Frontiers in Immunology

Original Research

Published on 20 Jan 2026

Paeoniflorin attenuates sepsis-induced liver injury by reprogramming macrophage polarization via the TLR4/NF-κB pathway

in Inflammation

Zhiwei Rong
Baitian Li
Chunzheng Liu
Lijun Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1751550

1,085 views

Original Research

Published on 20 Jan 2026

Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway

in Inflammation

Xiaoli Fang
Heng Deng
Ming Li
Xiang Gao
Chunrong He
Hui Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1730184

923 views

Original Research

Published on 20 Jan 2026

Shen-Hong-Tong-Luo formula ameliorates atherosclerosis by enhancing macrophage efferocytosis through activating the PPARγ/mfge8 pathway

in Inflammation

Yanyu Shi
Zepeng Zhang
Jiaqi Liu
Xiaolin Xu
Xue Xiao
Tianyang Zhang
Yuan Zhang
Haoran Cui
Xiangyan Li
Ying Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727378

1,153 views

Original Research

Published on 20 Jan 2026

Nrf2/HO-1–dependent inhibition of ferroptosis underlies the antioxidant effects of 5-O-methylvisammioside in colitis

in Inflammation

Donglin Li
Fagang Xu
Wei Wang
Chuan Jiang
Wenwen Cui
Zhong-an Guan
Chao Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1738408

778 views

Review

Accepted on 16 Jan 2026

Mechanisms and Therapeutic of Immunometabolic Reprogramming Driving Macrophage-Endothelial Cell Interactions in Sepsis-Associated ARDS from the Gut-Lung Axis Perspective

in Inflammation

Jia Tang
Mi Yan
Mengchun Li
Wanwei Li
Zhangxue Hu

Frontiers in Immunology

194 views

Original Research

Published on 15 Jan 2026

Multi-omics machine learning identifies diagnostic gene signatures and functionally supports PRKACB involvement in macrophage inflammatory responses in sepsis

in Inflammation

Lvying Yang
Sisi Teng
Zengwen Ma
Cunqiao Han
Weiwei Qian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611348

1,069 views

Review

Published on 15 Jan 2026

Progress in research on predictors of adverse outcomes in patients with nasal inflammatory diseases

in Inflammation

Jiang-Xue Liao
Xin Lin
Jing He
Hua-Jun Feng
Zhuo-Ping Liang
Gang Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740005

752 views

Original Research

Published on 14 Jan 2026

Inflammatory burden in dialysis patients: the role of alpha defensin

in Inflammation

Maanit Shapira
Adib Abo Aqil
Ameena Zahalka
Isis Abumouch
Naama Amsalem
Rami Abu Fanne

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718452

488 views

Original Research

Published on 14 Jan 2026

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities

in Inflammation

Wei Gao
Zhiyong Lin
Yuntao Bao
Mingjiang Liu
Guangtao Ma
Xianxiang Chen
Shuiping Yu
Yonglian Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711388

892 views

Review

Published on 14 Jan 2026

The clinical characteristics, mechanism and management of immune checkpoint inhibitor-related arthritis

in Inflammation

Jian Gao
Jinlin Miao
Zhinan Chen
Ping Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611692

1,036 views

Original Research

Published on 14 Jan 2026

Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production

in Inflammation

Wenjing Tang
Wenjie Chen
Na Li
Wei Li
Zhigang Lei
Wenhui Sun
Xuan Xie
Yihong Jiang
Ying Chen
Lei Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684836

1,224 views

Brief Research Report

Published on 14 Jan 2026

Epithelial extracellular vesicles induce inflammation and neutrophil activation in the Pseudomonas aeruginosa infected cystic fibrosis bronchial epithelium

in Inflammation

Meghan June Hirsch
Kuen-You Tsai
Luke I. Jones
Angela N. Morales
Hannah J. McIntire-Ray
Patrick H. Howze IV
Jarrod W. Barnes
Camilla Margaroli
Kristopher Genschmer
Stefanie Krick

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659951

819 views

Original Research

Published on 14 Jan 2026

m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies

in Inflammation

Yixian Chen
Qiaozhen Wei
Yuan Gan
Ba Wei
Qingmei Huang
Shuangjing Pan
Yujun Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709677

576 views

Original Research

Published on 14 Jan 2026

Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma

in Inflammation

Jiaxi Wang
Qingyi Zhu
Jingyi Bie
Yueyu Han
Hanqing Liu
Chuang Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722524

815 views

Original Research

Published on 13 Jan 2026

NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis

in Inflammation

Qingxian Tu
Xiaowei Gong
Xiaoxi Yuan
Yiyue Tang
Runze Huang
Qianfeng Jiang
Wei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712786

1,285 views

Original Research

Published on 13 Jan 2026

Impact of low-grade inflammation on neurological outcomes in patients with acute pontine infarction: a retrospective cohort study

in Inflammation

Junyu Zhu
Hai Zhou
Jierong Mo
Tianen Zhou
Jun Jiang
Zhiwen Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1744943

