Frontiers in Immunology | Immunological Tolerance and Regulation

Review

Published on 15 Oct 2025

Immune responses in retinal gene therapy: challenges, mechanisms, and future strategies

in Immunological Tolerance and Regulation

Yawei Ma
Yin Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664968

2,013 views

Mini Review

Published on 15 Oct 2025

Communication between gut microbiota-derived metabolites and the tumor microenvironment

in Immunological Tolerance and Regulation

Xinyi Hu
Bo Li
Yuanqing Li
Yushan Liang
Tingting Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649438

1,989 views

Original Research

Published on 08 Oct 2025

Bioinformatics identification of mitochondria and macrophage polarization-related genes in COPD and their potential mechanisms

in Immunological Tolerance and Regulation

Chenchen Zhang
Peishu Fu
Juanchun Yu
Lingling Liu
Xiong Wei
Xiao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675292

3,216 views

Original Research

Published on 30 Sep 2025

Single-cell mRNA analysis and surface marker expression profiling of circulating immune cells in humans with alpha-gal syndrome

in Immunological Tolerance and Regulation

Shailesh K. Choudhary
Scott P. Commins

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629310

2,687 views
1 citation

Original Research

Published on 25 Sep 2025

Gut commensal bacteria-derived polysaccharide sub-micron particles induce antigen-specific, tolerogenic responses

in Immunological Tolerance and Regulation

Rian Harriman
Allen B. Tu
Zhenyu Wang
Nicolas Radoc
Hamilton Kakwere
Jamal S. Lewis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599480

3,164 views

Correction

Published on 23 Sep 2025

Correction: Recurrent reproductive failure and celiac genetic susceptibility, a leading role of gluten

in Immunological Tolerance and Regulation

Eduardo de la Fuente-Munoz
Miguel Fernández-Arquero
Nabil Subhi-Issa
Kissy Guevara-Hoyer
Lydia Pilar Suárez
Raquel Gil Laborda
Marina Sánchez
Juliana Ochoa-Grullón
María Guzmán-Fulgencio
Ángela Villegas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701918

3,032 views

Original Research

Published on 22 Sep 2025

Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response

in Immunological Tolerance and Regulation

Olga Perik-Zavodskaia
Roman Perik-Zavodskii
Saleh Alrhmoun
Kirill Nazarov
Julia Shevchenko
Konstantin Zaitsev
Sergey Sennikov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644983

3,322 views
2 citations

Review

Published on 19 Sep 2025

Gaps in maternal-fetal interface rejection response: chronic histiocytic intervillositis

in Immunological Tolerance and Regulation

Xiaoqian Zhang
Zhenya Fang
Xietong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625701

3,910 views
1 citation

Original Research

Published on 17 Sep 2025

Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets

in Immunological Tolerance and Regulation

Miguel Ângelo-Dias
Catarina Gregório Martins
Mariana Mata
Madalena Barata
Ana Chung
Susana Sarzedas
Élia Fernandes
Cláudia Appleton
Jorge Lima
Luis Miguel Borrego

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634176

3,417 views
1 citation

Original Research

Published on 12 Sep 2025

Dexamethasone induced Dectin-1 activation enhances NLRP3 inflammasome activation

in Immunological Tolerance and Regulation

Ruth-Miriam Koerber
Sebastian Oberbeck
Philipp Kotthoff
Solveig N. Daecke
Peter Brossart
Stefanie A. E. Held

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656288

3,110 views

Original Research

Published on 08 Sep 2025

Decoding neutrophil extracellular traps and key gene drivers in unexplained pregnancy loss

in Immunological Tolerance and Regulation

Hui Ding
Lu Zhang
Wei Yang
Yu Liu
Chao Wang
Li Liu
Cheng Li
Liyuan Pan
Lin Chen
Meimei Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628337

3,196 views

Original Research

Published on 04 Sep 2025

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses

in Immunological Tolerance and Regulation

Carlos Plaza-Sirvent
Clara Bessen
Alisha W. Bronietzki
Katjana Klages
Marc Schuster
Jochen Huehn
Ingo Schmitz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1284391

