Frontiers in Immunology | Immunological Tolerance and Regulation

Original Research

Accepted on 29 Nov 2025

Cigarette Smoke Exposure Triggers Dendritic Cell-Derived Exosome-Mediated Th17 and Treg Polarization through an Autophagy-and Necroptosis-Associated SIRT1-Dependent Mechanism

in Immunological Tolerance and Regulation

Dongling Luo
Jifeng Liu
Leilei Ya
Chengxuan Ruan
Siyi Ou
Yiqian Wei
Qingyun Lin
Zhaohong Huang
Kaiwen Nong

Frontiers in Immunology

504 views

Systematic Review

Accepted on 28 Nov 2025

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: A comprehensive systematic literature review

in Immunological Tolerance and Regulation

Priya Kishnani
JMP Van Den Hout
Andreas Hahn
David Kronn
Yin-Hsiu Chien
Mei Han
Jennifer Heuterman
Susan Sparks
Colin Glen
Nadia Daba

Frontiers in Immunology

222 views

Review

Published on 27 Nov 2025

Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD

in Immunological Tolerance and Regulation

Huihui Zhao
Weili Wang
Pengchao Zhu
Zhaohong Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680878

1,560 views

Review

Published on 27 Nov 2025

Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunity

in Immunological Tolerance and Regulation

Qiwei Fan
Zhijie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703382

1,116 views

Review

Published on 25 Nov 2025

Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis

in Immunological Tolerance and Regulation

Riya Khilwani
Shailza Singh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649517

1,367 views

Original Research

Published on 25 Nov 2025

Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens

in Immunological Tolerance and Regulation

Yutong Xie
Jiacheng Zhang
Wenhan Yang
Zhiyu Pan
Lian Wang
Ju Lai
Kai Fan
Yalei Dai
Keqiang Zuo
Fei He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678927

1,202 views

Original Research

Published on 19 Nov 2025

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

in Immunological Tolerance and Regulation

Anna Slawek
Paulina Kubik
Mateusz Psurski
Anna Ewa Kedzierska
Anna Chelmonska-Soyta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648641

1,561 views

Original Research

Published on 18 Nov 2025

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc- and miR-214-3p/Stat3/GPX4 axis

in Immunological Tolerance and Regulation

Yao Shi
Changju Ma
Xiaojuan Tang
Haojie Su
Yue Lu
Jianan Wei
Li Li
Tianhua Huang
Xicheng Wang
Xintian Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674321

1,538 views

Review

Published on 17 Nov 2025

The past, present, and future of anti-idiotype antibodies

in Immunological Tolerance and Regulation

William J. Murphy
Craig P. Collins
Heinz Kohler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686107

1,237 views

Review

Published on 11 Nov 2025

Phytochemicals as modulators of dendritic cell functions: implications for tolerogenic cell-based therapy

in Immunological Tolerance and Regulation

Tünde Fekete
Kitti Pázmándi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653803

1,875 views

Original Research

Published on 05 Nov 2025

Identification and validation of paraptosis-related biomarkers in recurrent miscarriage

in Immunological Tolerance and Regulation

Yunhui Wan
Fang Fang
Qiao Wang
Jia Xu
Pei Zhu
Ying Cui
Lili Hou
Huimin Wang
Xiaoyong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656650

1,377 views

Review

Published on 04 Nov 2025

Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies

in Immunological Tolerance and Regulation

Ewelina Stelcer
Anna Wozniak
Dorota Magner
Joanna Zeyland

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663246

2,094 views

Review

Published on 03 Nov 2025

Use of regulatory cells for achieving functional tolerance of pig heart xenotransplants in humans: a literature review

in Immunological Tolerance and Regulation

Gheorghe Traian Braileanu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648926

1,333 views

Original Research

Published on 03 Nov 2025

Immune tolerance induction using the thyrotropin receptor epitope 78–94 (p37) prevents Graves’ disease in HLA-DR3 transgenic mice

in Immunological Tolerance and Regulation

Hidefumi Inaba
Itsuki Nonaka
Daiki Hashimoto
Moritoshi Hirono
Shuhei Morita
Hiroaki Kimura
Hiroshi Iwakura
Takashi Akamizu
Masanori Nakata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633350

1,364 views

Clinical Trial

Published on 31 Oct 2025

Immunomodulatory effects and mechanisms of Qi-Xu-Tiao-Ti formula in Qi-deficiency constitution: a randomized controlled trial integrated with multi-omics and network pharmacology analysis

in Immunological Tolerance and Regulation

Renyun Cui
Ming Fan
Chengzhi Yang
Cheng Chen
Jinlu Xia
Xi Liu
Guohui Zhang
Fangli Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675502

2,285 views

Original Research

Published on 30 Oct 2025

Proteomic analysis of exosomes from Brucella abortus-infected macrophages reveals possible mechanisms of immune evasion and host modulation

in Immunological Tolerance and Regulation

Francisco Álvarez
Vicente Arriagada
María Jesús Aburto
Ítalo Ferrari
Ilse Alvarado
José Barrales
Roberto Vidal
Felipe del Canto
Leonardo A. Gómez
Ángel A. Oñate

