Frontiers in Immunology

Original Research

Published on 09 Jun 2025

Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammatory cells, and development of exosome-based delivery for enhanced targeting

in Inflammation

Jingjian Dong
Yuntao Lv
Cailiang Zhao
Yuanrui Shi
Ruiming Tang
Liheng He
Ruiwen Fan
Xiaoyun Jia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1559874

4,163 views
1 citation

Original Research

Published on 06 Jun 2025

METTL3-mediated m6A modification regulates D-galactose-induced skin fibroblast senescence through miR-208a-5p

in Inflammation

Gaoxiang Huang
Sainan Sun
Mingde Liao
Jing Wang
Qing Yan
Jing Li
Yi Meng
Qi Wang
Zhen Guo
Jiyong Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577783

3,702 views
1 citation

Review

Published on 06 Jun 2025

Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies

in Inflammation

Shenglin Xia
Li Li
Zhexiong Shi
Nianyi Sun
Yu He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604652

5,002 views
1 citation

Original Research

Published on 06 Jun 2025

The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial

in Inflammation

Tuva B. Dahl
Ana Quiles-Jiménez
Kaspar Broch
Anne Kristine Anstensrud
Lars Gullestad
Geir Ø. Andersen
Ola Kleveland
Jonas Øgaard
Vigdis Bjerkeli
Azita Rashidi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1532325

2,355 views
1 citation

Original Research

Published on 06 Jun 2025

Wharton’s jelly-derived mesenchymal stem cells ameliorate high altitude-induced heart injury by promoting type 2 macrophage polarization via COX2-PGE2 pathway

in Inflammation

Wenhong Zhang
Li Zhao
Jing Cui
Yan Zhang
Dongtao Li
Zhibo Hong
Jiamin Liu
Shan Wang
Ningkun Zhang
Yang Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1538046

3,671 views
1 citation

Original Research

Published on 05 Jun 2025

Identification of key genes in membranous nephropathy and non-alcoholic fatty liver disease by bioinformatics and machine learning

in Inflammation

Jiachen Fan
Na Li
Yanfang Lu
Huixia Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564288

5,641 views

Original Research

Published on 05 Jun 2025

Integrated machine learning and single-cell RNA sequencing reveal COL4A2 and CXCL6 as oxidative stress-associated biomarkers in periodontitis

in Inflammation

Siyu Sun
Jing Ren
Xiujuan Zeng
Yanbin Chen
Qianbing Zhou
Junying Yang
Shan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598642

3,984 views
1 citation

Original Research

Published on 05 Jun 2025

Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis of health insurance claims in Japan

in Inflammation

Hiroyuki Koami
Yutaro Furukawa
Yuri Hirota
Akira Sasaki
Hirotaka Ogawa
Ayaka Matsuoka
Kota Shinada
Kento Nakayama
Ryota Sakurai
Sachiko Iwanaga

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601690

2,459 views

Original Research

Published on 04 Jun 2025

Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea

in Inflammation

Yue Song
Jinxia Ni
Jingxue Yuan
Ziniu Zhang
Dinghao Wang
Zhihao Xiong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563626

3,501 views
1 citation

Original Research

Published on 04 Jun 2025

Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation

in Inflammation

Jessica Hernandez
Fabian Johannes Pflieger
Julia Schäffer
Leona Bähr
Jenny Schneiders
Thomas Reichel
Marita Meurer
Benjamin Lamp
Natali Bettina Bauer
Karsten Krüger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578590

3,409 views

Review

Published on 04 Jun 2025

KLF feedback loops in innate immunity

in Inflammation

Jessica M. Salmon
Holly Adams
Graham W. Magor
Andrew C. Perkins

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606277

4,611 views
4 citations

Original Research

Published on 04 Jun 2025

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice

in Inflammation

Micah L. Willis
Roland F. Seim
Laura E. Herring
Angie L. Mordant
Thomas S. Webb
Gilbert R. Upchurch
Ashish K. Sharma
Bruce A. Cairns
Philip A. Efron
Shannon M. Wallet

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596598

3,191 views
1 citation

Original Research

Published on 03 Jun 2025

Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle

in Inflammation

Yangfan Cao
Jiawei Zhou
Helong Quan
Wei Li
Ting Li
Lifeng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597222

5,731 views
7 citations

Brief Research Report

Published on 03 Jun 2025

The role of major allergens Art v 1 and Art v 3 in Artemisia pollen-induced asthma: a mouse model study

in Inflammation

Nazugum Akhtemova
Akbota Sergazina
Turlan Bolatbekov
Guliza Rakhmatullayeva
Elmira Tailakova
Kairat Tabynov
Gleb Fomin
Lan Zhao
Zhongshan Gao
Kaissar Tabynov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590791

