Frontiers in Immunology | Cancer Immunity and Immunotherapy

Case Report

Accepted on 15 Aug 2025

Durable complete response to antigen-specific cytotoxic T lymphocyte (ACTL) therapy in advanced EGFR-TKI resistant lung adenocarcinoma: a case of adoptive cellular immunotherapy overcoming acquired targeted resistance

in Cancer Immunity and Immunotherapy

Chenghao Fu
Bian Chengyu
Weiyou Zhu
昊楠杜
Linrui Han
Jian Zhu
Jun Wang
Lei Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637165

210 views

Original Research

Accepted on 15 Aug 2025

Integrative Single-Cell and Machine Learning Analysis Predicts Lactylation-Driven Therapy Resistance in Prostate Cancer: A Molecular Docking and Experiments-Validated Framework for Treatment Optimization

in Cancer Immunity and Immunotherapy

Zhiyu Liu
Juan Wang
Yuqi Li
Yang Zeng
Qilong Wu
Xinyao Zhu
Tao Zhou
Qingfu Deng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647384

191 views

Original Research

Accepted on 15 Aug 2025

Disrupting β-Catenin/BCL9 Interaction with a Peptide Prodrug Boosts Immunotherapy in Colorectal Cancer

in Cancer Immunity and Immunotherapy

Peili Wang
Xiao Shang
Jingmei Wang
Weiming You
Yu Yao
Xiaoqiang Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662385

Review

Accepted on 15 Aug 2025

Characteristics of the Tumor Microenvironment and Potential Immunotherapy Strategies in Renal Cell Carcinoma

in Cancer Immunity and Immunotherapy

Hui Wen
Shi Zheng
Xiaoqin Zhu
Ling Wang
Dongping Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643533

Review

Published on 15 Aug 2025

Immune checkpoints in immune response to glioma: two sides of the same coin

in Cancer Immunity and Immunotherapy

Oxana Musatova
Vikas Kumar
Konstantin Vinogradov
Yury Rubtsov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639521

357 views

Original Research

Published on 15 Aug 2025

PU.1 upregulation is linked to improved prognosis in non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Katja Hohenberger
Denis I. Trufa
Arndt Hartmann
Susanne Mittler
Sonja Trump
Horia Sirbu
Susetta Finotto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604237

248 views

Review

Published on 15 Aug 2025

Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities

in Cancer Immunity and Immunotherapy

Xin Lai
Caizhi Li
Xinglinzi Tang
Xinyi Luo
Feiyan Wu
Yuhong Liang
Bihui Huang
Hang Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652398

497 views

Review

Published on 15 Aug 2025

CAR T cell therapy for central nervous system solid tumors: current progress and future directions

in Cancer Immunity and Immunotherapy

Yaroslav Kaminskiy
Vitaly Degtyarev
Alexey Stepanov
Michael Maschan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600403

453 views

Original Research

Published on 15 Aug 2025

The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target

in Cancer Immunity and Immunotherapy

Yunpeng Zou
Jianning Kang
Shaopeng Zhu
Xuechen Ren
Zheng Li
Jiayao Niu
Xuanzhe Qin
Hongbo Li
Lu Xiang
Wei Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651858

412 views

Review

Accepted on 14 Aug 2025

New dimensions of PD-1/PD-L1 inhibitor combination therapy in cancer treatment: current advances and future perspectives

in Cancer Immunity and Immunotherapy

Cheng Tong
Yue Wu
Renzhao Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616872

137 views

Original Research

Accepted on 14 Aug 2025

Physicochemical and biological characterization of a bispecific antibody in a CrossMab/KIH format that targets EGFR and VEGF-A

in Cancer Immunity and Immunotherapy

Safiat Ayinde
Shraboni Dutta
Nishant Mohan
Wen Jin Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659966

117 views

Correction

Accepted on 14 Aug 2025

Case Report: CAR-T therapy for primary cerebellar ALK-negative anaplastic large cell lymphoma

in Cancer Immunity and Immunotherapy

Zhongqing Zou
Sihan Lai
Hai Yi
Qian Zhang
Hao Yao
Hui Yang
Ling Zhang
ALEX H CHANG
Yi Su
Jin Rao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674954

128 views

Review

Accepted on 14 Aug 2025

Decoding Paraneoplastic Neuromyelitis Optica: A Multi-Omics Investigation of Tumor-Driven T and B Cell Dynamics

in Cancer Immunity and Immunotherapy

Wenjing Huang
Ruyu Lin
Xianyi Zeng
Hai Wang
Jichun Yan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665688

Original Research

Accepted on 14 Aug 2025

Safety and clinical outcomes of orelabrutinib, lenalidomide plus sintilimab for relapsed/refractory diffuse large B-cell lymphoma

in Cancer Immunity and Immunotherapy

Lingling Wang
Yongfen Huang
Dan Xu
Xiaoyong Wang
Hailiang Chu
Chunling Wang
Hao Xu
Wei Sang
Yuexin Cheng
Yuqing Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629224

Original Research

Accepted on 14 Aug 2025

Characterization of cancer-related fibroblasts (CAFs) in bladder cancer and construction of CAFs-based bladder cancer classification: insights from single-cell and multi-omics analysis

in Cancer Immunity and Immunotherapy

Zhan Wang
Zhaokai Zhou
Shuai Yang
Zhengrui Li
Run Shi
Ruizhi Wang
Kui Liu
Xiaojuan Tang
Qi Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580986

103 views

Original Research

Accepted on 14 Aug 2025

Liquid-liquid phase separation in Gastric Cancer: Identifying Novel Biomarkers and Therapeutic Targets through Gene Signature Analysis

in Cancer Immunity and Immunotherapy

Xianhui Wen
Miaomiao Cui
Junhua Zhang
Hai Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620390

116 views