Frontiers in Immunology | Immunological Tolerance and Regulation

Review

Published on 16 Jan 2026

Fibroblasts as a ruler of the immune microenvironment: measurement and modulation in tissue homeostasis and disease

in Immunological Tolerance and Regulation

Yanling Zhang
Xinyi Fang
Lian Yan
Lin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1752621

1,143 views

Original Research

Published on 16 Jan 2026

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

in Immunological Tolerance and Regulation

Biao Lei
Zhenyang Liu
Peifang Xie
Xuanxuan Li
Zhanyu Cui
Ruihan Chen
Bin Liu
Shihua Chen
Yaxin Li
Min Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1764754

953 views

Original Research

Published on 15 Jan 2026

Identification and validation of an endotoxin tolerance–based prognostic model with therapeutic insights in sepsis

in Immunological Tolerance and Regulation

Yu Xie
Yadong Su
Yin Qin
Qiuhong Zhang
Jie Liu
Yanlin Wu
Ning Du
Yu Jiang
Gang Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707490

1,043 views

Review

Published on 15 Jan 2026

Iron homeostasis and macrophage polarization in pulmonary fibrosis: mechanisms and therapeutic perspectives

in Immunological Tolerance and Regulation

Minlan Luo
Ali Al-waqeerah
Lili Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1742761

1,047 views

Review

Published on 12 Jan 2026

Integrin alpha L: structure, cellular functions, and emerging role in human diseases

in Immunological Tolerance and Regulation

Xianglin Wang
Guoya Yang
Yanpei Chen
Fang Zhu
Fuming Lian
Wenzhi Shen
Dehong Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707291

813 views

Systematic Review

Published on 08 Jan 2026

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: a comprehensive systematic literature review

in Immunological Tolerance and Regulation

Priya S. Kishnani
Johanna M. P. Van Den Hout
Andreas Hahn
David Kronn
Yin-Hsiu Chien
Mei Han
Jennifer Heuterman
Susan Sparks
Colin Glen
Nadia Daba

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690312

1,261 views
1 citation

Brief Research Report

Published on 07 Jan 2026

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

in Immunological Tolerance and Regulation

Gianpiero Lupoli
Stefano Bergamini
Jeannette Salsetta
Alessandro Mereu
Agata Cova
Elisa D’Angelo
Eriomina Shahaj
Elisabetta Vergani
Martina Stroscia
Emma Di Carlo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696460

1,274 views

Original Research

Published on 06 Jan 2026

Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro

in Immunological Tolerance and Regulation

Dongling Luo
Jifeng Liu
Leilei Ya
Chengxuan Ruan
Siyi Ou
Yiqian Wei
Qingyun Lin
Zhaohong Huang
Kaiwen Nong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715736

1,712 views

Perspective

Published on 05 Jan 2026

Considerations for biologics as front-line treatment in allergic diseases

in Immunological Tolerance and Regulation

Akash Kothari
Lisa Hung
Julia E. M. Upton

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746790

2,458 views

Original Research

Published on 05 Jan 2026

Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation

in Immunological Tolerance and Regulation

Julian Hölzenbein
Sabine Schramm
Falko M. Heinemann
Andreas Heinold
Anja Gäckler
Johanna Reinold
Benjamin Wilde
Yannik Busch
Nina Gruenen
Wolfgang Peter

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697839

1,419 views

Original Research

Published on 05 Jan 2026

Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy

in Immunological Tolerance and Regulation

Hui-Li Yang
Jia-Wei Shi
Zhen-Zhen Lai
Xin Li
Chun-Jie Gu
Zi-Meng Zheng
Hong-Bo Zhao
Jiang-Feng Ye
Li Wang
Ting Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1747323

1,093 views

Original Research

Published on 22 Dec 2025

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4+ T cells

in Immunological Tolerance and Regulation

Gabrielle Barran
Najib Naamane
Abdul Mannan Baru
Amy E. Anderson
Jane Falconer
Catharien M. U. Hilkens

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698413

2,224 views

Review

Published on 19 Dec 2025

Modular mastery of inflammation: umbilical cord mesenchymal stem cells as a therapeutic frontier

in Immunological Tolerance and Regulation

Li Yin
Chen-yang Sun
Gui-lai Chen
Zhuo Xiang
Bao-quan Hu
Fang Zhou
Qiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721947