577 views

Original Research

Published on 13 Jan 2026

CD71+ erythroid cells as a potential early biomarker for hemodynamic significant patent ductus arteriosus in preterm infants

in Inflammation

Ju Ae Shin
Jae Young Lee
Jeongmin Shin
Min Soo Kim
Young-Ah Youn
Joungok Kim
Eun-Jee Oh
Jin-Hee Oh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1738166

597 views

Original Research

Accepted on 12 Jan 2026

Anti-Inflammatory Effects of 1,8-cineol via NF-κB/COX-2 pathway in BEAS-2B cells and alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice

in Inflammation

Yanhong Wang
Jiaming Zhu
Xu Zhang
Fei Tong
Qiaoping Xu

Frontiers in Immunology

164 views

Original Research

Published on 12 Jan 2026

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization

in Inflammation

Ting Hong
Xinyu Liu
Zepai Chi
Guoyuan Liu
Yuanfeng Zhang
Xuanhao Lin
Peixiu Yao
Qingyun Gong
Yonghai Zhang
Xuwei Hong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683500

1,179 views

Original Research

Published on 12 Jan 2026

METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification

in Inflammation

Dong He
Xiaokun Jiang
Gengyin Guo
Jinfeng Ma
Jinyan Chen
Yongfei Zhang
Jianfeng Zhuang
Ping Xie
Zhen Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717319

885 views

Original Research

Published on 12 Jan 2026

TRIM29 drives ulcerative colitis by disrupting lipid metabolism via lysosomal dysfunction: a multi-omics and experimental study

in Inflammation

Xing-Zhou Guo
Lu-Yun Zhang
Zong-Biao Tan
Hao-Dong He
Ya-Fei Liu
Bao-Ping Yu
Wei-Guo Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728932

1,083 views

Original Research

Published on 12 Jan 2026

Single-cell transcriptional profiling revealed the protective effects of Buddleoside in sepsis-associated acute liver injury

in Inflammation

Qingmiao Shi
Na Lou
Leiya Fu
Ying Wang
Chen Xue
Shen Shen
Li Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713180

816 views

Correction

Published on 12 Jan 2026

Correction: Targeting c-Jun orchestrates heat stroke-induced myocardial injury and reveals its biomarker potential

in Inflammation

Yunfei Xiang
Rui Huang
Xuemei Jiang
Qingsong Chen
Can Luo
Hongxia Wang
Junyu Jiang
Jia Xie
Guangbin Huang
Menglong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1778549

433 views

Original Research

Published on 12 Jan 2026

Serum paraoxonase-1 as a marker of oxidative stress and pulmonary dysfunction in sarcoidosis: association with disease activity and prognostic potential

in Inflammation

Mine Büşra Bozkürk
Ersin Günay
Nalan Ogan
İpek Candemir
Uğurcan Eker
Alpaslan Öztürk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731991

619 views

5,824 articles

articles

Paeoniflorin attenuates sepsis-induced liver injury by reprogramming macrophage polarization via the TLR4/NF-κB pathway

Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway

Shen-Hong-Tong-Luo formula ameliorates atherosclerosis by enhancing macrophage efferocytosis through activating the PPARγ/mfge8 pathway

Nrf2/HO-1–dependent inhibition of ferroptosis underlies the antioxidant effects of 5-O-methylvisammioside in colitis

Mechanisms and Therapeutic of Immunometabolic Reprogramming Driving Macrophage-Endothelial Cell Interactions in Sepsis-Associated ARDS from the Gut-Lung Axis Perspective

Multi-omics machine learning identifies diagnostic gene signatures and functionally supports PRKACB involvement in macrophage inflammatory responses in sepsis

Progress in research on predictors of adverse outcomes in patients with nasal inflammatory diseases

Inflammatory burden in dialysis patients: the role of alpha defensin

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities

The clinical characteristics, mechanism and management of immune checkpoint inhibitor-related arthritis

Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production

Epithelial extracellular vesicles induce inflammation and neutrophil activation in the Pseudomonas aeruginosa infected cystic fibrosis bronchial epithelium

m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies

Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma

NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis

Impact of low-grade inflammation on neurological outcomes in patients with acute pontine infarction: a retrospective cohort study

CD71+ erythroid cells as a potential early biomarker for hemodynamic significant patent ductus arteriosus in preterm infants

Anti-Inflammatory Effects of 1,8-cineol via NF-κB/COX-2 pathway in BEAS-2B cells and alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization

METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification

TRIM29 drives ulcerative colitis by disrupting lipid metabolism via lysosomal dysfunction: a multi-omics and experimental study

Single-cell transcriptional profiling revealed the protective effects of Buddleoside in sepsis-associated acute liver injury

Correction: Targeting c-Jun orchestrates heat stroke-induced myocardial injury and reveals its biomarker potential

Serum paraoxonase-1 as a marker of oxidative stress and pulmonary dysfunction in sarcoidosis: association with disease activity and prognostic potential