Frontiers in Immunology | Molecular Innate Immunity

Original Research

Accepted on 30 Jan 2026

Identification of MTURN as a Trained Immunity-Related Biomarker for Heart Failure via Integrative Transcriptomic Machine Learning Analysis and Experimental Validation

in Molecular Innate Immunity

Tianyuan Yang
Zhixin Li
Mingliang Pan
Xiaohong Wang
Wei Huang
Nebahat Ece Kesten
Tianqing Peng
Guo-Chang Fan

Frontiers in Immunology

113 views

Original Research

Published on 30 Jan 2026

3-Hydroxystearic acid promotes cholesterol efflux and attenuates atherosclerosis via the ALKBH5/PAX-8/ABCA1 pathway

in Molecular Innate Immunity

Qin-Yi Zhou
Wang Liu
Zhen-Wang Zhao
Duo Gong
Xiao-Feng Ma
Chao-Ke Tang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1750021

856 views

Original Research

Published on 30 Jan 2026

Uridine diphosphate drives myeloid differentiation and functional reprogramming through dynamic transcriptional network

in Molecular Innate Immunity

Caterina Giordano
Debora Gentile
Emilio Straface
Raffaella Gallo
Costanza Maria Cristiani
Antonio Abatino
Arianna Pastore
Marilena Celano
Alessandro Arcucci
Francesco Albano

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743389

925 views

Review

Published on 30 Jan 2026

Extracellular vesicles in Graves’ disease and Graves’ orbitopathy: immunoregulatory mechanisms, biomarkers, and therapeutic potentials

in Molecular Innate Immunity

Yuqing Chen
Ying Yang
Shuo Yang
Wenjie Yuan
Lihong Jiang
Ruili Wei

Frontiers in Immunology

doi 10.3389/fimmu.2026.1762376

369 views

Review

Accepted on 29 Jan 2026

Forging Resilient Warriors Within: Exercise's Epic Role in Training Innate Immunity and Taming Inflammation's Storm

in Molecular Innate Immunity

Yahui Li
Dongdong Wang

Frontiers in Immunology

197 views

Original Research

Published on 29 Jan 2026

Artemisinin exerts anti-inflammatory effects in osteoarthritis through the inhibition of TGF-β1 signaling

in Molecular Innate Immunity

Xifan Zheng
Bo Yu
Yuansong Song
Yeping Chen
Zeming Li
Jun Yao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1717045

546 views

Original Research

Accepted on 28 Jan 2026

Humoral Immune Responses to Hyaluronan Oligosaccharides in Patients Undergoing Prosthetic Valve Surgery

in Molecular Innate Immunity

Daniel Bello-Gil
Sara Olivera-Ardid
Arnau Blasco-Lucas
Fabrizio Sbraga
Manuel Galiñanes
Thierry Le Tourneau
Jean Christian Roussel
Tomaso Bottio
Marta Vadori
Emanuele Cozzi

Frontiers in Immunology

208 views

Original Research

Accepted on 28 Jan 2026

Eosinophilic inflammation in hereditary angioedema: a single-center real-world retrospective chart review study

in Molecular Innate Immunity

Katharina Boch
Ralf J Ludwig
Dagmar Angela von Bubnoff
Andreas Recke

Frontiers in Immunology

143 views

Original Research

Published on 28 Jan 2026

The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis

in Molecular Innate Immunity

Yamin Song
Fangzheng Guo
Huiting Dai
Xiaoyu Zhou
Sihang Dong
Hui Zhang
Zhongqing Qian
Baiqing Li
Xiaojing Wang
Tao Xu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1707304

708 views

Original Research

Published on 28 Jan 2026

Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1fl/fl mice prevents the formation of connective tissue mast cells without affecting basophils: a new tool to investigate the specific role of CTMCs in disease

in Molecular Innate Immunity

Johanna Kramer
Jakob Schneider
Huiying Liu
Cinthia Silva-Vilches
Sonja Moos
Nadine Kamenjarin
Katrin Hodapp
Volodymyr Tsvilovskyy
Marc Freichel
Hans Christian Probst

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671735

569 views

Original Research

Published on 27 Jan 2026

Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection with Listeria monocytogenes and lymphocytic choriomeningitis virus

in Molecular Innate Immunity

Theresa Charlotte Christ
Justa Friebus-Kardash
Michael Bergerhausen
Abdelrahman Elwy
Hossam Abdelrahman
Lisa Holnsteiner
Tobias Tertel
Elisa Wiebeck
Ilka Geuer
Alexander Gerbaulet

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621608

700 views

Correction

Published on 26 Jan 2026

Correction: RBM39 shapes innate immunity by controlling expression of key factors of the interferon response

in Molecular Innate Immunity

Teng-Feng Li
Paul Rothhaar
Arthur Lang
Oliver Grünvogel
Ombretta Colasanti
Santa Mariela Olivera Ugarte
Jannik Traut
Antonio Piras
Nelson Acosta-Rivero
Vladimir Gonçalves Magalhães

Frontiers in Immunology

doi 10.3389/fimmu.2026.1782019

537 views

Mini Review

Published on 23 Jan 2026

m6A RNA modification and myeloid-derived suppressor cells: mechanistic insights and clinical prospects

in Molecular Innate Immunity

Chunhong Li
Xiulin Jiang
Yixiao Yuan
Xi Chen
Shanrui Pu
Kun Lian
Lihua Li
Qiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1694842

755 views

Review

Published on 22 Jan 2026

Revisiting ventilator-induced lung injury: from mechanical power to immunometabolic interaction

in Molecular Innate Immunity

Yuelian Luo
Zixuan Wu
Jinglei Wu
Zijian You
Yue Chen
Xinquan Wei
Yujie Liang
Jiancong Yang
Mingbo Luo
Jie Chen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1754983

729 views

Original Research

Accepted on 21 Jan 2026

Establishing an Untargeted Lipidomics Workflow for Cellular Analysis: Insights into Endothelial Cell Function in Anaphylaxis

in Molecular Innate Immunity

María Isabel Delgado Dolset
Andrea Escolar-Peña
Sergio Fernández-Bravo
René Neuhaus
Rosario Gonzalez-Mendiola
Coral Barbas
Domingo Barber
Jose Julio Laguna
Maria M Escribese
Vanesa Esteban

Frontiers in Immunology

204 views

Mini Review

Published on 21 Jan 2026

The multifaceted regulatory effect of icariin on macrophages: a mini-review

in Molecular Innate Immunity

Juan Gao
Jin-Hong Gao
Yan-Fen Zhang
Da Gao
Ya-Peng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1765533

664 views

Original Research

Published on 21 Jan 2026

Erythrocyte membrane-encapsulated SZF nanocomposites for hyperuricemia therapy

in Molecular Innate Immunity

Weiwei Liu
Xin Guan
Luobing Wang
Chengjie Zhang
Boyi Shen
Yuke Zeng
Dongdong Li
Guangjin Pu
Jing Hu
Jiandong Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695253

674 views

Original Research

Accepted on 20 Jan 2026

GNPAT Promotes Immunosuppression in Hepatocellular Carcinoma by Activating the Plasmalogen-PPARγ Pathway to Drive M2 Macrophage Polarization

in Molecular Innate Immunity

Meng Hu
Nan Zhang
Yanqi Wa
Xiao-Ming Wang
Yun Shi
Min Yao
Lian-Guo Hou
Lingling Jiang

Frontiers in Immunology

215 views

Original Research

Published on 20 Jan 2026

Allergen extract outperforms molecular components in basophil activation test in a pediatric cohort

in Molecular Innate Immunity

Alexandre Chhing
Simone Choi
Dounia Khelifi-Touhami
Aïcha Abbas
Eric Ballot
Nathalie Cottel
Sarah Saf
Garance Germain
Nathalie Lambert
Pierre Challier

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701351

848 views

Original Research

Published on 19 Jan 2026

Temporal dynamics of macrophage transcriptional profiles during zebrafish wound healing

in Molecular Innate Immunity

Christina Begon-Pescia
Laurent Manchon
Resul Özbilgiç
Stéphanie Boireau
Anaïs Louis
Simon Georges
Mai Nguyen-Chi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721612

1,370 views
1 citation

General Commentary

Published on 16 Jan 2026

Commentary: Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

in Molecular Innate Immunity

Jintao Cui
Bin Xu
Penghui Zhang
Songfu Han
Chaoyanng Guo
Limin Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1752400

806 views

Original Research

Published on 16 Jan 2026

Combined therapy with the estrogen receptor ERα and IFNα-2b suppresses HBV replication by inducing GBP1 expression

in Molecular Innate Immunity

Yadi Li
Jiaojiao Gong
Guili Tan
Haiying Luo
Xiaoxia Hu
Bo Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698786

871 views

Original Research

Published on 16 Jan 2026

Macrophage immunometabolic reprogramming impairs tissue regeneration in type 2 diabetes zebrafish model

in Molecular Innate Immunity

Leonel Witcoski Junior
Jordana Dinorá de Lima
André Guilherme Portela de Paula
Thais Sibioni Berti Bastos
Rebeca Bosso dos Santos Luz
Israel Henrique Bini
Matheus Brandemarte Severino
Luis Eduardo Alves Damasceno
Lais Cavalieri Paredes
Amanda Girardi Somensi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698674

1,019 views

Correction

Published on 16 Jan 2026

Correction: Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

in Molecular Innate Immunity

Ya-ping Li
Xin-jian Niu
Ge Zhang
On-kei Chan
Nuo Sun
Bo Hu
Zi-jian Shi
Dong-yun Ouyang
Xian-hui He
Qing-bing Zha

Frontiers in Immunology

doi 10.3389/fimmu.2026.1782391

384 views

3,597 articles

articles

Identification of MTURN as a Trained Immunity-Related Biomarker for Heart Failure via Integrative Transcriptomic Machine Learning Analysis and Experimental Validation

3-Hydroxystearic acid promotes cholesterol efflux and attenuates atherosclerosis via the ALKBH5/PAX-8/ABCA1 pathway

Uridine diphosphate drives myeloid differentiation and functional reprogramming through dynamic transcriptional network

Extracellular vesicles in Graves’ disease and Graves’ orbitopathy: immunoregulatory mechanisms, biomarkers, and therapeutic potentials

Forging Resilient Warriors Within: Exercise's Epic Role in Training Innate Immunity and Taming Inflammation's Storm

Artemisinin exerts anti-inflammatory effects in osteoarthritis through the inhibition of TGF-β1 signaling

Humoral Immune Responses to Hyaluronan Oligosaccharides in Patients Undergoing Prosthetic Valve Surgery

Eosinophilic inflammation in hereditary angioedema: a single-center real-world retrospective chart review study

The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis

Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1fl/fl mice prevents the formation of connective tissue mast cells without affecting basophils: a new tool to investigate the specific role of CTMCs in disease

Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection with Listeria monocytogenes and lymphocytic choriomeningitis virus

Correction: RBM39 shapes innate immunity by controlling expression of key factors of the interferon response

m6A RNA modification and myeloid-derived suppressor cells: mechanistic insights and clinical prospects

Revisiting ventilator-induced lung injury: from mechanical power to immunometabolic interaction

Establishing an Untargeted Lipidomics Workflow for Cellular Analysis: Insights into Endothelial Cell Function in Anaphylaxis

The multifaceted regulatory effect of icariin on macrophages: a mini-review

Erythrocyte membrane-encapsulated SZF nanocomposites for hyperuricemia therapy

GNPAT Promotes Immunosuppression in Hepatocellular Carcinoma by Activating the Plasmalogen-PPARγ Pathway to Drive M2 Macrophage Polarization

Allergen extract outperforms molecular components in basophil activation test in a pediatric cohort

Temporal dynamics of macrophage transcriptional profiles during zebrafish wound healing

Commentary: Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

Combined therapy with the estrogen receptor ERα and IFNα-2b suppresses HBV replication by inducing GBP1 expression

Macrophage immunometabolic reprogramming impairs tissue regeneration in type 2 diabetes zebrafish model

Correction: Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages