Frontiers in Immunology | Antigen Presenting Cell Biology

Original Research

Published on 28 Aug 2024

Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity

in Antigen Presenting Cell Biology

Michel Siegel
Anna-Lena Bolender
Axel Ducret
Johannes Fraidling
Katharina Hartman
Cary M. Looney
Olivier Rohr
Timothy P. Hickling
Hubert Kettenberger
Martin Lechmann

Frontiers in Immunology

doi 10.3389/fimmu.2024.1406643

4,909 views
5 citations

Original Research

Published on 23 Aug 2024

Cellular stress increases DRIP production and MHC Class I antigen presentation

in Antigen Presenting Cell Biology

Natalie Pach
Michael Basler

Frontiers in Immunology

doi 10.3389/fimmu.2024.1445338

4,425 views
3 citations

Original Research

Published on 20 Aug 2024

Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics

in Antigen Presenting Cell Biology

Michel Siegel
Aman Padamsey
Anna-Lena Bolender
Patrick Hargreaves
Johannes Fraidling
Axel Ducret
Katharina Hartman
Cary M. Looney
Cristina Bertinetti-Lapatki
Olivier Rohr

Frontiers in Immunology

doi 10.3389/fimmu.2024.1406804

6,341 views
4 citations

Original Research

Published on 14 Aug 2024

Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development

in Antigen Presenting Cell Biology

Moe Tominaga
Tomofumi Uto
Tomohiro Fukaya
Shuya Mitoma
Dieter Riethmacher
Kunihiko Umekita
Yoshihiro Yamashita
Katsuaki Sato

Frontiers in Immunology

doi 10.3389/fimmu.2024.1200461

3,118 views
5 citations

Mini Review

Published on 06 Aug 2024

Evaluating in vivo approaches for studying the roles of thymic DCs in T cell development in mice

in Antigen Presenting Cell Biology

Yi Wang
Mark M. W. Chong

Frontiers in Immunology

doi 10.3389/fimmu.2024.1451974

2,716 views
1 citation

Original Research

Published on 26 Jun 2024

Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term

in Antigen Presenting Cell Biology

Nida Ozarslan
Joshua F. Robinson
Sirirak Buarpung
M. Yvonne Kim
Megan R. Ansbro
Jason Akram
Dennis J. Montoya
Moses R. Kamya
Abel Kakuru
Grant Dorsey

Frontiers in Immunology

doi 10.3389/fimmu.2024.1384361

4,158 views
2 citations

Original Research

Published on 24 Jun 2024

Anandamide modulation of monocyte-derived Langerhans cells: implications for immune homeostasis and skin inflammation

in Antigen Presenting Cell Biology

Zsófia Pénzes
Dorottya Horváth
Petra Molnár
Tünde Fekete
Kitti Pázmándi
Attila Bácsi
Attila Gábor Szöllősi

Frontiers in Immunology

doi 10.3389/fimmu.2024.1423776

5,477 views
8 citations

Original Research

Published on 06 Jun 2024

A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment

in Antigen Presenting Cell Biology

Juntao Chen
Renhui Chen
Jingang Huang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1372432

7,721 views
7 citations

Original Research

Published on 15 May 2024

The cholera toxin B subunit induces trained immunity in dendritic cells and promotes CD8 T cell antitumor immunity

in Antigen Presenting Cell Biology

Araceli Tepale-Segura
Julián A. Gajón
Samira Muñoz-Cruz
Octavio Castro-Escamilla
Laura C. Bonifaz

Frontiers in Immunology

doi 10.3389/fimmu.2024.1362289

8,801 views
15 citations

Original Research

Published on 08 May 2024

FASTMAP—a flexible and scalable immunopeptidomics pipeline for HLA- and antigen-specific T-cell epitope mapping based on artificial antigen-presenting cells

in Antigen Presenting Cell Biology

Luisa Weisbrod
Luigi Capriotti
Marco Hofmann
Valerie Spieler
Herbert Dersch
Bernd Voedisch
Peter Schmidt
Susanne Knake

