Frontiers in Immunology | Cancer Immunity and Immunotherapy

Study Protocol

Accepted on 19 Dec 2025

Personalized Neoantigen DC Vaccine Combined with Camrelizumab Following Definitive Therapy in Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (CHANT-241): Protocol for a Randomized Controlled Trial

in Cancer Immunity and Immunotherapy

Yueyun Chen
Yue Zheng
Huashan Shi
Wenjie Yang
Heng Xu
Yang Li
Zhenyu Ding

Frontiers in Immunology

196 views

Original Research

Accepted on 19 Dec 2025

Neoadjuvant Serplulimab and SOX Chemotherapy for Locally Advanced Gastric Cancer: Pathological Responses and Systemic Immune Signatures from a Phase II Trial

in Cancer Immunity and Immunotherapy

Hongjie Zhan
Liang Liu
Mingzhi Cai
Weilin Sun

Frontiers in Immunology

136 views

Mini Review

Accepted on 19 Dec 2025

Decoding Inflammatory Regulation in Ovarian Cancer at Single-Cell Resolution

in Cancer Immunity and Immunotherapy

Jianghao Yu
Zhou Tingting
Shuangyu Chen
Jialin Zhu
Lu Xu
Yi-bo He
Wei Chen

Frontiers in Immunology

243 views

Review

Accepted on 19 Dec 2025

The Neuro-Immune Axis in Cancer: Mechanisms of Innervation-Driven Tumor Progression and Therapeutic Opportunities

in Cancer Immunity and Immunotherapy

Liang Zhang
Dantong Zhu
Junyi Wang
Jiyang Guo
Mingzhe Jiang
Xinhui Qi
Zhendong Zheng

Frontiers in Immunology

166 views

Mini Review

Published on 19 Dec 2025

Nutritional intervention alleviates T cell exhaustion and empowers anti-tumor immunity

in Cancer Immunity and Immunotherapy

Yuqi Xu
Wenhui Yuan
Ke Li
Peng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689317

716 views

Review

Published on 19 Dec 2025

Advances in the application of PD-1/PD-L1 immunotherapy for prostate cancer: a review

in Cancer Immunity and Immunotherapy

Guangqiang Hu
Zeng Li
Yongji Chen
Hong Liao
Shukui Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664587

862 views

Original Research

Published on 19 Dec 2025

Anti-VEGF immunotherapy with HEBERSaVax suppresses melanoma growth and metastasis via angiogenesis blockade and enhanced T-cell infiltration

in Cancer Immunity and Immunotherapy

Yanelys Morera-Díaz
Josune García-Sanmartín
Camila Canaán-Haden
Mónica Bequet-Romero
Isabel Gonzalez-Moya
Marta Ayala-Ávila
Srdan Tadic
Pablo Garrido
Judit Narro-Íñiguez
Dasha Fuentes-Morales

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667651

703 views

Review

Published on 19 Dec 2025

The metabolism-immune axis in colorectal cancer: remodeling the tumor microenvironment through metabolite signaling

in Cancer Immunity and Immunotherapy

Shaofan Hu
Hui Heng
Fang Yang
Meng Wang
Guoxiang Liu
Yuancai Xiang
Hongming Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735873

980 views

Original Research

Published on 19 Dec 2025

SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer

in Cancer Immunity and Immunotherapy

Mei Huang
Run Shi
Cong Xu
Yihan Zhang
Xiaoyue Du
Shaodi Wen
Chunbin Wang
Feng Jiang
Guoren Zhou
Xin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735479

637 views

Original Research

Published on 19 Dec 2025

LST1: a novel biomarker for efferocytosis in the co-occurrence of type 2 diabetes mellitus and clear cell renal cell carcinoma

in Cancer Immunity and Immunotherapy

Yuru Yang
Tingting Chen
Zhicheng Xu
Jialing Cai
Wenli Wang
Lan Pan
Xiaotian Cheng
Andong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737749

694 views

Original Research

Published on 19 Dec 2025

Development and validation of an interpretable machine learning model for predicting progression-free survival after immunotherapy in patients with non-small cell lung cancer: a multicenter study

in Cancer Immunity and Immunotherapy

Ya Li
Ji Xia
Tianchu He
Yong Hu
Daobin Zhou
Dan Zou
Benlan Li
Min Zhang
Zhongjun Huang
Mi Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686260

631 views

Mini Review

Published on 19 Dec 2025

The dual role of glucocorticoids in the breast cancer immune microenvironment: mechanisms and therapeutic implications

in Cancer Immunity and Immunotherapy

Bianping Liang
Xinglan Wang
Yunrui Fu
Mingxue Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719277

626 views

Original Research

Published on 19 Dec 2025

Hepatotoxicity associated with anti-neoplastic agents: a pharmacovigilance analysis of the Food and Drug Administration Adverse Event Reporting System database

in Cancer Immunity and Immunotherapy

Lei Shi
Yan Wang
Ying Qu
Rong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665425

507 views

Original Research

Published on 19 Dec 2025

Chronic stress drives ovarian cancer progression via myeloid-derived suppressor cells infiltration and Notch signaling pathway activation

in Cancer Immunity and Immunotherapy

Yadiel A. Rivera-López
Alanis P. Torres-Rosado
Jaydiel A. Casiano-Martínez
Luinet L. Meléndez-Rodríguez
Raian Imad-Hamad
Sofía M. Hernández-Carrasquillo
Luis M. Rivera-Pérez
Melanie Ortiz-León
Orlando I. Torres-Rodríguez
Alexandra N. Aquino-Acevedo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593299

1,675 views

Review

Published on 19 Dec 2025

Application and challenges of tumor organoid technology in precision immunotherapy

in Cancer Immunity and Immunotherapy

Xiaoming Zhao
Jun Gao
Yinan Liu
Yawen Shi
Meng Zhang
Chen Zhang
Jinghong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723995

833 views

Correction

Published on 19 Dec 2025

Correction: Epigenetic activation of CD274/PD-L1 by the MSL complex expands its role beyond dosage compensation

in Cancer Immunity and Immunotherapy

Aiping Wen
Xuanfei Feng
Yingying Li
Xueli Cui
Qixian Zou
Yong Cai
Jingji Jin
Yunxiao He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761945

680 views

Case Report

Published on 19 Dec 2025

Severe systemic cutaneous adverse reactions following camrelizumab therapy: a case report and literature review

in Cancer Immunity and Immunotherapy

Yuan-dong Sun
Wen-jia Guo
Jian-jun Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714201

667 views

Original Research

Published on 19 Dec 2025

PSMD14 drives lung adenocarcinoma progression through HMMR stabilization and dual activation of TGF-β/Smad and PI3K/AKT/mTOR signaling

in Cancer Immunity and Immunotherapy

Rui Chen
Shijing Wang
Junping Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720799

480 views

Original Research

Accepted on 18 Dec 2025

Intra-tumoral NK cells and their Association with Patient Outcomes: A novel Prognostic model Incorporating NK Cells and Clinicopathologic features in Gastric Cancer

in Cancer Immunity and Immunotherapy

Masanori Oshi
Yuko Tamura
Rongrong Wu
Colin J. Rog
Li Yan
Kizuki Yuza
Takashi Kosaka
Hirotoshi Akiyama
Takashi Ishikawa
Kazuaki Takabe

Frontiers in Immunology

125 views

Original Research

Accepted on 18 Dec 2025

Integrated Multi-Omics and Single-Cell Analysis Identify SERPINE1 as a Key Mediator of the Inflammatory Tumor Microenvironment in PDAC

in Cancer Immunity and Immunotherapy

Di Wang
Qing Chen
Can-ming Li
Yan Xie
Chunhui Yuan
Ren Lang
Wen-Tao Jiang

Frontiers in Immunology

156 views

Systematic Review

Accepted on 18 Dec 2025

Global Assessment of Hepatic Safety in Novel Immunotherapies: A systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Minyan Ye
Yinuo Dong
Xiaoyun Li
Yang Zhi
Yuping Lu
Jieting Tang
Wei Zhong
Xiaohong Lei
Yimin Mao
Sha Huang

Frontiers in Immunology

131 views

Editorial

Accepted on 18 Dec 2025

Editorial: Unveiling the Next Generation of Cancer Immunity & Immunotherapy

in Cancer Immunity and Immunotherapy

Mohanraj Sadasivam
Nethaji Muniraj
Thangavel Chellappagounder

Frontiers in Immunology

306 views

Original Research

Accepted on 18 Dec 2025

Sex-specific differences in abscopal responses to combined radiotherapy and immune checkpoint inhibition – insights from a multicenter study

in Cancer Immunity and Immunotherapy

Maike Trommer
Alexander Rühle
Felix Ehret
Allison Lamrani
Charlotte Schmitter
Justus Kaufmann
Matthias Mäurer
Georg Wurschi
Ping Jiang
Andrea Baehr

Frontiers in Immunology

120 views

Original Research

Accepted on 18 Dec 2025

A Ligand-Centered Framework for γδ T Cell Activation in Colorectal Cancer Revealed by Single-Cell and Transformer-Based Perturbation

in Cancer Immunity and Immunotherapy

Ran Ran
Douglas K. Brubaker

Frontiers in Immunology

9,296 articles

articles

Personalized Neoantigen DC Vaccine Combined with Camrelizumab Following Definitive Therapy in Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (CHANT-241): Protocol for a Randomized Controlled Trial

Neoadjuvant Serplulimab and SOX Chemotherapy for Locally Advanced Gastric Cancer: Pathological Responses and Systemic Immune Signatures from a Phase II Trial

Decoding Inflammatory Regulation in Ovarian Cancer at Single-Cell Resolution

The Neuro-Immune Axis in Cancer: Mechanisms of Innervation-Driven Tumor Progression and Therapeutic Opportunities

Nutritional intervention alleviates T cell exhaustion and empowers anti-tumor immunity

Advances in the application of PD-1/PD-L1 immunotherapy for prostate cancer: a review

Anti-VEGF immunotherapy with HEBERSaVax suppresses melanoma growth and metastasis via angiogenesis blockade and enhanced T-cell infiltration

The metabolism-immune axis in colorectal cancer: remodeling the tumor microenvironment through metabolite signaling

SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer

LST1: a novel biomarker for efferocytosis in the co-occurrence of type 2 diabetes mellitus and clear cell renal cell carcinoma

Development and validation of an interpretable machine learning model for predicting progression-free survival after immunotherapy in patients with non-small cell lung cancer: a multicenter study

The dual role of glucocorticoids in the breast cancer immune microenvironment: mechanisms and therapeutic implications

Hepatotoxicity associated with anti-neoplastic agents: a pharmacovigilance analysis of the Food and Drug Administration Adverse Event Reporting System database

Chronic stress drives ovarian cancer progression via myeloid-derived suppressor cells infiltration and Notch signaling pathway activation

Application and challenges of tumor organoid technology in precision immunotherapy

Correction: Epigenetic activation of CD274/PD-L1 by the MSL complex expands its role beyond dosage compensation

Severe systemic cutaneous adverse reactions following camrelizumab therapy: a case report and literature review

PSMD14 drives lung adenocarcinoma progression through HMMR stabilization and dual activation of TGF-β/Smad and PI3K/AKT/mTOR signaling

Intra-tumoral NK cells and their Association with Patient Outcomes: A novel Prognostic model Incorporating NK Cells and Clinicopathologic features in Gastric Cancer

Integrated Multi-Omics and Single-Cell Analysis Identify SERPINE1 as a Key Mediator of the Inflammatory Tumor Microenvironment in PDAC

Global Assessment of Hepatic Safety in Novel Immunotherapies: A systematic review and meta-analysis

Editorial: Unveiling the Next Generation of Cancer Immunity & Immunotherapy

Sex-specific differences in abscopal responses to combined radiotherapy and immune checkpoint inhibition – insights from a multicenter study

A Ligand-Centered Framework for γδ T Cell Activation in Colorectal Cancer Revealed by Single-Cell and Transformer-Based Perturbation