Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 17 Apr 2025

TGFB1/CXCL5 axis regulation by LCN2 overexpression: a promising strategy to inhibit colorectal cancer metastasis and enhance prognosis

in Cancer Immunity and Immunotherapy

Xiaotian Song
Shuai Xu
Dan Song
Juan Wang
Bin Bai
Yanxin An
Bin Yang
Shiqi Wang
Qingchuan Zhao
Pengfei Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548635

185 views

Original Research

Published on 17 Apr 2025

A new predictive factor VGF based on IHC experiments, gene pathways and molecular functional groups for tumor immune microenvironment and prognosis of adrenocortical carcinoma

in Cancer Immunity and Immunotherapy

Junpeng Chi
Keyuan Lou
Jiankun Zhang
Jitao Wu
Yuanshan Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1542780

194 views

Case Report

Published on 17 Apr 2025

SMARCA4-deficient NSCLC treated with first-line tislelizumab and fruquintinib achieved remarkable tumor regression: case report and literature review

in Cancer Immunity and Immunotherapy

Jie Dong
Jinli Zhang
Hongming Pan
Chongwei Wang
Jin Sheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1521828

283 views

Original Research

Published on 17 Apr 2025

The role and machine learning analysis of mitochondrial autophagy-related gene expression in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Binyu Wang
Di Liu
Danfei Shi
Xinmin Li
Yong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1509315

319 views

Clinical Trial

Published on 17 Apr 2025

Influence of polyfunctional Tbet+ T cells on specific clinical events in chronic lymphocytic leukaemia

in Cancer Immunity and Immunotherapy

Yeong Jer Lim
Andrew D. Duckworth
Kim Clarke
Paul Kennedy
Indrani Karpha
Melanie Oates
Matthew Gornall
Nagesh Kalakonda
Joseph R. Slupsky
Andrew R. Pettitt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528405

254 views

Review

Published on 17 Apr 2025

Epigenetic modifications in breast cancer: from immune escape mechanisms to therapeutic target discovery

in Cancer Immunity and Immunotherapy

Ziyu Kang
Junlin Wang
Jiyan Liu
Li Du
Xiaofei Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584087

266 views

Original Research

Published on 17 Apr 2025

Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations

in Cancer Immunity and Immunotherapy

Nikolett Gémes
Benedek Rónaszéki
Szabolcs Modok
Zita Borbényi
Imre Földesi
Éva Trucza
Blanka Godza
Zsuzsanna László
Balázs Csernus
László Krenács

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563386

240 views

Review

Published on 17 Apr 2025

Revisiting the role of cancer-associated fibroblasts in tumor microenvironment

in Cancer Immunity and Immunotherapy

Xiaolei Lan
Wenyang Li
Kai Zhao
Jianpeng Wang
Shifang Li
Hai Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582532

257 views

Original Research

Published on 17 Apr 2025

ALDOC promotes neuroblastoma progression and modulates sensitivity to chemotherapy drugs by enhancing aerobic glycolysis

in Cancer Immunity and Immunotherapy

Yunpeng Chen
Haixia Zhu
Yishu Luo
Tianyue Xie
Youyang Hu
Zhiwei Yan
Weichao Ji
YaXuan Wang
Qiyou Yin
Hua Xian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1573815

281 views

Original Research

Published on 17 Apr 2025

BTG2-deficient mast cells remodel the tumor and tumor-draining lymph node microenvironment leading to chemotherapy resistance in breast cancer

in Cancer Immunity and Immunotherapy

Xiaoqian Zhang
Jiayi Wang
Ziyu Liu
Jiahuai Wen
Mengling Kang
Chen Fang
Liping Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1562700

191 views

Original Research

Published on 17 Apr 2025

The impact of antibiotic use on outcomes of relapsed/refractory multiple myeloma patients treated with CAR-T therapy

in Cancer Immunity and Immunotherapy

Lingling Yin
Bin Lv
Jiao Ge
Yuekun Qi
Jieyun Xia
Sha Ma
Ying Wang
Yang Liu
Dian Zhou
Jiang Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566016

238 views

Mini Review

Published on 17 Apr 2025

Enhancing the physiological characteristics of chimeric antigen receptor natural killer cells by synthetic biology

in Cancer Immunity and Immunotherapy

Shuochao Ji
Cheng Jin
Xinjiang Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592121

226 views

Case Report

Published on 17 Apr 2025

Case Report: Exploring delayed hyperprogressive disease: a case study of post-immunotherapy in lung cancer

in Cancer Immunity and Immunotherapy

Jie Zhou
Kexin Cao
Jin-Xia Wei
Biao Wang
Meng-Jie Li
Jian Zhu
Guo-Ping Ai
Qiu-Lian Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552547

194 views

Clinical Trial

Published on 17 Apr 2025

Updates from a single-center phase 2 study of PD-1 inhibitor combined with hypomethylating agent plus CAG regimen in patients with relapsed/refractory acute myeloid leukemia

in Cancer Immunity and Immunotherapy

Hui-Sheng Zhou
Yong-Feng Su
Jun Wang
Ya-Lei Hu
An Wang
Lei Xu
Yi-Zhi Wang
Xuan Zheng
Yu-Qing Li
Kai-Li Min

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533467

113 views

Original Research

Accepted on 16 Apr 2025

Identification of shared neoantigens derived from frameshift mutations in the APC gene

in Cancer Immunity and Immunotherapy

Peng Zhao
Clara Effenberger
Saki Matsumoto
Toshihiro Tanaka
Yusuke Nakamura
Kazuma Kiyotani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574955

104 views

Original Research

Accepted on 16 Apr 2025

Bispecific antibody targeting shared indel-derived neoantigen of APC

in Cancer Immunity and Immunotherapy

Clara Effenberger
Xiaojing Wu
Peng Zhao
Saki Matsumoto
Yusuke Nakamura
Kazuma Kiyotani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574958