Frontiers in Immunology | Cancer Immunity and Immunotherapy

Study Protocol

Published on 18 Aug 2025

Short-course PD-1 blockade in locally advanced nasopharyngeal carcinoma: a phase II randomized trial protocol (Tori-013)

in Cancer Immunity and Immunotherapy

Hongyuan Jia
Junchao Wang
Ling Zhang
Haijun Li
Yalei Du
Wenjuan Luo
Zou Wei
Xiaohui Wang
Weidong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633243

112 views

Editorial

Published on 18 Aug 2025

Editorial: Exploring KLF4’s role in immune cell function and disease progression

in Cancer Immunity and Immunotherapy

H. Daniel Lacorazza
Walden Ai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672030

150 views

Original Research

Published on 18 Aug 2025

Tumor associated neutrophils promote prostate cancer progression by mediating neutrophil trap secretion through PSMA1- NF-κB-HIF-1α signaling axis

in Cancer Immunity and Immunotherapy

Qian Dai
Hua Wang
Fang Li
Runchun Huang
Chenjun Jiang
Liuya Yuan
Yayun Wang
Xun Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1467357

257 views

Original Research

Published on 18 Aug 2025

FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2

in Cancer Immunity and Immunotherapy

Ming Wang
Fulin Ge
Cheng Wu
Binbin Su
Xiaoyu Dong
Shiping Xu
Hui Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611375

146 views

Original Research

Accepted on 17 Aug 2025

Central memory-enriched Vγ9Vδ2 γδ T cells via TGF-β expansion demonstrate enhanced in vivo efficacy against metastatic osteosarcoma

in Cancer Immunity and Immunotherapy

Jordan A Silva
Kokila Gunasinghe
Hunter C Jonus
Gianna Branella
Austre Y Schiaffino Bustamante
Jennifer Okalova
Jason T Yustein
H Trent Spencer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657760

112 views

Case Report

Accepted on 15 Aug 2025

Durable complete response to antigen-specific cytotoxic T lymphocyte (ACTL) therapy in advanced EGFR-TKI resistant lung adenocarcinoma: a case of adoptive cellular immunotherapy overcoming acquired targeted resistance

in Cancer Immunity and Immunotherapy

Chenghao Fu
Bian Chengyu
Weiyou Zhu
昊楠杜
Linrui Han
Jian Zhu
Jun Wang
Lei Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637165

267 views

Original Research

Accepted on 15 Aug 2025

Integrative Single-Cell and Machine Learning Analysis Predicts Lactylation-Driven Therapy Resistance in Prostate Cancer: A Molecular Docking and Experiments-Validated Framework for Treatment Optimization

in Cancer Immunity and Immunotherapy

Zhiyu Liu
Juan Wang
Yuqi Li
Yang Zeng
Qilong Wu
Xinyao Zhu
Tao Zhou
Qingfu Deng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647384

213 views

Original Research

Accepted on 15 Aug 2025

Disrupting β-Catenin/BCL9 Interaction with a Peptide Prodrug Boosts Immunotherapy in Colorectal Cancer

in Cancer Immunity and Immunotherapy

Peili Wang
Xiao Shang
Jingmei Wang
Weiming You
Yu Yao
Xiaoqiang Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662385

Review

Accepted on 15 Aug 2025

Characteristics of the Tumor Microenvironment and Potential Immunotherapy Strategies in Renal Cell Carcinoma

in Cancer Immunity and Immunotherapy

Hui Wen
Shi Zheng
Xiaoqin Zhu
Ling Wang
Dongping Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643533

105 views

Review

Published on 15 Aug 2025

Immune checkpoints in immune response to glioma: two sides of the same coin

in Cancer Immunity and Immunotherapy

Oxana Musatova
Vikas Kumar
Konstantin Vinogradov
Yury Rubtsov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639521

397 views

Original Research

Published on 15 Aug 2025

PU.1 upregulation is linked to improved prognosis in non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Katja Hohenberger
Denis I. Trufa
Arndt Hartmann
Susanne Mittler
Sonja Trump
Horia Sirbu
Susetta Finotto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604237

308 views

Review

Published on 15 Aug 2025

Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities

in Cancer Immunity and Immunotherapy

Xin Lai
Caizhi Li
Xinglinzi Tang
Xinyi Luo
Feiyan Wu
Yuhong Liang
Bihui Huang
Hang Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652398

515 views

Review

Published on 15 Aug 2025

CAR T cell therapy for central nervous system solid tumors: current progress and future directions

in Cancer Immunity and Immunotherapy

Yaroslav Kaminskiy
Vitaly Degtyarev
Alexey Stepanov
Michael Maschan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600403

501 views

Original Research

Published on 15 Aug 2025

The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target

in Cancer Immunity and Immunotherapy

Yunpeng Zou
Jianning Kang
Shaopeng Zhu
Xuechen Ren
Zheng Li
Jiayao Niu
Xuanzhe Qin
Hongbo Li
Lu Xiang
Wei Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651858

589 views

Review

Accepted on 14 Aug 2025

New dimensions of PD-1/PD-L1 inhibitor combination therapy in cancer treatment: current advances and future perspectives

in Cancer Immunity and Immunotherapy

Cheng Tong
Yue Wu
Renzhao Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616872

154 views

Original Research

Accepted on 14 Aug 2025

Physicochemical and biological characterization of a bispecific antibody in a CrossMab/KIH format that targets EGFR and VEGF-A

in Cancer Immunity and Immunotherapy

Safiat Ayinde
Shraboni Dutta
Nishant Mohan
Wen Jin Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659966

117 views