Frontiers in Immunology

Methods

Published on 10 Dec 2025

A 41-marker 37-color full spectrum flow cytometry panel for the deep immunophenotyping of human peripheral and liver natural killer cells

in NK and Innate Lymphoid Cell Biology

Alberta Gerarda Antonia Paul
Konrad H. H. Reichel
Juan J. Garcia-Vallejo
Lara R. Heij
Maria C. Jaimes
Yacine Kharraz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609732

3,070 views

Brief Research Report

Published on 10 Dec 2025

Utility of blood DNA methylation and immune cell-type estimates to identify clinically relevant links between immunity and health conditions in a large cohort

in Inflammation

Marisol Herrera-Rivero
Jan Homann
Christina M. Lill
Matthias Nauck
Wolfgang Lieb
Jens Kuhle
Heike Minnerup
Marco Hermesdorf
Klaus Berger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613557

714 views

Case Report

Published on 10 Dec 2025

MRI features and preliminary diagnostic assessment using large language models of cystic tumor progression mimicking radiation necrosis in brain metastasis patients treated with immunotherapy: case report

in Cancer Immunity and Immunotherapy

Guirong Tan
Mingchen Cai
Yu Lu
Amy Liu
Shimin Li
Gang Xiao
Lijuan Zhong
Lijia Li
Yichuan Hu
Qiong Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661918

1,337 views

Review

Published on 10 Dec 2025

Metabolic reprogramming and immune regulation in acute myeloid leukemia

in Cancer Immunity and Immunotherapy

Xiaogang Hao
Chenyang Fan
Lixiang Yan
Reaila Jianati
Yifei Guo
Xinli Zhou
Gengda Zhu
Yucheng Zhang
Chengyulong Zheng
Ying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655005

1,863 views
1 citation

Case Report

Published on 10 Dec 2025

MRI-negative myelitis, especially after COVID-19: a case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Mitsuyoshi Tamura
Yohei Yagi
Satoki Hanayama
Satoko Yoshizaki
Kazumoto Shibuya
Hiroki Masuda
Masahiro Mori

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708018

1,688 views

Review

Published on 10 Dec 2025

MicroRNAs orchestrating host and vector-borne protozoan interactions: bridging immune modulation and cross-species communication

in Parasite Immunology

Jianyong Li
Feng Zhu
Jian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673237

884 views

Original Research

Published on 10 Dec 2025

Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Chao Yang
Miao Ma
Kangjie Yu
Yi Wang
Yuting Zhang
Yan Shen
Jun Wang
Xiaoke Wang
Lulu Luo
Ya Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665078

1,647 views

Case Report

Published on 10 Dec 2025

Case Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Chunyan Huang
Daorong Hong
Xiaoqing Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631323

1,180 views

Original Research

Published on 10 Dec 2025

Prognostic Significance of baseline systemic inflammation markers in PD-L1-negative advanced non-small cell lung cancer patients treated with the BRICS sequential regimen

in Cancer Immunity and Immunotherapy

Jianxin Chen
Ming Lin
Jian Wang
Junhui Wang
Yonghai Peng
Zongyang Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686521

1,212 views

Perspective

Published on 10 Dec 2025

Recent progress in pig-to-human kidney xenotransplantation

in Alloimmunity and Transplantation

Pei Tao
Kaiyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735113

2,264 views

Original Research

Published on 10 Dec 2025

Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis of Leishmania infantum

in Parasite Immunology

Cinthia L. Hudachek
Bayan Zhanbolat
Yani Chen
Mary E. Wilson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593829

1,604 views

Review

Published on 10 Dec 2025

Immune-mediated blood-brain barrier disruption after ischemic stroke: mechanisms and therapeutic targets

in Inflammation

Hanjing Wang
Zhang Yiqiang
Jie Cai
Jiawei Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716041

2,207 views

Review

Published on 10 Dec 2025

Multi-omics approach to dissect the significance of lipid metabolism in helper T cell subset

in Inflammation

Toshio Kanno
Keiko Nakano
Yukie Iwao
Yusuke Endo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708616

1,454 views
1 citation

Original Research

Published on 10 Dec 2025

Efficacy and safety of immunotherapy rechallenge in second-line treatment after failure of first-line immune checkpoint inhibitors combined with chemotherapy in advanced gastric cancer: a retrospective study

in Cancer Immunity and Immunotherapy

Fei Li
Wenjing Gong
Miaomiao Yang
Aina Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697712

1,863 views

Original Research

Published on 10 Dec 2025

Insomnia and anxiety: exploring their hidden effect on natural killer cells among young female adults

in NK and Innate Lymphoid Cell Biology

Renad M. Alhamawi
Fatmah A. Halawani
Sima F. Hakeem
Hadeel A. Alslimi
Ebraheim M. Alhamawi
Ahmed M. Aljohani
Ibrahim N. Mohammed
Heba M. Zahid
Yahya A. Almutawif

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698155

5,385 views

Case Report

Published on 10 Dec 2025

IgG4-related disease presenting with hypercalcemia: case report and mechanistic insights

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yaxin Li
Xing Niu
Ling Li
Zhangxue Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720791

