Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 16 Dec 2025

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

in Molecular Innate Immunity

David Eikrem
Vivek A. Manivel
Jacob Whittaker
Osama A. Hamad
Camilla Mohlin
Anna Adler
Claudia Dührkop
Roland Ebert
Yuji Teramura
Kristina N. Ekdahl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729532

601 views

Correction

Accepted on 15 Dec 2025

Correction: Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

in Molecular Innate Immunity

Xiuping Liang
Li Yanhong
Ziyi Tang
Yubin Luo
Yi Liu

Frontiers in Immunology

290 views

Original Research

Accepted on 15 Dec 2025

Dual Role of ACE2 in Regulating Inflammation Triggered by Omicron S1 and Other SARS-CoV-2 Spike Variants

in Molecular Innate Immunity

Annamaria Pedoto
Juan Manuel Lozano Gil
Maria Ocaña Esparza
Ana Maria Conesa Hernandez
Sergio Candel Camacho
MARIA L. CAYUELA
Victoriano Mulero
Sylwia Dominika Tyrkalska

Frontiers in Immunology

280 views

Review

Published on 15 Dec 2025

Immunobiology of pulmonary fibrosis

in Molecular Innate Immunity

Samik Bindu
Hadida Yasmin
Uttam Barman
Subhradip Pandit
Khaled Masmoudi
Uday Kishore

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708716

735 views

Editorial

Accepted on 12 Dec 2025

Editorial: Sentinels of the Immune System: Tissue-Resident Macrophages (TRMs) in the Battle Against Infection and Autoimmunity

in Molecular Innate Immunity

Lalit Batra
Shilpi Giri
Shailesh K Shahi

Frontiers in Immunology

127 views

Brief Research Report

Published on 11 Dec 2025

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19

in Molecular Innate Immunity

Sruthi Vijaya Retnakumar
Suraj Chandrabhan Singh
Camille Chauvin
Jagadeesh Bayry

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718240

767 views

Original Research

Published on 11 Dec 2025

Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

in Molecular Innate Immunity

Mengkui Han
Junchi Xu
Xunxun Wu
Zhiqing Hu
Xiaoyuan Hu
Xiaolong Zhu
Cailin Chen
Qinkao Xuan
Yang Li
Chuanwu Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671149

714 views

Mini Review

Published on 11 Dec 2025

Tumor associated macrophages in gastric cancer dual roles in immune evasion and clinical implications for targeted therapy

in Molecular Innate Immunity

Chang Wang
Xu Fan
Xiaomen Sun
Yi Xu
Yanna Sun
Jidong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706744

739 views

Original Research

Accepted on 09 Dec 2025

Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

in Molecular Innate Immunity

Min Chu
Ding Ma
Zhan Song
Li Liang
Fengjuan Xing
Hongchu Bao

Frontiers in Immunology

146 views

Review

Accepted on 09 Dec 2025

The Multifaceted Role of Post-Translational Modifications in Macrophage Polarization: From Mechanisms to Therapeutic Targets

in Molecular Innate Immunity

Rui Guo
Feng Qi

Frontiers in Immunology

147 views

Review

Accepted on 08 Dec 2025

Ferroptosis-Immune-Metabolic Axis in Asthma: Mechanistic Crosstalk, Endotype-Specific Regulation, and Translational Targeting

in Molecular Innate Immunity

Feng-Xian Ni
Jie Hu
Pei-Sheng Chen
Huihui Chen
Dong-Hui Huang
Zebo Jiang

Frontiers in Immunology

149 views

Original Research

Accepted on 08 Dec 2025

Regnase-1 in cDC1 Controls T Cell Priming and Shapes the Dynamics of Experimental Autoimmune Encephalomyelitis

in Molecular Innate Immunity

Osamu Takeuchi
Xingyu Rong
Hai Wang
Shintaro Muraoka
Takuya Uehata
Masanori Yoshinaga
Tsuneyasu Kaisho

Frontiers in Immunology

287 views

Original Research

Accepted on 08 Dec 2025

Modulation of IRAK4 as a Therapeutic Strategy Against Monosodium Urate-and Xanthine-Induced Inflammation in Macrophages and HepG2 Cells

in Molecular Innate Immunity

Sadiq Umar
Huan T Chang
Mark M Cline
Sriram Ravindran

Frontiers in Immunology

178 views

Review

Published on 08 Dec 2025

Cardiolipin’s multifaceted role in immune response: a focus on interacting proteins

in Molecular Innate Immunity

Zhuodong Chai
Yuqi Zhou
Sukria Hossain
Khanh Huynh
Sahelosadat Hajimirzaei
Yan Zhang
Jiaqian Qi
Guoying Zhang
Zhenyu Li
Yinan Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680326

811 views

Review

Published on 08 Dec 2025

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

in Molecular Innate Immunity

Yichen Fan
Zihao Dong
Yufeng Wu
Hao Wen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692365

1,228 views

Original Research

Accepted on 04 Dec 2025

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcome

in Molecular Innate Immunity

Emmanuelle Degeorges
Stéphane Mouret
Pauline Girard
Camille Niveau
Mélanie Cettour-Cave
Eleonora Sosa Cuevas
Florence De Fraipont
Julie Charles
Philippe Saas
CAROLINE ASPORD

Frontiers in Immunology

169 views

Review

Published on 04 Dec 2025

Epigenetic modifications in vascular inflammation

in Molecular Innate Immunity

Linyi Tang
Liyun Li
Yang Liu
Xin Zhang
Xinglin Wang
Zaiyong Zheng
Ping Yang
Haoran Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711579

791 views

Case Report

Accepted on 03 Dec 2025

Possible C3 Nephritic Factor–Driven Complement-Mediated Severe Hemolytic Anemia and Acute Kidney Injury in a Child with Bordetella parapertussis Infection

in Molecular Innate Immunity

Steffen Ullitz Ullitz Thorsen
Anne Todsen Hansen
Hans Jakob Hartling
Hanne Vibeke Hansen Marquart
Line Gutte Borgwardt
Mira Marie Laustsen
Lillemor Melander Skattum
Alex Christian Yde Nielsen
Line Thousig Sehested
Hanne Nørgaard

Frontiers in Immunology

260 views

Original Research

Published on 03 Dec 2025

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

in Molecular Innate Immunity

Soumitra Mohanty
John Kerr White
Yundi Yin
Taj Muhammad
Isak Demirel
Adam A. Strömstedt
Sunithi Gunasekera
Natalia Ferraz
Ulf Göransson
Annelie Brauner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705805

1,087 views

Original Research

Accepted on 02 Dec 2025

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming

in Molecular Innate Immunity

Christopher Kalischer
Phani Sankar Potru
Nele Lehmann
Jannik Jahn
Björn Spittau

Frontiers in Immunology

205 views

Review

Published on 02 Dec 2025

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing

in Molecular Innate Immunity

Priyanka Talukdar
Peter H. Winegar
Graham A. Hudson
Maria C. T. Astolfi
Jamie L. Inman
Jay D. Keasling
Harshini Mukundan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677995

1,424 views

Mini Review

Published on 01 Dec 2025

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

in Molecular Innate Immunity

Yingshi Bao
Zixuan Chen
Yutong Su
Tingting Guo
Huaping Du
Xianjun Jia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682030

1,039 views

Original Research

Accepted on 30 Nov 2025

Pre-partum blood leukocyte profile distinguishes gestational inflammatory stages to prognosticate birth-related adverse outcomes

in Molecular Innate Immunity

Hari Shankar
Yash Gupta
Neeta Kumar
Vinoth Gnana Chellaiyan Devanbu
William M Trochim
Almira Lydia Hoogesteijn
Jeanne Marie Fair
Raja Babu Singh Kushwah
Michelle Iandiorio
Andrew Yen

Frontiers in Immunology

159 views

Original Research

Accepted on 30 Nov 2025

The Role of Gasdermin-Mediated Mitochondrial RNA Release in Amplifying Secondary Immune Response During Microbial Infection

in Molecular Innate Immunity

Uzair Afaq
Muhammad Suhaib Qudus
Siyu Liu
Kailang Wu
Jianguo Wu
YU CHEN
Mingfu Tian

Frontiers in Immunology

156 views

3,557 articles

articles

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Correction: Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

Dual Role of ACE2 in Regulating Inflammation Triggered by Omicron S1 and Other SARS-CoV-2 Spike Variants

Immunobiology of pulmonary fibrosis

Editorial: Sentinels of the Immune System: Tissue-Resident Macrophages (TRMs) in the Battle Against Infection and Autoimmunity

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19

Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

Tumor associated macrophages in gastric cancer dual roles in immune evasion and clinical implications for targeted therapy

Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

The Multifaceted Role of Post-Translational Modifications in Macrophage Polarization: From Mechanisms to Therapeutic Targets

Ferroptosis-Immune-Metabolic Axis in Asthma: Mechanistic Crosstalk, Endotype-Specific Regulation, and Translational Targeting

Regnase-1 in cDC1 Controls T Cell Priming and Shapes the Dynamics of Experimental Autoimmune Encephalomyelitis

Modulation of IRAK4 as a Therapeutic Strategy Against Monosodium Urate-and Xanthine-Induced Inflammation in Macrophages and HepG2 Cells

Cardiolipin’s multifaceted role in immune response: a focus on interacting proteins

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcome

Epigenetic modifications in vascular inflammation

Possible C3 Nephritic Factor–Driven Complement-Mediated Severe Hemolytic Anemia and Acute Kidney Injury in a Child with Bordetella parapertussis Infection

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

Pre-partum blood leukocyte profile distinguishes gestational inflammatory stages to prognosticate birth-related adverse outcomes

The Role of Gasdermin-Mediated Mitochondrial RNA Release in Amplifying Secondary Immune Response During Microbial Infection