Frontiers in Immunology | Immunological Tolerance and Regulation

Original Research

Published on 25 Nov 2025

Multiple tail vein injections of adipose-derived mesenchymal stem cells ameliorate allergic rhinitis in mice: superior efficacy of prolonged regimens

in Immunological Tolerance and Regulation

Yutong Xie
Jiacheng Zhang
Wenhan Yang
Zhiyu Pan
Lian Wang
Ju Lai
Kai Fan
Yalei Dai
Keqiang Zuo
Fei He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678927

1,970 views

Original Research

Published on 19 Nov 2025

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

in Immunological Tolerance and Regulation

Anna Slawek
Paulina Kubik
Mateusz Psurski
Anna Ewa Kedzierska
Anna Chelmonska-Soyta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648641

1,994 views

Original Research

Published on 18 Nov 2025

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc- and miR-214-3p/Stat3/GPX4 axis

in Immunological Tolerance and Regulation

Yao Shi
Changju Ma
Xiaojuan Tang
Haojie Su
Yue Lu
Jianan Wei
Li Li
Tianhua Huang
Xicheng Wang
Xintian Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674321

2,179 views

Review

Published on 17 Nov 2025

The past, present, and future of anti-idiotype antibodies

in Immunological Tolerance and Regulation

William J. Murphy
Craig P. Collins
Heinz Kohler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686107

2,014 views

Review

Published on 11 Nov 2025

Phytochemicals as modulators of dendritic cell functions: implications for tolerogenic cell-based therapy

in Immunological Tolerance and Regulation

Tünde Fekete
Kitti Pázmándi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653803

2,587 views
1 citation

Original Research

Published on 05 Nov 2025

Identification and validation of paraptosis-related biomarkers in recurrent miscarriage

in Immunological Tolerance and Regulation

Yunhui Wan
Fang Fang
Qiao Wang
Jia Xu
Pei Zhu
Ying Cui
Lili Hou
Huimin Wang
Xiaoyong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656650

1,867 views

Review

Published on 04 Nov 2025

Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies

in Immunological Tolerance and Regulation

Ewelina Stelcer
Anna Wozniak
Dorota Magner
Joanna Zeyland

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663246

2,904 views

Review

Published on 03 Nov 2025

Use of regulatory cells for achieving functional tolerance of pig heart xenotransplants in humans: a literature review

in Immunological Tolerance and Regulation

Gheorghe Traian Braileanu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648926

1,869 views

Original Research

Published on 03 Nov 2025

Immune tolerance induction using the thyrotropin receptor epitope 78–94 (p37) prevents Graves’ disease in HLA-DR3 transgenic mice

in Immunological Tolerance and Regulation

Hidefumi Inaba
Itsuki Nonaka
Daiki Hashimoto
Moritoshi Hirono
Shuhei Morita
Hiroaki Kimura
Hiroshi Iwakura
Takashi Akamizu
Masanori Nakata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633350

1,780 views
1 citation

Clinical Trial

Published on 31 Oct 2025

Immunomodulatory effects and mechanisms of Qi-Xu-Tiao-Ti formula in Qi-deficiency constitution: a randomized controlled trial integrated with multi-omics and network pharmacology analysis

in Immunological Tolerance and Regulation

Renyun Cui
Ming Fan
Chengzhi Yang
Cheng Chen
Jinlu Xia
Xi Liu
Guohui Zhang
Fangli Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675502

2,850 views

Original Research

Published on 30 Oct 2025

Proteomic analysis of exosomes from Brucella abortus-infected macrophages reveals possible mechanisms of immune evasion and host modulation

in Immunological Tolerance and Regulation

Francisco Álvarez
Vicente Arriagada
María Jesús Aburto
Ítalo Ferrari
Ilse Alvarado
José Barrales
Roberto Vidal
Felipe del Canto
Leonardo A. Gómez
Ángel A. Oñate

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685245

2,521 views

Opinion

Published on 30 Oct 2025

If Tregs were people: regulation as the quiet architecture of immunity and society

in Immunological Tolerance and Regulation

Bruno B. Andrade
Mariana Araújo-Pereira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720091

