Frontiers in Immunology | Cytokines and Soluble Mediators in Immunity

Review

Published on 04 Jun 2025

Soluble SARS-CoV-2 Spike glycoprotein: considering some potential pathogenic effects

in Cytokines and Soluble Mediators in Immunity

Bruno Azzarone
Nadine Landolina
Francesca Romana Mariotti
Lorenzo Moretta
Enrico Maggi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616106

6,571 views
1 citation

Original Research

Published on 03 Jun 2025

High-fat diet-induced adipose tissue-resident macrophages, T cells, and dendritic cells modulate chronic inflammation and adipogenesis during obesity

in Cytokines and Soluble Mediators in Immunity

Mousumi Mandal
Md Abdullah Al Mamun
Ahmed Rakib
Udai P. Singh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524544

6,042 views
5 citations

Review

Published on 02 Jun 2025

Role of interleukin-16 in human diseases: a novel potential therapeutic target

in Cytokines and Soluble Mediators in Immunity

Timothy B. Niewold
Julia S. Lehman
Iva Gunnarsson
Alexander Meves
Vilija Oke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524026

4,980 views
5 citations

Original Research

Published on 30 May 2025

Cytokine concentration in peripheral blood of patients with childhood obesity

in Cytokines and Soluble Mediators in Immunity

Jia Mai
Min Wang
Ying Guo
Ling Yang
HongJian Xie
Lan Mei
ZiYao Zhu
XiaoJuan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606375

1,897 views
1 citation

Original Research

Published on 30 May 2025

Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection

in Cytokines and Soluble Mediators in Immunity

Thor Ueland
Rebecca Jane Cox
Annika E. Michelsen
Elisabeth Berg Fjelltveit
Kari Otterdal
Tuva Dahl
Fan Zhou
Rebecca Elyanow
Pål Aukrust
Bjørn Blomberg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578208

3,847 views

Original Research

Published on 30 May 2025

Association between pan-immune-inflammation value and Serum Klotho levels: a cross-sectional analysis of renal function mediation

in Cytokines and Soluble Mediators in Immunity

Mingjie Liu
Xuan Zhou
Han Xu
Yan Wang
Yuting Duan
Xiangru Guo
Bai Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567367

3,501 views
2 citations

Original Research

Published on 28 May 2025

Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression

in Cytokines and Soluble Mediators in Immunity

Fangmin Zhong
Fangyi Yao
Jing Liu
Qun Fang
Xiajing Yu
Bo Huang
Xiaozhong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570903

2,625 views

Original Research

Published on 27 May 2025

Endogenous SLPI contributes to the regulation of inflammatory responses in peritoneal macrophages by modulating MMP-9 production

in Cytokines and Soluble Mediators in Immunity

Mariia Tyshchenko
Natalia Pocałuń
Patrycja Kwiecińska
Joanna Cichy
Mieszko M. Wilk
Ewa Oleszycka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563845

2,938 views

Original Research

Published on 26 May 2025

Developing an in vitro osteochondral micro-physiological system for modeling cartilage-bone crosstalk in arthritis

in Cytokines and Soluble Mediators in Immunity

Kyra W. Y. Smith
Stephanie L. Fung
Hsin-Fang Wu
Irene Chiesa
Giovanni Vozzi
Carmelo De Maria
Riccardo Gottardi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1495613

3,855 views
4 citations

Original Research

Published on 23 May 2025

TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury

in Cytokines and Soluble Mediators in Immunity

Ting Zhou
Ziyao Zhang
Yawen Zhan
Meiying Wang
Mi Wu
Xiufang Weng
Younian Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583235

5,161 views
1 citation

General Commentary

Published on 20 May 2025

Commentary: Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling

in Cytokines and Soluble Mediators in Immunity

Giulia Valdiserra
Clelia Di Salvo
Matteo Fornai
Luca Antonioli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604337

2,954 views
3 citations

Original Research

Published on 08 May 2025

Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster

in Cytokines and Soluble Mediators in Immunity

Shayane Martins Rodrigues Gomes
Marcelo Ribeiro-Alves
Roberto Stefan de Almeida Ribeiro
Andréia Carolinne de Souza Brito
Vinicius da Cunha Lisboa
Samara Galdino de Azevedo
Jeane de Souza Nogueira
Leda dos Reis Castilho
Luís Cristóvão Sobrino Pôrto
Silvia Amaral Gonçalves da Silva

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576430

3,824 views
1 citation

Original Research

Published on 06 May 2025

Characterization and correlation analysis of oral NET markers and inflammatory factor levels in patients after orthodontic treatment: a pilot study

in Cytokines and Soluble Mediators in Immunity

Qian Liu
Axian Wang
Donghui Guo
Houzhuo Luo
Shishu Fang
Zhixin Song
Yi Wen
Fang Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1490637

2,106 views

Original Research

Published on 02 May 2025

Apolipoprotein M expression modifies the sphingolipid landscape in murine blood and lymph

in Cytokines and Soluble Mediators in Immunity

Victoria A. Blaho
Joshua T. Minyard

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572959

2,771 views

Editorial

Published on 01 May 2025

Editorial: The immunological events of macrophages in the course of sepsis

in Cytokines and Soluble Mediators in Immunity

Shiyun Wu
Xu Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610868

1,718 views

Review

Published on 01 May 2025

The effects of interleukin-21 in the biology of transplant rejection

in Cytokines and Soluble Mediators in Immunity

Xiandong Zeng
Yixiao Pan
Qiang Xia
Kang He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571828

