Frontiers in Immunology | Cancer Immunity and Immunotherapy

Systematic Review

Accepted on 13 Feb 2026

Neoadjuvant Chemoradiotherapy With or Without PD-1 Inhibitors in MMR‑Proficient Non‑Metastatic Rectal Cancer: A Meta-Analysis of Randomized Controlled Trials

in Cancer Immunity and Immunotherapy

Yuegang Li
Chengcheng Han
Jianqiang Tang

Frontiers in Immunology

Editorial

Accepted on 13 Feb 2026

Editorial: Immuno-metabolic Approaches for the Treatment of Hepatobiliary and Pancreatic Tumors

in Cancer Immunity and Immunotherapy

Yuanxia Han
Luyu Yang
Jianwei Xu
Hengrui Liu
Ran Wei

Frontiers in Immunology

Case Report

Accepted on 13 Feb 2026

Sintilimab-Induced Toxic Epidermal Necrolysis Complicated in Advanced Gastric Cancer: A Case Report and Literature Review

in Cancer Immunity and Immunotherapy

Qi Zhao
Rui-Ke Cao
Hai-Peng Zou
Rui-Bin Wang
Ling-Xia Yu
Wei Zhang
Li-Na Wang
Yandong Miao

Frontiers in Immunology

Original Research

Accepted on 13 Feb 2026

Occupational Silica Exposure Drives Systemic Immune Dysregulation and Tumor Microenvironment Susceptibility: Evidence from a Real-World Study

in Cancer Immunity and Immunotherapy

Hao Gao
Hui Zhang
Luo Qiang
Jingyi Zhao
Liu Baishan

Frontiers in Immunology

126 views

Correction

Published on 13 Feb 2026

Correction: LncRNAs in tumor metabolic reprogramming and tumor microenvironment remodeling

in Cancer Immunity and Immunotherapy

Jianhang Jiao
Yangzhi Zhao
Qimei Li
Shunzi Jin
Zhongshan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1800183

182 views

Review

Published on 13 Feb 2026

Reprogramming the immunosuppressive breast cancer microenvironment: integrating cellular, metabolic, and stromal targets for rational immunotherapy

in Cancer Immunity and Immunotherapy

Chang Ma
Hoon Koon Teoh
Yang Zhao
Yifan Wang
Jun Zhao
Yan Liu
Chen Zhao
Hooi Tin Ong

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760782

157 views

Case Report

Published on 13 Feb 2026

Daratumumab-based salvage therapy enables umbilical cord blood transplantation in multiline refractory, elderly T-lymphoblastic lymphoma: a case report

in Cancer Immunity and Immunotherapy

Qian Yang
Lei Yang
Ping Cai
Yong-hui Ji
Jing-dong Zhou
Jun Qian

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743398

213 views

Case Report

Published on 13 Feb 2026

Subacute liver failure caused by immunotherapy in a patient with gastric cancer was improved after multimodal treatment with artificial liver combined with liver-protective drugs: a case report

in Cancer Immunity and Immunotherapy

Yueer Wang
Yanfei Wen
Yuxin Jiang
Chen Li
Haiyan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1755661

343 views

Original Research

Published on 13 Feb 2026

Spatial transcriptomics reveals the mechanistic role of lactate metabolism in the pancreatic ductal adenocarcinoma microenvironment

in Cancer Immunity and Immunotherapy

Fan Gao
Zhe Tang
Jie Lian
Luting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743187

322 views

Case Report

Published on 13 Feb 2026

Born with two faces: sequential DLBCL, NOS and TFHL-AI with TET2 mutation – a case report

in Cancer Immunity and Immunotherapy

Qing Li
Shishuo Dai
Chenlu Yang
Weiping Liu
Yu Wu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1698958

183 views

Original Research

Published on 13 Feb 2026

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

in Cancer Immunity and Immunotherapy

Morgane Peroz
Nicolas Roussot
Alis Ilie
David Rageot
Valentin Derangere
Caroline Truntzer
François Ghiringhelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1750816

217 views

Original Research

Published on 13 Feb 2026

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

in Cancer Immunity and Immunotherapy

Yiyuan Cui
Sicong Li
Zhibin Wu
Yue Jin
Jingjie Yu
Yufan Chen
Jiayang Chen
Jinyuan Chang
Yijing Yan
Xinyu Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1685902

184 views

Original Research

Accepted on 12 Feb 2026

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

in Cancer Immunity and Immunotherapy

Genshen Zhong
Biao Liu
Xue Gong
Qi Wang
Shuyin Zheng
Xinyu Luo
Xingya Zhang
Biliang Hu
Minna Wu
Zhiguo Chen

Frontiers in Immunology

162 views

Original Research

Accepted on 12 Feb 2026

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

in Cancer Immunity and Immunotherapy

Katarzyna Węgierek-Ciura
Agnieszka Szczygieł
Anna Rudawska
Jagoda Mierzejewska
Joanna Rossowska
Bożena Szermer-Olearnik
Marta Świtalska
Tomasz Goszczynski
Elżbieta Pajtasz-Piasecka

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

in Cancer Immunity and Immunotherapy

Xiaohua Zheng
Yutao Zou
Ting Li
Huoying Pan
Jiangle Liu
Jingxuan He
Haoyu Ju
Weiqi Wang

