Frontiers in Immunology

Case Report

Published on 05 Dec 2025

Sequential pseudoallogeneic CAR20/22/19 T-cell therapy in patient with diffuse large B-cell lymphoma relapse after allo-HSCT: a case report

in Cancer Immunity and Immunotherapy

Yu Xiong
Shaomei Feng
Weicheng Liu
Qinlong Zheng
Biping Deng
Zhihui Li
Defeng Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687478

1,369 views

Systematic Review

Published on 05 Dec 2025

Risk factors of serofast state in patients undergoing syphilis: a meta-analysis of 17 cohort studies

in Microbial Immunology

Xin Zeng
Yuan Ouyang
Haoyun Wang
Linna Liu
Jiaxin Chen
Chengbin Zhu
Hong Huang
Jin Lin
Yanan Niu
Lan Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689904

1,624 views

Methods

Published on 05 Dec 2025

A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling

in Vaccines and Molecular Therapeutics

Valentina Di Salvatore
Federica Cernuto
Giulia Russo
Francesco Pappalardo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628583

2,382 views

Systematic Review

Published on 05 Dec 2025

Visualized knowledge mapping on the current research trends and emerging areas of neuroimmune modulation in the past two decades

in Multiple Sclerosis and Neuroimmunology

Xu Han
Yan Zhou
Xiyao Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671578

1,637 views

Original Research

Published on 05 Dec 2025

Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yiwen Jia
Yuntian Xia
Siyuan Chen
Guangming Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711302

1,241 views

Mini Review

Published on 05 Dec 2025

Next-generation vaccines against bacterial pathogens: mRNA and beyond

in Vaccines and Molecular Therapeutics

Huimin Chen
Ye Gu
Lei Song
Lihui Si

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709794

3,318 views

Original Research

Published on 05 Dec 2025

Integration of single-cell and bulk RNA-seq via machine learning to reveal ferroptosis- and lipid metabolism-driven immune landscape heterogeneity and predict immunotherapy response in colon cancer

in Cancer Immunity and Immunotherapy

Weifeng Wang
Xuanhao Lin
Chufa Zheng
Peixiu Yao
Dejin Xie
Yiyan Lin
Xiaozhong Wang
Weiqin Hong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699079

3,016 views

Case Report

Published on 05 Dec 2025

Massive lower gastrointestinal bleeding due to rupture of the superior mesenteric artery branch in Behçet’s disease: case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jing-fen Ye
Jian-long Guan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668761

1,225 views

Original Research

Published on 05 Dec 2025

An integrated immunoinformatic approach to design a novel multiepitope chimeric vaccine against Mycoplasma phocimorsus as a causal agent of bloodstream infections

in Vaccines and Molecular Therapeutics

Rongrong Yu
Ahmad Hasan
Muhammad Ibrahim
Wadi B. Alonazi
Li Bin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719398

1,220 views

Original Research

Published on 05 Dec 2025

Pig regulatory macrophages as a donor-derived immune modulators in xenotransplantation

in Immunological Tolerance and Regulation

Phu Chi Vu
Nhat Minh Dang
Vinh Phuoc Nguyen
Jonghyeok Jung
Joohyun Shim
Jeong Ho Hwang
Thi Xoan Hoang
Ik Jin Yun
Jae Young Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718937

1,876 views

Original Research

Published on 04 Dec 2025

Identification of a ubiquitin-binding domain protein, CD2AP, in predicting the prognosis and treatment of lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Qinjin Dai
Li Li
Mingfeng He
Jin Huang
Zhixiang Bo
Jishan Yin
Ying Ye

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726531

1,823 views

Original Research

Published on 04 Dec 2025

Advancing breast cancer biomarkers: a centromere-related gene signature integrated with single-cell analysis for prognostic prediction

in Cancer Immunity and Immunotherapy

Ye Lu
Shengbin Pei
Wenxiang Zhang
Zheng Qu
Xiangyu Wang
Siqing Liu
Hao Dong
Kan Yonemori
Yi Fang
Xiangyi Kong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678603

1,349 views

Review

Published on 04 Dec 2025

Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes

in Inflammation

Tingyu Yang
Jiapan An
Xinqi Xu
Bin Li
Zhimin Dou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717465

1,552 views

Original Research

Published on 04 Dec 2025

Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP–CD74 signaling and CXCL1 as diagnostic biomarkers

in Inflammation

Shan He
Fei Ma
Meng Yu
Jia-man Wu
You-ming Gong
Ke-wang Luo
Hong Chang
Qi Liang
Yan Ning

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707497

1,747 views

Review

Published on 04 Dec 2025

Epigenetic modifications in vascular inflammation

in Molecular Innate Immunity

Linyi Tang
Liyun Li
Yang Liu
Xin Zhang
Xinglin Wang
Zaiyong Zheng
Ping Yang
Haoran Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711579

1,484 views

Original Research

Published on 04 Dec 2025

Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

in Cancer Immunity and Immunotherapy

Lu Zou
Jingjing Chen
Xinyuan Bai
Yingxin Wang
Changchang Lu
Qiaoli Wang
Subiyinuer Tuerhong
Mengzhu Li
Qinghua Zheng
Fanyan Meng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693755

1,949 views

Review

Published on 04 Dec 2025

Unlocking the mystery of the PD-1/PD-L1 axis: beyond the checkpoint hype

in Cancer Immunity and Immunotherapy

Pierre-Hubert Desimpel
Pierre-Florent Petit
Benoit J Van den Eynde
Jingjing Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708873

2,907 views
1 citation

Review

Published on 04 Dec 2025

The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Manuel Ruiz-Pablos
Bruno Paiva
Aintzane Zabaleta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710571

7,128 views
1 citation

Brief Research Report

Published on 04 Dec 2025

A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Sarina C. Lowe
Madelaine Leitman
Noah Yan
Alexander Hoffmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707719

1,425 views

Mini Review

Published on 04 Dec 2025

Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle

in Inflammation

Ludmila Müller
Svetlana Di Benedetto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708280

4,600 views
1 citation

Original Research

Published on 04 Dec 2025

Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer

in Cancer Immunity and Immunotherapy

Clara Sánchez-Menéndez
Jaime Rodríguez-Pérez
Daniel Fuertes
Valentina Leguizamon
María González-Sanmartín
Elena Mateos
Miguel Cervero
Esther San José
Gonzalo Sanz
Edurne Álvaro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692382

2,457 views

Original Research

Published on 04 Dec 2025

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules

in Immunological Tolerance and Regulation

Saif Al-Haidar
Martin Schønemann-Lund
Mikkel Gybel-Brask
Jakob Stensballe
Lars Andresen
Pär I. Johansson
Morten H. Bestle
Søren Skov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656815

1,264 views

Review

Published on 04 Dec 2025

Temporal dynamics of IgG-mediated immunometabolic dysfunction: from acute obesity to chronic aging

in B Cell Biology

Sohyun Kim
Junghyun Kim
Hyung-Lae Lee
Man S. Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661391

1,990 views

Original Research

Published on 04 Dec 2025

Risk of uveitis among children with autoimmune diseases: a nationwide matched-cohort study of 3,643 cases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

De-Yi Liu
Hou-Ting Kuo
Bing-Qi Wu
Henry Bair
Peng-Tai Tien
Ning-Yi Hsia
Alan Y. Hsu
Yih‐Dih Cheng
Yow‐Wen Hsieh
Yu‐Han Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717805

1,345 views

49,989 articles

articles

Sequential pseudoallogeneic CAR20/22/19 T-cell therapy in patient with diffuse large B-cell lymphoma relapse after allo-HSCT: a case report

Risk factors of serofast state in patients undergoing syphilis: a meta-analysis of 17 cohort studies

A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and in silico gene expression profiling

Visualized knowledge mapping on the current research trends and emerging areas of neuroimmune modulation in the past two decades

Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity

Next-generation vaccines against bacterial pathogens: mRNA and beyond

Integration of single-cell and bulk RNA-seq via machine learning to reveal ferroptosis- and lipid metabolism-driven immune landscape heterogeneity and predict immunotherapy response in colon cancer

Massive lower gastrointestinal bleeding due to rupture of the superior mesenteric artery branch in Behçet’s disease: case report

An integrated immunoinformatic approach to design a novel multiepitope chimeric vaccine against Mycoplasma phocimorsus as a causal agent of bloodstream infections

Pig regulatory macrophages as a donor-derived immune modulators in xenotransplantation

Identification of a ubiquitin-binding domain protein, CD2AP, in predicting the prognosis and treatment of lung adenocarcinoma

Advancing breast cancer biomarkers: a centromere-related gene signature integrated with single-cell analysis for prognostic prediction

Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes

Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP–CD74 signaling and CXCL1 as diagnostic biomarkers

Epigenetic modifications in vascular inflammation

Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

Unlocking the mystery of the PD-1/PD-L1 axis: beyond the checkpoint hype

The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity

A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease

Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle

Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules

Temporal dynamics of IgG-mediated immunometabolic dysfunction: from acute obesity to chronic aging

Risk of uveitis among children with autoimmune diseases: a nationwide matched-cohort study of 3,643 cases