3,614 views
1 citation

Original Research

Published on 28 Apr 2025

Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response

in Cytokines and Soluble Mediators in Immunity

Jorgo Lika
James A. Votava
Rupsa Datta
Carlos A. Mellado Fritz
Aleksandr M. Kralovec
Frances M. Smith
Anna Huttenlocher
Melissa C. Skala
Jing Fan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572927

4,132 views
2 citations

Original Research

Published on 17 Apr 2025

Concomitant autoimmunity and late cancers in adult-onset immunodeficiency due to neutralizing anti-IFN-γ autoantibodies

in Cytokines and Soluble Mediators in Immunity

Wan-Ting Tsai
Chih-Yun Cheng
Hsin-Yun Sun
Bei-Chia Guo
Ying-Chieh Chiang
Chiao-Feng Cheng
Yi-Hua Pan
Un-In Wu
Jann-Tay Wang
Wang-Huei Sheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1526439

3,550 views
1 citation

Original Research

Published on 14 Apr 2025

Impact of alcohol consumption on outcomes and potential of immune biomarkers for postoperative complications in trauma patients

in Cytokines and Soluble Mediators in Immunity

Mohammad Majd Hammour
Yelda Anuk
Regina Breinbauer
Romina H. Aspera-Werz
Yuxuan Xin
Guanqiao Chen
Tina Histing
Sabrina Ehnert
Andreas K. Nüssler
Stefan Döbele

Frontiers in Immunology

doi 10.3389/fimmu.2025.1492288

2,964 views

Original Research

Published on 11 Apr 2025

Hematological and biochemical markers and cytokine levels in hospitalized psychiatric patients with COVID-19

in Cytokines and Soluble Mediators in Immunity

Huirong Dai
Chih-Jung Chang
Zishun Li
Farong Liu
Qiao Zhang
Yixuan Bai
Pan You

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536117

2,419 views

Original Research

Published on 11 Apr 2025

LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway

in Cytokines and Soluble Mediators in Immunity

Gang Yuan
Qudi Qiao
Aolin Jiang
Zehui Jiang
Haihua Luo
Lin Huang
Jieyan Wang
Yong Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1549749

5,127 views

Original Research

Published on 08 Apr 2025

High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis

in Cytokines and Soluble Mediators in Immunity

Ping Wang
Yaxiong Li
Li Zhao
Bin Liu
Zhibin Cai
Peng Zhang
Peng Li
Xuezhen Gao
Yong Zhan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1537497

1,718 views

Review

Published on 03 Apr 2025

Epigenetics of maternal-fetal interface immune microenvironment and placental related pregnancy complications

in Cytokines and Soluble Mediators in Immunity

Xueqin Ma
Xin Chen
Xuefeng Mu
Min Cao
Yan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1549839

3,862 views
5 citations

Mini Review

Published on 31 Mar 2025

The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications

in Cytokines and Soluble Mediators in Immunity

Ting Zhao
Congyue Wang
Yuhan Liu
Bo Li
Mingjia Shao
Wuyang Zhao
Chuang Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1555414

5,011 views
19 citations

1,282 articles

articles

Soluble SARS-CoV-2 Spike glycoprotein: considering some potential pathogenic effects

High-fat diet-induced adipose tissue-resident macrophages, T cells, and dendritic cells modulate chronic inflammation and adipogenesis during obesity

Role of interleukin-16 in human diseases: a novel potential therapeutic target

Cytokine concentration in peripheral blood of patients with childhood obesity

Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection

Association between pan-immune-inflammation value and Serum Klotho levels: a cross-sectional analysis of renal function mediation

Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression

Endogenous SLPI contributes to the regulation of inflammatory responses in peritoneal macrophages by modulating MMP-9 production

Developing an in vitro osteochondral micro-physiological system for modeling cartilage-bone crosstalk in arthritis

TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury

Commentary: Guselkumab binding to CD64+ IL-23–producing myeloid cells enhances potency for neutralizing IL-23 signaling

Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster

Characterization and correlation analysis of oral NET markers and inflammatory factor levels in patients after orthodontic treatment: a pilot study

Apolipoprotein M expression modifies the sphingolipid landscape in murine blood and lymph

Editorial: The immunological events of macrophages in the course of sepsis

The effects of interleukin-21 in the biology of transplant rejection

Mitochondrial metabolism is rapidly re-activated in mature neutrophils to support stimulation-induced response

Concomitant autoimmunity and late cancers in adult-onset immunodeficiency due to neutralizing anti-IFN-γ autoantibodies

Impact of alcohol consumption on outcomes and potential of immune biomarkers for postoperative complications in trauma patients

Hematological and biochemical markers and cytokine levels in hospitalized psychiatric patients with COVID-19

LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway

High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis

Epigenetics of maternal-fetal interface immune microenvironment and placental related pregnancy complications

The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications