Frontiers in Immunology | Molecular Innate Immunity

Mini Review

Published on 01 Dec 2025

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

in Molecular Innate Immunity

Yingshi Bao
Zixuan Chen
Yutong Su
Tingting Guo
Huaping Du
Xianjun Jia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682030

1,558 views
1 citation

Original Research

Published on 28 Nov 2025

Differential DNA methylation in infants with IgE- and non-IgE-mediated cow’s milk allergy and its association with acquired tolerance

in Molecular Innate Immunity

Rebeca López-Gómez
Marta Gil-Martínez
Ana Ladrón-Guevara
Jose Manuel Rodrigo-Muñoz
Clara Lorente-Sorolla
Daniel Rodríguez-González
Zahara García de Castro
Gema Guillén-Sánchez
Antonio Serrano-Santiago
Raquel Mirasierra-Pérez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571987

1,252 views

Original Research

Published on 28 Nov 2025

IL-9 and IL-24 biomarkers in the transcriptional signature of contact dermatitis to methylisothiazolinone

in Molecular Innate Immunity

Taynah Cohen de Melo
Mirian Nacagami Sotto
Iara Grigoletto Fernandes
Emanuella Sarmento Alho De Sousa
Frederico Moraes Ferreira
Gabriel Benevides Simões
Yasmim Álefe Leuzzi Ramos
Marcella Soares Pincelli
Vitor Manuel Silva dos Reis
Maria Notomi Sato

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685396

1,072 views

Editorial

Published on 28 Nov 2025

Editorial: Unraveling circRNAs and miRNAs: key regulators in immune-related diseases

in Molecular Innate Immunity

Mohamad S. Hakim
Aqsa Ikram
Mounir M. Salem-Bekhit
Zulqarnain Baloch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739926

754 views

Original Research

Published on 27 Nov 2025

Carbonic anhydrase 8 regulates basophil activation and interleukin 4 production

in Molecular Innate Immunity

Jianya Peng
Chandler B. Sy
Siyuan Zhao
Arman Sawhney
Vanessa Espinosa
Marissa N. Schroeter
John J. Ponessa
Krupa Chavan
Alexander D. Lemenze
Amariliz Rivera

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694105

954 views

Review

Published on 27 Nov 2025

Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

in Molecular Innate Immunity

Xiuping Liang
Yanhong Li
Ziyi Tang
Yubin Luo
Yi Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718092

2,825 views
1 citation

Original Research

Published on 26 Nov 2025

C3 mutations and poor pegcetacoplan response in paroxysmal nocturnal hemoglobinuria

in Molecular Innate Immunity

Santiago Rodríguez de Córdoba
Andrea Reparaz Suevos
Silvia González Sanz
Francisco J. Fernández
M. Cristina Vega
Enrique Colado Varela
Alejandro Lada Colunga
Juan Carlos Vallejo Llamas
Ana Pilar Gonzalez-Rodríguez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723596

1,862 views
1 citation

Mini Review

Published on 26 Nov 2025

Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape

in Molecular Innate Immunity

Zhaoping Tan
Binyue Sheng
Lu Chen
Hong Dong
Yaqin Deng
Yunyun Li
Cong Liu
Han Wang
Zi Yang
Ting Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689114

2,100 views
1 citation

Editorial

Published on 25 Nov 2025

Editorial: Role of endogenous regulators of innate immunity in sepsis

in Molecular Innate Immunity

Haichao Wang
Xianzhong Meng
Daolin Tang
Yongming Yao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1745170

1,227 views

Review

Published on 25 Nov 2025

Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential

in Molecular Innate Immunity

Cheng-Liang Mao
Chen-Huan Yu
Song-Lin Jiang
Zhen-Hua Ying
Xing-Yi Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717671

3,339 views

Original Research

Published on 24 Nov 2025

Circulating innate lymphoid cells and IL-18 as potential immune biomarkers in thymic tumors

in Molecular Innate Immunity

Daniela Claudia Maresca
Maria Rosaria Saponaro
Evelina La Civita
Marianna Tortora
Benedetta Romano
Erica Pietroluongo
Fabio Somma
Mario Giuliano
Alberto Servetto
Giovannella Palmieri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705648

1,555 views

Original Research

Published on 21 Nov 2025

Phosphorylation-driven effector switching of Rab7 and Rab12 by the leucine-rich repeat kinase 1 in mast cells

in Molecular Innate Immunity

Jana Omar-Kabha
Sewar Omari
Yaara Gorzalczany
Fatima Amer-Sarsour
Elisabeth Kleeblatt
Mitsunori Fukuda
Avraham Ashkenazi
Ronit Sagi-Eisenberg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709196

1,279 views

General Commentary

Published on 20 Nov 2025

Commentary: Complement genetic variants and FH desialylation in S. pneumoniae-haemolytic uraemic syndrome

in Molecular Innate Immunity

Laura M. Baas
Nicole C. A. J. van de Kar
Marloes A. H. M. Michels
Lambertus P. van den Heuvel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707529

