Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 02 Oct 2025

Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury

in Molecular Innate Immunity

Tianle Cheng
Yong Xu
Ziwei Liu
Yanchen Wang
Ze Zhang
Wenlin Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637692

2,793 views

Original Research

Published on 01 Oct 2025

Integrated proteomics and single-cell transcriptomics reveal potential therapeutic targets in Wilson’s disease patients

in Molecular Innate Immunity

Yue Qi
Minghui Sun
Fang Xu
Hao Zhou
Lihua Yuan
Xinlei Yu
Sirui Cao
Rui Hua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635137

2,008 views

Systematic Review

Published on 01 Oct 2025

Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context

in Molecular Innate Immunity

Hongyu Li
Xianwei Li
Yunhuan Zhu
Jialu Xu
Qingzhi Zhao
Xintong Chen
Yijie Zhang
Ling Zhao
Yutong Chen
Ruiqi Weng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671434

2,136 views

Original Research

Published on 01 Oct 2025

Increased levels of ficolin-1 and of C3dg are independently associated with high risk of infection in patients with chronic kidney disease: a prospective cohort study

in Molecular Innate Immunity

Solbjørg Sagedal
Markus Hovd
Anders Åsberg
Tom Eirik Mollnes
Olav Klingenberg
Torbjørn Fossum Heldal
Bartlomiej J. Witczak
Trine Korsgaard Hejlesen
Anne Troldborg
Steffen Thiel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645347

1,525 views

Review

Published on 01 Oct 2025

Unraveling angioedema: diagnostic challenges and emerging therapies

in Molecular Innate Immunity

Felix Johnson
Benedikt Hofauer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681763

2,797 views

Review

Published on 01 Oct 2025

From stress signals to fertility challenges: the role of damage-associated molecular patterns in male reproduction

in Molecular Innate Immunity

Heran Cao
Shujuan Liu
Shichao Cui
Hua Nie
Xiaohua Liu
Weibing Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598451

2,617 views

Original Research

Published on 01 Oct 2025

Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide

in Molecular Innate Immunity

Bin Zhou
Zhaoying Lv
Ruijuan Zu
Jianbo Liu
Yuting Yang
Zongguang Zhou
Yuan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556600

1,468 views

Original Research

Published on 30 Sep 2025

P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity

in Molecular Innate Immunity

Priota Islam
Julia Y. Chu
Stephen A. Chetwynd
Rachael Walker
Phillip T. Hawkins
Heidi C. E. Welch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591006

2,033 views
1 citation

Review

Published on 29 Sep 2025

Exploring the pathogenesis of MAFLD from an immunological perspective: from the perspective of the cGAS/STING/NF-κB signaling pathway

in Molecular Innate Immunity

Ruiyuan Tian
Yong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674018

2,466 views

Review

Published on 29 Sep 2025

Synthesis, function, and therapeutic potential of glycosphingolipids

in Molecular Innate Immunity

Liang Dong
Zhi Cao
Weidong Han
Zhiqiang Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673713

1,891 views

Original Research

Published on 29 Sep 2025

The functional Mi-2/Foxo complex targets PGRP-SC2 for the Drosophila immune defense against bacterial infection

in Molecular Innate Immunity

Xianrui Zheng
Umar Ali
Yiheng Jin
Erwen Ding
Yangyang Zhu
Muhammad Usama
Qingshuang Cai
Shanming Ji

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664564

1,765 views

Original Research

Published on 25 Sep 2025

Bridging inflammation and proliferation: scRNA-seq analysis of chemotactic and growth factor signaling in mouse skin wound repair

in Molecular Innate Immunity

Lingzhang Meng
Hongmian Li
Jian Song
Wenxian Lin
Xiuli Mao
Xiamin Zhang
Mingyue Yang
Kezhao Wu
Liu Lu
Feiteng Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654043

1,817 views

Review

Published on 25 Sep 2025

Roles of microRNAs in acute lung injury and acute respiratory distress syndrome: mechanisms and clinical potential

in Molecular Innate Immunity

Pengyu Wang
Dingyuan Lai
Litong Jin
Yi Xue

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570128

1,578 views

Review

Published on 25 Sep 2025

Succinate in innate immunity: linking metabolic reprogramming to immune modulation

in Molecular Innate Immunity

Reham Atallah
Juergen Gindlhuber
Akos Heinemann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661948

3,002 views

Original Research

Published on 25 Sep 2025

Establishment and validation of the prediction model based on lymphocyte subsets for acute kidney injury in sepsis patients

in Molecular Innate Immunity

Leyi Wang
Qi Liu
Changdong Wu
Ming Hou
Zhiwei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674673

1,966 views

Mini Review

Published on 25 Sep 2025

Ubiquitination in macrophage plasticity: from inflammatory to immunometabolic pathways

in Molecular Innate Immunity

Jianing Liu
Magdalena Paolino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621328

2,086 views

Original Research

Published on 25 Sep 2025

Single-cell multi-omics dissection of c-Myb/AURKA-mediated autophagy and metabolic reprogramming in diabetic adipose-derived stem cells

in Molecular Innate Immunity

Yating Yin
Wenwen Shao
Wen Zha
Bin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665909

1,752 views

Review

Published on 25 Sep 2025

Mechanisms of innate immune cells in Metabolic dysfunction-associated steatotic liver disease

in Molecular Innate Immunity

Yao Yao
Qiong Wu
Bin Fan
Xin Peng
Mingwei Sheng
Fengmei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599748

2,770 views

Original Research

Published on 23 Sep 2025

Single-cell multi-omics and nursing follow-up prognostic modeling reveal SLFN4-mediated neutrophil dysregulation in traumatic brain injury

in Molecular Innate Immunity

Wenping Tang
Yang Wang
Fu Zhao
Yang Hong
Lina Wang
Wanyan Xu
Fangfang Ding
Tingting Shi
Jing Ke
Li Zhuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669800

2,608 views

Mini Review

Published on 22 Sep 2025

Targeting tumor-associated macrophages in non-small cell lung cancer: mechanisms, prognosis, and therapeutic opportunities

in Molecular Innate Immunity

Dameng Hao
Shengjie Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679537

3,357 views

Review

Published on 19 Sep 2025

Therapeutic roles and molecular mechanisms of Cuscutae Semen in reproductive diseases

in Molecular Innate Immunity

Kun Li
Haixia Zheng
Wenjie Hao
Yanni Kong
Qianru Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659342

2,302 views

Original Research

Published on 18 Sep 2025

Immunopathology in PMM2-CDG: Defective glycosylation impact in the TNFα -TNFR1 signalling pathway

in Molecular Innate Immunity

Carlota Pascoal
Pedro Granjo
Rebeka Kodríková
Marta Falcão
Ana C. Santos
Inês Teodoro
Zuzana Pakanová
Marek Nemčovič
Jan Mucha
Margarida Castro-Caldas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655354

3,229 views

Original Research

Published on 18 Sep 2025

PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism

in Molecular Innate Immunity

Nan Wu
Renkai Wang
Shensheng Nian
Hao Zhang
Panyu Zhou
Hao Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637232

2,576 views

Original Research

Published on 17 Sep 2025

HERV-K10 as a mediator of immune modulation in hepatitis infections

in Molecular Innate Immunity

Salih Özer
Romano Strobelt
Anna D. Kosinska
Goar Frishman
Jochen M. Wettengel
Lisa Pleninger
Nina Körber
Wen Liang
Edanur Ates Öz
Marisol Zuniga

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624774

2,580 views

3,544 articles

articles

Multi-omics analysis reveals neutrophil heterogeneity and key molecular drivers in sepsis-associated acute kidney injury

Integrated proteomics and single-cell transcriptomics reveal potential therapeutic targets in Wilson’s disease patients

Systematic review of structural and immunological features of mollusk toll-like receptors in aquaculture context

Increased levels of ficolin-1 and of C3dg are independently associated with high risk of infection in patients with chronic kidney disease: a prospective cohort study

Unraveling angioedema: diagnostic challenges and emerging therapies

From stress signals to fertility challenges: the role of damage-associated molecular patterns in male reproduction

Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide

P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity

Exploring the pathogenesis of MAFLD from an immunological perspective: from the perspective of the cGAS/STING/NF-κB signaling pathway

Synthesis, function, and therapeutic potential of glycosphingolipids

The functional Mi-2/Foxo complex targets PGRP-SC2 for the Drosophila immune defense against bacterial infection

Bridging inflammation and proliferation: scRNA-seq analysis of chemotactic and growth factor signaling in mouse skin wound repair

Roles of microRNAs in acute lung injury and acute respiratory distress syndrome: mechanisms and clinical potential

Succinate in innate immunity: linking metabolic reprogramming to immune modulation

Establishment and validation of the prediction model based on lymphocyte subsets for acute kidney injury in sepsis patients

Ubiquitination in macrophage plasticity: from inflammatory to immunometabolic pathways

Single-cell multi-omics dissection of c-Myb/AURKA-mediated autophagy and metabolic reprogramming in diabetic adipose-derived stem cells

Mechanisms of innate immune cells in Metabolic dysfunction-associated steatotic liver disease

Single-cell multi-omics and nursing follow-up prognostic modeling reveal SLFN4-mediated neutrophil dysregulation in traumatic brain injury

Targeting tumor-associated macrophages in non-small cell lung cancer: mechanisms, prognosis, and therapeutic opportunities

Therapeutic roles and molecular mechanisms of Cuscutae Semen in reproductive diseases

Immunopathology in PMM2-CDG: Defective glycosylation impact in the TNFα -TNFR1 signalling pathway

PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism

HERV-K10 as a mediator of immune modulation in hepatitis infections