2,079 views

Review

Published on 01 Sep 2025

Revisiting Tregs in cancer and beyond: immunological control and therapeutic potential

in Immunological Tolerance and Regulation

Lei Zheng
Dan Wu
Hongwei Xie
Hai Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581093

4,891 views

Review

Published on 01 Sep 2025

Functional interaction between immune checkpoints and lipid metabolism in the development of arteriosclerosis obliterans

in Immunological Tolerance and Regulation

Junyi Zhang
Liyuan Cui
Xinhang Meng
Yujie Luo
Jingmin Ou
Songcun Wang
Mingke Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665454

2,173 views
1 citation

Original Research

Published on 28 Aug 2025

Bone marrow-derived extracellular vesicles from multiple myeloma patients promote adaptive immune dysfunction via HLA-G, PD-1, and PD-L1

in Immunological Tolerance and Regulation

Debora Soncini
Danilo Marimpietri
Francesco Ladisa
Francesco Lai
Irma Airoldi
Roberto Gramignoli
Michele Cea
Fabio Morandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640168

2,176 views

Original Research

Published on 28 Aug 2025

Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface

in Immunological Tolerance and Regulation

Eszter Tóth
Máté Posta
Dániel Györffy
Orsolya Oravecz
Emese Farkas
Andrea Balogh
Claudia Escher
Magdalena Bober
András Szilágyi
Petronella Hupuczi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621168

3,306 views

Review

Published on 27 Aug 2025

Natural antidepressants in neuroimmunomodulation: molecular mechanisms, action targets, and therapeutic potential

in Immunological Tolerance and Regulation

Shimeng Lv
Linghui Kong
Xia Zhong
Ruirui Shang
Yitong Lu
Guangheng Zhang
Haonan Gao
Xin Hou
Guoqiang Li
Xiaowen Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642001

2,759 views

Editorial

Published on 25 Aug 2025

Editorial: Genes, cells, and macroenvironments: regulating the immune response in extreme conditions

in Immunological Tolerance and Regulation

Giuseppina Pennesi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674347

1,401 views

Original Research

Published on 22 Aug 2025

4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells

in Immunological Tolerance and Regulation

Hanna Steppuhn
Katja Hohenberger
Susanne Mittler
Sonja Trump
Christine Carvalho
Manfred Rauh
Andreas B. Wild
Nikolaos G. Papadopoulos
Susetta Finotto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640499

2,423 views

Editorial

Published on 22 Aug 2025

Editorial: Immune plasticity in mixed pattern rheumatic diseases

in Immunological Tolerance and Regulation

Matilde Otero-Losada
Rodolfo Kölliker-Frers
Radjesh Bisoendial
Francisco Capani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665204

1,280 views

Original Research

Published on 21 Aug 2025

Promotion of Treg/Th17 balance in MRL/lpr mice by Jianpi-Zishen Formula via modulation of DNMT1-mediated Foxp3 methylation

in Immunological Tolerance and Regulation

Ming Li
Lijun Pang
Yunfei Li
Junjie Chen
Shuangshuang Shang
Chuanbing Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631631

2,688 views

Original Research

Published on 13 Aug 2025

Identification of Rhododendron mariae extraction as a new attachment inhibitor against dengue virus by targeting the envelope protein domain III

in Immunological Tolerance and Regulation

Chunyang Tian
Yuanru Zheng
Dongkai Tang
Haiyan Tian
Lingzhu Shi
Xuemei He
Jianhai Yu
Lijun Yan
Huihui Cao
Wei Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663878

2,649 views

Editorial

Published on 12 Aug 2025

Editorial: Immunology at the feto-maternal interface

in Immunological Tolerance and Regulation

Amir-Hassan Zarnani
Mahmood Jeddi-Tehrani
Marie-Pierre Piccinni
Maria Laura Zenclussen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667375

2,230 views
1 citation

Original Research

Published on 11 Aug 2025

Identification and validation of expression and functions of ferroptosis-related gene HILPDA in early-onset preeclampsia placentas

in Immunological Tolerance and Regulation

Qianghua Wang
Xuegu Wang
Jiaojiao Fei
Chuanyue Jiang
Yafen Tao
Nana Yang
Huijuan Chen
Chengli Dou
Biao Ding
Danli Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627057

3,043 views