Frontiers in Immunology | Comparative Immunology

Original Research

Published on 21 Aug 2025

Immunogenetic diversity of MHC class II B-Lβ genes in Brazilian Caipiras (free-range) chickens laying blue eggs

in Comparative Immunology

Carlos André da Veiga Lima Rosa Costamilan
Ediane Paludo
Marcos Edgar Herkenhoff
Fábio Pértille
André Luigi Soares de Souza
Carolina Rosai Mendes
Guilherme Dilarri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644110

1,505 views

Original Research

Published on 21 Aug 2025

Identification of galectin-9 and its antibacterial function in Yellow River carp (Cyprinus carpio haematopterus)

in Comparative Immunology

Li Wang
Yuanyuan Hu
Xudong Li
Ziyan Zhang
Nan Wang
Limin Chao
Chengfei Li
Pei Gao
Jinyou Ma
Lei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654890

1,540 views

Original Research

Published on 20 Aug 2025

Protective immune response in rainbow trout (Oncorhynchus mykiss) against the parasitic nematode Anisakis simplex

in Comparative Immunology

Kaan Kumas
Maja Hauptmann Andersen
Rzgar Jaafar
Cyril Henard
Per Walter Kania
Kurt Buchmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646450

2,222 views
1 citation

Review

Published on 20 Aug 2025

Comprehensive review of macrophage models: primary cells and immortalized lines across species

in Comparative Immunology

Tiansong Ding
Yuhan Du
Bin Yang
Wenfan Tian
Jiapei Li
Jinghong Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640935

6,004 views
5 citations

Original Research

Published on 13 Aug 2025

Integrated analysis of single cell and spatial transcriptomics revealed a metastasis mechanism mediated by fatty acid metabolism in lymph nodes of head and neck cancer

in Comparative Immunology

Jinru Weng
Jiajie Mao
Yixing Li
Jun Zhao
Xiaolin Nong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614498

3,262 views
1 citation

Original Research

Published on 04 Aug 2025

Dietary supplementation with nano-zinc modulates the expression of the antiviral immune gene IRF3: a novel report

in Comparative Immunology

Amrita Tah
Aruna Pal
Paresh Nath Chatterjee
Debasis De
Achinta Mahato
Argha Chakraborty
Manti Debnath
Sovan Roy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583956

1,992 views

Original Research

Published on 01 Aug 2025

Single-cell transcriptomics unveils leukocyte heterogeneity in the gills of Larimichthys crocea in response to parasitic infection

in Comparative Immunology

Qiuhua Li
Meiyan Wang
Chenhao Li
Ngoc Tuan Tran
Jingqun Ao
Shengkang Li
Xinhua Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633701

2,630 views

Review

Published on 01 Aug 2025

The FcRn from gene to protein and function: comparison between species

in Comparative Immunology

Luz Belinda Ortiz-Alegría
Lizbeth Xicoténcatl-García
Irma Cañedo-Solares
Claudia Patricia Rico-Torres
Fernando Gómez-Chávez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608426

3,580 views
3 citations

Original Research

Published on 30 Jul 2025

Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to Campylobacter jejuni inoculation

in Comparative Immunology

Yanan Zhao
Yuanmei Wang
Liying Liu
Yanru Ren
Long Liu
Jiayi Wang
Xianyao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630008

2,160 views

Original Research

Published on 25 Jul 2025

Programmed cell death signatures-driven microglial transformation in Alzheimer’s disease: single-cell transcriptomics and functional validation

in Comparative Immunology

Mi-Mi Li
Ying-Xia Yang
Ya-Li Huang
Shu-Juan Wu
Wan-Li Huang
Li-Chao Ye
Ying-Ying Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610717

4,415 views
1 citation

Original Research

Published on 22 Jul 2025

Feed status and skin injury modulate immunopathology, global gene expression, and survival in channel catfish during virulent Aeromonas hydrophila infection

in Comparative Immunology

Yesutor K. Soku
Miles D. Lange
Jason W. Abernathy
Nithin M. Sankappa
Craig A. Shoemaker
Karl Hayden
Linnea K. Andersen
Ida Phillips
Toufic Nashar
Temesgen Samuel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642531

2,349 views

Original Research

Published on 16 Jul 2025

Integrated transcriptomic and immune enzymatic analyses uncover coordinated immunometabolic responses in large yellow croaker (Larimichthys crocea) to Metanophrys sp. infection

in Comparative Immunology

Ruiling Zhou
Kangshuai Sun
Xiao Xie
Fei Yin
Jorge Galindo-Villegas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636453

2,691 views
5 citations

Original Research

Published on 10 Jul 2025

Grass carp Trim47 restricts GCRV infection via SPRY domain-mediated autophagic degradation of nonstructural proteins and disruption of viral inclusion bodies

in Comparative Immunology

Wei Yan
Yang Chen
Dong Yan
Jie Zhang
Ming Xian Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623014

2,029 views

Original Research

Published on 09 Jul 2025

Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomics

in Comparative Immunology

Xinchi Shang
Xinghua Che
Kai Ma
Bo Ma
Huizhi Sun
Wenhua Wu
Hailong He
Meiqi Xing
Wei Xu
Yongquan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633174

2,000 views
2 citations

Original Research

Published on 02 Jul 2025

Protective IgM-mediated immunity against Vibrio anguillarum in Atlantic cod with evolutionary losses of mhc class II and cd4

in Comparative Immunology

Alexandra Jonsson
Adrián López-Porras
Simen Foyn Nørstebø
Naomi Croft Guslund
Henning Sørum
Shuo-Wang Qiao
Finn-Eirik Johansen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579541

