Frontiers in Immunology | Comparative Immunology

Original Research

Published on 09 Jan 2026

LILRB1 and LILRB2 genomics and transcriptomics in macaque and baboon species: polymorphism, diversification, and extensive alternative splicing

in Comparative Immunology

Natasja G. de Groot
Nanine de Groot
Corrine M. C. Heijmans
Annemiek J. M. de Vos-Rouweler
Marit K. H. van der Wiel
Jesse Bruijnesteijn

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706720

794 views

Original Research

Published on 08 Jan 2026

A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against Clostridium perfringens-driven diseases

in Comparative Immunology

Qi Jia
Haoyu Xiang
Ting Le
Jing Wang
Jitao Chang
Fang Wang
Chao Sun
Wanbo Tai
Zhigang Jiang
Xin Yin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1748171

965 views

Original Research

Published on 08 Jan 2026

Octopamine modulates the innate immune response in Drosophila melanogaster

in Comparative Immunology

Karin Uliczka
Stephanie Papenmeier
Beate Höschler
Christina Wagner
Thomas Roeder
Holger Heine

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720126

739 views

Editorial

Published on 07 Jan 2026

Editorial: Cell-mediated innate immunity in aquatic invertebrates and fish: what’s new?

in Comparative Immunology

Maria Rosaria Coscia
Rita Marino
Daniela Melillo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1749877

942 views

Original Research

Published on 07 Jan 2026

Characterization of T cell responses against Fusobacterium necrophorum naturally-induced foot rot in dairy cows

in Comparative Immunology

Yi Yang
Lulu Zhang
Chen Yu
Sheng Zhang
Chunmei Ye
Zhangping Yang
Zhipeng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714457

639 views

Correction

Published on 06 Jan 2026

Correction: High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

in Comparative Immunology

Myung-Chul Kim
Taeeun Gu
Hyeewon Seo
Yewon Moon
Nicholas Borcherding
Ryan Kolb
Yubin Kim
Youngmin Yun
Woo-Jin Song
Chung-Young Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1773404

617 views

Original Research

Published on 29 Dec 2025

Analysis of CDR3 region diversity with different lengths in bovine immunoglobulin heavy chain genes

in Comparative Immunology

Haidong Zhao
Xiaoqin Tang
Yuelang Zhang
Mingli Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722984

1,370 views

Original Research

Published on 18 Dec 2025

High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

in Comparative Immunology

Myung-Chul Kim
Taeeun Gu
Hyeewon Seo
Yewon Moon
Nicholas Borcherding
Ryan Kolb
Yubin Kim
Youngmin Yun
Woo-Jin Song
Chung-Young Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680437

1,824 views

Original Research

Published on 17 Dec 2025

Integrated bioinformatics and machine learning reveal pan-apoptosis and immune infiltration signatures in diabetic nephropathy

in Comparative Immunology

Yu Liu
Wenqian Lu
Zhicong Xiang
Yuli Shen
Baoyi Ni
Hequn Zou
Xiaofei Shao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659065

2,454 views

Original Research

Published on 16 Dec 2025

High-altitude immune remodeling in children with Mycoplasma pneumoniae pneumonia: a multi-center transcriptome study

in Comparative Immunology

Yingying Luo
Jing Hou
Weifen Lu
Haixia Cao
Erwa Hao
Yaogang Zhang
Feng Liu
Yifan Zhu
Yanyan Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704739

1,138 views

Original Research

Published on 15 Dec 2025

A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism

in Comparative Immunology

Alexandre Menezes
Ana Beatriz Walter-Nuno
Emylle Costa-Bartuli
Daniel Moreira
Tatiana El-Bacha
Ana Paula Méndez
Anderson Amarante
Nathan Kistenmacker
Pâmela Huaman
Mileane Busch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704301

1,684 views

Original Research

Published on 11 Dec 2025

The contribution of amphibian macrophage subsets to scarless regeneration of skin wounds

in Comparative Immunology

Christina N. Garvey Griffith
Kelsey A. Hauser
Bradley Abramson
Elissa R. Chapkin
Elizabeth J. Jones
Anju N. Duttargi
Leon Grayfer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713361

1,177 views

Original Research

Published on 04 Dec 2025

A broadly adaptable protocol for isolating Kupffer cells from non-model species: application to Mastomys natalensis and its susceptibility to Old World mammarenaviruses

in Comparative Immunology

Nicolas Corrales
Katharina Hansen-Kant
Angelika Lander
Joseph B. Prescott

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713374

1,244 views

Correction

Published on 04 Dec 2025

Correction: Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in Lateolabrax maculatus

in Comparative Immunology

Zixiang Wu
Jiarong Guo
Kangle Lu
Kai Song
Ling Wang
Ruijuan Ma
Chunxiao Zhang
Xueshan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691775

797 views

Review

Accepted on 01 Dec 2025

TWEAK-Fn14: A promising target for cardio-cerebrovascular diseases and brain-heart syndrome

in Comparative Immunology

Qinglin Fei
Chang Jun
Tingcan Jiang
Guoqiang Guan
Yujuan Liang
Cuicui Cheng
Guangxu Xiao
Qiuyan Guo
Guanwei Fan
Yan Zhu

