Frontiers in Immunology

Original Research

Published on 03 Dec 2025

Gut microbiota-driven dysbiosis of the SCFA-immune axis in pediatric allergic rhinitis-constipation comorbidity: mechanisms and synbiotic remodeling

in Microbial Immunology

WeiKeng Yang
Xiaojiao Zhang
Bin Wu
Binyu Ni
Hongbin Lin
Congfu Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639359

1,724 views

Original Research

Published on 03 Dec 2025

Multiplexed longitudinal analysis of the cellular and microbial dynamics of acute polymicrobial sepsis in mice

in Inflammation

Tori E. Peacock
Kenny Johnson
Abhinav R. Cheedipudi
Ahmed D. Mohammed
Ryan A. W. Ball
J. Hunter Cox
Savannah K. Pender
Amy Jolly
Kandy T. Velázquez
Jay Potts

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682451

1,660 views

Original Research

Published on 03 Dec 2025

In the diffuse large B-cell lymphoma microenvironment, autophagy genes are upregulated in pro-inflammatory macrophages and linked to BCL2 overexpression

in Cancer Immunity and Immunotherapy

Miguel Resanoa
Alba Delgado
Claudia Rodiño
Marina Villar
Ana Aiastui
Mounia S. Braza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676563

1,576 views

Original Research

Published on 03 Dec 2025

Impact of chronic social stress on molecular markers of skin regeneration during experimental excisional wounding

in Microbial Immunology

Lyudmyla Makyeyeva
Igor Belenichev
Olena Aliyeva
Oleksandr Frolov
Pavlo Petakh
Oleksandr Kamyshnyi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656214

1,462 views

Review

Published on 03 Dec 2025

Expanding the immunotherapy universe in extensive-stage small cell lung cancer: from chemoimmunotherapy backbone to next-wave combinations

in Cancer Immunity and Immunotherapy

Xiang Chi
Yan Dong
Lide Zhu
Di Su
Haolin Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693401

1,965 views
1 citation

Original Research

Published on 03 Dec 2025

Single-cell RNA sequencing reveals heterogeneity among AT2 epithelial cells in the lung adenocarcinoma microenvironment

in Cancer Immunity and Immunotherapy

Zimeng Cao
Xuefeng Bai
Jing Li
Jinru Cai
Gang Cao
Yuncai Xiao
Wei Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735459

1,969 views

Review

Published on 03 Dec 2025

Dual role of complement in neuronal repair

in Multiple Sclerosis and Neuroimmunology

Agnieszka Lukomska
Peter Ciesielski
Mariusz Z. Ratajczak
Magdalena Kucia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712452

1,787 views

Correction

Published on 03 Dec 2025

Correction: Platelet alloimmunization in transfusion-dependent thalassemia patients from Southern China (2014-2023)

in Alloimmunity and Transplantation

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1755852

503 views

Original Research

Published on 03 Dec 2025

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

in Molecular Innate Immunity

Soumitra Mohanty
John Kerr White
Yundi Yin
Taj Muhammad
Isak Demirel
Adam A. Strömstedt
Sunithi Gunasekera
Natalia Ferraz
Ulf Göransson
Annelie Brauner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705805

1,663 views

Correction

Published on 03 Dec 2025

Correction: Leukocyte dynamics in Cynomolgus monkeys following heterotopic heart allotransplantation under costimulation pathway blockade

in Alloimmunity and Transplantation

Gheorghe Braileanu
Agnes M. Azimzadeh
Tianshu Zhang
Lars Burdorf
Richard N. Pierson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1732897

651 views

Original Research

Published on 03 Dec 2025

IL-10 and IL-2R as combined predictors of intravenous immunoglobulin resistance in Kawasaki disease: a retrospective cohort study

in Cytokines and Soluble Mediators in Immunity

Hui-Ying Wang
Sun Chen
Chun Zhang
Ji-Hong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646502

1,158 views

Review

Published on 03 Dec 2025

Recent advances in targeting the cGAS–STING pathway for immunotherapy in orthopedic diseases

in Cancer Immunity and Immunotherapy

Feipeng Wu
Shan Hui
Dapeng Li
Guoqing Pan
Wenchao Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726423

3,105 views

Review

Published on 03 Dec 2025

Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications

in Systems Immunology

Aleksandra Szredzka
Anna Chwastowicz
Joanna Pergoł
Paweł Matryba

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697854

3,114 views

Original Research

Published on 03 Dec 2025

Variant-adapted COVID-19 vaccine boosters enhance humoral immunity and limit IgG4 accumulation in solid cancer patients

in Vaccines and Molecular Therapeutics

Chiara Piubelli
Matteo Valerio
Donato Zipeto
Elisa Orlandi
Sara Caldrer
Francesco Rizzolo
Katrine Barbero
Elisabetta Vezzelli
Natasha Gianesini
Sonia Zamboni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699177

1,627 views

Brief Research Report

Published on 03 Dec 2025

T-cell receptors that are k-binding have defined sequence features

in T Cell Biology

Hyunjin Park
Jonathan Krog
Brandon Carter
Pallavi A. Balivada
Emily M. Pogue
Samyuktha Anand
Michael E. Birnbaum
David K. Gifford