Frontiers in Immunology

doi 10.3389/fimmu.2024.1386160

9,912 views
3 citations

Original Research

Published on 05 Apr 2024

The functional role of L-fucose on dendritic cell function and polarization

in Antigen Presenting Cell Biology

Chase Burton
Amirreza Bitaraf
Kara Snyder
Chaomei Zhang
Sean J. Yoder
Dorina Avram
Dongliang Du
Xiaoqing Yu
Eric K. Lau

Frontiers in Immunology

doi 10.3389/fimmu.2024.1353570

5,059 views
2 citations

Original Research

Published on 25 Mar 2024

Differences in F pocket impact on HLA I genetic associations with autoimmune diabetes

in Antigen Presenting Cell Biology

Xu Ren
A. W. Peshala Amarajeewa
M. D. Tharushika Jayasinghe
Malgorzata A. Garstka

Frontiers in Immunology

doi 10.3389/fimmu.2024.1342335

4,130 views

Original Research

Published on 20 Mar 2024

The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E

in Antigen Presenting Cell Biology

Simon Brackenridge
Nessy John
Klaus Früh
Persephone Borrow
Andrew J. McMichael

Frontiers in Immunology

doi 10.3389/fimmu.2024.1329032

5,473 views
5 citations

Original Research

Published on 16 Jan 2024

Evaluating NetMHCpan performance on non-European HLA alleles not present in training data

in Antigen Presenting Cell Biology

Thomas Karl Atkins
Arnav Solanki
George Vasmatzis
James Cornette
Marc Riedel

Frontiers in Immunology

doi 10.3389/fimmu.2023.1288105

6,037 views
8 citations

Original Research

Published on 11 Jan 2024

Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis

in Antigen Presenting Cell Biology

Victoria R. Adams
Leonard B. Collins
Taufika Islam Williams
Jennifer Holmes
Paul Hess
Hannah M. Atkins
Grace Scheidemantle
Xiaojing Liu
Mareca Lodge
Aaron J. Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2023.1302006

6,038 views
7 citations

Correction

Published on 06 Dec 2023

Corrigendum: Modulation of immune response by nanoparticle-based immunotherapy against food allergens

in Antigen Presenting Cell Biology

Sivadas Swathi Krishna
Syeda Ayesha Farhana
Ardra T.P.
Shalam M. Hussain
Vidya Viswanad
Muhammed Hassan Nasr
Ram Kumar Sahu
Jiyauddin Khan

Frontiers in Immunology

doi 10.3389/fimmu.2023.1332906

1,291 views

Original Research

Published on 29 Nov 2023

Identification of dendritic cell precursor from the CD11c+ cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand

in Antigen Presenting Cell Biology

Hyunju In
Ji Soo Park
Hyun Soo Shin
Seul Hye Ryu
Moah Sohn
Wanho Choi
Sejung Park
Soomin Hwang
Jeyun Park
Lihua Che

Frontiers in Immunology

doi 10.3389/fimmu.2023.1179981

7,420 views
6 citations

Original Research

Published on 10 Nov 2023

Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development

in Antigen Presenting Cell Biology

M. Violet Lee
Ola M. Saad
Sylvia Wong
Jason LaMar
Lynn Kamen
Ben Ordonia
Rachel Melendez
Azadeh Hassanzadeh
Shan Chung
Surinder Kaur

Frontiers in Immunology

doi 10.3389/fimmu.2023.1295285

7,430 views
12 citations

Original Research

Published on 06 Nov 2023

A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation

in Antigen Presenting Cell Biology

Johanna Maria Hölken
Katja Friedrich
Marion Merkel
Nelli Blasius
Ursula Engels
Timo Buhl
Karsten Rüdiger Mewes
Lars Vierkotten
Nicole Elisabeth Teusch

Frontiers in Immunology

doi 10.3389/fimmu.2023.1276151

9,588 views
21 citations

Original Research

Published on 13 Oct 2023

An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture

in Antigen Presenting Cell Biology

Shintaro Matsuba
Hiroki Ura
Fumiji Saito
Chie Ogasawara
Shigetaka Shimodaira
Yo Niida
Nobuyuki Onai

Frontiers in Immunology

doi 10.3389/fimmu.2023.1264609

5,406 views
2 citations

Original Research

Published on 22 Aug 2023

The dual role of cannabidiol on monocyte-derived dendritic cell differentiation and maturation

in Antigen Presenting Cell Biology

Zsófia Pénzes
Shahrzad Alimohammadi
Dorottya Horváth
Attila Oláh
Balázs István Tóth
Attila Bácsi
Attila Gábor Szöllősi

Frontiers in Immunology

doi 10.3389/fimmu.2023.1240800

7,980 views
9 citations

Review

Published on 17 Aug 2023

Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS

in Antigen Presenting Cell Biology

Collin Laaker
Cameron Baenen
Kristóf G. Kovács
Matyas Sandor
Zsuzsanna Fabry

Frontiers in Immunology

doi 10.3389/fimmu.2023.1233908

11,783 views
24 citations

Original Research

Published on 28 Jul 2023

Combining deep mutational scanning to heatmap of HLA class II binding of immunogenic sequences to preserve functionality and mitigate predicted immunogenicity

in Antigen Presenting Cell Biology

Coline Sivelle
Raphael Sierocki
Youen Lesparre
Aurore Lomet
Wagner Quintilio
Steven Dubois
Evelyne Correia
Ana Maria Moro
Bernard Maillère
Hervé Nozach

Frontiers in Immunology

doi 10.3389/fimmu.2023.1197919

4,585 views
6 citations

Review

Published on 15 Jun 2023

Chaperone function in antigen presentation by MHC class I molecules—tapasin in the PLC and TAPBPR beyond

in Antigen Presenting Cell Biology

David H. Margulies
Jiansheng Jiang
Javeed Ahmad
Lisa F. Boyd
Kannan Natarajan

Frontiers in Immunology

doi 10.3389/fimmu.2023.1179846

7,771 views
13 citations

583 articles

articles

Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity

Cellular stress increases DRIP production and MHC Class I antigen presentation

Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics

Crucial role of dendritic cells in the generation of anti-tumor T-cell responses and immunogenic tumor microenvironment to suppress tumor development

Evaluating in vivo approaches for studying the roles of thymic DCs in T cell development in mice

Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term

Anandamide modulation of monocyte-derived Langerhans cells: implications for immune homeostasis and skin inflammation

A pan-cancer single-cell transcriptional analysis of antigen-presenting cancer-associated fibroblasts in the tumor microenvironment

The cholera toxin B subunit induces trained immunity in dendritic cells and promotes CD8 T cell antitumor immunity

FASTMAP—a flexible and scalable immunopeptidomics pipeline for HLA- and antigen-specific T-cell epitope mapping based on artificial antigen-presenting cells

The functional role of L-fucose on dendritic cell function and polarization

Differences in F pocket impact on HLA I genetic associations with autoimmune diabetes

The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E

Evaluating NetMHCpan performance on non-European HLA alleles not present in training data

Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis

Corrigendum: Modulation of immune response by nanoparticle-based immunotherapy against food allergens

Identification of dendritic cell precursor from the CD11c+ cells expressing high levels of MHC class II molecules in the culture of bone marrow with FLT3 ligand

Development of a semi-automated MHC-associated peptide proteomics (MAPPs) method using streptavidin bead-based immunoaffinity capture and nano LC-MS/MS to support immunogenicity risk assessment in drug development

A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation

An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture

The dual role of cannabidiol on monocyte-derived dendritic cell differentiation and maturation

Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS

Combining deep mutational scanning to heatmap of HLA class II binding of immunogenic sequences to preserve functionality and mitigate predicted immunogenicity

Chaperone function in antigen presentation by MHC class I molecules—tapasin in the PLC and TAPBPR beyond