1,886 views

Editorial

Published on 01 Jul 2025

Editorial: Environmental stressors and aquatic animal immune system function

in Comparative Immunology

Christopher J. Martyniuk
Erchao Li
Matthew L. Rise

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610969

1,703 views

Review

Published on 25 Jun 2025

RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium subsp. paratuberculosis

in Comparative Immunology

Gerard Badia-Bringué
Marta Alonso-Hearn

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597736

1,917 views
2 citations

Original Research

Published on 24 Jun 2025

ISGylation and E3 ubiquitin ligases: an Atlantic salmon genetic perspective

in Comparative Immunology

Unni Grimholt
Hilde Sindre
Arvind Y. M. Sundaram

Frontiers in Immunology

doi 10.3389/fimmu.2025.1554680

2,511 views

Review

Published on 23 Jun 2025

The battle between bacterial infection and autophagy in aquatic animals

in Comparative Immunology

Qi Wang
He Xu
Jiaxue Jin
Yankai Yang
Lothar Jänsch
Senlin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614182

2,020 views
2 citations

Brief Research Report

Published on 23 Jun 2025

A fish-specific antimicrobial peptide MsPiscidin2 inactivates MSRV and confers protection in largemouth bass

in Comparative Immunology

Chenjie Fei
Ziwen Wang
Yang Hu
Li Nie
Jiong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629256

1,685 views

Review

Published on 20 Jun 2025

Toward understanding sexual immune dimorphism in humans

in Comparative Immunology

Tomasz J. Nowak
Michael P. Muehlenbein

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570565

4,031 views
4 citations

Original Research

Published on 18 Jun 2025

Peptidoglycan derived from Lacticaseibacillus rhamnosus and Lactobacillus acidophilus suppress TLR2/1-mediated inflammation in bovine endometrial epithelial cells

in Comparative Immunology

Elham Waehama
Kenji Fukuda
Alireza Mansouri
Malinda Hulugalla
Ihshan Akthar
Mohamed Samy Yousef
Akio Miyamoto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622307

2,640 views

Original Research

Published on 18 Jun 2025

Functional feed ingredients modulate the immune response of RTgutGC cells to LPS-induced inflammation

in Comparative Immunology

Malene Malchus Fosse
Laura Rivera Méndez
Tania Rodríguez-Ramos
Brian Dixon
Henrik Sundh
Rolf Erik Olsen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616076

2,658 views

Original Research

Published on 17 Jun 2025

Subclinical ketosis in postpartum dairy cows alters the adipose tissue immunological profile in a depot-specific manner

in Comparative Immunology

Tainara C. Michelotti
Bruno C. Menarim
Alexandra P. Tegeler
Jean F. Fiallo Diez
Vinicius S. Machado
Yava Jones-Hall
Oscar J. Benitez
Shavahn C. Loux
Clarissa Strieder-Barboza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578669

2,112 views
1 citation

1,425 articles

articles

Immunogenetic diversity of MHC class II B-Lβ genes in Brazilian Caipiras (free-range) chickens laying blue eggs

Identification of galectin-9 and its antibacterial function in Yellow River carp (Cyprinus carpio haematopterus)

Protective immune response in rainbow trout (Oncorhynchus mykiss) against the parasitic nematode Anisakis simplex

Comprehensive review of macrophage models: primary cells and immortalized lines across species

Integrated analysis of single cell and spatial transcriptomics revealed a metastasis mechanism mediated by fatty acid metabolism in lymph nodes of head and neck cancer

Dietary supplementation with nano-zinc modulates the expression of the antiviral immune gene IRF3: a novel report

Single-cell transcriptomics unveils leukocyte heterogeneity in the gills of Larimichthys crocea in response to parasitic infection

The FcRn from gene to protein and function: comparison between species

Transcriptome-wide N6-methyladenosinem modifications analysis of chicken cecum in responding to Campylobacter jejuni inoculation

Programmed cell death signatures-driven microglial transformation in Alzheimer’s disease: single-cell transcriptomics and functional validation

Feed status and skin injury modulate immunopathology, global gene expression, and survival in channel catfish during virulent Aeromonas hydrophila infection

Integrated transcriptomic and immune enzymatic analyses uncover coordinated immunometabolic responses in large yellow croaker (Larimichthys crocea) to Metanophrys sp. infection

Grass carp Trim47 restricts GCRV infection via SPRY domain-mediated autophagic degradation of nonstructural proteins and disruption of viral inclusion bodies

Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomics

Protective IgM-mediated immunity against Vibrio anguillarum in Atlantic cod with evolutionary losses of mhc class II and cd4

Editorial: Environmental stressors and aquatic animal immune system function

RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium subsp. paratuberculosis

ISGylation and E3 ubiquitin ligases: an Atlantic salmon genetic perspective

The battle between bacterial infection and autophagy in aquatic animals

A fish-specific antimicrobial peptide MsPiscidin2 inactivates MSRV and confers protection in largemouth bass

Toward understanding sexual immune dimorphism in humans

Peptidoglycan derived from Lacticaseibacillus rhamnosus and Lactobacillus acidophilus suppress TLR2/1-mediated inflammation in bovine endometrial epithelial cells

Functional feed ingredients modulate the immune response of RTgutGC cells to LPS-induced inflammation

Subclinical ketosis in postpartum dairy cows alters the adipose tissue immunological profile in a depot-specific manner