Frontiers in Immunology

Original Research

Published on 27 Oct 2025

Decoding immune-metabolic crosstalk in ARDS: a transcriptomic exploration of biomarkers, cellular dynamics, and therapeutic pathways

in Inflammation

Ting Wu
Yuan Lu
Qin Wang
Wei Zhou
Ming Ding
Jing Huang
Jingyuan Xu
Shuzhen Wei
Min Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1615748

1,699 views

Original Research

Published on 27 Oct 2025

Bone marrow mesenchymal stem cells alleviate smoke inhalation injury by regulating alveolar macrophage polarization via the CD200-CD200R pathway

in Inflammation

Ziling Ding
Yong Zhuang
Yunlong Zhao
Jie Shi
Xiaoqin Guo
Haojun Fan
Qi Lv

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645460

1,345 views

Original Research

Published on 24 Oct 2025

Single-cell RNA sequencing analysis reveals the critical role of fibroblasts in aortic progeria-associated vascular remodeling in Hutchinson-Gilford progeria syndrome mice

in Inflammation

Qian Sun
Liehao Yang
Zilong Zhou
Nan Wu
Chunyi Li
Qianying Hu
Xianling Cong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638083

1,541 views

Review

Published on 24 Oct 2025

The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives

in Inflammation

Chao Lei
Dongjie Wu
Houyan Zhang
Zhiya Yang
Bohao Huang
Jie Wang
Yanbo Li
Wenliang Lv

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670213

2,295 views

Original Research

Published on 24 Oct 2025

Identification of CAF signature genes and construction of CAF-based risk signature in hepatocellular carcinoma by multi-omics analysis

in Inflammation

Wenchen Qian
Kezhi Wu
Zhu Shen
Bowen Ni
Haojie Zheng
Yawei Liu
Manlan Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690174

1,758 views

Mini Review

Published on 24 Oct 2025

The immunosuppressive mechanisms induced by sepsis and the corresponding treatment strategies

in Inflammation

Qinfen Gao
Yajun Teng
Ling Zhu
Wei Zhang
Zengzheng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643194

2,600 views

Original Research

Published on 24 Oct 2025

NF-κB/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye

in Inflammation

Cuipei Lin
Jiaxin Wu
Yuxin Jing
Jingbin Xie
Jiayan Xiang
Qiwei Fan
Jiangman Liu
Jingheng Du
Xiukui Tan
Zhudan Zhuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684290

1,950 views

Original Research

Published on 24 Oct 2025

Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention

in Inflammation

Alejandra P. Garza
Lorena Morton
Anna-Lena Motsch
Christian Puta
Marvin Stiebler
Yves Lading
Sabyasachi Chakrabarty
Stefanie Schreiber
Edit I. Buzás
Rüdiger Braun-Dullaeus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661161

2,366 views
1 citation

Original Research

Published on 24 Oct 2025

Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells

in Inflammation

Joshua Flynn
Anne Marie Baird
Eamon Breen
Michael Carty
Ciara S. McNevin
Lisa McDermott
Elaine M. Kenny
John Davis Coakley
Thomas Ryan
Derek G. Doherty

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667186

1,350 views

Original Research

Published on 23 Oct 2025

Benralizumab for adults with rare and off-label eosinophilic disorders: a 52-week prospective, single-center study

in Inflammation

Aviv Talmon
Oded Shamriz
Limor Rubin
Yaarit Ribak
Iris Aynor
Adam Nevo
Anna Elia
Meitav Ben Sion
Esther Forkosh
Alon Y. Hershko

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702989

1,365 views

Review

Published on 23 Oct 2025

Research progress on cellular behavior of CaSR in cardiovascular diseases

in Inflammation

Xinyu Liu
Tao Xie
Javeria Qadir
Shuang Li
Tianshuang Xu
Yang Lu
Xiaotian Ge
Hui Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672536

827 views

Original Research

Published on 22 Oct 2025

Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID

in Inflammation

Hengrui Liu
Zewen Xu
Ilayda Karsidag
Panpan Wang
Jieling Weng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689507

5,219 views

Editorial

Published on 22 Oct 2025

Editorial: The role of inflammation in organ injury

in Inflammation

Zhen Guo
Di Fan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717035

1,010 views

Original Research

Published on 22 Oct 2025

Narrowband ultraviolet B radiation attenuates nucleus pulposus pyroptosis to ameliorate intervertebral disc degeneration by activating NRF2/KEAP1 antioxidant pathway

in Inflammation

Helou Zhang
Xinyun Tang
Huiqing Zhou
Chengcong Zhou
Zhiguo Zhang
Shuchao Shen
Xuliang Fang
Jiazhe Du
Shenghua Cheng
Jinjie Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663674

1,396 views

Original Research

Published on 22 Oct 2025

Development of a diagnostic model for MASLD and identification of daidzein as the potential drug using bioinformatics analysis and experiments

in Inflammation

Tao Wang
Hao Zhang
Kaixia Wang
Chunxue Liu
Nan Kong
Luocheng Zhou
Lihong Qu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698740