1,115 views

Editorial

Published on 28 Oct 2025

Editorial: Exploring immunomodulation to balance maladaptive inflammation and restore tissue homeostasis

in Immunological Tolerance and Regulation

David M. Smadja
Maxime Jeljeli
Alexandre G. Lellouch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723620

1,443 views

Systematic Review

Published on 27 Oct 2025

Comparing the circulating immune profile of women with and without recurrent implantation failure: a systematic review and meta-analysis

in Immunological Tolerance and Regulation

Daxina Bhatt
Yousef Alebrahim
Abdullah Shahzad
Lamiya Mohiyiddeen
Elizabeth Mann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627514

1,762 views

Original Research

Published on 24 Oct 2025

Impaired NLRP3 inflammasome signaling diverts pyroptotic to apoptotic caspase activation in macrophages

in Immunological Tolerance and Regulation

Ying-qing Gan
Yuan-wen Cai
Xiu-wen Liang
Ling-Zhi Wang
Fu-li Shi
Nuo Sun
Ya-ping Li
Rong Xu
Bo Hu
Qing-bing Zha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631152

2,381 views

Clinical Trial

Published on 22 Oct 2025

Trends in allergen-reactive CRTH2+ T cells and TARC associated with successful outcomes in a phase 2 cashew oral immunotherapy study

in Immunological Tolerance and Regulation

Sayantani B. Sindher
Andrea Fernandes
Monali Manohar
Shu Cao
Sheena Gupta
Ella Parsons
Dinara Bogetic
Divya Kumar
Jessica Rogers
Julia Thompson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655975

3,410 views

Original Research

Published on 21 Oct 2025

Human leukocyte antigen-G isoform HLA-G2/6, but not HLA-G1/4/5, is an independent indicator of poor survival in patients with colorectal cancer

in Immunological Tolerance and Regulation

Xia Zhang
Qiu-Yue Han
Jian-Gang Zhang
Jiao Lin
Wei-Hua Yan
Aifen Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672144

2,011 views

Original Research

Published on 16 Oct 2025

Ex vivo expanded human regulatory T cells promote cholesterol efflux and PON1 expression in oxLDL-exposed macrophages via gap junction-mediated cAMP transfer

in Immunological Tolerance and Regulation

Caraugh Jane Albany
Daniela Mastronicola
Momchil Popov
Wladislaw Stroukov
Anthony S. Wierzbicki
Rocio Teresa Martinez-Nunez
Giovanna Lombardi
Cristiano Scottà

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662925

3,396 views

Mini Review

Published on 15 Oct 2025

Communication between gut microbiota-derived metabolites and the tumor microenvironment

in Immunological Tolerance and Regulation

Xinyi Hu
Bo Li
Yuanqing Li
Yushan Liang
Tingting Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649438

2,430 views
1 citation

Review

Published on 15 Oct 2025

Immune responses in retinal gene therapy: challenges, mechanisms, and future strategies

in Immunological Tolerance and Regulation

Yawei Ma
Yin Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664968

2,661 views
2 citations

Original Research

Published on 08 Oct 2025

Bioinformatics identification of mitochondria and macrophage polarization-related genes in COPD and their potential mechanisms

in Immunological Tolerance and Regulation

Chenchen Zhang
Peishu Fu
Juanchun Yu
Lingling Liu
Xiong Wei
Xiao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675292

3,790 views

Original Research

Published on 30 Sep 2025

Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome

in Immunological Tolerance and Regulation

Shailesh K. Choudhary
Scott P. Commins

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629310

3,356 views
1 citation

Original Research

Published on 25 Sep 2025

Gut commensal bacteria-derived polysaccharide sub-micron particles induce antigen-specific, tolerogenic responses

in Immunological Tolerance and Regulation

Rian Harriman
Allen B. Tu
Zhenyu Wang
Nicolas Radoc
Hamilton Kakwere
Jamal S. Lewis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599480

3,425 views

Correction

Published on 23 Sep 2025

Correction: Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten

in Immunological Tolerance and Regulation

Eduardo de la Fuente-Munoz
Miguel Fernández-Arquero
Nabil Subhi-Issa
Kissy Guevara-Hoyer
Lydia Pilar Suárez
Raquel Gil Laborda
Marina Sánchez
Juliana Ochoa-Grullón
María Guzmán-Fulgencio
Ángela Villegas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701918

3,188 views