Frontiers in Immunology | Comparative Immunology

Original Research

Published on 16 Jun 2025

Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia

in Comparative Immunology

Madison N. Myers
Miguel Chirivi
Jose M. dos Santos Neto
Jair Parales-Girón
Lynn C. Worden
Adam L. Lock
G. Andres Contreras

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595888

2,578 views

Original Research

Published on 06 Jun 2025

Culicoides allergens expressed in insect cells induce sulphidoleukotriene release from peripheral blood leukocytes of horses affected with insect bite hypersensitivity

in Comparative Immunology

Sigridur Jonsdottir
Sara Björk Stefansdottir
Jelena Mirkovitch
Anja Ziegler
Sigurbjörg Torsteinsdottir
Eliane Marti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597233

2,117 views
1 citation

Original Research

Published on 05 Jun 2025

Unveiling regulatory variants in the blood transcriptome and their association with immunity traits in pigs

in Comparative Immunology

Teodor Jové-Juncà
Daniel Crespo-Piazuelo
Carles Hernández-Banqué
Olga González-Rodríguez
Lingzhao Fang
Raquel Quintanilla
Maria Ballester

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582982

2,285 views

Original Research

Published on 05 Jun 2025

Identification of the microglia-associated signature in experimental autoimmune encephalomyelitis

in Comparative Immunology

Yan Wu
Jianhong Wang
Bo Chen
Yuxue Guo
Ping Gan
Yanbing Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581878

3,674 views
2 citations

Original Research

Published on 03 Jun 2025

Inactivated Rothia nasimurium promotes a persistent antiviral immune status in porcine alveolar macrophages

in Comparative Immunology

Aida Tort-Miró
Uxía Alonso
Beatriz Martín-Mur
Jordana Muñoz-Basagoiti
Yan Zeng
David Marín-Moraleda
Enrique Ezcurra
Sergio Montaner-Tarbes
María J. Navas
Marta Muñoz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584092

3,783 views
1 citation

Review

Published on 03 Jun 2025

Autophagy in aquatic animals: mechanisms, implications, and future directions

in Comparative Immunology

Md. Abu Kawsar
Diponkor Adikari
Yang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612178

3,310 views

Original Research

Published on 30 May 2025

Evolutionary insights into Interleukin-12 family targets across 405 species

in Comparative Immunology

Weibin Wang
Dawei Li
Kaiyong Luo
Baozheng Chen
Xuzhen Li
Tingting Hao
Dazhong Guo
Yang Dong
Ya Ning

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584460

2,607 views

Original Research

Published on 28 May 2025

PD-1 is conserved from sharks to humans: new insights into PD-1, PD-L1, PD-L2, and SHP-2 evolution

in Comparative Immunology

Ryohei Kondo
Kohei Kondo
Kei Nabeshima
Akihiko Nishikimi
Yasumasa Ishida
Toshiaki Shigeoka
Johannes M. Dijkstra

Frontiers in Immunology

doi 10.3389/fimmu.2025.1573492

4,339 views

Original Research

Published on 26 May 2025

Host-driven evolution of PCV2: insights into genetic diversity and adaptation

in Comparative Immunology

Giovanni Franzo
Matteo Legnardi
Francesca Poletto
Riccardo Baston
Mattia Cecchinato
Michele Drigo
Claudia Maria Tucciarone

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577436

2,534 views
2 citations

Original Research

Published on 26 May 2025

Integrated transcriptomic and microbiomic analyses reveal mechanisms of Decapod iridescent virus 1 resistance in Macrobrachium rosenbergii

in Comparative Immunology

Jingwen Hao
Yukun Jie
Zhibin Lu
Tiantian Ye
Jilun Meng
Cui Liu
Junjun Yan
Yutong Zheng
Zaijie Dong
Zhimin Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611481

2,494 views
2 citations

Original Research

Published on 21 May 2025

Alleviating effect of vine tea on Aeromonas hydrophila infection revealed by small RNA transcriptome analyses of loach liver

in Comparative Immunology

Wenqing Lai
Yuqin Qiu
Shengnan Pan
Aijun Wan
Xueyang Wang
Dingding Lv
Lishang Dai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584985

1,660 views
1 citation

Original Research

Published on 20 May 2025

Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs

in Comparative Immunology

Naoya Maekawa
Satoru Konnai
Kei Watari
Hiroto Takeuchi
Takeshi Nakanishi
Taro Tachibana
Kenji Hosoya
Sangho Kim
Ryohei Kinoshita
Ryo Owaki

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570717

4,690 views
2 citations

Original Research

Published on 19 May 2025

TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis

in Comparative Immunology

Miguel Chirivi
Ursula Abou-Rjeileh
Madison Myers
Jair Parales-Giron
Lynn Worden
Adam L. Lock
G. Andres Contreras

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591210

2,919 views
4 citations

Original Research

Published on 19 May 2025

Evidence for trans-generational immune priming against Vibrio splendidus in the oyster Crassostrea gigas

in Comparative Immunology

Xiaorui Song
Weilin Wang
Miren Dong
Chang Liu
Chuanyan Yang
Lingling Wang
Linsheng Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536562

1,951 views
1 citation

Original Research

Published on 15 May 2025

Bioinformatics analyses of the proteome of Holothuria tubulosa coelomic fluid and the first evidence of primary cilium in coelomocyte cells

in Comparative Immunology

Laura La Paglia
Manuela Mauro
Vincenzo Arizza
Alfonso Urso
Sugár Simon
Laszlo Drahos
Vita di Stefano
Claudio Luparello
Mirella Vazzana
Aiti Vizzini