2,905 views
2 citations

Systematic Review

Published on 02 Jun 2025

Unravelling the link between chronic inflammation and primary hyperparathyroidism: a systematic review

in Inflammation

Ana Gheorghe-Milea
Oana Stănoiu-Pînzariu
Carmen Emanuela Georgescu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563967

3,137 views
1 citation

Original Research

Published on 02 Jun 2025

IFN-γ gene polymorphisms +874 T/A and +2109 A/G are associated with the serofast state after early syphilis treatment: a prospective observational study

in Inflammation

Konrad Kaminiów
Martyna Kiołbasa
Maciej Pastuszczak

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602527

1,852 views

Editorial

Published on 30 May 2025

Editorial: Molecular mechanisms and therapeutic strategies in inflammation

in Inflammation

Jiannan Zheng
Mingjun Du
Wei Ye
Jiaheng Xie
Pengpeng Zhang
Chenjun Huang
Haoran Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626548

2,241 views
1 citation

Original Research

Published on 30 May 2025

Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation

in Inflammation

Zhiguang Han
Chengxu Lei
Zhenyu Zhou
Yutong Liu
Yuanli Zhao
Shihao He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592343

2,902 views
2 citations

Original Research

Published on 30 May 2025

Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration

in Inflammation

Idan Farber
Muhammad Wated
Ronen Schuster
Lihie Sheffer
Yuval Anav
Navit Ogen-Shtern
Alexandra Tsitrina
Diya Tacruri
Anna Bunin
Noah Benjamin Nagar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1586039

2,359 views
1 citation

Original Research

Published on 29 May 2025

Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation

in Inflammation

Shufang Liu
Yan Zhang
Yanan Zhao
Ping Wu
Shouyuan Tian
Han-Qing Pang
Zhifang Wu
Sijin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567572

3,354 views
1 citation

Review

Published on 29 May 2025

Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis

in Inflammation

Wei Shao
Zilong Wang
Jian Wu
Tianting Guo
Jianwen Mo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579113

3,089 views

Original Research

Published on 29 May 2025

Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration

in Inflammation

Hao Li
Lei Miao
Jiayuan Wu
Ye Wang
Jiyuan Xia
Da He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589849

3,446 views

Original Research

Published on 29 May 2025

Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models

in Inflammation

Katarzyna Drzewicka
Katarzyna M. Głuchowska
Michal Mlącki
Bartłomiej Hofman
Irina Tuszyńska
Tristram A. J. Ryan
Katarzyna Piwowar
Bartosz Wilczyński
Dorota Dymkowska
Marcin M. Grzybowski

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544973

18,079 views
1 citation

Review

Published on 29 May 2025

The extracellular vesicle-based treatment: a developing strategy for periodontal diseases

in Inflammation

Xuan Zhang
Hanyu Gao
Li Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1480292

2,803 views
4 citations

5,618 articles

articles

Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammatory cells, and development of exosome-based delivery for enhanced targeting

METTL3-mediated m6A modification regulates D-galactose-induced skin fibroblast senescence through miR-208a-5p

Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies

The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial

Wharton’s jelly-derived mesenchymal stem cells ameliorate high altitude-induced heart injury by promoting type 2 macrophage polarization via COX2-PGE2 pathway

Identification of key genes in membranous nephropathy and non-alcoholic fatty liver disease by bioinformatics and machine learning

Integrated machine learning and single-cell RNA sequencing reveal COL4A2 and CXCL6 as oxidative stress-associated biomarkers in periodontitis

Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis of health insurance claims in Japan

Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea

Partial depletion of circulating neutrophil granulocytes in mice exacerbates the inflammatory response and hypothermia during LPS induced severe systemic inflammation

KLF feedback loops in innate immunity

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice

Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle

The role of major allergens Art v 1 and Art v 3 in Artemisia pollen-induced asthma: a mouse model study

Unravelling the link between chronic inflammation and primary hyperparathyroidism: a systematic review

IFN-γ gene polymorphisms +874 T/A and +2109 A/G are associated with the serofast state after early syphilis treatment: a prospective observational study

Editorial: Molecular mechanisms and therapeutic strategies in inflammation

Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation

Alpha-1 antitrypsin promotes re-epithelialization by regulating inflammation and migration

Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation

Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis

Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration

Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models

The extracellular vesicle-based treatment: a developing strategy for periodontal diseases