Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 02 Jan 2026

The role of gasdermin-mediated mitochondrial RNA release in amplifying secondary immune response during microbial infection

in Molecular Innate Immunity

Uzair Afaq
Muhammad Suhaib Qudus
Siyu Liu
Kailang Wu
Yu Chen
Mingfu Tian
Jianguo Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668763

1,323 views

Correction

Published on 02 Jan 2026

Correction: Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

in Molecular Innate Immunity

Xiuping Liang
Yanhong Li
Ziyi Tang
Yubin Luo
Yi Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761117

907 views

Original Research

Published on 02 Jan 2026

STING activation by teniposide: a potential direct mechanism beyond cGAS stimulation

in Molecular Innate Immunity

Javier Arranz-Herrero
Laura Marquez-Cantudo
Sergio Rius-Rocabert
Rubén M. Buey
Adrian Velazquez-Campoy
Vicent Tur-Planells
Adolfo Garcia-Sastre
Lisa Miorin
Beatriz de Pascual-Teresa
Claire Coderch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677836

2,398 views

Editorial

Published on 22 Dec 2025

Editorial: The role of glycolipids and sphingolipids in the differentiation and function of innate immune cells

in Molecular Innate Immunity

Kazuhisa Iwabuchi
Moriya Tsuji
Kohji Kasahara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1758633

1,386 views

Original Research

Published on 19 Dec 2025

Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

in Molecular Innate Immunity

Ya-ping Li
Xin-jian Niu
Ge Zhang
On-kei Chan
Nuo Sun
Bo Hu
Zi-jian Shi
Dong-yun Ouyang
Xian-hui He
Qing-bing Zha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726408

2,005 views

Mini Review

Published on 18 Dec 2025

TAM Plasticity under androgen deprivation therapy and PARP inhibition in prostate cancer: a multi-omics perspective

in Molecular Innate Immunity

Shuangming Chen
Weiwei Cai
Chunlin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1745168

2,639 views

Editorial

Published on 18 Dec 2025

Editorial: Community series in biology of C-reactive protein, volume II

in Molecular Innate Immunity

Alok Agrawal
Yi Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1751020

666 views

Original Research

Published on 18 Dec 2025

Impact of recombinant expression in Komagataella phaffii on the allergenic properties of the peanut allergen Ara h 2

in Molecular Innate Immunity

Andrea Wangorsch
Annette Jamin
Sonja Wolfheimer
Melanie Albrecht
Stefan Vieths
Jonas Lidholm
Stephan Scheurer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713823

1,177 views

Original Research

Published on 18 Dec 2025

Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

in Molecular Innate Immunity

Huili Zhao
Shenao Zhang
Yinjiao Wang
Haiyan Zhang
Peng Du
Aihong Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739812

1,353 views
1 citation

Editorial

Published on 16 Dec 2025

Editorial: Macrophages: allies or merciless enemies in musculoskeletal systems

in Molecular Innate Immunity

M. Alaa Terkawi
Ken Kadoya
Tsutomu Endo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746089

790 views

Original Research

Published on 16 Dec 2025

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

in Molecular Innate Immunity

David Eikrem
Vivek A. Manivel
Jacob Whittaker
Osama A. Hamad
Camilla Mohlin
Anna Adler
Claudia Dührkop
Roland Ebert
Yuji Teramura
Kristina N. Ekdahl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729532

1,277 views

Review

Published on 15 Dec 2025

Immunobiology of pulmonary fibrosis

in Molecular Innate Immunity

Samik Bindu
Hadida Yasmin
Uttam Barman
Subhradip Pandit
Khaled Masmoudi
Uday Kishore

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708716

2,220 views

Brief Research Report

Published on 11 Dec 2025

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19

in Molecular Innate Immunity

Sruthi Vijaya Retnakumar
Suraj Chandrabhan Singh
Camille Chauvin
Jagadeesh Bayry

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718240

1,558 views
1 citation

Original Research

Published on 11 Dec 2025

Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

in Molecular Innate Immunity

Mengkui Han
Junchi Xu
Xunxun Wu
Zhiqing Hu
Xiaoyuan Hu
Xiaolong Zhu
Cailin Chen
Qinkao Xuan
Yang Li
Chuanwu Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671149

1,398 views

Mini Review

Published on 11 Dec 2025

Tumor associated macrophages in gastric cancer dual roles in immune evasion and clinical implications for targeted therapy

in Molecular Innate Immunity

Chang Wang
Xu Fan
Xiaomen Sun
Yi Xu
Yanna Sun
Jidong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706744

2,019 views

Review

Published on 08 Dec 2025

Cardiolipin’s multifaceted role in immune response: a focus on interacting proteins

in Molecular Innate Immunity

Zhuodong Chai
Yuqi Zhou
Sukria Hossain
Khanh Huynh
Sahelosadat Hajimirzaei
Yan Zhang
Jiaqian Qi
Guoying Zhang
Zhenyu Li
Yinan Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680326

1,509 views

Review

Published on 08 Dec 2025

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

in Molecular Innate Immunity

Yichen Fan
Zihao Dong
Yufeng Wu
Hao Wen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692365

3,181 views

Review

Published on 04 Dec 2025

Epigenetic modifications in vascular inflammation

in Molecular Innate Immunity

Linyi Tang
Liyun Li
Yang Liu
Xin Zhang
Xinglin Wang
Zaiyong Zheng
Ping Yang
Haoran Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711579

1,469 views

Original Research

Published on 03 Dec 2025

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

in Molecular Innate Immunity

Soumitra Mohanty
John Kerr White
Yundi Yin
Taj Muhammad
Isak Demirel
Adam A. Strömstedt
Sunithi Gunasekera
Natalia Ferraz
Ulf Göransson
Annelie Brauner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705805

1,653 views

Review

Published on 02 Dec 2025

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing

in Molecular Innate Immunity

Priyanka Talukdar
Peter H. Winegar
Graham A. Hudson
Maria C. T. Astolfi
Jamie L. Inman
Jay D. Keasling
Harshini Mukundan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677995

2,577 views

Mini Review

Published on 01 Dec 2025

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

in Molecular Innate Immunity

Yingshi Bao
Zixuan Chen
Yutong Su
Tingting Guo
Huaping Du
Xianjun Jia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682030

1,551 views
1 citation

Original Research

Published on 28 Nov 2025

Differential DNA methylation in infants with IgE- and non-IgE-mediated cow’s milk allergy and its association with acquired tolerance

in Molecular Innate Immunity

Rebeca López-Gómez
Marta Gil-Martínez
Ana Ladrón-Guevara
Jose Manuel Rodrigo-Muñoz
Clara Lorente-Sorolla
Daniel Rodríguez-González
Zahara García de Castro
Gema Guillén-Sánchez
Antonio Serrano-Santiago
Raquel Mirasierra-Pérez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571987

1,248 views

Original Research

Published on 28 Nov 2025

IL-9 and IL-24 biomarkers in the transcriptional signature of contact dermatitis to methylisothiazolinone

in Molecular Innate Immunity

Taynah Cohen de Melo
Mirian Nacagami Sotto
Iara Grigoletto Fernandes
Emanuella Sarmento Alho De Sousa
Frederico Moraes Ferreira
Gabriel Benevides Simões
Yasmim Álefe Leuzzi Ramos
Marcella Soares Pincelli
Vitor Manuel Silva dos Reis
Maria Notomi Sato

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685396

1,068 views

Editorial

Published on 28 Nov 2025

Editorial: Unraveling circRNAs and miRNAs: key regulators in immune-related diseases

in Molecular Innate Immunity

Mohamad S. Hakim
Aqsa Ikram
Mounir M. Salem-Bekhit
Zulqarnain Baloch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739926

752 views

3,597 articles

articles

The role of gasdermin-mediated mitochondrial RNA release in amplifying secondary immune response during microbial infection

Correction: Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

STING activation by teniposide: a potential direct mechanism beyond cGAS stimulation

Editorial: The role of glycolipids and sphingolipids in the differentiation and function of innate immune cells

Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

TAM Plasticity under androgen deprivation therapy and PARP inhibition in prostate cancer: a multi-omics perspective

Editorial: Community series in biology of C-reactive protein, volume II

Impact of recombinant expression in Komagataella phaffii on the allergenic properties of the peanut allergen Ara h 2

Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

Editorial: Macrophages: allies or merciless enemies in musculoskeletal systems

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Immunobiology of pulmonary fibrosis

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19

Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

Tumor associated macrophages in gastric cancer dual roles in immune evasion and clinical implications for targeted therapy

Cardiolipin’s multifaceted role in immune response: a focus on interacting proteins

Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues

Epigenetic modifications in vascular inflammation

Synthetic antimicrobial peptide LD4-PP protects the host against E. coli-induced cell death

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

Differential DNA methylation in infants with IgE- and non-IgE-mediated cow’s milk allergy and its association with acquired tolerance

IL-9 and IL-24 biomarkers in the transcriptional signature of contact dermatitis to methylisothiazolinone

Editorial: Unraveling circRNAs and miRNAs: key regulators in immune-related diseases