Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 01 Jul 2025

Genomic and immune profiling of prognostic risk groups in IgM gammopathy reveals novel biomarkers beyond MYD88 L265P

in Cancer Immunity and Immunotherapy

David F. Moreno
Ferran Nadeu
Fara Brasó-Maristany
Sergi Vaqué
Sara Paz
Joan Mañé
Oriol Cardús
Elena Medina
Ester Lozano
Luis Gerardo Rodríguez-Lobato

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604089

232 views

Original Research

Published on 01 Jul 2025

Identification and validation of genes related to stem cells and telomere maintenance mechanisms as biomarkers for breast cancer

in Cancer Immunity and Immunotherapy

Shuang Zhen
Lifeng Huang
Qiannan Zhu
Rui Chen
Jue Wang
Xiaoming Zha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618193

117 views

Original Research

Published on 01 Jul 2025

Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade

in Cancer Immunity and Immunotherapy

Charlotte N. Hill
Gabriela Maita
Camille Cabrolier
Constanza Aros
Ana Maria Vega-Letter
Pamela Gonzalez
Alexis M. Kalergis
Patricia Luz-Crawford
Gareth I. Owen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600792

161 views

Original Research

Published on 01 Jul 2025

Toripalimab plus chemotherapy versus chemotherapy as first-line therapy for extensive-stage small cell lung cancer: a cost-effectiveness analysis

in Cancer Immunity and Immunotherapy

Longfeng Zhang
Hongcai Chen
Huide Zhu
Zhiwei Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591517

150 views

Original Research

Published on 01 Jul 2025

Interventional treatment combined with immunotargeted therapy in unresectable combined hepatocellular-cholangiocarcinoma: a real-world retrospective cohort study

in Cancer Immunity and Immunotherapy

Yan-Song Lin
Li-Yan Wu
Li-Hui Lin
Xia Yang
Fang-Yi Liu
Yan-Qin Wu
Zhen Ding
Yu-Jing Liang
Jing-Ping Yun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591127

195 views

Original Research

Published on 01 Jul 2025

Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer

in Cancer Immunity and Immunotherapy

Haiyang Du
Gao Si
Jiqing Si
Xuejie Song
Fuchun Si

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579184

165 views

Perspective

Published on 01 Jul 2025

CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects

in Cancer Immunity and Immunotherapy

Jia-Wen Wang
Ying-Fa Feng
Jia-Hui Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629879

256 views

Original Research

Published on 01 Jul 2025

Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

in Cancer Immunity and Immunotherapy

Hisataka Ogawa
Tomoya Ekawa
Yu Mizote
Takashi Akazawa
Hideaki Tahara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1506204

180 views

Review

Accepted on 30 Jun 2025

Overcoming resistant cancerous tumors through combined photodynamic and immunotherapy (photoimmunotherapy)

in Cancer Immunity and Immunotherapy

Glory Kah
Heidi Abrahamse

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633953

Original Research

Accepted on 30 Jun 2025

Systematic Analysis of ZDHHC9 as a Potential Prognostic and Immunotherapy Biomarker in Breast cancer

in Cancer Immunity and Immunotherapy

Desheng Zhou
Zhenpeng Wu
Yachao Cui
Doudou Wang
Hejun Song
Jun Chen
Hong Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609621

Original Research

Accepted on 30 Jun 2025

Integrated multi-omics and machine learning reveal an immunogenic cell death-related signature for prognostic stratification and therapeutic optimization in colorectal cancer

in Cancer Immunity and Immunotherapy

Siyu Hou
Shanshan Heng
Shaozhuo Xie
Yuanchun Zhao
Jiajia Chen
Chunjiang Yu
Yuxin Lin
Xin Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606874

101 views

Review

Accepted on 30 Jun 2025

Harnessing Immunotherapy: Cancer Vaccines as Novel Therapeutic Strategies for Brain Tumor

in Cancer Immunity and Immunotherapy

Klaudia Kiel
Raziye Piranlioglu
Jakub Godlewski
Agnieszka Bronisz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588081

Review

Accepted on 30 Jun 2025

Clinical Application Prospects of Traditional Chinese Medicine as Adjuvant Therapy for Metabolic Reprogramming in Colorectal Cancer

in Cancer Immunity and Immunotherapy

Zhexian Liu
Xingqi Guo
Xinxin Dong
Tong Xia
Siping Ma
Yanxi Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630279

Review

Accepted on 30 Jun 2025

Deciphering the Mechanistic Roles of ADARs in Cancer Pathogenesis, Tumor Immune Evasion, and Drug Resistance

in Cancer Immunity and Immunotherapy

Yangfang He
Fei Yin
Yue Qiao
Yan Yan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621585

Original Research

Accepted on 30 Jun 2025

Liver metastases in thyroid cancer: epidemiology, risk stratification and survival Outcomes in the immunotherapy era

in Cancer Immunity and Immunotherapy

Ming-Lu Xu
Yang-Yang Wang
Li-Ping Xie
Ning Ding
Jia-Jun Hui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624181

Original Research

Accepted on 30 Jun 2025

Autonomic Nervous System Development-Related Signature as Novel Predictive Biomarkers for Immunotherapy in Pan-Cancers

in Cancer Immunity and Immunotherapy

Cunen Wu
Weiwei Xue
Yuwen Zhuang
Dayue Darrel Dayue
Zhou Zhou
Xiaoxiao Wang
Zhenfeng Wu
Jin-Yong Zhou
Xiangkun Huan
Ruiping Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611890