1,386 views

Original Research

Published on 10 Dec 2025

Circulating PD-1+ effector memory T cells predict anti-PD-1 efficacy in advanced gastric cancer

in Cancer Immunity and Immunotherapy

Kongcheng Wang
Jie Shao
Kai Xin
Lianru Zhang
Baorui Liu
Wenxiu Chen
Qin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720724

1,364 views

Original Research

Published on 10 Dec 2025

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

in T Cell Biology

Akihiro Shimba
Satoru Munakata
Shinya Abe
Guangwei Cui
Ryoma Kato
Masaki Miyazaki
Atsuhiro Ichihara
Koichi Ikuta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566935

1,144 views

Original Research

Published on 10 Dec 2025

Impact of celiac disease on patients with familial Mediterranean fever: a nationwide study based on the Türkiye database

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Rıfat Bozkuş
Serdar Can Güven
Salih Başer
Nuray Yılmaz Çakmak
Hasan Satış
Emin Gemcioğlu
Naim Ata
Şuayip Birinci

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675131

1,256 views

Systematic Review

Published on 10 Dec 2025

A bibliometric analysis of vaccine research on Chikungunya virus: contributors, trends, and emerging frontiers

in Vaccines and Molecular Therapeutics

Da Shao
Zengwei Kou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692556

2,014 views

Original Research

Accepted on 09 Dec 2025

Neuronal autoantibodies associated with poorer neuropsychological and motor outcomes 6 months after stroke: Results from the PHYS-STROKE trial

in Multiple Sclerosis and Neuroimmunology

Charlotte Pietrock
Konrad Neumann
Kristin Rentzsch
Harald Prüss
Andreas Meisel
Matthias Endres
Alexander Heinrich Nave

Frontiers in Immunology

365 views

Original Research

Published on 09 Dec 2025

Multiomics analysis demonstrated that TOPBP1 interacting checkpoint and Replication Regulator may serve as an immune-related biomarker indicative of poor prognosis in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Chengbin Lin
Ziyi Chen
Wenbin Song
Long He
Hongyan Yu
Gaofeng Liang
Keyun Zhu
Jinxian He
Cangchang Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740279

1,905 views

Review

Published on 09 Dec 2025

Immunometabolism and male reproductive function: linking inflammation, oxidative stress, and declining fertility

in Inflammation

Jiedong Zhou
Shian Hu
Yong Ouyang
Yucheng Kong
Min Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736492

2,291 views

Original Research

Published on 09 Dec 2025

Brain-infiltrated monocyte macrophages in a rat model of temporal lobe epilepsy: revisiting the pro-inflammatory paradigm

in Multiple Sclerosis and Neuroimmunology

Wanda Grabon
Nadia Gasmi
Anatole Lang
Anne Ruiz
Béatrice Georges
Victor Blot
Michaël Ogier
Sylvain Rheims
Fabrice P Navarro
Laurent Bezin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695856

1,377 views

49,931 articles

articles

A 41-marker 37-color full spectrum flow cytometry panel for the deep immunophenotyping of human peripheral and liver natural killer cells

Utility of blood DNA methylation and immune cell-type estimates to identify clinically relevant links between immunity and health conditions in a large cohort

MRI features and preliminary diagnostic assessment using large language models of cystic tumor progression mimicking radiation necrosis in brain metastasis patients treated with immunotherapy: case report

Metabolic reprogramming and immune regulation in acute myeloid leukemia

MRI-negative myelitis, especially after COVID-19: a case report and literature review

MicroRNAs orchestrating host and vector-borne protozoan interactions: bridging immune modulation and cross-species communication

Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis

Case Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies

Prognostic Significance of baseline systemic inflammation markers in PD-L1-negative advanced non-small cell lung cancer patients treated with the BRICS sequential regimen

Recent progress in pig-to-human kidney xenotransplantation

Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis of Leishmania infantum

Immune-mediated blood-brain barrier disruption after ischemic stroke: mechanisms and therapeutic targets

Multi-omics approach to dissect the significance of lipid metabolism in helper T cell subset

Efficacy and safety of immunotherapy rechallenge in second-line treatment after failure of first-line immune checkpoint inhibitors combined with chemotherapy in advanced gastric cancer: a retrospective study

Insomnia and anxiety: exploring their hidden effect on natural killer cells among young female adults

IgG4-related disease presenting with hypercalcemia: case report and mechanistic insights

Circulating PD-1+ effector memory T cells predict anti-PD-1 efficacy in advanced gastric cancer

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

Impact of celiac disease on patients with familial Mediterranean fever: a nationwide study based on the Türkiye database

A bibliometric analysis of vaccine research on Chikungunya virus: contributors, trends, and emerging frontiers

Neuronal autoantibodies associated with poorer neuropsychological and motor outcomes 6 months after stroke: Results from the PHYS-STROKE trial

Multiomics analysis demonstrated that TOPBP1 interacting checkpoint and Replication Regulator may serve as an immune-related biomarker indicative of poor prognosis in lung adenocarcinoma

Immunometabolism and male reproductive function: linking inflammation, oxidative stress, and declining fertility

Brain-infiltrated monocyte macrophages in a rat model of temporal lobe epilepsy: revisiting the pro-inflammatory paradigm