871 views

Original Research

Published on 19 Nov 2025

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

in Molecular Innate Immunity

Hongyan Sui
Rosana Wiscovitch-Russo
Silvia Cachaco
Jun Yang
Whitney Bruchey
Sylvain Laverdure
Qian Chen
Tomozumi Imamichi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708516

1,499 views

Original Research

Published on 19 Nov 2025

Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis

in Molecular Innate Immunity

Yuhan Sun
Ke Lin
Ling Wang
Jingwen Ai
Jingjing Zhao
Ruiwen Sun
Xiaoyang Cheng
Yanmin Wan
Peng Cui
Sen Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659425

1,996 views

Original Research

Published on 19 Nov 2025

Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection

in Molecular Innate Immunity

Zhuo Li
Fan Yang
Jun Fu
Zhi-Yuan Li
Li-Bo Hao
Lin Yuan
Ji-Ying Chen
Chi Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648150

972 views

Original Research

Published on 18 Nov 2025

RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge

in Molecular Innate Immunity

Krishna J. Majithia
M. Brittany Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692421

1,669 views

Original Research

Published on 17 Nov 2025

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target

in Molecular Innate Immunity

Jie Zheng
Kangjie Qin
Xiaoqin Wang
Banghai Feng
Yuting Zhang
Yiyu Wang
Han Qin
Qiuyu Dai
Xinxin Liu
Kun Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682846

1,998 views

Original Research

Published on 17 Nov 2025

Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target

in Molecular Innate Immunity

Fan Lu
Houkang Lei
Xiang Xiao
Luzhu Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700781

2,175 views

Original Research

Published on 14 Nov 2025

Extracellular microRNAs modulate human microglial function through TLR8

in Molecular Innate Immunity

Hannah Weidling
Edyta Motta
Leonard D. Kuhrt
Christina Krüger
Caio Andreeta Figueiredo
Thomas Wallach
Silke Frahm
Sebastian Diecke
Susanne A. Wolf
Helmut Kettenmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645062

2,700 views
1 citation

Review

Published on 13 Nov 2025

Circular RNAs and their emerging roles in muscular immune-related diseases

in Molecular Innate Immunity

Felicita Urzi
Anja Srpčič
Katja Lakota

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675567

2,128 views

Original Research

Published on 13 Nov 2025

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1

in Molecular Innate Immunity

Yoichi Dotake
Takahiro Matsuyama
Kentaro Machida
Hiromi Matsuyama
Koichi Takagi
Keiko Mizuno
Keiko Kan-o
Tomoyuki Kuwaki
Hiromasa Inoue
Kentaro Tanaka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655919

2,322 views

Editorial

Published on 10 Nov 2025

Editorial: Oral immunology – interplay of molecules, cells and oral tissue environment

in Molecular Innate Immunity

James Deschner
Kerstin Galler
Jonathan Jantsch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729801

802 views

Original Research

Published on 04 Nov 2025

Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation

in Molecular Innate Immunity

Li Huang
Yuwei Sun
Yi Zheng
Shicheng Qiu
Jianping Zheng
Chunhan Sun
Mingwei Chen
Shaowei Zheng
Yirong Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679987

2,234 views

3,601 articles

articles

From neuroinflammation to gliomagenesis: immune drivers of malignant transformation in the CNS

Differential DNA methylation in infants with IgE- and non-IgE-mediated cow’s milk allergy and its association with acquired tolerance

IL-9 and IL-24 biomarkers in the transcriptional signature of contact dermatitis to methylisothiazolinone

Editorial: Unraveling circRNAs and miRNAs: key regulators in immune-related diseases

Carbonic anhydrase 8 regulates basophil activation and interleukin 4 production

Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

C3 mutations and poor pegcetacoplan response in paroxysmal nocturnal hemoglobinuria

Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape

Editorial: Role of endogenous regulators of innate immunity in sepsis

Neutrophil extracellular traps in rheumatoid arthritis: pathogenic mechanisms and therapeutic potential

Circulating innate lymphoid cells and IL-18 as potential immune biomarkers in thymic tumors

Phosphorylation-driven effector switching of Rab7 and Rab12 by the leucine-rich repeat kinase 1 in mast cells

Commentary: Complement genetic variants and FH desialylation in S. pneumoniae-haemolytic uraemic syndrome

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis

Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection

RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target

Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target

Extracellular microRNAs modulate human microglial function through TLR8

Circular RNAs and their emerging roles in muscular immune-related diseases

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1

Editorial: Oral immunology – interplay of molecules, cells and oral tissue environment

Deciphering oligomeric proanthocyanidins’ dual osteoprotective mechanisms at single-cell resolution: NR4A1-mediated PTGS2 suppression and β-catenin-Runx2 activation