1,586 views

Original Research

Published on 22 Oct 2025

CD44 and CLDN3 as immune-metabolic regulators in acute pancreatitis: a multi-modal transcriptomics study and experimental validation

in Inflammation

Xinwei Wang
Cheng Hu
Tian Liu
Rui Yang
Yuxin Shen
Shihang Zhang
Lihui Deng
Qing Xia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665200

1,234 views

Review

Published on 21 Oct 2025

Fundamental and emerging insights into innate and adaptive immunity in inflammatory bowel diseases

in Inflammation

Giovanni Monteleone
Carlo Calisi
Silvia Salvatori
Irene Marafini

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665530

2,303 views
1 citation

Original Research

Published on 21 Oct 2025

Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice

in Inflammation

Luiz Adriano Damasceno Queiroz
Rafael Santos Barros
Josiane Betim Assis
Camille Cristine Caldeira Silva
Walter Miguel Turato
Sofia Xavier Bustia
Stephen Fernandes Rodrigues
Anderson Sá-Nunes
Joilson O. Martins

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682406

1,947 views

Systematic Review

Published on 21 Oct 2025

Mind-body therapies for pro-inflammatory cytokines in patients with depression: findings from a systematic review of randomized controlled trials

in Inflammation

Zhengyang Mei
Shi Luo
Chenyi Cai
Chifong Lam
Tingfeng Wang
Haichang Jia
Longjiang Chen
Ranran He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677872

1,387 views

Correction

Published on 20 Oct 2025

Correction: Identification and analysis of diverse cell death patterns in osteomyelitis via microarray-based transcriptome profiling and clinical data

in Inflammation

Tianxuan Feng
Peisheng Chen
Fengfei Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721889

599 views

Review

Published on 20 Oct 2025

Exosome-based modulation of ferroptosis in neurological disorders: mechanisms, therapeutic potential, and translational challenges

in Inflammation

Xiaoying Bao
Liwei Chen
Hong Yu
Yunan Xie
Liangxiao Luo
Li Luo
Hanbing Wang
Rongbing Chen
Yongwei Cheng
Da Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677808

2,373 views

Original Research

Published on 20 Oct 2025

LncRNA NRIR inhibits osteogenesis by promoting macrophage M1 polarization through RSAD2/NF-κB axis in peri-implantitis

in Inflammation

Renshengjie Zhao
Lan Wang
Yang Zhou
Keming Xiao
Qiqi Liu
Ke Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650984

1,678 views

Review

Published on 17 Oct 2025

Liposome-mediated macrophage reprogramming: emerging strategies for chronic disease therapy

in Inflammation

Hongnv Zhang
Nan Hu
Zhenghao Wang
Shaodong Zhai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653642

2,565 views
2 citations

Original Research

Published on 17 Oct 2025

The inflammatory architecture reflects the effects of pharmacological and genetic interventions on resolution of TLR2-mediated inflammation

in Inflammation

Clara Kramer
Sandra Pierre
Nicole Zander
Anja Kolbinger
Blerina Aliraj
Andreas Weigert
Klaus Scholich

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633348

1,727 views

5,616 articles

articles

Decoding immune-metabolic crosstalk in ARDS: a transcriptomic exploration of biomarkers, cellular dynamics, and therapeutic pathways

Bone marrow mesenchymal stem cells alleviate smoke inhalation injury by regulating alveolar macrophage polarization via the CD200-CD200R pathway

Single-cell RNA sequencing analysis reveals the critical role of fibroblasts in aortic progeria-associated vascular remodeling in Hutchinson-Gilford progeria syndrome mice

The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives

Identification of CAF signature genes and construction of CAF-based risk signature in hepatocellular carcinoma by multi-omics analysis

The immunosuppressive mechanisms induced by sepsis and the corresponding treatment strategies

NF-κB/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye

Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention

Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells

Benralizumab for adults with rare and off-label eosinophilic disorders: a 52-week prospective, single-center study

Research progress on cellular behavior of CaSR in cardiovascular diseases

Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID

Editorial: The role of inflammation in organ injury

Narrowband ultraviolet B radiation attenuates nucleus pulposus pyroptosis to ameliorate intervertebral disc degeneration by activating NRF2/KEAP1 antioxidant pathway

Development of a diagnostic model for MASLD and identification of daidzein as the potential drug using bioinformatics analysis and experiments

CD44 and CLDN3 as immune-metabolic regulators in acute pancreatitis: a multi-modal transcriptomics study and experimental validation

Fundamental and emerging insights into innate and adaptive immunity in inflammatory bowel diseases

Effects of Long-term low-dose intermittent rapamycin administration on glucose metabolism and immune system of SAMP8 and SAMR1 mice

Mind-body therapies for pro-inflammatory cytokines in patients with depression: findings from a systematic review of randomized controlled trials

Correction: Identification and analysis of diverse cell death patterns in osteomyelitis via microarray-based transcriptome profiling and clinical data

Exosome-based modulation of ferroptosis in neurological disorders: mechanisms, therapeutic potential, and translational challenges

LncRNA NRIR inhibits osteogenesis by promoting macrophage M1 polarization through RSAD2/NF-κB axis in peri-implantitis

Liposome-mediated macrophage reprogramming: emerging strategies for chronic disease therapy

The inflammatory architecture reflects the effects of pharmacological and genetic interventions on resolution of TLR2-mediated inflammation