Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 13 Feb 2026

Spatial transcriptomics reveals the mechanistic role of lactate metabolism in the pancreatic ductal adenocarcinoma microenvironment

in Cancer Immunity and Immunotherapy

Fan Gao
Zhe Tang
Jie Lian
Luting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743187

419 views

Original Research

Published on 13 Feb 2026

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

in Cancer Immunity and Immunotherapy

Yiyuan Cui
Sicong Li
Zhibin Wu
Yue Jin
Jingjie Yu
Yufan Chen
Jiayang Chen
Jinyuan Chang
Yijing Yan
Xinyu Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1685902

213 views

Original Research

Published on 13 Feb 2026

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

in Cancer Immunity and Immunotherapy

Morgane Peroz
Nicolas Roussot
Alis Ilie
David Rageot
Valentin Derangere
Caroline Truntzer
François Ghiringhelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1750816

275 views

Original Research

Accepted on 12 Feb 2026

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

in Cancer Immunity and Immunotherapy

Genshen Zhong
Biao Liu
Xue Gong
Qi Wang
Shuyin Zheng
Xinyu Luo
Xingya Zhang
Biliang Hu
Minna Wu
Zhiguo Chen

Frontiers in Immunology

170 views

Original Research

Accepted on 12 Feb 2026

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

in Cancer Immunity and Immunotherapy

Katarzyna Węgierek-Ciura
Agnieszka Szczygieł
Anna Rudawska
Jagoda Mierzejewska
Joanna Rossowska
Bożena Szermer-Olearnik
Marta Świtalska
Tomasz Goszczynski
Elżbieta Pajtasz-Piasecka

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

in Cancer Immunity and Immunotherapy

Xiaohua Zheng
Yutao Zou
Ting Li
Huoying Pan
Jiangle Liu
Jingxuan He
Haoyu Ju
Weiqi Wang

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

in Cancer Immunity and Immunotherapy

Alexandre Bertucci
Khaoula Taleb
Emilien Billon
Téo Fernez
Philippe Rochigneux

Frontiers in Immunology

Case Report

Accepted on 12 Feb 2026

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

in Cancer Immunity and Immunotherapy

Yanyan Li
Hongke Wang
Guochen Xing
Xiaodan Guo
Shanyong Yi

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis

in Cancer Immunity and Immunotherapy

Gaby Schaap
Soroush Ghaffari
Jim Middelburg
Marjolein Sluijter
Lisa Griffioen
Tom A.W. Schoufour
Ruud H.M. Wijdeven
Jacques Neefjes
Ramon Arens
Jon Weidanz

Frontiers in Immunology

131 views

Original Research

Accepted on 12 Feb 2026

IQDMA disrupts STAT5 nuclear transport through CDC42-PAK2 axis collapse in cutaneous T-cell lymphoma

in Cancer Immunity and Immunotherapy

Saptaswa Dey
Helena Sorger
Michaela Schlederer
Isabella Perchthaler
Martin Metzelder
Lukas Kenner
Richard Moriggl
Peter Wolf

Frontiers in Immunology

Systematic Review

Accepted on 12 Feb 2026

Efficacy and Safety of Neoadjuvant Immunotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Network Meta-Analysis and Real-World Study

in Cancer Immunity and Immunotherapy

Mengfei Sun
Pengjie Yang
Ling Qi
Ting Yang
Weishi Wang
Yongjun Yu
Jingjing ZHANG
Benben Zhu
Yong Li

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

Cross-dataset adaptation of voxel-level deep radiomics for predicting survival in inoperable locally advanced NSCLC treated with immunotherapy

in Cancer Immunity and Immunotherapy

Jin Wang
Zhaoyu Jiang
Wenhao Ji
Han Cheng
Zhen Zhang
Andre Dekker
Leonard Wee
Meng Yan
Xiaojing Lai

Frontiers in Immunology

139 views

Original Research

Accepted on 12 Feb 2026

Transdermal bicarbonate buffer therapy increases intra-tumoral pH and elicits anti-tumor responses in bladder cancer

in Cancer Immunity and Immunotherapy

Oluwaseyi Oluwatola
Sarah Bazargan
Pietro Irrera
Darwin Chang
Ashley Thomas
Jamie Blauvelt
Matthew S Beatty
MacLean Hall
Christopher J Whelan
Veronica Estrella

Frontiers in Immunology

201 views

Original Research

Accepted on 12 Feb 2026

Efficacy and Safety of Secondary Induction Radiotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma with Poor Responses to Neoadjuvant Immunochemotherapy: A Retrospective Study

in Cancer Immunity and Immunotherapy

Huilai Lv
Ping Zhang
Liang Dai
Weilu Ding
Songping Xie
Hongjing Jiang
Xiaofeng Duan
Ke-Neng Chen
Ziqiang Tian

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

The impact of Chronic Comorbidities on Cancer Immunoediting: Challenges and Opportunities for Immunotherapies

in Cancer Immunity and Immunotherapy

Kassandra Ofelia Rodriguez-Aguillon
Monica Lizeth Gonzalez-Gonzalez
Kenny Misael Calvillo-Rodriguez
Cristina Rodriguez-Padilla
Ana Carolina Martinez-Torres

Frontiers in Immunology

Original Research

Published on 12 Feb 2026

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod

in Cancer Immunity and Immunotherapy

Caitlin D. Lemke-Miltner
Sue E. Blackwell
Chaobo Yin
Travis D. Fischer
George J. Weiner

Frontiers in Immunology

doi 10.3389/fimmu.2026.1769287

589 views

Mini Review

Published on 12 Feb 2026

Clinically oriented immune heterogeneity in prostate cancer: emerging targets and strategies

in Cancer Immunity and Immunotherapy

MingWei Zhan
BinBin Zhao
Junjie Wu
Kai Li
Yibo Chen
Haote Chen
Lin Zhao
Jingyu Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753718

398 views

Original Research

Published on 12 Feb 2026

Decoding the role of RPL38 in lung adenocarcinoma: a multi-omics approach

in Cancer Immunity and Immunotherapy

Lu Zhang
Fei Teng
Yuan Wang
Yang Chen
Qiuxia Liu
Fengsheng Dai
Liang Yu
Chenguo Yao
Zhiqiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1778481

368 views

Mini Review

Published on 12 Feb 2026

Tumor immune-vascular crosstalk: synergy and translation of immune checkpoint inhibitors and anti-angiogenic agents in melanoma

in Cancer Immunity and Immunotherapy

Yijie Xie
I. Ho
Zhipeng Liu
Keyu Chen
Minjie Zhou
Guodong Ha
Lincheng Duan
Zhengyu Zhao
Dingjun Cai

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760044

449 views

Case Report

Published on 12 Feb 2026

Temporal association of diffuse large B-cell lymphoma with PD-1 inhibitor therapy in a patient with gastric adenocarcinoma: a case report

in Cancer Immunity and Immunotherapy

Yiqing Jiang
Kun Wu
Jia Hu
Mingxin Yu
Yuhang Xu
Zihan Xu
Rongxuan Cao
Yi Zhang
Yanfang Gao
Shuzhen Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1763711

452 views

Editorial

Published on 12 Feb 2026

Editorial: Mechanisms and therapeutic opportunities of T-cell impairment in cancer immunity and immunotherapy

in Cancer Immunity and Immunotherapy

Guillaume Beyrend-Frizon

Frontiers in Immunology

doi 10.3389/fimmu.2026.1795868

496 views

Correction

Published on 12 Feb 2026

Correction: Editorial: Unveiling the next generation of cancer immunity & immunotherapy

in Cancer Immunity and Immunotherapy

Mohanraj Sadasivam
Nethaji Muniraj
Chellappagounder Thangavel

Frontiers in Immunology

doi 10.3389/fimmu.2026.1784505

237 views

Original Research

Published on 12 Feb 2026

NCF2 facilitates M2 macrophage polarization in glioblastoma through activation of the notch1–osteopontin axis

in Cancer Immunity and Immunotherapy

Yinsong Zhang
Na Li
Hongbo Cheng
Yi Xiang
Guozhu Sun

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743950

450 views

Review

Published on 12 Feb 2026

The emerging role of m6A methylation in prostate-related diseases: mechanisms and clinical implications

in Cancer Immunity and Immunotherapy

Qinghua Xie
Hongyan Zhao
Xuan Yang
Hongqi Zhang
Hong Liu
Jinghua Pan
Yan Li
Danping Fan
Xinrong Fan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1685015

258 views

9,632 articles

articles

Spatial transcriptomics reveals the mechanistic role of lactate metabolism in the pancreatic ductal adenocarcinoma microenvironment

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis

IQDMA disrupts STAT5 nuclear transport through CDC42-PAK2 axis collapse in cutaneous T-cell lymphoma

Efficacy and Safety of Neoadjuvant Immunotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Network Meta-Analysis and Real-World Study

Cross-dataset adaptation of voxel-level deep radiomics for predicting survival in inoperable locally advanced NSCLC treated with immunotherapy

Transdermal bicarbonate buffer therapy increases intra-tumoral pH and elicits anti-tumor responses in bladder cancer

Efficacy and Safety of Secondary Induction Radiotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma with Poor Responses to Neoadjuvant Immunochemotherapy: A Retrospective Study

The impact of Chronic Comorbidities on Cancer Immunoediting: Challenges and Opportunities for Immunotherapies

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod

Clinically oriented immune heterogeneity in prostate cancer: emerging targets and strategies

Decoding the role of RPL38 in lung adenocarcinoma: a multi-omics approach

Tumor immune-vascular crosstalk: synergy and translation of immune checkpoint inhibitors and anti-angiogenic agents in melanoma

Temporal association of diffuse large B-cell lymphoma with PD-1 inhibitor therapy in a patient with gastric adenocarcinoma: a case report

Editorial: Mechanisms and therapeutic opportunities of T-cell impairment in cancer immunity and immunotherapy

Correction: Editorial: Unveiling the next generation of cancer immunity & immunotherapy

NCF2 facilitates M2 macrophage polarization in glioblastoma through activation of the notch1–osteopontin axis

The emerging role of m6A methylation in prostate-related diseases: mechanisms and clinical implications