Frontiers in Immunology | Immunological Tolerance and Regulation

Original Research

Published on 13 Aug 2025

Identification of Rhododendron mariae extraction as a new attachment inhibitor against dengue virus by targeting the envelope protein domain III

in Immunological Tolerance and Regulation

Chunyang Tian
Yuanru Zheng
Dongkai Tang
Haiyan Tian
Lingzhu Shi
Xuemei He
Jianhai Yu
Lijun Yan
Huihui Cao
Wei Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663878

459 views

Editorial

Accepted on 12 Aug 2025

EDITORIAL: Genes, Cells, and Macroenvironments: Regulating the Immune Response in Extreme Conditions

in Immunological Tolerance and Regulation

Giuseppina Pennesi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674347

Editorial

Published on 12 Aug 2025

Editorial: Immunology at the feto-maternal interface

in Immunological Tolerance and Regulation

Amir-Hassan Zarnani
Mahmood Jeddi-Tehrani
Marie-Pierre Piccinni
Maria Laura Zenclussen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667375

472 views

Review

Accepted on 11 Aug 2025

Natural Antidepressants in Neuroimmunomodulation: Molecular Mechanisms, Action Targets, and Therapeutic Potential

in Immunological Tolerance and Regulation

Shimeng Lv
Ling Hui Kong
Ruirui Shang
Xia Zhong
Yitong Lu
Guangheng Zhang
Haonan Gao
Xin Hou
Guoqiang Li
Xiaowen Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642001

154 views

Original Research

Published on 11 Aug 2025

Identification and validation of expression and functions of ferroptosis-related gene HILPDA in early-onset preeclampsia placentas

in Immunological Tolerance and Regulation

Qianghua Wang
Xuegu Wang
Jiaojiao Fei
Chuanyue Jiang
Yafen Tao
Nana Yang
Huijuan Chen
Chengli Dou
Biao Ding
Danli Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627057

599 views

Original Research

Accepted on 08 Aug 2025

Bone Marrow-Derived Extracellular Vesicles from Multiple Myeloma Patients Promote Adaptive Immune Dysfunction via HLA-G, PD-1, and PD-L1

in Immunological Tolerance and Regulation

Debora Soncini
Danilo Marimpietri
Francesco Ladisa
Francesco Lai
Irma Airoldi
Roberto Gramignoli
Michele Cea
Fabio Morandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640168

179 views

Original Research

Accepted on 07 Aug 2025

Immune Dysregulation in Preeclampsia: Integrative Analysis of Peripheral Transcriptomes and Placental Single-Cell Land-scapes

in Immunological Tolerance and Regulation

Shu Zheng
Huimin Shen
Peng Xu
Chang Shu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638603

130 views

Original Research

Accepted on 30 Jul 2025

4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells

in Immunological Tolerance and Regulation

Hanna Steppuhn
Katja Hohenberger
Susanne Mittler
Sonja Trump
Manfred Rauh
Andreas B Wild
Nikolaos (Nikos) G Papadopoulos
Susetta Finotto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640499

291 views

Editorial

Published on 30 Jul 2025

Editorial: Immune modulation and angiogenesis in regenerative and developmental processes

in Immunological Tolerance and Regulation

Niv Pencovich
Timucin Taner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662121

566 views

Editorial

Accepted on 29 Jul 2025

EDITORIAL: Immune Plasticity in Mixed Pattern Rheumatic Diseases

in Immunological Tolerance and Regulation

Matilde Otero-Losada
Rodolfo Alberto Kolliker Frers
Radjesh Bisoendial
Francisco Capani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665204

232 views

Brief Research Report

Published on 29 Jul 2025

Hyporesponsive fetus-specific T cell responses in multiparous human pregnancy

in Immunological Tolerance and Regulation

Jessica C. Morgan
Grace E. Hynes
Jared M. Pollard
Michael S. Andrade
Jong Cheol Jeong
Anita S. Chong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634430

647 views

Original Research

Accepted on 28 Jul 2025

Promotion of Treg/Th17 Balance in MRL/lpr Mice by Jianpi-Zishen Formula Via Modulation of DNMT1-Mediated Foxp3 Methylation

in Immunological Tolerance and Regulation

Ming Li
Lijun Pang
Yunfei Li
Junjie Chen
Shuangshuang Shang
Chuanbing Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631631

138 views

Original Research

Accepted on 24 Jul 2025

Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in alpha-gal syndrome

in Immunological Tolerance and Regulation

Shailesh K. Choudhary
Scott P Commins

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629310

367 views

Opinion

Published on 23 Jul 2025

‘Immune reset plus’: the case for combining immunotherapies to maintain self-tolerance in autoimmune diseases

in Immunological Tolerance and Regulation

Fabrina Gaspal
Parth Narendran
Sky T. H. Ng
Michael J. Price
David C. Wraith

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634090

1,218 views

Mini Review

Published on 22 Jul 2025

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons

in Immunological Tolerance and Regulation

Michael D. Kulis
Jessica R. Humphrey
James W. Krempski
Edwin H. Kim
Johanna M. Smeekens

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617153

1,510 views

Review

Published on 17 Jul 2025

Macrophages in chronic infections: regulation and remodeling

in Immunological Tolerance and Regulation

Hongle Cui
Min Wang
Sitan Jiao
Sirui Tian
Hui Liu
Bo Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594988

808 views