Frontiers in Immunology | Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Review

Published on 17 Sep 2025

Innovations in immunotherapy for autoimmune diseases: recent breakthroughs and future directions

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

May A. Alsayb

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647066

7,006 views
2 citations

Clinical Trial

Published on 17 Sep 2025

B cell and anti-PLA2R antibody-guided rituximab therapy in idiopathic membranous nephropathy: a prospective multi-center cohort study in the East Coastal Region of China

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yili Xu
Liang Wang
Chunming Jiang
Dong Sun
Min Yang
Jin Liu
Xiaobin Liu
Cheng Wan
Caixia Liu
Bo Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633532

2,586 views

Brief Research Report

Published on 17 Sep 2025

Cell-free DNA integrity and complement C4d as novel liquid biopsy biomarkers for paraneoplastic and non-paraneoplastic autoimmune encephalitis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Aigli G. Vakrakou
Maria-Evgenia Brinia
Anastasia Cheiraki
Anastasia Alexaki
Anna Papadopoulou
Giannis Vatsellas
Vasileia Kokala Dimitropoulou
Anastasia Derventzi
Vassilios C. Constantinides
Panos Stathopoulos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640532

1,885 views

Editorial

Published on 16 Sep 2025

Editorial: Community series in the role of monocytes/macrophages in autoimmunity and autoinflammation, volume II

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Naoki Iwamoto
Atsushi Kawakami
Sachiko Miyake
Keishi Fujio

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699650

1,173 views

Review

Published on 15 Sep 2025

Clinical heterogeneity and prognostic determinants in rheumatoid vasculitis: a systematic analysis of organ-specific manifestations, therapeutic outcomes, and biomarker correlations

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Dongyi Wang
Le Lu
Junyi Shen
Yuping Zhang
Muzi Li
Wei Shang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628504

1,723 views

Case Report

Published on 15 Sep 2025

Case Report: A rare case of complex Behçet’s disease complicated with acute tubular necrosis and IgA nephropathy, coexists with myelodysplastic syndrome, trisomy 8 and intestinal involvement

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Peipei Zhang
Wen Zhang
Hong Xia
Zhenliang Fan
Junfen Fan
Hongzhen Ma
Chunli Zhang
Shuyan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618495

2,111 views

Case Report

Published on 15 Sep 2025

DKA with negative DM-autoantibodies, complicated by GBS and RESLES: a case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Nan Tian
Yanwen Yang
Qiang Liu
Zeli Ma
Ying Wang
Xuan Li
Xu Wang
Yanzi Jin
Rong Chen
Yajun Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597365

1,769 views

Original Research

Published on 15 Sep 2025

Morphological and quantitative CT features of anterior mediastinal lesions in TAFRO syndrome and idiopathic multicentric Castleman disease

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Lamiaa Mohamed
Masataka Umeda
Shin Tsutsui
Ryo Toya
Ayaka Umetsu
Mizuna Otsuka
Yushiro Endo
Toshimasa Shimizu
Shoichi Fukui
Remi Sumiyoshi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656489

1,462 views

Case Report

Published on 12 Sep 2025

Telitacicept as a novel B cell-targeted therapy in autoimmune encephalitis: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Zhishan Jiang
Huafeng Liang
Sheng Chen
Qinming Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640790

2,395 views

Case Report

Published on 12 Sep 2025

Case Report: Psychogenic purpura in a uremic patient on peritoneal dialysis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Lin Zhang
Hanqing Zhang
Yuetong Zhao
Tao Zhang
Zhengjie Zhu
Yanheng Qiao
Yongming Tian
Hang Su
Jie Li
Bo Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625126

1,360 views

Editorial

Published on 12 Sep 2025

Editorial: Cellular and molecular regulators in non-neoplastic immune-mediated diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Noha M. Elemam
Iman M. Talaat
Omar A. El Meligy
Jennifer E. Hundt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694308

1,105 views

Review

Published on 12 Sep 2025

RIPK1 signaling pathways: implications for autoimmune and neuroinflammatory diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Abigail Pajulas
Jonathan T. Sims
Eric P. Hanson
Andrew C. Vendel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642593

3,184 views

Original Research

Published on 12 Sep 2025

Monoclonal immunoglobulins on red blood cells: a potential supplementary diagnostic indicator for monoclonal gammopathies

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Benxia Bing
Xiaowei Yang
Chenghua Wang
Liang Xu
Shiqing Cheng
Yun Liu
Qiuhan Wang
Chunjuan Zhai
Bing Zhao
Rong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636162

1,233 views

Case Report

Published on 12 Sep 2025

Case Report: Subacute combined degeneration of the spinal cord mimic accompanying adaptor protein-3B2-IgG

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Ying Liu
Guo-Hui Gao
Jie Lin
Chong Sun
Yan-Yin Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598033

1,559 views
1 citation

Original Research

Published on 12 Sep 2025

Isolated C3 hypocomplementemia as an early predictor of chronic kidney disease in lupus nephritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Simeone Andrulli
Lucio Manenti
Francesco Reggiani
Isabella Pisani
Domenico Giannese
Gisella Vischini
Giovanni Valsecchi
Giulia Godeas
Giuseppe Gigliotti
Pasquale Esposito

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655825

2,958 views
1 citation

Review

Published on 11 Sep 2025

Spontaneous remission in primary membranous nephropathy: mechanisms, predictive factors, and implications for personalized management

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Mengqi Wu
Yanhao Chen
Zixin He
Youping Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651810

2,538 views
1 citation

Case Report

Published on 11 Sep 2025

Diagnosing Rickettsia felis infection with Metagenomic Next-Generation Sequencing (mNGS) in a patient with ankylosing spondylitis: a case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Mengyao Liu
Yang Cheng
Xinchang Wang
Zhaochun He
Kepeng Yang
Kai Chen
Yongsheng Fan
Weijie Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643599

1,925 views
1 citation

Review

Published on 11 Sep 2025

Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Siyu Liang
Lei Wan
Siyu Wang
Mengyu Zhang
Ying Wang
Wenwen Min
Yu Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633752

1,961 views

Case Report

Published on 10 Sep 2025

Overlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and mixed connective tissue disease: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Ziyu Wang
Ling Wu
Zhihao Zhang
Chenyang Zhang
Ertao Jia
Hongling Geng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644259

2,077 views

Case Report

Published on 10 Sep 2025

Induced pemphigus erythematosus after treatment for plaque psoriasis with secukinumab: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Fengming Hu
Hong Peng
Jian Gong
Xiaohua Tao
Xi Wang
Jianwei Bao
Pingxiu He
Lismin Dirwanto
Mingqiang Liu
Hongbing Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612422

2,337 views
2 citations

Original Research

Published on 09 Sep 2025

Artemisinin derivatives modulate KEAP1-NRF2-xCT pathway to alleviate Sjögren’s disease: insights from scRNA-seq and systems biology

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yong Luo
Liuting Zeng
Yanan Wang
Qianyue Yang
Chang Liu
Xiaojun Tang
Genhong Yao
Lingyun Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626230

4,094 views

Case Report

Published on 09 Sep 2025

Case Report: Life-threatening overlap of hemophagocytic syndrome and atypical hemolytic uremic syndrome in a patient with autoimmune polyglandular syndrome type 1 successfully treated with targeted immunotherapy

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Emma Coppola
Giuliana Giardino
Roberta Romano
Donatella Capalbo
Paola Italiani
Diana Boraschi
Antonio De Rosa
Elisabetta Toriello
Annateresa Palatucci
Valentina Rubino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667000

2,066 views

Case Report

Published on 09 Sep 2025

Anti-contactin-1 autoimmune nodopathy with thymoma: case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Takumi Tashiro
Hidenori Ogata
Motoi Kuwahara
Haruo Nishijima
Kenichiro Nogami
Takahiro Yamaguchi
Hitoshi Hayashida
Guzailiayi Maimaitijiang
Ryo Yamasaki
Jun-ichi Kira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662299

2,266 views

Original Research

Published on 09 Sep 2025

Increased risk of antiphospholipid syndrome in patients with psoriasis: a retrospective cohort study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Qian Wang
Ran Cui
Yu Du
Yu-Hsun Wang
James Cheng-Chung Wei
Sheng-Ming Dai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620768

2,098 views

2,002 articles

articles

Innovations in immunotherapy for autoimmune diseases: recent breakthroughs and future directions

B cell and anti-PLA2R antibody-guided rituximab therapy in idiopathic membranous nephropathy: a prospective multi-center cohort study in the East Coastal Region of China

Cell-free DNA integrity and complement C4d as novel liquid biopsy biomarkers for paraneoplastic and non-paraneoplastic autoimmune encephalitis

Editorial: Community series in the role of monocytes/macrophages in autoimmunity and autoinflammation, volume II

Clinical heterogeneity and prognostic determinants in rheumatoid vasculitis: a systematic analysis of organ-specific manifestations, therapeutic outcomes, and biomarker correlations

Case Report: A rare case of complex Behçet’s disease complicated with acute tubular necrosis and IgA nephropathy, coexists with myelodysplastic syndrome, trisomy 8 and intestinal involvement

DKA with negative DM-autoantibodies, complicated by GBS and RESLES: a case report and literature review

Morphological and quantitative CT features of anterior mediastinal lesions in TAFRO syndrome and idiopathic multicentric Castleman disease

Telitacicept as a novel B cell-targeted therapy in autoimmune encephalitis: a case report

Case Report: Psychogenic purpura in a uremic patient on peritoneal dialysis

Editorial: Cellular and molecular regulators in non-neoplastic immune-mediated diseases

RIPK1 signaling pathways: implications for autoimmune and neuroinflammatory diseases

Monoclonal immunoglobulins on red blood cells: a potential supplementary diagnostic indicator for monoclonal gammopathies

Case Report: Subacute combined degeneration of the spinal cord mimic accompanying adaptor protein-3B2-IgG

Isolated C3 hypocomplementemia as an early predictor of chronic kidney disease in lupus nephritis

Spontaneous remission in primary membranous nephropathy: mechanisms, predictive factors, and implications for personalized management

Diagnosing Rickettsia felis infection with Metagenomic Next-Generation Sequencing (mNGS) in a patient with ankylosing spondylitis: a case report and literature review

Crossing the metabolic homeostasis divide: panoramic decoding of therapeutic targets for metabolic-inflammatory crosstalk in rheumatoid arthritis

Overlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and mixed connective tissue disease: a case report

Induced pemphigus erythematosus after treatment for plaque psoriasis with secukinumab: a case report

Artemisinin derivatives modulate KEAP1-NRF2-xCT pathway to alleviate Sjögren’s disease: insights from scRNA-seq and systems biology

Case Report: Life-threatening overlap of hemophagocytic syndrome and atypical hemolytic uremic syndrome in a patient with autoimmune polyglandular syndrome type 1 successfully treated with targeted immunotherapy

Anti-contactin-1 autoimmune nodopathy with thymoma: case report and literature review

Increased risk of antiphospholipid syndrome in patients with psoriasis: a retrospective cohort study