Frontiers in Immunology

Original Research

Published on 09 Dec 2025

Multiomics analysis demonstrated that TOPBP1 interacting checkpoint and Replication Regulator may serve as an immune-related biomarker indicative of poor prognosis in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Chengbin Lin
Ziyi Chen
Wenbin Song
Long He
Hongyan Yu
Gaofeng Liang
Keyun Zhu
Jinxian He
Cangchang Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740279

1,905 views

Review

Published on 09 Dec 2025

Immunometabolism and male reproductive function: linking inflammation, oxidative stress, and declining fertility

in Inflammation

Jiedong Zhou
Shian Hu
Yong Ouyang
Yucheng Kong
Min Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736492

2,291 views

Original Research

Published on 09 Dec 2025

Brain-infiltrated monocyte macrophages in a rat model of temporal lobe epilepsy: revisiting the pro-inflammatory paradigm

in Multiple Sclerosis and Neuroimmunology

Wanda Grabon
Nadia Gasmi
Anatole Lang
Anne Ruiz
Béatrice Georges
Victor Blot
Michaël Ogier
Sylvain Rheims
Fabrice P Navarro
Laurent Bezin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695856

1,377 views

Original Research

Published on 09 Dec 2025

TSC1 deficiency drives immune evasion in colorectal cancer via mTORC1-mediated dysregulation of PD-L1 sialylation

in Cancer Immunity and Immunotherapy

Xuemei Guan
Fengru Zhang
Yao Tang
Pengyu Bai
Wenyuan Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692210

1,608 views

Editorial

Published on 09 Dec 2025

Editorial: Bispecific antibodies and their conjugates in solid tumors and hematological malignancies

in Cancer Immunity and Immunotherapy

Mirosława Püsküllüoğlu
Renata Pacholczak-Madej

Frontiers in Immunology

doi 10.3389/fimmu.2025.1752360

647 views

Original Research

Published on 09 Dec 2025

Lyg1 deficiency aggravated LPS-induced chronic epididymal inflammation and sperm dysfunction in mouse

in Inflammation

XueXia Liu
YuXiao Zhang
JiaLu Wei
BenJiao Gong
XiaoXin Wang
FuJun Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699581

1,178 views

Original Research

Published on 09 Dec 2025

Metastatic organ count stratifies survival in immunotherapy-treated metastatic colorectal cancer: a retrospective cohort study

in Cancer Immunity and Immunotherapy

Hai-Yan Fu
Yi-Yang Zhang
Yan Wang
Jin-Shan Huang
Jia-Hao Tian
Na Wang
Kun-Hao Bai
Zhi-Qiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679041

1,005 views

Original Research

Published on 09 Dec 2025

B-1 cells contribute to increased total IgM and shape IgG autoreactivity profiles in Lyn-/- mice but are not a major source of lupus-associated pathogenic autoantibodies

in B Cell Biology

Kristina Ottens
Anne B. Satterthwaite

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721021

1,232 views

Review

Published on 09 Dec 2025

In vitro derivation of megakaryocytes and platelets from induced pluripotent stem cells: developmental foundations and translational perspectives

in Alloimmunity and Transplantation

Maciej Mazurek
Wojciech Młynarski
Dawid P. Grzela

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720048

1,782 views

Mini Review

Published on 09 Dec 2025

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

in Immunological Tolerance and Regulation

Xeni Beli
Nikolaos Savvopoulos
Dionysia Kefala
Memnon Lysandrou
Maria Liga
Alexandros Spyridonidis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716778

1,595 views

Mini Review

Published on 09 Dec 2025

Cancer-associated fibroblasts in cholangiocarcinoma: the central nexus of tumor-stroma crosstalk and therapeutic translation

in Cancer Immunity and Immunotherapy

Shaozhen Rui
Yuqi Liu
Yongqing Zhao
Xiaoliang Zhu
Shanhui Liao
Wence Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725948

1,615 views

Perspective

Published on 09 Dec 2025

Cross-talk between aging resilience pathways and autoimmunity onset

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Rahul Mittal
Danay Saavedra
Mannat Mittal
Khemraj Hirani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712575

1,761 views

Original Research

Published on 09 Dec 2025

Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes

in Cancer Immunity and Immunotherapy

Alice Burchett Darantiere
Hao Chen
Julian Najera
Scott Howard
Meenal Datta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626024

1,423 views
1 citation

Original Research

Published on 09 Dec 2025

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1

in Viral Immunology

Zhongwen Hu
Hossam Abdelrahman
Abdelrahman Elwy
Fei Kuang
Swati Dhiman
Shafaqat Ali
Marcel Marson
Lisa Holnsteiner
Thamer A. Hamdan
Justa Friebus-Kardash

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638403

2,563 views

Original Research

Published on 09 Dec 2025

The role of leptospiral proteins in immune evasion and inflammatory response stimulation in HEK293T cell monolayers

in Microbial Immunology

Igor R. M. Silva
Aline F. Teixeira
Ana L. T. O. Nascimento

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689798

1,052 views

Systematic Review

Published on 09 Dec 2025

The association between ankylosing spondylitis and the risk of venous thromboembolism: a meta-analysis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Quan Hu
Mei Mei
Ruihan Liu
Qiang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670965

1,413 views

Mini Review

Published on 09 Dec 2025

Perineural invasion as a neuro−immune niche in head and neck cancer: mechanisms of immune evasion and therapeutic implications

in Cancer Immunity and Immunotherapy

Simin Li
Hui Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719675

2,643 views
1 citation

Review

Published on 09 Dec 2025

Circular RNA in hepatocellular carcinoma: emerging therapeutic strategies

in Cancer Immunity and Immunotherapy

Gregor Jazbec
Tadeja Režen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722576

1,687 views

Original Research

Published on 09 Dec 2025

Modulation of TLR7, TYK2 and OAS1 expression during SARS-CoV-2 infection

in Viral Immunology

Estíbaliz Alegría-Carrasco
Marta Jaén-Castaño
Pablo Delgado-Wicke
Nelly D. Zurita-Cruz
Nuria Montes
Emilia Roy-Vallejo
Sara Fernández de Córdoba-Oñate
Ana Nicolao-Gómez
Rosa Carracedo-Rodríguez
Ana Marcos-Jiménez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713928

1,169 views

Original Research

Published on 09 Dec 2025

Organ-specific role of neutrophil extracellular traps in shaping the postoperative thrombo-inflammatory niche in pancreatic ductal adenocarcinoma: a multi-model machine learning and mechanistic study

in Cancer Immunity and Immunotherapy

Songping Cui
Di Wang
Shaocheng Lyu
Jincan Huang
Ren Lang
Jing Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728391

1,107 views

Editorial

Published on 09 Dec 2025

Editorial: Enhancing CAR T-cell therapy with imaging

in Vaccines and Molecular Therapeutics

Egesta Lopci
Dorine de Jong
Laurent Dercle

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705002

719 views

Review

Published on 09 Dec 2025

Emerging roles for methionine metabolism in immune cell fate and function

in Cancer Immunity and Immunotherapy

Shaojuan Liu
Xiaotian Tang
Min Huang
Jianian Tang
Yiwen Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701505

1,559 views

Review

Published on 09 Dec 2025

Chemokines and their receptors in oral squamous cell carcinoma: mechanisms, clinical significance, and therapeutic implications

in Cancer Immunity and Immunotherapy

Dandan Li
Shuangshuang Chen
Jiahao Ji
Zhenwu Wang
Han Zhou
Ziyi Liao
Qun Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689695

1,557 views

Original Research

Published on 09 Dec 2025

Cost-effectiveness analysis of toripalimab plus bevacizumab versus sorafenib as first-line treatment for advanced hepatocellular carcinoma in China

in Cancer Immunity and Immunotherapy

Zhengxiong Li
Jing He
Kai Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676293

1,457 views

49,958 articles

articles

Multiomics analysis demonstrated that TOPBP1 interacting checkpoint and Replication Regulator may serve as an immune-related biomarker indicative of poor prognosis in lung adenocarcinoma

Immunometabolism and male reproductive function: linking inflammation, oxidative stress, and declining fertility

Brain-infiltrated monocyte macrophages in a rat model of temporal lobe epilepsy: revisiting the pro-inflammatory paradigm

TSC1 deficiency drives immune evasion in colorectal cancer via mTORC1-mediated dysregulation of PD-L1 sialylation

Editorial: Bispecific antibodies and their conjugates in solid tumors and hematological malignancies

Lyg1 deficiency aggravated LPS-induced chronic epididymal inflammation and sperm dysfunction in mouse

Metastatic organ count stratifies survival in immunotherapy-treated metastatic colorectal cancer: a retrospective cohort study

B-1 cells contribute to increased total IgM and shape IgG autoreactivity profiles in Lyn-/- mice but are not a major source of lupus-associated pathogenic autoantibodies

In vitro derivation of megakaryocytes and platelets from induced pluripotent stem cells: developmental foundations and translational perspectives

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

Cancer-associated fibroblasts in cholangiocarcinoma: the central nexus of tumor-stroma crosstalk and therapeutic translation

Cross-talk between aging resilience pathways and autoimmunity onset

Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1

The role of leptospiral proteins in immune evasion and inflammatory response stimulation in HEK293T cell monolayers

The association between ankylosing spondylitis and the risk of venous thromboembolism: a meta-analysis

Perineural invasion as a neuro−immune niche in head and neck cancer: mechanisms of immune evasion and therapeutic implications

Circular RNA in hepatocellular carcinoma: emerging therapeutic strategies

Modulation of TLR7, TYK2 and OAS1 expression during SARS-CoV-2 infection

Organ-specific role of neutrophil extracellular traps in shaping the postoperative thrombo-inflammatory niche in pancreatic ductal adenocarcinoma: a multi-model machine learning and mechanistic study

Editorial: Enhancing CAR T-cell therapy with imaging

Emerging roles for methionine metabolism in immune cell fate and function

Chemokines and their receptors in oral squamous cell carcinoma: mechanisms, clinical significance, and therapeutic implications

Cost-effectiveness analysis of toripalimab plus bevacizumab versus sorafenib as first-line treatment for advanced hepatocellular carcinoma in China