1,747 views

Original Research

Published on 16 Dec 2025

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

in Immunological Tolerance and Regulation

Elisa Talker
Tanja Gerlza
Philippe Stas
Christina Trojacher
Tiziana Adage
Andreas J. Kungl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679409

1,182 views

Original Research

Published on 11 Dec 2025

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

in Immunological Tolerance and Regulation

Wang Luoying
Yi Xingcheng
Cong Donghang
Long Mengtuan
Wang Ping
Zhang Lijuan
Li Yupeng
Zhao Tianyi
Chen Hongyu
Wang Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694985

1,950 views

Mini Review

Published on 09 Dec 2025

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

in Immunological Tolerance and Regulation

Xeni Beli
Nikolaos Savvopoulos
Dionysia Kefala
Memnon Lysandrou
Maria Liga
Alexandros Spyridonidis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716778

1,565 views

Original Research

Published on 08 Dec 2025

Immunogenicity risk assessment of peptide-related impurities identified in generic teriparatide products

in Immunological Tolerance and Regulation

Aimee E. Mattei
Brian J. Roberts
Sandra Lelias
Shah Miah
Kristina E. Howard
James L. Weaver
Daniela Verthelyi
Eric S. Pang
Katie Edwards
Anne S. De Groot

Frontiers in Immunology

doi 10.3389/fimmu.2025.1730346

3,537 views

Original Research

Published on 08 Dec 2025

WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface

in Immunological Tolerance and Regulation

Lingyu Chang
Jiani Guo
Xi Xue
Yang Yan
Xinyi Li
Weijie Zhao
Xiaoli Sun
Jiajia Chen
Meirong Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712898

1,728 views

Original Research

Published on 05 Dec 2025

Pig regulatory macrophages as a donor-derived immune modulators in xenotransplantation

in Immunological Tolerance and Regulation

Phu Chi Vu
Nhat Minh Dang
Vinh Phuoc Nguyen
Jonghyeok Jung
Joohyun Shim
Jeong Ho Hwang
Thi Xoan Hoang
Ik Jin Yun
Jae Young Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718937

1,856 views

Original Research

Published on 04 Dec 2025

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules

in Immunological Tolerance and Regulation

Saif Al-Haidar
Martin Schønemann-Lund
Mikkel Gybel-Brask
Jakob Stensballe
Lars Andresen
Pär I. Johansson
Morten H. Bestle
Søren Skov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656815

1,239 views

Original Research

Published on 01 Dec 2025

Immune dysregulation in preeclampsia: integrative analysis of peripheral transcriptomes and placental single-cell land-scapes

in Immunological Tolerance and Regulation

Shu Zheng
Peng Xu
Huimin Shen
Chang Shu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638603

1,892 views

Review

Published on 27 Nov 2025

Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD

in Immunological Tolerance and Regulation

Huihui Zhao
Weili Wang
Pengchao Zhu
Zhaohong Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680878

2,601 views
1 citation

Review

Published on 27 Nov 2025

Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunity

in Immunological Tolerance and Regulation

Qiwei Fan
Zhijie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703382

1,994 views

Review

Published on 25 Nov 2025

Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis

in Immunological Tolerance and Regulation

Riya Khilwani
Shailza Singh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649517

1,980 views

1,661 articles

articles

Fibroblasts as a ruler of the immune microenvironment: measurement and modulation in tissue homeostasis and disease

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

Identification and validation of an endotoxin tolerance–based prognostic model with therapeutic insights in sepsis

Iron homeostasis and macrophage polarization in pulmonary fibrosis: mechanisms and therapeutic perspectives

Integrin alpha L: structure, cellular functions, and emerging role in human diseases

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: a comprehensive systematic literature review

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro

Considerations for biologics as front-line treatment in allergic diseases

Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation

Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4+ T cells

Modular mastery of inflammation: umbilical cord mesenchymal stem cells as a therapeutic frontier

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

Harnessing the immunomodulatory properties of HLA-G for advanced immunotherapies

Immunogenicity risk assessment of peptide-related impurities identified in generic teriparatide products

WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface

Pig regulatory macrophages as a donor-derived immune modulators in xenotransplantation

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules

Immune dysregulation in preeclampsia: integrative analysis of peripheral transcriptomes and placental single-cell land-scapes

Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD

Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunity

Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis