Frontiers in Immunology

Original Research

Published on 08 Dec 2025

SCPEP1+ basal cells are associated with the remodeling of oxidative stress signaling networks in idiopathic pulmonary fibrosis

in Inflammation

Xiang Zhou
Tong Lu
Ran Xu
Chenghao Wang
Simiao Chen
Jing Chen
Xiaoyan Chang
Meifeng Li
Jiaxin Shi
Chengyu Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676086

667 views

Original Research

Published on 08 Dec 2025

SHKBP1 is a target for sepsis: evidence from WGCNA and multiple machine learning algorithms

in Inflammation

Fan Wu
Junlin Lu
Yi Liu
Runquan Zhou
Wenjuan Li
Mingxing Wang
Shan Xu
Yuanhui Sheng
Dan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709188

365 views

Original Research

Accepted on 05 Dec 2025

THE METABOLIC-IMMUNE INTERFACE OF OBESITY IN COVID-19: A ROLE FOR ANGIOTENSIN II AND INFLAMMATORY CYTOKINES

in Inflammation

Cintia M Rodrigues
Juliane D Santos
Bruna C. Chaves Garcia
Marcelo H Ottoni
Karine Beatriz Costa
Marina L Costa
Vivian G Figueiredo
Daniel Macedo
Danilo Bretas De Oliveira
Etel Rocha-Vieira

Frontiers in Immunology

137 views

Correction

Accepted on 05 Dec 2025

Correction: Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration

in Inflammation

Viola Niemann
Fedor Brack
Luca Rolauer
Janet Kaczur
Patrick Petzsch
Karl Köhrer
Christine Quast
Norbert Gerdes
Pascal Bouvain
Katharina Voigt

Frontiers in Immunology

204 views

Original Research

Published on 05 Dec 2025

Novel ubiquitination-related biomarkers for Crohn’s disease identified by multi-omics study and experimental validation

in Inflammation

Jia Hu
Kai Nie
Xiaoyan Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687606

608 views

Original Research

Published on 05 Dec 2025

Monocyte–red blood cell crosstalk supports clearance and heme metabolism in sickle cell anemia

in Inflammation

Marina Dorigatti Borges
Matheus Ajeje de Souza
Izabela Felice Paes
Daniela Pinheiro Leonardo
Dulcinéia Martins Albuquerque
Carolina Lanaro
Sara Teresinha Ollala Saad
Renata Sesti-Costa
Fernando Ferreira Costa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699306

494 views

Original Research

Published on 05 Dec 2025

Soluble epoxide hydrolase inhibition preserves alveolar bone in experimental periodontitis with estrogen deficiency

in Inflammation

Charles Ritter
Pedro Silva Pacheco
Lila Batista Trajano Mattos
Mariana Quirino Silveira Soares
Debora Duarte Moreira
Izabel Regina Fischer Rubira-Bullen
Marco Antonio Hungaro Duarte
Jeroen Van Dessel
Bruce D. Hammock
Laura Carbone

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708504

441 views

Review

Published on 05 Dec 2025

Beyond oxidative stress: Ferroptosis as a novel orchestrator in neurodegenerative disorders

in Inflammation

Yaqiao Yi
Pu Jia
Peipei Xie
Xiru Peng
Xuan Zhu
Shuting Yin
Yanfang Luo
Ying Deng
Lifei Wan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683876

602 views

Original Research

Published on 05 Dec 2025

A multi-omics approach combining causal inference and in vivo validation identifies key protein drivers of alcohol-associated liver disease

in Inflammation

Qingyi Zhou
Xuan Ma
Qianqian Cui
Lei Zhang
Chao Yao
Zilu Zhang
Xiaoli Wang
Liang Chu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714502

1,226 views

Review

Published on 05 Dec 2025

Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations

in Inflammation

Ebru Karpuzoglu
Steven D. Holladay
Robert M. Gogal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704203

717 views

Review

Published on 05 Dec 2025

Targeting ferroptosis: novel therapeutic approaches and intervention strategies for kidney diseases

in Inflammation

Yanfang Luo
Muyang Long
Xueqin Wu
Liuting Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700004

553 views

Mini Review

Accepted on 04 Dec 2025

Molecular Mechanisms of Streptococcal Disruption of the Blood-Brain Barrier and Their Pathogenic Role in Bacterial Meningitis

in Inflammation

Yumei Shi
Tao Liang
Chao Shi
Benhai Yao
Bo Xiong
JUN ZHANG

Frontiers in Immunology

123 views

Original Research

Accepted on 04 Dec 2025

Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome

in Inflammation

Morgan A Taylor
Rebecca Boland
Samuel Houle
Zoe Tapp
Amara Davis
Christopher Cotter
John Sheridan
Jonathan Godbout
Olga N Kokiko-Cochran

Frontiers in Immunology

156 views

Review

Published on 04 Dec 2025

Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes

in Inflammation

Tingyu Yang
Jiapan An
Xinqi Xu
Bin Li
Zhimin Dou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717465

805 views

Original Research

Published on 04 Dec 2025

Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP–CD74 signaling and CXCL1 as diagnostic biomarkers

in Inflammation

Shan He
Fei Ma
Meng Yu
Jia-man Wu
You-ming Gong
Ke-wang Luo
Hong Chang
Qi Liang
Yan Ning

