiers in Immunology

Original Research

Published on 11 Dec 2025

Fruquintinib saddles tumor immune tolerance by curbing pro-tumoral immature myeloid cell populations

in Cancer Immunity and Immunotherapy

Lucía Suárez
María Martínez-Azcona
Irantzu Serrano-Mendioroz
Leticia Fernández-Rubio
María Esperanza Rodríguez-Ruiz
Ana Rouzaut

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699980

1,518 views

Original Research

Published on 11 Dec 2025

Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment

in Viral Immunology

Mauro Voi
Antonella Sangalli
Erica Ginevra Milano
Carola De Martinis
Elisa Orlandi
Stefano Tamburin
Elisa Mantovani
Angela Federico
Massimiliano Lanzafame
Emanuela Lattuada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703026

1,360 views

Clinical Trial

Published on 11 Dec 2025

Phase 1 study of chidamide in combination with venetoclax, azacitidine, aclarubicin, cytarabine and G-CSF for refractory/relapsed acute myeloid leukemia: clinical safety, efficacy, and correlative analysis

in Cancer Immunity and Immunotherapy

Yanan Wen
Jingjing Yang
Xiawei Zhang
Qingyang Liu
Wenjing Gao
Lili Dong
Weijia Zhao
Sai Huang
Daihong Liu
Yu Jing

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698710

1,703 views
1 citation

Review

Published on 11 Dec 2025

Experimental animal models of acute respiratory distress syndrome: one-hit and two-hit establishment application

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yue Zhao
Xin Li
Yanhua Ou
Xiangran Cai
Weijian Huang
Shuhua He
Sisi Liang
Ning Wang
Linliang Song
Meixia Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649074

1,365 views

Brief Research Report

Published on 11 Dec 2025

Plasmodium vivax infection-driven modulation of sterol carrier protein reveals a metabolic link to reproductive physiology in Anopheles stephensi

in Vaccines and Molecular Therapeutics

Seena Kumari
Pooja Yadav
Nirmala Sankhala
Jyoti Rani
Gunjan Sharma
Charu Chauhan
Sanjay Tevatiya
Rajnikant Dixit

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703479

1,383 views

Original Research

Published on 11 Dec 2025

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

in Immunological Tolerance and Regulation

Wang Luoying
Yi Xingcheng
Cong Donghang
Long Mengtuan
Wang Ping
Zhang Lijuan
Li Yupeng
Zhao Tianyi
Chen Hongyu
Wang Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694985

1,958 views

Original Research

Published on 11 Dec 2025

Development of a humanized mouse model of graft-versus-host disease to assess human regulatory T cell function

in T Cell Biology

Charline Beguin
Oswin Kwan
Grégory Ehx
Stéphanie Humblet-Baron
Murat Cem Köse
Sophie Dubois
Lorenzo Canti
Justine Courtois
Coline Daulne
Jo Caers

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717133

2,030 views

Case Report

Published on 11 Dec 2025

Case report of acute hepatorenal failure induced by third-line treatment with tislelizumab in a patient with cholangiocarcinoma: was influenza virus the culprit?

in Cancer Immunity and Immunotherapy

Xuebing Zhang
Xia Zhang
Hang Yin
Weiguo Zhang
Bin Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631953

1,286 views

Original Research

Published on 10 Dec 2025

RARS1 inhibits ENO1 ubiquitination and degradation to protect against ferroptosis in hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Shouge Zang
Jvlong Ma
Lichang Chen
Di Cui
Jiangtao Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686597

1,599 views

Original Research

Published on 10 Dec 2025

Health-related quality of life and psychosocial outcomes in long-term survivors treated with immune checkpoint inhibitors: a nationwide multicenter study

in Cancer Immunity and Immunotherapy

Taha Koray Sahin
Fatih Atalah
Bahadir Koylu
Ahmet Oruc
Aydin Acarbay
Akgun Karakok
Sevgi Dogan
Cevat Ilteris Kikili
Görkem Turhan
Gamze Emin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693295

1,542 views

Original Research

Published on 10 Dec 2025

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia

in Primary Immunodeficiencies

Chi Huu Nguyen
Katarina Zmajkovicova
Angelina Sekirnik
Sarah Taplin
Myriam Defontis
Jacob R. Bledsoe
Arthur G. Taveras
Lars Karlsson
Robert Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658987

2,668 views

Original Research

Published on 10 Dec 2025

RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking

in Cancer Immunity and Immunotherapy

Ye Li
Tian Zhan
Tianfu Chen
Qianwen Zhong
Sheng Xiao
Aiyuan Wang
Yisheng Jiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704080

1,037 views

Review

Published on 10 Dec 2025

Mechanistic roles of neutrophil heterogeneity in tumour pathogenesis

in Cancer Immunity and Immunotherapy

Hua Lin
Yutian Liao
Zhonghui Chen
Ye Chen
Yating Chen
Yulin Wang
Zhanfei Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721090

1,276 views

Perspective

Published on 10 Dec 2025

Oncolytic virus therapy for osteosarcoma: mechanisms, opportunities, and challenges

in Cancer Immunity and Immunotherapy

Jia-Wen Wang
Xiaolei Ge
Jia-Hui Liu
Xiaoyu Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724768

1,793 views

Original Research

Published on 10 Dec 2025

Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn’s disease: insights from a systems biology and artificial intelligence-based approach

in Systems Immunology

Ignacio Marín-Jiménez
Mónica Sierra-Ausín
Teresa Letosa-Abián
Jesús Aparicio
Carmen Montoto-Otero
Silvia Sánchez-Ramón

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699203

1,710 views

Review

Published on 10 Dec 2025

Research progress on the induction of immunogenic cell death in tumor immunotherapy using a sonodynamic therapy nanoparticle delivery system

in Cancer Immunity and Immunotherapy

Yang Du
Jiangnan Yang
An Xu
Shuai Chen
Deyuan Fu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681773

1,885 views

Review

Published on 10 Dec 2025

Traditional Chinese medicine as potential adjuvants for tumor vaccines: a review of types, mechanisms, and forms

in Cancer Immunity and Immunotherapy

Yongjia Cui
Lutian Gong
Lei Chang
Wenping Lu
Siqing Zhao
Zhili Zhuo
Xiangyang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661694

1,650 views

Review

Published on 10 Dec 2025

Research progress on the role and mechanism of circadian clock gene PER1 in the occurrence and development of multiple diseases

in Inflammation

Yuxiang Zhao
Yujin Li
Tingting Lu
Xinyue Huang
Kerui Chen
Lina Tan
Lihua Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715457

1,642 views

Original Research

Published on 10 Dec 2025

COL8A1 as a pro-inflammatory mediator bridges immune evasion and therapy resistance in glioma

in Cancer Immunity and Immunotherapy

Jiachong Wang
Jiale Li
Jun Peng
Chunyuan Zhang
Zigui Chen
Changfeng Miao
Chunhai Tang
Qisheng Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727298

1,133 views

Case Report

Published on 10 Dec 2025

Blastic plasmacytoid dendritic cell neoplasm secondary to acute myeloid leukemia with shared mutations in TET2 and DNMT3A: a case report and literature review

in Cancer Immunity and Immunotherapy

Yao Sun
Yingjie Liu
Na Liu
Xiaohui Zhang
Wenrong Huang
Liangding Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656157

918 views

Review

Published on 10 Dec 2025

Progress in the preparation of an active immunization model of anti-N-methyl-D-aspartate receptor encephalitis in animals

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Kuikui Zeng
Yuting Liu
Sai Yang
Lingjuan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585353

1,251 views

Systematic Review

Published on 10 Dec 2025

Survival benefits of different immunotherapies for hepatocellular carcinoma: a meta-analysis highlighting age, gender, etiology, and tumor burden

in Cancer Immunity and Immunotherapy

Ming-Cheng Guan
Na Li
Qian Ding
Di Sun
Hao Li
Mei Yang
Lei Hong
Hong Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713151

2,019 views

Original Research

Published on 10 Dec 2025

Maternal western-style diet alters Kupffer cell proportion leading to metabolic dysfunction-associated steatotic liver disease when challenged with western diet in adulthood

in Nutritional Immunology

Sarah J. Miller
Rachel C. Janssen
Wanke Zhao
Karen R. Jonscher
Hua Zhong
Christa I. DeVette
Jacob E. Friedman
Kurt A. Zimmerman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698609

1,513 views

Correction

Published on 10 Dec 2025

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

in Systems Immunology

Dan Chen
Xiyi Huang
Chun Wang
Cheng Zheng
Yunhao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746347

617 views

49,864 articles

articles

Fruquintinib saddles tumor immune tolerance by curbing pro-tumoral immature myeloid cell populations

Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment

Phase 1 study of chidamide in combination with venetoclax, azacitidine, aclarubicin, cytarabine and G-CSF for refractory/relapsed acute myeloid leukemia: clinical safety, efficacy, and correlative analysis

Experimental animal models of acute respiratory distress syndrome: one-hit and two-hit establishment application

Plasmodium vivax infection-driven modulation of sterol carrier protein reveals a metabolic link to reproductive physiology in Anopheles stephensi

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

Development of a humanized mouse model of graft-versus-host disease to assess human regulatory T cell function

Case report of acute hepatorenal failure induced by third-line treatment with tislelizumab in a patient with cholangiocarcinoma: was influenza virus the culprit?

RARS1 inhibits ENO1 ubiquitination and degradation to protect against ferroptosis in hepatocellular carcinoma

Health-related quality of life and psychosocial outcomes in long-term survivors treated with immune checkpoint inhibitors: a nationwide multicenter study

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia

RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking

Mechanistic roles of neutrophil heterogeneity in tumour pathogenesis

Oncolytic virus therapy for osteosarcoma: mechanisms, opportunities, and challenges

Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn’s disease: insights from a systems biology and artificial intelligence-based approach

Research progress on the induction of immunogenic cell death in tumor immunotherapy using a sonodynamic therapy nanoparticle delivery system

Traditional Chinese medicine as potential adjuvants for tumor vaccines: a review of types, mechanisms, and forms

Research progress on the role and mechanism of circadian clock gene PER1 in the occurrence and development of multiple diseases

COL8A1 as a pro-inflammatory mediator bridges immune evasion and therapy resistance in glioma

Blastic plasmacytoid dendritic cell neoplasm secondary to acute myeloid leukemia with shared mutations in TET2 and DNMT3A: a case report and literature review

Progress in the preparation of an active immunization model of anti-N-methyl-D-aspartate receptor encephalitis in animals

Survival benefits of different immunotherapies for hepatocellular carcinoma: a meta-analysis highlighting age, gender, etiology, and tumor burden

Maternal western-style diet alters Kupffer cell proportion leading to metabolic dysfunction-associated steatotic liver disease when challenged with western diet in adulthood

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis