Frontiers in Immunology

Case Report

Published on 08 Dec 2025

Challenging manifestations of ANCA-associated vasculitis treated with avacopan: two case reports

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Aglaia Chalkia
Anastasia Politi
Isavella Tryfonos
Christos Koutsianas
Harikleia Gakiopoulou
Dimitrios Vassilopoulos
Dimitrios Petras

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717889

1,473 views

Original Research

Published on 08 Dec 2025

A multi-omic machine learning approach deconstructs the role of amino acid metabolism in the immune microenvironment and prognosis of colon adenocarcinoma

in Cancer Immunity and Immunotherapy

Hua Zhong
Jiangdong Jin
Yi Zhang
Nuo Chen
Anya Liu
Chenfei Jiang
Wenbing Zhang
Zirui He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719555

1,166 views

Review

Published on 08 Dec 2025

Gut microbiome, a novel precision medicine biomarker for hepatocellular carcinoma

in Microbial Immunology

Pin-Jung Chen
Suzanne Devkota
Stephen Shiao
Andrew Hendifar
Ju Dong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568962

1,893 views

Original Research

Published on 08 Dec 2025

SCPEP1+ basal cells are associated with the remodeling of oxidative stress signaling networks in idiopathic pulmonary fibrosis

in Inflammation

Xiang Zhou
Tong Lu
Ran Xu
Chenghao Wang
Simiao Chen
Jing Chen
Xiaoyan Chang
Meifeng Li
Jiaxin Shi
Chengyu Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676086

2,192 views

Original Research

Published on 08 Dec 2025

Novel nanobody-161 binds tumor necrosis factor receptor 2 (TNFR2) to exert an anti-tumor effect but does not block TNFα-binding

in Cancer Immunity and Immunotherapy

Liang Huang
Chao Kong
Yuhao Hu
Michael Zhang
Shuangqi Li
Wanjing Wang
Hui Guan
Mei Ling Lim
Zhen Zhang
Wenhai Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694313

1,861 views

Original Research

Published on 08 Dec 2025

Multi-omics spatial characteristics of CD8+TRM cells in hepatocellular carcinoma and immunotherapy response prediction

in Cancer Immunity and Immunotherapy

Shipeng Li
Ju Ma
Xinqiang Li
Bingbing Qiao
Liancai Wang
Deyu Li
Hua Zhou
Haixu Xu
Jinzhen Cai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710741

1,775 views

Original Research

Published on 08 Dec 2025

WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface

in Immunological Tolerance and Regulation

Lingyu Chang
Jiani Guo
Xi Xue
Yang Yan
Xinyi Li
Weijie Zhao
Xiaoli Sun
Jiajia Chen
Meirong Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712898

1,739 views

Original Research

Published on 08 Dec 2025

Plastic cannulas mitigate arteriovenous fistula stenosis by suppressing the CFB-mediated inflammatory cascade

in Cytokines and Soluble Mediators in Immunity

Dongjuan Zhang
Deyang Kong
MingMing Zhao
Zhanci Ou
Lu Ma
Ka Qi
Yang Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715417

936 views

Original Research

Published on 08 Dec 2025

SHKBP1 is a target for sepsis: evidence from WGCNA and multiple machine learning algorithms

in Inflammation

Fan Wu
Junlin Lu
Yi Liu
Runquan Zhou
Wenjuan Li
Mingxing Wang
Shan Xu
Yuanhui Sheng
Dan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709188

1,053 views

Original Research

Published on 08 Dec 2025

The local cellular response to Human Papillomavirus focuses on basal layer restoration as visualized in situ by specific cellular neighborhoods near infected cells

in Viral Immunology

Roderick C. Slieker
Ziena Abdulrahman
Saskia Santegoets
Mariette I. E. van Poelgeest
Marij J. P. Welters
Sjoerd H. van der Burg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728629

1,595 views

Review

Published on 08 Dec 2025

Cancer stem cells in hepatocellular carcinoma: therapy resistance and emerging treatments

in Cancer Immunity and Immunotherapy

Dipesh Kumar Yadav
Rajesh Kumar Yadav
Alina Singh
Yi Huang
Dandan Bao
Zhangwei Yang
Hanzhang Huang
Yin Jiang
Pengwei Wang
Sisi Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704868

3,092 views

Review

Published on 08 Dec 2025

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

in Molecular Innate Immunity

Yichen Fan
Zihao Dong
Yufeng Wu
Hao Wen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692365

3,195 views

Review

Published on 08 Dec 2025

Multi-omics-driven biomarker discovery in autoimmune diseases: a comprehensive review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yi Zhang
Haofeng Xu
Lijuan Xu
Shasha Jiang
Yan Yu
Heping Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652211

1,897 views
2 citations

Case Report

Published on 08 Dec 2025

Successful ECMO support for cardiogenic shock induced by immune checkpoint inhibitor-associated myocarditis: a case report and literature review

in Cancer Immunity and Immunotherapy

Yujing Zhang
Ruiting Li
Yongxiang Jiang
Shengwen Sun
Yin Yuan
You Shang
Huaqing Shu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646040

1,537 views

Review

Published on 08 Dec 2025

JAK/STAT in human diseases: a common axis in immunodeficiencies and hematological disorders

in Primary Immunodeficiencies

Reda Djidjik
Lydia Lamara Mahammed
Lilya Meriem Berkani
Ines Allam
Alaa Hamidou Benmoussa
Merzak Gharnaout
Brahim Belaid

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669688

2,501 views

Original Research

Published on 08 Dec 2025

Whole transcriptome analysis and preliminary construction of ceRNA networks in obstetric antiphospholipid syndrome

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Lan Zhang
Tingting Dong
Xiaoyu Ji
Pengzheng Chen
Xietong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663849

1,097 views

Original Research

Accepted on 05 Dec 2025

GJA5 and ATP1A1 perturbations recapitulate inflammation-related beat irregularities in iPSC-based atrial myocardium tissue model

in Alloimmunity and Transplantation

Thomas Hutschalik
Albert Dasí
Leto L Riebel
Maury Wiendels
Frederikus Bakker
Lucas J.A.M. Beckers
Koen C. Kriege
Susanne M. Valster
Roland C.M. Vulders
Ozan Özgül

Frontiers in Immunology

558 views

Original Research

Published on 05 Dec 2025

Association of pharmacokinetic biomarkers with early immune recovery following HLA-haploidentical hematopoietic cell transplantation

in Alloimmunity and Transplantation

Guofang Shen
Timothy W. Synold
Shanzay Khan
David A. Horne
Christopher G. Kanakry
Ryotaro Nakamura

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694754

1,394 views

Original Research

Published on 05 Dec 2025

Novel ubiquitination-related biomarkers for Crohn’s disease identified by multi-omics study and experimental validation

in Inflammation

Jia Hu
Kai Nie
Xiaoyan Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687606

1,604 views

Brief Research Report

Published on 05 Dec 2025

HLA-vaccine transplantations for refractory leukemia: beyond double-unit cord blood

in Alloimmunity and Transplantation

Wing Leung
Michaela Su-Fern Seng
Thi Ngoc Anh Pham
Debbra Chong
Ah Moy Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726216

1,265 views

Original Research

Published on 05 Dec 2025

Screening and identification of human HPV18VLP neutralizing antibodies from women receiving HPV vaccine

in Cancer Immunity and Immunotherapy

Yaru Gu
Rui Zhang
Wenhao Wang
Jinrui Zhou
Bixia Liu
Yan Zheng
Houyi Zuo
Yexiang Du
Ying Wang
Renjian Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712231

1,204 views

Original Research

Published on 05 Dec 2025

Azacitidine as maintenance therapy in pediatric de novo acute myeloid leukemia

in Cancer Immunity and Immunotherapy

Chunping Wu
Chunxia Cai
Mei Li
Nainong Li
Yongzhi Zheng
Hao Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696125

1,427 views

Review

Published on 05 Dec 2025

Viral manipulation of the HLA class I antigen processing and presentation pathway

in Viral Immunology

Dominic S Nolan
Arwen F Altenburg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694498

1,839 views
1 citation

Original Research

Published on 05 Dec 2025

IL-1β, TNF-α, and IL-10 reduce cell viability and differentially alter biofilm structure and gene expression levels in Staphylococcus aureus USA 300

in Microbial Immunology

Adriana N. Zavala-Hernández
Christian Salto-Reyes
Alejandro Bravo-Patiño
Víctor M. Baizabal-Aguirre
Juan J. Valdez-Alarcón

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665397

1,285 views
1 citation

49,958 articles

articles

Challenging manifestations of ANCA-associated vasculitis treated with avacopan: two case reports

A multi-omic machine learning approach deconstructs the role of amino acid metabolism in the immune microenvironment and prognosis of colon adenocarcinoma

Gut microbiome, a novel precision medicine biomarker for hepatocellular carcinoma

SCPEP1+ basal cells are associated with the remodeling of oxidative stress signaling networks in idiopathic pulmonary fibrosis

Novel nanobody-161 binds tumor necrosis factor receptor 2 (TNFR2) to exert an anti-tumor effect but does not block TNFα-binding

Multi-omics spatial characteristics of CD8+TRM cells in hepatocellular carcinoma and immunotherapy response prediction

WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface

Plastic cannulas mitigate arteriovenous fistula stenosis by suppressing the CFB-mediated inflammatory cascade

SHKBP1 is a target for sepsis: evidence from WGCNA and multiple machine learning algorithms

The local cellular response to Human Papillomavirus focuses on basal layer restoration as visualized in situ by specific cellular neighborhoods near infected cells

Cancer stem cells in hepatocellular carcinoma: therapy resistance and emerging treatments

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

Multi-omics-driven biomarker discovery in autoimmune diseases: a comprehensive review

Successful ECMO support for cardiogenic shock induced by immune checkpoint inhibitor-associated myocarditis: a case report and literature review

JAK/STAT in human diseases: a common axis in immunodeficiencies and hematological disorders

Whole transcriptome analysis and preliminary construction of ceRNA networks in obstetric antiphospholipid syndrome

GJA5 and ATP1A1 perturbations recapitulate inflammation-related beat irregularities in iPSC-based atrial myocardium tissue model

Association of pharmacokinetic biomarkers with early immune recovery following HLA-haploidentical hematopoietic cell transplantation

Novel ubiquitination-related biomarkers for Crohn’s disease identified by multi-omics study and experimental validation

HLA-vaccine transplantations for refractory leukemia: beyond double-unit cord blood

Screening and identification of human HPV18VLP neutralizing antibodies from women receiving HPV vaccine

Azacitidine as maintenance therapy in pediatric de novo acute myeloid leukemia

Viral manipulation of the HLA class I antigen processing and presentation pathway

IL-1β, TNF-α, and IL-10 reduce cell viability and differentially alter biofilm structure and gene expression levels in Staphylococcus aureus USA 300