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621201

2,653 views

Original Research

Published on 03 Dec 2025

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

in Inflammation

Ya Zhang
Qian Tian
Yuan Zhu
Tianhui Wang
Yongchao Yu
Lan Wang
Lijuan Shao
Xiangang Mo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644135

1,578 views

Review

Published on 03 Dec 2025

COVID-19 vaccine-induced autoimmune hyperthyroidism: Graves’ disease

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Avaniyapuram Kannan Murugan
Ali S. Alzahrani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699210

8,380 views
1 citation

Original Research

Published on 03 Dec 2025

Decoding ascitic immunological niches with multi-modal machine learning reveals prognostic and chemoresistant determinants in ovarian cancer

in Cancer Immunity and Immunotherapy

Lin Yang
Tianhui He
Jing Wang
Xiaolan Zhang
Lin Zeng
Qinkun Sun
Yuelin Song
Yufei Nie
Xinran Gao
Chunliang Shang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698793

1,443 views

Mini Review

Published on 03 Dec 2025

Beyond the joints: mechanistic insights and multidisciplinary strategies for spondyloarthritis-associated uveitis

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Shuyue Pan
Ling Xiang
Zhi Cao
Zhi Yang
Rui-Juan Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715107

1,238 views

Clinical Trial

Published on 03 Dec 2025

Combination immunotherapy and anti-angiogenic therapy shows promising efficacy in NSCLC patients with recurrent or refractory brain metastases and negative driver genes

in Cancer Immunity and Immunotherapy

Liwei Sun
Bonian Chen
Bin Wang
Jinduo Li
Lin Li
Caijuan Tian
Hongbo Zhang
Pengfei Liu
Xiaomin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684759

1,997 views
1 citation

Original Research

Published on 02 Dec 2025

Identification and validation of prognostic genes and prognostic models associated with cutaneous melanoma and integrative stress response

in Cancer Immunity and Immunotherapy

Zhaoqi Zhang
Ying Wang
Wei Yin
Qingyang Lei
Yuqiao Fu
Yingzi Liang
Ruilei Li
Ke Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689103

1,740 views

Original Research

Published on 02 Dec 2025

Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration

in Inflammation

Hongxing Zhang
Bin Dai
Jiafeng Peng
Minglei Gao
Danyang Li
Xiaowei Xiang
Junchen Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671961

1,844 views

Correction

Published on 02 Dec 2025

Correction: From spheroids to organoids: next-generation models for CAR-T cell therapy research in solid tumors

in Cancer Immunity and Immunotherapy

Mégane Jassin
Alix Block
Laury Désiront
Louise Vrancken
Céline Grégoire
Frédéric Baron
Grégory Ehx
Thi Tham Nguyen
Jo Caers

Frontiers in Immunology

doi 10.3389/fimmu.2025.1738434

908 views

Mini Review

Published on 02 Dec 2025

Macrophages: their role in immunity and their relationship with fatty acids in health and disease

in Inflammation

Mayte Rueda-Munguía
Luis Alberto Luévano-Martínez
Gerardo García-Rivas
Elena Cristina Castillo
Omar Lozano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694892

2,395 views

49,989 articles

articles

Gut microbiota-driven dysbiosis of the SCFA-immune axis in pediatric allergic rhinitis-constipation comorbidity: mechanisms and synbiotic remodeling

Multiplexed longitudinal analysis of the cellular and microbial dynamics of acute polymicrobial sepsis in mice

In the diffuse large B-cell lymphoma microenvironment, autophagy genes are upregulated in pro-inflammatory macrophages and linked to BCL2 overexpression

Impact of chronic social stress on molecular markers of skin regeneration during experimental excisional wounding

Expanding the immunotherapy universe in extensive-stage small cell lung cancer: from chemoimmunotherapy backbone to next-wave combinations

Single-cell RNA sequencing reveals heterogeneity among AT2 epithelial cells in the lung adenocarcinoma microenvironment

Dual role of complement in neuronal repair

Correction: Platelet alloimmunization in transfusion-dependent thalassemia patients from Southern China (2014-2023)

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

Correction: Leukocyte dynamics in Cynomolgus monkeys following heterotopic heart allotransplantation under costimulation pathway blockade

IL-10 and IL-2R as combined predictors of intravenous immunoglobulin resistance in Kawasaki disease: a retrospective cohort study

Recent advances in targeting the cGAS–STING pathway for immunotherapy in orthopedic diseases

Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications

Variant-adapted COVID-19 vaccine boosters enhance humoral immunity and limit IgG4 accumulation in solid cancer patients

T-cell receptors that are k-binding have defined sequence features

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

COVID-19 vaccine-induced autoimmune hyperthyroidism: Graves’ disease

Decoding ascitic immunological niches with multi-modal machine learning reveals prognostic and chemoresistant determinants in ovarian cancer

Beyond the joints: mechanistic insights and multidisciplinary strategies for spondyloarthritis-associated uveitis

Combination immunotherapy and anti-angiogenic therapy shows promising efficacy in NSCLC patients with recurrent or refractory brain metastases and negative driver genes

Identification and validation of prognostic genes and prognostic models associated with cutaneous melanoma and integrative stress response

Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration

Correction: From spheroids to organoids: next-generation models for CAR-T cell therapy research in solid tumors

Macrophages: their role in immunity and their relationship with fatty acids in health and disease