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539751

1,976 views
2 citations

Original Research

Published on 15 May 2025

Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in Lateolabrax maculatus

in Comparative Immunology

Zixiang Wu
Jiarong Guo
Kangle Lu
Kai Song
Ling Wang
Ruijuan Ma
Chunxiao Zhang
Xueshan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592806

2,178 views
1 citation

Original Research

Published on 05 May 2025

Cecropin anisaxin-2S has in vitro immunomodulatory, but not antiproliferative and antiviral properties

in Comparative Immunology

Jovana Majstorović
Anush Arakelyan
Željka Trumbić
Jan Kamiš
Mikolaj Adamek
Tomislav Rončević
Vedrana Čikeš Čulić
Jiří Kyslík
Martin Palus
Ivan Fiala

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567505

3,192 views
1 citation

Original Research

Published on 01 May 2025

Immune mechanism of n-butanol extract of Clerodendrum bungei against loach infected with Aeromonas hydrophila

in Comparative Immunology

Ya-Jie Li
Xin-Ya Dong
Hong-Hui Li
Jin-Guo Luo
Xing-Yu Chen
Xu-Dong Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597463

2,189 views

Review

Published on 30 Apr 2025

From Biomphalaria glabrata to Drosophila melanogaster and Anopheles gambiae: the diversity and role of FREPs and Dscams in immune response

in Comparative Immunology

Hongyu Li
Qingzhi Zhao
Jialu Xu
Xianwei Li
Xintong Chen
Yijie Zhang
Hairun Li
Yunhuan Zhu
Mingcheng Liu
Ling Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579905

2,803 views
2 citations

Original Research

Published on 28 Apr 2025

Genome-wide association study and transcriptomic analysis reveal the crucial role of sting1 in resistance to visceral white-nodules disease in Larimichthys polyactis

in Comparative Immunology

Jiajie Zhu
Feng Liu
Ting Ye
Qian Li
Haowen Liu
Sifang Liu
Tianle Zhang
Dandan Guo
Junquan Zhu
Bao Lou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1562307

2,087 views
2 citations

Case Report

Published on 28 Apr 2025

Case Report: The effect of asplenia on the response to influenza vaccination and passive transfer of immunity in an adult female pig

in Comparative Immunology

Michael C. Rahe
John J. Byrne
Danielle Meritet
Erika Gruber
Stephanie N. Langel
Elisa Crisci

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568142

1,790 views

Original Research

Published on 28 Apr 2025

Characterization of temporal expression of immune genes in female locust challenged by fungal pathogen, Aspergillus sp.

in Comparative Immunology

Muhammad Saad Waqas
Xiao Xu
Pengfei Zhang
Jin Guo
Shaojing Hu
Yinwei You
Long Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565964

1,501 views
1 citation

Review

Published on 14 Apr 2025

The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations

in Comparative Immunology

Beining Zhang
Ruiqun Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587414

6,185 views
11 citations

Original Research

Published on 10 Apr 2025

Temporal changes in the transcriptome profile of Macrobrachium rosenbergii in response to decapod iridescent virus 1 infection

in Comparative Immunology

Jingwen Hao
Yukun Jie
Zhibin Lu
Tiantian Ye
Jilun Meng
Cui Liu
Junjun Yan
Yutong Zheng
Zaijie Dong
Zhimin Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575476

2,658 views
2 citations

1,425 articles

articles

Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia

Culicoides allergens expressed in insect cells induce sulphidoleukotriene release from peripheral blood leukocytes of horses affected with insect bite hypersensitivity

Unveiling regulatory variants in the blood transcriptome and their association with immunity traits in pigs

Identification of the microglia-associated signature in experimental autoimmune encephalomyelitis

Inactivated Rothia nasimurium promotes a persistent antiviral immune status in porcine alveolar macrophages

Autophagy in aquatic animals: mechanisms, implications, and future directions

Evolutionary insights into Interleukin-12 family targets across 405 species

PD-1 is conserved from sharks to humans: new insights into PD-1, PD-L1, PD-L2, and SHP-2 evolution

Host-driven evolution of PCV2: insights into genetic diversity and adaptation

Integrated transcriptomic and microbiomic analyses reveal mechanisms of Decapod iridescent virus 1 resistance in Macrobrachium rosenbergii

Alleviating effect of vine tea on Aeromonas hydrophila infection revealed by small RNA transcriptome analyses of loach liver

Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs

TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis

Evidence for trans-generational immune priming against Vibrio splendidus in the oyster Crassostrea gigas

Bioinformatics analyses of the proteome of Holothuria tubulosa coelomic fluid and the first evidence of primary cilium in coelomocyte cells

Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in Lateolabrax maculatus

Cecropin anisaxin-2S has in vitro immunomodulatory, but not antiproliferative and antiviral properties

Immune mechanism of n-butanol extract of Clerodendrum bungei against loach infected with Aeromonas hydrophila

From Biomphalaria glabrata to Drosophila melanogaster and Anopheles gambiae: the diversity and role of FREPs and Dscams in immune response

Genome-wide association study and transcriptomic analysis reveal the crucial role of sting1 in resistance to visceral white-nodules disease in Larimichthys polyactis

Case Report: The effect of asplenia on the response to influenza vaccination and passive transfer of immunity in an adult female pig

Characterization of temporal expression of immune genes in female locust challenged by fungal pathogen, Aspergillus sp.

The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations

Temporal changes in the transcriptome profile of Macrobrachium rosenbergii in response to decapod iridescent virus 1 infection