Frontiers in Immunology | Immunological Tolerance and Regulation

Original Research

Published on 22 Sep 2025

Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response

in Immunological Tolerance and Regulation

Olga Perik-Zavodskaia
Roman Perik-Zavodskii
Saleh Alrhmoun
Kirill Nazarov
Julia Shevchenko
Konstantin Zaitsev
Sergey Sennikov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644983

3,753 views
2 citations

Review

Published on 19 Sep 2025

Gaps in maternal-fetal interface rejection response: chronic histiocytic intervillositis

in Immunological Tolerance and Regulation

Xiaoqian Zhang
Zhenya Fang
Xietong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625701

4,348 views
3 citations

Original Research

Published on 17 Sep 2025

Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets

in Immunological Tolerance and Regulation

Miguel Ângelo-Dias
Catarina Gregório Martins
Mariana Mata
Madalena Barata
Ana Chung
Susana Sarzedas
Élia Fernandes
Cláudia Appleton
Jorge Lima
Luis Miguel Borrego

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634176

3,761 views
2 citations

Original Research

Published on 12 Sep 2025

Dexamethasone induced Dectin-1 activation enhances NLRP3 inflammasome activation

in Immunological Tolerance and Regulation

Ruth-Miriam Koerber
Sebastian Oberbeck
Philipp Kotthoff
Solveig N. Daecke
Peter Brossart
Stefanie A. E. Held

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656288

3,417 views

Original Research

Published on 08 Sep 2025

Decoding neutrophil extracellular traps and key gene drivers in unexplained pregnancy loss

in Immunological Tolerance and Regulation

Hui Ding
Lu Zhang
Wei Yang
Yu Liu
Chao Wang
Li Liu
Cheng Li
Liyuan Pan
Lin Chen
Meimei Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628337

3,601 views
1 citation

Original Research

Published on 04 Sep 2025

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses

in Immunological Tolerance and Regulation

Carlos Plaza-Sirvent
Clara Bessen
Alisha W. Bronietzki
Katjana Klages
Marc Schuster
Jochen Huehn
Ingo Schmitz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1284391

2,392 views

Review

Published on 01 Sep 2025

Revisiting Tregs in cancer and beyond: immunological control and therapeutic potential

in Immunological Tolerance and Regulation

Lei Zheng
Dan Wu
Hongwei Xie
Hai Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581093

5,942 views
3 citations

Review

Published on 01 Sep 2025

Functional interaction between immune checkpoints and lipid metabolism in the development of arteriosclerosis obliterans

in Immunological Tolerance and Regulation

Junyi Zhang
Liyuan Cui
Xinhang Meng
Yujie Luo
Jingmin Ou
Songcun Wang
Mingke Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665454

2,538 views
1 citation

Original Research

Published on 28 Aug 2025

Bone marrow-derived extracellular vesicles from multiple myeloma patients promote adaptive immune dysfunction via HLA-G, PD-1, and PD-L1

in Immunological Tolerance and Regulation

Debora Soncini
Danilo Marimpietri
Francesco Ladisa
Francesco Lai
Irma Airoldi
Roberto Gramignoli
Michele Cea
Fabio Morandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640168

2,579 views

Original Research

Published on 28 Aug 2025

Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface

in Immunological Tolerance and Regulation

Eszter Tóth
Máté Posta
Dániel Györffy
Orsolya Oravecz
Emese Farkas
Andrea Balogh
Claudia Escher
Magdalena Bober
András Szilágyi
Petronella Hupuczi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621168

3,855 views
1 citation

Review

Published on 27 Aug 2025

Natural antidepressants in neuroimmunomodulation: molecular mechanisms, action targets, and therapeutic potential

in Immunological Tolerance and Regulation

Shimeng Lv
Linghui Kong
Xia Zhong
Ruirui Shang
Yitong Lu
Guangheng Zhang
Haonan Gao
Xin Hou
Guoqiang Li
Xiaowen Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642001

3,429 views
1 citation

Editorial

Published on 25 Aug 2025

Editorial: Genes, cells, and macroenvironments: regulating the immune response in extreme conditions

in Immunological Tolerance and Regulation

Giuseppina Pennesi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674347

1,591 views

Original Research

Published on 22 Aug 2025

4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells

in Immunological Tolerance and Regulation

Hanna Steppuhn
Katja Hohenberger
Susanne Mittler
Sonja Trump
Christine Carvalho
Manfred Rauh
Andreas B. Wild
Nikolaos G. Papadopoulos
Susetta Finotto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640499

2,900 views
1 citation

Editorial

Published on 22 Aug 2025

Editorial: Immune plasticity in mixed pattern rheumatic diseases

in Immunological Tolerance and Regulation

Matilde Otero-Losada
Rodolfo Kölliker-Frers
Radjesh Bisoendial
Francisco Capani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665204

1,436 views

Original Research

Published on 21 Aug 2025

Promotion of Treg/Th17 balance in MRL/lpr mice by Jianpi-Zishen Formula via modulation of DNMT1-mediated Foxp3 methylation

in Immunological Tolerance and Regulation

Ming Li
Lijun Pang
Yunfei Li
Junjie Chen
Shuangshuang Shang
Chuanbing Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631631

3,109 views

Original Research

Published on 13 Aug 2025

Identification of Rhododendron mariae extraction as a new attachment inhibitor against dengue virus by targeting the envelope protein domain III

in Immunological Tolerance and Regulation

Chunyang Tian
Yuanru Zheng
Dongkai Tang
Haiyan Tian
Lingzhu Shi
Xuemei He
Jianhai Yu
Lijun Yan
Huihui Cao
Wei Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663878

3,024 views

Editorial

Published on 12 Aug 2025

Editorial: Immunology at the feto-maternal interface

in Immunological Tolerance and Regulation

Amir-Hassan Zarnani
Mahmood Jeddi-Tehrani
Marie-Pierre Piccinni
Maria Laura Zenclussen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667375

2,530 views
1 citation

Original Research

Published on 11 Aug 2025

Identification and validation of expression and functions of ferroptosis-related gene HILPDA in early-onset preeclampsia placentas

in Immunological Tolerance and Regulation

Qianghua Wang
Xuegu Wang
Jiaojiao Fei
Chuanyue Jiang
Yafen Tao
Nana Yang
Huijuan Chen
Chengli Dou
Biao Ding
Danli Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627057

3,570 views

Editorial

Published on 30 Jul 2025

Editorial: Immune modulation and angiogenesis in regenerative and developmental processes

in Immunological Tolerance and Regulation

Niv Pencovich
Timucin Taner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662121

1,452 views

Brief Research Report

Published on 29 Jul 2025

Hyporesponsive fetus-specific T cell responses in multiparous human pregnancy

in Immunological Tolerance and Regulation

Jessica C. Morgan
Grace E. Hynes
Jared M. Pollard
Michael S. Andrade
Jong Cheol Jeong
Anita S. Chong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634430

1,839 views
2 citations

Opinion

Published on 23 Jul 2025

‘Immune reset plus’: the case for combining immunotherapies to maintain self-tolerance in autoimmune diseases

in Immunological Tolerance and Regulation

Fabrina Gaspal
Parth Narendran
Sky T. H. Ng
Michael J. Price
David C. Wraith

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634090

3,650 views
1 citation

Mini Review

Published on 22 Jul 2025

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons

in Immunological Tolerance and Regulation

Michael D. Kulis
Jessica R. Humphrey
James W. Krempski
Edwin H. Kim
Johanna M. Smeekens

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617153

6,115 views
3 citations

Review

Published on 17 Jul 2025

Macrophages in chronic infections: regulation and remodeling

in Immunological Tolerance and Regulation

Hongle Cui
Min Wang
Sitan Jiao
Sirui Tian
Hui Liu
Bo Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594988

3,153 views
2 citations

Review

Published on 14 Jul 2025

Decidual macrophage subsets and polarization puzzle during the human early pregnancy

in Immunological Tolerance and Regulation

Huiling Liu
Liping Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610891

2,745 views
3 citations

1,661 articles

articles

Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response

Gaps in maternal-fetal interface rejection response: chronic histiocytic intervillositis

Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets

Dexamethasone induced Dectin-1 activation enhances NLRP3 inflammasome activation

Decoding neutrophil extracellular traps and key gene drivers in unexplained pregnancy loss

Loss of ATG5 impairs CD4+ T cell activation and promotes anti-tumor responses

Revisiting Tregs in cancer and beyond: immunological control and therapeutic potential

Functional interaction between immune checkpoints and lipid metabolism in the development of arteriosclerosis obliterans

Bone marrow-derived extracellular vesicles from multiple myeloma patients promote adaptive immune dysfunction via HLA-G, PD-1, and PD-L1

Novel proteomics biomarkers of recurrent pregnancy loss reflect the dysregulation of immune interactions at the maternal-fetal interface

Natural antidepressants in neuroimmunomodulation: molecular mechanisms, action targets, and therapeutic potential

Editorial: Genes, cells, and macroenvironments: regulating the immune response in extreme conditions

4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells

Editorial: Immune plasticity in mixed pattern rheumatic diseases

Promotion of Treg/Th17 balance in MRL/lpr mice by Jianpi-Zishen Formula via modulation of DNMT1-mediated Foxp3 methylation

Identification of Rhododendron mariae extraction as a new attachment inhibitor against dengue virus by targeting the envelope protein domain III

Editorial: Immunology at the feto-maternal interface

Identification and validation of expression and functions of ferroptosis-related gene HILPDA in early-onset preeclampsia placentas

Editorial: Immune modulation and angiogenesis in regenerative and developmental processes

Hyporesponsive fetus-specific T cell responses in multiparous human pregnancy

‘Immune reset plus’: the case for combining immunotherapies to maintain self-tolerance in autoimmune diseases

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons

Macrophages in chronic infections: regulation and remodeling

Decidual macrophage subsets and polarization puzzle during the human early pregnancy