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685245

2,007 views

Opinion

Published on 30 Oct 2025

If Tregs were people: regulation as the quiet architecture of immunity and society

in Immunological Tolerance and Regulation

Bruno B. Andrade
Mariana Araújo-Pereira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720091

958 views

Editorial

Published on 28 Oct 2025

Editorial: Exploring immunomodulation to balance maladaptive inflammation and restore tissue homeostasis

in Immunological Tolerance and Regulation

David M. Smadja
Maxime Jeljeli
Alexandre G. Lellouch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723620

982 views

Systematic Review

Published on 27 Oct 2025

Comparing the circulating immune profile of women with and without recurrent implantation failure: a systematic review and meta-analysis

in Immunological Tolerance and Regulation

Daxina Bhatt
Yousef Alebrahim
Abdullah Shahzad
Lamiya Mohiyiddeen
Elizabeth Mann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627514

1,364 views

Original Research

Published on 24 Oct 2025

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

in Immunological Tolerance and Regulation

Ying-qing Gan
Yuan-wen Cai
Xiu-wen Liang
Ling-Zhi Wang
Fu-li Shi
Nuo Sun
Ya-ping Li
Rong Xu
Bo Hu
Qing-bing Zha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631152

1,962 views

Clinical Trial

Published on 22 Oct 2025

Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study

in Immunological Tolerance and Regulation

Sayantani B. Sindher
Andrea Fernandes
Monali Manohar
Shu Cao
Sheena Gupta
Ella Parsons
Dinara Bogetic
Divya Kumar
Jessica Rogers
Julia Thompson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655975

3,012 views

Original Research

Published on 21 Oct 2025

Human leukocyte antigen-G isoform HLA-G2/6, but not HLA-G1/4/5, is an independent indicator of poor survival in patients with colorectal cancer

in Immunological Tolerance and Regulation

Xia Zhang
Qiu-Yue Han
Jian-Gang Zhang
Jiao Lin
Wei-Hua Yan
Aifen Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672144

1,675 views

Original Research

Accepted on 20 Oct 2025

Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation

in Immunological Tolerance and Regulation

Julian Hölzenbein
Sabine Schramm
Falko M. Heinemann
Andreas Heinold
Anja Gäckler
Johanna Reinold
Benjamin Wilde
Yannik Busch
Nina Gruenen
Wolfgang Peter

Frontiers in Immunology

268 views

Original Research

Published on 16 Oct 2025

Ex vivo expanded human regulatory T cells promote cholesterol efflux and PON1 expression in oxLDL-exposed macrophages via gap junction-mediated cAMP transfer

in Immunological Tolerance and Regulation

Caraugh Jane Albany
Daniela Mastronicola
Momchil Popov
Wladislaw Stroukov
Anthony S. Wierzbicki
Rocio Teresa Martinez-Nunez
Giovanna Lombardi
Cristiano Scottà

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662925

3,039 views

1,643 articles

articles

Cigarette Smoke Exposure Triggers Dendritic Cell-Derived Exosome-Mediated Th17 and Treg Polarization through an Autophagy-and Necroptosis-Associated SIRT1-Dependent Mechanism

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: A comprehensive systematic literature review

Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD

Breach and restoration of retinal immune privilege: barrier failure, innate dysregulation, and adaptive autoimmunity

Dual signaling cascade regulating gut-lung axis in Interleukin-6/Interleukin-17 for NSCLC immuno pathogenesis

Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc- and miR-214-3p/Stat3/GPX4 axis

The past, present, and future of anti-idiotype antibodies

Phytochemicals as modulators of dendritic cell functions: implications for tolerogenic cell-based therapy

Identification and validation of paraptosis-related biomarkers in recurrent miscarriage

Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies

Use of regulatory cells for achieving functional tolerance of pig heart xenotransplants in humans: a literature review

Immune tolerance induction using the thyrotropin receptor epitope 78–94 (p37) prevents Graves’ disease in HLA-DR3 transgenic mice

Immunomodulatory effects and mechanisms of Qi-Xu-Tiao-Ti formula in Qi-deficiency constitution: a randomized controlled trial integrated with multi-omics and network pharmacology analysis

Proteomic analysis of exosomes from Brucella abortus-infected macrophages reveals possible mechanisms of immune evasion and host modulation

If Tregs were people: regulation as the quiet architecture of immunity and society

Editorial: Exploring immunomodulation to balance maladaptive inflammation and restore tissue homeostasis

Comparing the circulating immune profile of women with and without recurrent implantation failure: a systematic review and meta-analysis

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study

Human leukocyte antigen-G isoform HLA-G2/6, but not HLA-G1/4/5, is an independent indicator of poor survival in patients with colorectal cancer

Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation

Ex vivo expanded human regulatory T cells promote cholesterol efflux and PON1 expression in oxLDL-exposed macrophages via gap junction-mediated cAMP transfer