Frontiers in Immunology

159 views

Original Research

Published on 28 Nov 2025

Unique TCR loci architecture in newts: TRA and TRD separation in Pleurodeles waltl

in Comparative Immunology

Magdalena Migalska
Wiesław Babik

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696217

1,170 views

Review

Published on 27 Nov 2025

What’s cooking? The effect of temperature on the immune response

in Comparative Immunology

Julie M. Old
Brian Dixon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701016

2,163 views
1 citation

Original Research

Published on 26 Nov 2025

Interactions between the oyster larvae pathogen Vibrio ostreicida and the bivalve hosts Mytilus galloprovincialis and Magallana gigas

in Comparative Immunology

Martina Leonessi
Manon Auguste
Jose R. Lopez
Teresa Balbi
Caterina Ciacci
Caterina Oliveri
Luigi Vezzulli
Dolors Furones
Laura Canesi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711477

1,036 views
2 citations

Original Research

Published on 26 Nov 2025

Dynamics of Vibrio ostreicida in Mytilus galloprovincialis through in vivo infections

in Comparative Immunology

Martina Leonessi
Jose R. Lopez
Yanis Cruz-Quintana
Manon Auguste
Karl B. Andree
Margarita Fernandez-Tejedor
Luigi Vezzulli
Dolors Furones
Laura Canesi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727164

892 views

Original Research

Published on 26 Nov 2025

Adopting orphan receptors: zebrafish Tlr4 homologs mediate responses to group IX/X transition metals

in Comparative Immunology

Aaron P.D. Fox
Tracy S. Lee
Sakina N. Mithaiwala
Niall M. Pollock
Asna Latif
Amit P. Bhavsar
W. Ted Allison

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679375

1,052 views

Review

Published on 26 Nov 2025

Astragalus polysaccharides: structure-immunomodulation relationships, multi-target pharmacological activities, and cutting-edge applications in immune modulation

in Comparative Immunology

Bo Wang
Banglong Wu
Yingjuan Ma
Xiaofeng Liu
Lijun Tao
Limin Jia
Xiaoling Ding
Xuebing Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714898

1,879 views
1 citation

Original Research

Published on 25 Nov 2025

Ovine macrophage identity and plasticity: novel insights into CSF-driven polarization and species-specific responses

in Comparative Immunology

Yanina P. Hecker
Montserrat Coronado
Clara Hurtado-Morillas
David Arranz-Solís
Roberto Sánchez-Sánchez
Ángel Corbí
Luis Miguel Ortega-Mora

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680086

1,261 views

Review

Published on 20 Nov 2025

Immune functions of avian erythrocytes: a comprehensive review from basic biology to pathogen-induced responses

in Comparative Immunology

Fujuan Cai
Yuzhen Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675279

1,583 views

Original Research

Published on 19 Nov 2025

Different kinetics of humoral response against individual antigens in the ovine model of Toxoplasma gondii infection and its pathological association

in Comparative Immunology

Paula Formigo
Ignacio Gual
Germán J. Cantón
Luisa F. Mendoza Morales
Emiliano Sosa
Agustina Soto Cabrera
Valeria Scioli
Claudia Morsella
Valeria A. Sander
Dadin P. Moore

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701645

1,068 views

1,448 articles

articles

LILRB1 and LILRB2 genomics and transcriptomics in macaque and baboon species: polymorphism, diversification, and extensive alternative splicing

A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against Clostridium perfringens-driven diseases

Octopamine modulates the innate immune response in Drosophila melanogaster

Editorial: Cell-mediated innate immunity in aquatic invertebrates and fish: what’s new?

Characterization of T cell responses against Fusobacterium necrophorum naturally-induced foot rot in dairy cows

Correction: High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

Analysis of CDR3 region diversity with different lengths in bovine immunoglobulin heavy chain genes

High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

Integrated bioinformatics and machine learning reveal pan-apoptosis and immune infiltration signatures in diabetic nephropathy

High-altitude immune remodeling in children with Mycoplasma pneumoniae pneumonia: a multi-center transcriptome study

A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism

The contribution of amphibian macrophage subsets to scarless regeneration of skin wounds

A broadly adaptable protocol for isolating Kupffer cells from non-model species: application to Mastomys natalensis and its susceptibility to Old World mammarenaviruses

Correction: Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in Lateolabrax maculatus

TWEAK-Fn14: A promising target for cardio-cerebrovascular diseases and brain-heart syndrome

Unique TCR loci architecture in newts: TRA and TRD separation in Pleurodeles waltl

What’s cooking? The effect of temperature on the immune response

Interactions between the oyster larvae pathogen Vibrio ostreicida and the bivalve hosts Mytilus galloprovincialis and Magallana gigas

Dynamics of Vibrio ostreicida in Mytilus galloprovincialis through in vivo infections

Adopting orphan receptors: zebrafish Tlr4 homologs mediate responses to group IX/X transition metals

Astragalus polysaccharides: structure-immunomodulation relationships, multi-target pharmacological activities, and cutting-edge applications in immune modulation

Ovine macrophage identity and plasticity: novel insights into CSF-driven polarization and species-specific responses

Immune functions of avian erythrocytes: a comprehensive review from basic biology to pathogen-induced responses

Different kinetics of humoral response against individual antigens in the ovine model of Toxoplasma gondii infection and its pathological association