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707497

966 views

Mini Review

Published on 04 Dec 2025

Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle

in Inflammation

Ludmila Müller
Svetlana Di Benedetto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708280

758 views

Original Research

Published on 03 Dec 2025

Multiplexed longitudinal analysis of the cellular and microbial dynamics of acute polymicrobial sepsis in mice

in Inflammation

Tori E. Peacock
Kenny Johnson
Abhinav R. Cheedipudi
Ahmed D. Mohammed
Ryan A. W. Ball
J. Hunter Cox
Savannah K. Pender
Amy Jolly
Kandy T. Velázquez
Jay Potts

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682451

697 views

Original Research

Published on 03 Dec 2025

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

in Inflammation

Ya Zhang
Qian Tian
Yuan Zhu
Tianhui Wang
Yongchao Yu
Lan Wang
Lijuan Shao
Xiangang Mo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644135

525 views

Original Research

Accepted on 02 Dec 2025

Functional physiological, psychological, and biochemical Reactivity to Socially Evaluated Cold Pressor Test in Hereditary Angioedema Patients (FRoSEn)

in Inflammation

Beatrice De Maria
Luca Ranucci
Clara Gino
Azzurra Cesoni Marcelli
Lorenza Chiara Zingale
Aida Zulueta
Laura Adelaide Dalla Vecchia
Alessandra Gorini
Francesca Perego

Frontiers in Immunology

241 views

Original Research

Accepted on 02 Dec 2025

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

in Inflammation

Danying Zhu
Guang Li
Lang Yuan
Zeyu Zeng
Na Dong
Chao Wang
Chen MIng
Lijian Xie
Guohui Ding
Libing Shen

Frontiers in Immunology

130 views

Review

Published on 02 Dec 2025

From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD

in Inflammation

Siyu Zeng
Yanqiu Zhang
Shiran Li
Zhimin Li
Pengfei Li
Jingxian Xie
Jiao Zhang
Liling Xie
Yong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698832

743 views

Original Research

Published on 02 Dec 2025

Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration

in Inflammation

Hongxing Zhang
Bin Dai
Jiafeng Peng
Minglei Gao
Danyang Li
Xiaowei Xiang
Junchen Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671961

742 views

Mini Review

Published on 02 Dec 2025

Macrophages: their role in immunity and their relationship with fatty acids in health and disease

in Inflammation

Mayte Rueda-Munguía
Luis Alberto Luévano-Martínez
Gerardo García-Rivas
Elena Cristina Castillo
Omar Lozano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694892

857 views

Original Research

Published on 02 Dec 2025

Unraveling the anti-inflammatory effects of Mediterranean diet in patients with cancer remission

in Inflammation

Michele Francesco Di Tolla
Michele Libutti
Giovanna D’Onofrio
Alessandra Riccio
Serena Cabaro
Michele Longo
Alessia Parascandolo
Giusy Ferraro
Elia Formisano
Vittoria D’Esposito

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666611

1,251 views

5,617 articles

articles

SCPEP1+ basal cells are associated with the remodeling of oxidative stress signaling networks in idiopathic pulmonary fibrosis

SHKBP1 is a target for sepsis: evidence from WGCNA and multiple machine learning algorithms

THE METABOLIC-IMMUNE INTERFACE OF OBESITY IN COVID-19: A ROLE FOR ANGIOTENSIN II AND INFLAMMATORY CYTOKINES

Correction: Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration

Novel ubiquitination-related biomarkers for Crohn’s disease identified by multi-omics study and experimental validation

Monocyte–red blood cell crosstalk supports clearance and heme metabolism in sickle cell anemia

Soluble epoxide hydrolase inhibition preserves alveolar bone in experimental periodontitis with estrogen deficiency

Beyond oxidative stress: Ferroptosis as a novel orchestrator in neurodegenerative disorders

A multi-omics approach combining causal inference and in vivo validation identifies key protein drivers of alcohol-associated liver disease

Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations

Targeting ferroptosis: novel therapeutic approaches and intervention strategies for kidney diseases

Molecular Mechanisms of Streptococcal Disruption of the Blood-Brain Barrier and Their Pathogenic Role in Bacterial Meningitis

Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome

Research progress on pyroptosis regulated by mesenchymal stem cell-derived exosomes

Neutrophil-mediated immune dysregulation in recurrent miscarriage: implications of APP–CD74 signaling and CXCL1 as diagnostic biomarkers

Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle

Multiplexed longitudinal analysis of the cellular and microbial dynamics of acute polymicrobial sepsis in mice

Causal inference of CLEC5A and ISG20 in atherosclerosis: integrating Mendelian randomization and eQTL evidence

Functional physiological, psychological, and biochemical Reactivity to Socially Evaluated Cold Pressor Test in Hereditary Angioedema Patients (FRoSEn)

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD

Integration of single-cell sequencing and machine learning identifies key macrophage-associated genetic signatures in lumbar disc degeneration

Macrophages: their role in immunity and their relationship with fatty acids in health and disease

Unraveling the anti-inflammatory effects of Mediterranean diet in patients with cancer remission