Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 12 Feb 2026

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod

in Cancer Immunity and Immunotherapy

Caitlin D. Lemke-Miltner
Sue E. Blackwell
Chaobo Yin
Travis D. Fischer
George J. Weiner

Frontiers in Immunology

doi 10.3389/fimmu.2026.1769287

629 views

Mini Review

Published on 12 Feb 2026

Tumor immune-vascular crosstalk: synergy and translation of immune checkpoint inhibitors and anti-angiogenic agents in melanoma

in Cancer Immunity and Immunotherapy

Yijie Xie
I. Ho
Zhipeng Liu
Keyu Chen
Minjie Zhou
Guodong Ha
Lincheng Duan
Zhengyu Zhao
Dingjun Cai

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760044

463 views

Mini Review

Published on 12 Feb 2026

Clinically oriented immune heterogeneity in prostate cancer: emerging targets and strategies

in Cancer Immunity and Immunotherapy

MingWei Zhan
BinBin Zhao
Junjie Wu
Kai Li
Yibo Chen
Haote Chen
Lin Zhao
Jingyu Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753718

412 views

Original Research

Published on 12 Feb 2026

Baseline glucose-to-lymphocyte ratio predicts nivolumab outcomes in advanced non-small cell lung cancer: a multicenter retrospective study

in Cancer Immunity and Immunotherapy

Mustafa Ersoy
Umut Kefeli
Devrim Cabuk
Ertugrul Bayram
Duygu Bayir
Oktay Bozkurt
Muslih Ürün
Ramazan Coşar
Teoman Sakalar
Emel Mutlu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1714533

448 views

Review

Published on 12 Feb 2026

The emerging role of m6A methylation in prostate-related diseases: mechanisms and clinical implications

in Cancer Immunity and Immunotherapy

Qinghua Xie
Hongyan Zhao
Xuan Yang
Hongqi Zhang
Hong Liu
Jinghua Pan
Yan Li
Danping Fan
Xinrong Fan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1685015

266 views

Original Research

Published on 12 Feb 2026

Identification and validation of prognostic genes related to glycolysis and M2 macrophage in hepatocellular carcinoma: an integrated analysis of bulk RNA sequencing and single-cell RNA sequencing

in Cancer Immunity and Immunotherapy

Anqi Wang
Lina You
Ming Zuo
Zhanao He
Hong Yang
Wukui Huang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1710411

538 views

Original Research

Published on 12 Feb 2026

Nocardia rubra cell wall skeleton-induced MARCO expression: implications for improved phagocytosis and cytokine secretion in tumor-associated macrophages

in Cancer Immunity and Immunotherapy

Guiyuan Zhou
Wei Chen
Xiaomin Dong
Qianyu Guo
Xue Bai
Yan Zheng
Lei Zhang
Suxia Shao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1611476

391 views

Original Research

Published on 12 Feb 2026

A composite biomarker based on early dynamic changes in lactate dehydrogenase and PD-L1 expression enhances outcome prediction for immunochemotherapy in HER2-negative advanced gastric cancer

in Cancer Immunity and Immunotherapy

Yue Zhang
Yang Tian
Xiaoli Wei
Lu Bai
Meiqi Song
Yuanzhi Guo
Tianlai Liu
Xing Li
Weiqi Shan
Huaxing Wu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1659007

255 views

Original Research

Published on 12 Feb 2026

Construction of circadian clock signature for tumor microenvironment in predicting survival of esophageal squamous cell carcinoma

in Cancer Immunity and Immunotherapy

Yiping Xiang
Xuelian Cui
Zhe Cui

Frontiers in Immunology

doi 10.3389/fimmu.2026.1738892

707 views

Original Research

Published on 12 Feb 2026

Association between peripheral IFN-γ+ cytotoxic lymphocytes and response to PD-1/PD-L1-based therapy in hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Hui Lu
Huijuan Fang
Mengqi Ruan
Zhi Duang
Yan Wang
Wenwen Liu
Qin Wang
Qiang Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1738116

292 views

Systematic Review

Published on 12 Feb 2026

Correlation between PD-L1 expression and clinical pathology, immunobiological markers, and prognosis in gastroenteropancreatic neuroendocrine neoplasms: a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Qiming Zheng
Shangbo Jin
Xinyue Xie
Qingjun Guo
Chiyi Chen
Wentao Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1772011

282 views

Original Research

Published on 12 Feb 2026

ALDH1L2 orchestrates redox–growth coupling in renal carcinoma: pan-cancer evidence and mechanistic validation of the ROS–Akt/mTOR/S6K axis

in Cancer Immunity and Immunotherapy

Chao Jiang
Songsong Liu
Liwen Zhang
Shiji Li
Jinyou Wang
Yi Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1768010

382 views

Original Research

Published on 12 Feb 2026

Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases

in Cancer Immunity and Immunotherapy

Sookyung Hwang
Paul D. Bates
Vasiliki Valkanioti
Chih-Chun Chang
Sandro Mecozzi
Christian M. Capitini

Frontiers in Immunology

doi 10.3389/fimmu.2026.1772375

450 views

Original Research

Accepted on 11 Feb 2026

Single-Cell Profiling of PBMCs Reveals an Immune Signature of irAEs in Anti-PD-1-Treated Acral Melanoma Patients

in Cancer Immunity and Immunotherapy

Qi Bao
Jie Pan
Zhefang Wang

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

MRPS28 serves as a biomarker of diagnostic, prognostic, and immune modulation in pan-cancer and promotes breast cancer malignant phenotypes

in Cancer Immunity and Immunotherapy

Xiangdong Guo
Shixing Wang
Yunlong Lu
Rensang Cai
Zhifei Luo
Jiaying Hu
Fenggui Xue
Haiyan Niu

Frontiers in Immunology

Systematic Review

Accepted on 11 Feb 2026

Comparison of drug regimens for recurrent or metastatic cervical cancer: a systematic review and network meta-analysis

in Cancer Immunity and Immunotherapy

Jin Zhou
Wentao Ye
Stéphanie Nirina Ranarisoa
Tian Lei

Frontiers in Immunology

102 views

Review

Accepted on 11 Feb 2026

Targeting MDSCs in Cancer: Emerging Immunotherapeutic and Metabolic Strategies

in Cancer Immunity and Immunotherapy

Shubhankar Dash
Patryk Firmanty
Monika Chomczyk
Vakul Mohanty
Wenxue Ma
Natalia Baran

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

UNRAVELLING THE COMPLEXITY OF THE INTERACTIONS AMONG VACCIMEL, BCG AND BLOOD MONOCYTES

in Cancer Immunity and Immunotherapy

Erika Schwab
Brenda Carles
ALICIA INES BRAVO
María Victoria Echenique
Agustina De Franc
Mariano Guillermo Bonanno
María Marcela Barrio
José Mordoh

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

A Combined Immune–Nutritional Score (GRIm–CONUT) as a Prognostic Indicator in Neoadjuvant-Treated Esophageal Squamous Cell Carcinoma

in Cancer Immunity and Immunotherapy

Qichang Xie
Junpeng Zhan
Xiaolin Ye
Cheng Huang
Chun Chen
Bin Zheng
Guobing Xu
Zhang Yang
Yong Zhu

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

Decoding the Role of Macrophage LAP3 in Lung Cancer – Integration of Single-Cell Technologies and Machine Learning Reveals an Orchestrating Immunometabolic Circuit at the Tumor-Epithelial Interface

in Cancer Immunity and Immunotherapy

yunlong dong
Zhibin Fei
Xuanguang Li
Hongsheng Guo
Wencheng Zhang
Hongjie Zhao
Mengmeng Jiang
Xu Chang
Guangshun Wang

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in Non-Small Cell Lung Cancer

in Cancer Immunity and Immunotherapy

Qingsheng Liu
Xufeng Liu
Han Zhang
Yuhang Jiang
Ying Shi
QiuQiao Mu
Yuhao Jing
Daqiang Sun

Frontiers in Immunology

513 views

Original Research

Accepted on 11 Feb 2026

Integrative Pan-Cancer Analysis Reveals AARS2 as a Lactylation-Associated Biomarker and Therapeutic Target in Colon Adenocarcinoma

in Cancer Immunity and Immunotherapy

Mingyang Zou
Zixuan Ding
Wenxin Yu
Yixin Pan
Xinyue Wu
Yulan Song
Shaobo Wu
Jiebin Pan

Frontiers in Immunology

Original Research

Published on 11 Feb 2026

A fully human IgG1 antibody targeting MICA α1 domain inhibits interaction with NKG2D and activates immune effector functions against MICA-expressing cells

in Cancer Immunity and Immunotherapy

Ivo Campos
Fabiola González-Herrera
Yuneisy Guerra
María José Garrido
Nicolás Fehring
Carla Diaz
Douglas J. Matthies
Mauricio González
Samantha Tello
Fabián Tempio

Frontiers in Immunology

doi 10.3389/fimmu.2026.1740184

880 views

Original Research

Published on 11 Feb 2026

Characterizing tumor microenvironment heterogeneity in EBV+ nTNKL vs ENKTL using spatial transcriptomics and MIF

in Cancer Immunity and Immunotherapy

Siyu Qian
Zeyuan Wang
Yue Zhang
Wanyue Zhao
Honghan Qiao
Xiaoyan Feng
Yukai Duan
Boyuan Su
Shifeng Hao
Zhenzhen Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1717844

450 views

9,631 articles

articles

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod

Tumor immune-vascular crosstalk: synergy and translation of immune checkpoint inhibitors and anti-angiogenic agents in melanoma

Clinically oriented immune heterogeneity in prostate cancer: emerging targets and strategies

Baseline glucose-to-lymphocyte ratio predicts nivolumab outcomes in advanced non-small cell lung cancer: a multicenter retrospective study

The emerging role of m6A methylation in prostate-related diseases: mechanisms and clinical implications

Identification and validation of prognostic genes related to glycolysis and M2 macrophage in hepatocellular carcinoma: an integrated analysis of bulk RNA sequencing and single-cell RNA sequencing

Nocardia rubra cell wall skeleton-induced MARCO expression: implications for improved phagocytosis and cytokine secretion in tumor-associated macrophages

A composite biomarker based on early dynamic changes in lactate dehydrogenase and PD-L1 expression enhances outcome prediction for immunochemotherapy in HER2-negative advanced gastric cancer

Construction of circadian clock signature for tumor microenvironment in predicting survival of esophageal squamous cell carcinoma

Association between peripheral IFN-γ+ cytotoxic lymphocytes and response to PD-1/PD-L1-based therapy in hepatocellular carcinoma

Correlation between PD-L1 expression and clinical pathology, immunobiological markers, and prognosis in gastroenteropancreatic neuroendocrine neoplasms: a systematic review and meta-analysis

ALDH1L2 orchestrates redox–growth coupling in renal carcinoma: pan-cancer evidence and mechanistic validation of the ROS–Akt/mTOR/S6K axis

Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases

Single-Cell Profiling of PBMCs Reveals an Immune Signature of irAEs in Anti-PD-1-Treated Acral Melanoma Patients

MRPS28 serves as a biomarker of diagnostic, prognostic, and immune modulation in pan-cancer and promotes breast cancer malignant phenotypes

Comparison of drug regimens for recurrent or metastatic cervical cancer: a systematic review and network meta-analysis

Targeting MDSCs in Cancer: Emerging Immunotherapeutic and Metabolic Strategies

UNRAVELLING THE COMPLEXITY OF THE INTERACTIONS AMONG VACCIMEL, BCG AND BLOOD MONOCYTES

A Combined Immune–Nutritional Score (GRIm–CONUT) as a Prognostic Indicator in Neoadjuvant-Treated Esophageal Squamous Cell Carcinoma

Decoding the Role of Macrophage LAP3 in Lung Cancer – Integration of Single-Cell Technologies and Machine Learning Reveals an Orchestrating Immunometabolic Circuit at the Tumor-Epithelial Interface

Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in Non-Small Cell Lung Cancer

Integrative Pan-Cancer Analysis Reveals AARS2 as a Lactylation-Associated Biomarker and Therapeutic Target in Colon Adenocarcinoma

A fully human IgG1 antibody targeting MICA α1 domain inhibits interaction with NKG2D and activates immune effector functions against MICA-expressing cells

Characterizing tumor microenvironment heterogeneity in EBV+ nTNKL vs ENKTL using spatial transcriptomics and MIF