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

in Cancer Immunity and Immunotherapy

Alexandre Bertucci
Khaoula Taleb
Emilien Billon
Téo Fernez
Philippe Rochigneux

Frontiers in Immunology

Case Report

Accepted on 12 Feb 2026

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

in Cancer Immunity and Immunotherapy

Yanyan Li
Hongke Wang
Guochen Xing
Xiaodan Guo
Shanyong Yi

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis

in Cancer Immunity and Immunotherapy

Gaby Schaap
Soroush Ghaffari
Jim Middelburg
Marjolein Sluijter
Lisa Griffioen
Tom A.W. Schoufour
Ruud H.M. Wijdeven
Jacques Neefjes
Ramon Arens
Jon Weidanz

Frontiers in Immunology

115 views

Original Research

Accepted on 12 Feb 2026

IQDMA disrupts STAT5 nuclear transport through CDC42-PAK2 axis collapse in cutaneous T-cell lymphoma

in Cancer Immunity and Immunotherapy

Saptaswa Dey
Helena Sorger
Michaela Schlederer
Isabella Perchthaler
Martin Metzelder
Lukas Kenner
Richard Moriggl
Peter Wolf

Frontiers in Immunology

Systematic Review

Accepted on 12 Feb 2026

Efficacy and Safety of Neoadjuvant Immunotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Network Meta-Analysis and Real-World Study

in Cancer Immunity and Immunotherapy

Mengfei Sun
Pengjie Yang
Ling Qi
Ting Yang
Weishi Wang
Yongjun Yu
Jingjing ZHANG
Benben Zhu
Yong Li

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

Cross-dataset adaptation of voxel-level deep radiomics for predicting survival in inoperable locally advanced NSCLC treated with immunotherapy

in Cancer Immunity and Immunotherapy

Jin Wang
Zhaoyu Jiang
Wenhao Ji
Han Cheng
Zhen Zhang
Andre Dekker
Leonard Wee
Meng Yan
Xiaojing Lai

Frontiers in Immunology

133 views

Original Research

Accepted on 12 Feb 2026

Transdermal bicarbonate buffer therapy increases intra-tumoral pH and elicits anti-tumor responses in bladder cancer

in Cancer Immunity and Immunotherapy

Oluwaseyi Oluwatola
Sarah Bazargan
Pietro Irrera
Darwin Chang
Ashley Thomas
Jamie Blauvelt
Matthew S Beatty
MacLean Hall
Christopher J Whelan
Veronica Estrella

Frontiers in Immunology

176 views

Original Research

Accepted on 12 Feb 2026

Efficacy and Safety of Secondary Induction Radiotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma with Poor Responses to Neoadjuvant Immunochemotherapy: A Retrospective Study

in Cancer Immunity and Immunotherapy

Huilai Lv
Ping Zhang
Liang Dai
Weilu Ding
Songping Xie
Hongjing Jiang
Xiaofeng Duan
Ke-Neng Chen
Ziqiang Tian

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

The impact of Chronic Comorbidities on Cancer Immunoediting: Challenges and Opportunities for Immunotherapies

in Cancer Immunity and Immunotherapy

Kassandra Ofelia Rodriguez-Aguillon
Monica Lizeth Gonzalez-Gonzalez
Kenny Misael Calvillo-Rodriguez
Cristina Rodriguez-Padilla
Ana Carolina Martinez-Torres

Frontiers in Immunology

9,603 articles

articles

Neoadjuvant Chemoradiotherapy With or Without PD-1 Inhibitors in MMR‑Proficient Non‑Metastatic Rectal Cancer: A Meta-Analysis of Randomized Controlled Trials

Editorial: Immuno-metabolic Approaches for the Treatment of Hepatobiliary and Pancreatic Tumors

Sintilimab-Induced Toxic Epidermal Necrolysis Complicated in Advanced Gastric Cancer: A Case Report and Literature Review

Occupational Silica Exposure Drives Systemic Immune Dysregulation and Tumor Microenvironment Susceptibility: Evidence from a Real-World Study

Correction: LncRNAs in tumor metabolic reprogramming and tumor microenvironment remodeling

Reprogramming the immunosuppressive breast cancer microenvironment: integrating cellular, metabolic, and stromal targets for rational immunotherapy

Daratumumab-based salvage therapy enables umbilical cord blood transplantation in multiline refractory, elderly T-lymphoblastic lymphoma: a case report

Subacute liver failure caused by immunotherapy in a patient with gastric cancer was improved after multimodal treatment with artificial liver combined with liver-protective drugs: a case report

Spatial transcriptomics reveals the mechanistic role of lactate metabolism in the pancreatic ductal adenocarcinoma microenvironment

Born with two faces: sequential DLBCL, NOS and TFHL-AI with TET2 mutation – a case report

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis

IQDMA disrupts STAT5 nuclear transport through CDC42-PAK2 axis collapse in cutaneous T-cell lymphoma

Efficacy and Safety of Neoadjuvant Immunotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Network Meta-Analysis and Real-World Study

Cross-dataset adaptation of voxel-level deep radiomics for predicting survival in inoperable locally advanced NSCLC treated with immunotherapy

Transdermal bicarbonate buffer therapy increases intra-tumoral pH and elicits anti-tumor responses in bladder cancer

Efficacy and Safety of Secondary Induction Radiotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma with Poor Responses to Neoadjuvant Immunochemotherapy: A Retrospective Study

The impact of Chronic Comorbidities on Cancer Immunoediting: Challenges and Opportunities for Immunotherapies