Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 29 Jan 2025

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

in Molecular Innate Immunity

Adrián Martín-Ambrosio Doménech
Silvia González Sanz
Bárbara Márquez Tirado
Lucia Juana-López
Elena Goicoechea de Jorge
Santiago Rodríguez de Córdoba
Héctor Martín Merinero

Frontiers in Immunology

doi 10.3389/fimmu.2025.1522651

276 views

Original Research

Published on 29 Jan 2025

Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model

in Molecular Innate Immunity

Tereza Hornikova
Anna Jelinkova
Zuzana Jiraskova Zakostelska
Tomas Thon
Stepan Coufal
Andrea Polouckova
Eliska Kopelentova
Miloslav Kverka
Peter Makovicky
Helena Tlaskalova-Hogenova

Frontiers in Immunology

doi 10.3389/fimmu.2024.1509691

448 views

Correction

Accepted on 28 Jan 2025

Corrigendum: [Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs]

in Molecular Innate Immunity

Lisa Hurler
Erik J.M. Toonen
Erika Kajdácsi
Bregje Van Bree
Ricardo Brandwijk
Wieke De Bruin
Paul Lyons
Laura Bergamaschi
György Sinkovits
László Cervenak

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561850

Original Research

Accepted on 28 Jan 2025

Single-cell analysis of CD14+CD16+ monocytes identifies a subpopulation with an enhanced migratory and inflammatory phenotype

in Molecular Innate Immunity

Vanessa Y. Ruiz
Tina M. Calderon
Rosiris Leon-Rivera
Vanessa Chilunda
Jinghang Zhang
Joan W. Berman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1475480

Original Research

Accepted on 28 Jan 2025

Acute hypoxia modulate macrophage phenotype accompanied with transcriptome re-programming and metabolic re-modeling

in Molecular Innate Immunity

Bao Liu
Bingda Sun
Gang Wu
Yao Long
Gang Xu
Jian Chen
Yuqi Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534009

Original Research

Published on 28 Jan 2025

IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy

in Molecular Innate Immunity

Dylan Krajewski
Saurav Ranjitkar
Nathan Jordan
Sallie S. Schneider
Clinton B. Mathias

Frontiers in Immunology

doi 10.3389/fimmu.2025.1526498

274 views

Original Research

Accepted on 27 Jan 2025

Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 Antitrypsin Deficiency

in Molecular Innate Immunity

Jungnam Lee
Naweed Mohammad
Kyudong Han
Tammy Flagg-Dowie
Maria Magallon
Mark Brantly
Karina A Serban

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543729

Original Research

Published on 24 Jan 2025

Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance

in Molecular Innate Immunity

Santiago Rodríguez de Córdoba
Andrea Reparaz
Daniel Sanchez
Sheila Pinto
Lucia Juana Lopez
Héctor Martin Merinero
Iria Calvete
Julian Perez-Perez
Sydney S. Jellison
Yuzhou Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1527016

537 views

Original Research

Published on 24 Jan 2025

Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish

in Molecular Innate Immunity

Yihong Zheng
Yinuo Liu
Jin Tian
Shuhong Liu
Gaowei Ma
Yupeng Xie
Chenhua Zheng
Zekai Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1542964

399 views

Original Research

Published on 23 Jan 2025

Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence

in Molecular Innate Immunity

Xiaoyin Wu
Buyu Guo
Xingyu Chang
Yuxuan Yang
Qianqian Liu
Jiahui Liu
Yichen Yang
Kang Zhang
Yumei Ma
Songbo Fu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1427626

708 views

Original Research

Published on 22 Jan 2025

Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity

in Molecular Innate Immunity

Leonore Raudszus
Farbod Bahreini
Susanne Allan
Kai-Uwe Kalies
Charles C. Caldwell
Kathrin Kalies

Frontiers in Immunology

doi 10.3389/fimmu.2024.1494400

779 views

Original Research

Published on 21 Jan 2025

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings

in Molecular Innate Immunity

Steven P. Treon
Camille N. Kotton
David J. Park
Giorgia Moranzoni
Camilla K. Lemvigh
Joseph C. Gathe
Tilly A. Varughese
Christopher F. Barnett
Johnny M. Belenchia
Nina M. Clark

Frontiers in Immunology

doi 10.3389/fimmu.2024.1369619

1,261 views

Mini Review

Accepted on 20 Jan 2025

The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases

in Molecular Innate Immunity

Chunyan Deng
Dongyan Chen
Liang Yang
Yubiao Zhang
Cheng Jin
Yue Li
Qihong Lin
Mingjing Luo
Ruihao Zheng
Baozhen Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1522200

Original Research

Published on 20 Jan 2025

TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins

in Molecular Innate Immunity

Špela Knez
Mojca Narat
Jernej Ogorevc

Frontiers in Immunology

doi 10.3389/fimmu.2024.1490478

674 views

Review

Published on 17 Jan 2025

Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases

in Molecular Innate Immunity

Fengjuan Lin
Huiyu Luo
Jiexian Wang
Qing Li
Longying Zha

Frontiers in Immunology

doi 10.3389/fimmu.2024.1479330

539 views

Original Research

Published on 17 Jan 2025

Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaque

in Molecular Innate Immunity

Yifeng Zhang
Shuxian Lu
Liang Qiu
Manman Qin
Dan Shan
Lianhua Xie
Yao Yi
Jun Yu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1528475

793 views

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Articles

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model

Corrigendum: [Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs]

Single-cell analysis of CD14+CD16+ monocytes identifies a subpopulation with an enhanced migratory and inflammatory phenotype

Acute hypoxia modulate macrophage phenotype accompanied with transcriptome re-programming and metabolic re-modeling

IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy

Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 Antitrypsin Deficiency

Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance

Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish

Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence

Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings

The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases

TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins

Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases

Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaque