Frontiers in Immunology | Molecular Innate Immunity

Review

Published on 17 Sep 2025

Immunotherapy strategies targeting tumor-associated macrophages and their mechanisms of action in tumor progression

in Molecular Innate Immunity

Haixia Zhu
Jingjing Shao
Lili Shao
Liuhuan Cai
Chunyan Gu
Qin Ge
Jibin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680455

2,179 views
1 citation

Review

Published on 17 Sep 2025

The role of cGAS-STING signaling in the liver and gastrointestinal system: from signaling networks to target intervention

in Molecular Innate Immunity

Zhengli Tan
Jiayue Shi
Shiyi Zhang
Yanyao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682992

2,219 views

Original Research

Published on 17 Sep 2025

Clinical laboratory analytes and platelet-associated parameters as surrogate markers of subclinical inflammation in latent tuberculosis infection

in Molecular Innate Immunity

Sivaprakasam T. Selvavinayagam
Adukkadukkam Anusree
Yean K. Yong
Sathish Sankar
Asha Frederick
Manivannan Rajeshkumar
Masilamani S. Kumar
Palani Sampath
Ganga Sankar
Chitrali L. Roy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662454

2,946 views

Mini Review

Published on 16 Sep 2025

The innate immune axis drives aortic dissection pathogenesis through inflammation and presents novel therapeutic targets

in Molecular Innate Immunity

Can Xu
Wenping Chen
Xinyu Nie
Rui Xu
Xingyue Feng
Zhifen Chen
Dongjin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654622

3,263 views

Original Research

Published on 11 Sep 2025

SIFD-associated TRNT1 deficiency unveils importance of TSPO during macrophage antibacterial and antiviral responses

in Molecular Innate Immunity

Duale Ahmed
Angelo Slade
Thet Fatica
Stephen Baird
Krishna Bhattarai
Thérèse Atallah
Edana Cassol
Martin Holcik

Frontiers in Immunology

doi 10.3389/fimmu.2025.1497766

2,421 views

Mini Review

Published on 11 Sep 2025

Advance in therapies targeting tumor-associated macrophages in ovarian cancer

in Molecular Innate Immunity

Man Li
Yue Ma
Tinggeng Dai
Yongxin Wang
Ying Yue

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677839

3,279 views

Mini Review

Published on 10 Sep 2025

The role of IL-2 in type 2 immunity

in Molecular Innate Immunity

Naoya Tatsumi
Yosuke Kumamoto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622187

2,278 views

Original Research

Published on 09 Sep 2025

Large extracellular vesicles derived from LPS-preconditioned cardiomyocytes alleviate myocarditis via mediating macrophage polarization and modulating p38 MAPK pathway

in Molecular Innate Immunity

Yanjie Jiang
Yingnan You
Yaxue Xie
Shan Zhou
Mengjie Ma
Bo Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629676

2,226 views
1 citation

Review

Published on 08 Sep 2025

The feasibility of targeting macrophage for disease treatment: roles of CEBPD

in Molecular Innate Immunity

Tian Fan
Shaoling Lin
Jingjing Zhou
Jia Chen
Lexun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650161

3,578 views

Original Research

Published on 08 Sep 2025

Prognostic model of ubiquitination-related genes in ovarian cancer based on transcriptomic analysis and experimental validation

in Molecular Innate Immunity

Xiaojing Lin
Shu Zhao
Licheng Li
Yuying Huang
Qiang Zhong
Huali Luo
Qizhu Zhang
Shuxiong Xu
Qinshan Li
Mengxing Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654180

4,124 views

Original Research

Published on 05 Sep 2025

Impact of ERAP1 downregulation on the pathogenesis of DSS-induced colitis and therapeutic response to sulfasalazine

in Molecular Innate Immunity

Bushra Riaz
Hye-Myung Ryu
S. M. Shamsul Islam
Rahar Babita
Je Kyung Seong
Ho Lee
Eunjoo H. Lee
Seonghyang Sohn

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645678

2,170 views

Mini Review

Published on 05 Sep 2025

Dysfunction of natural killer cells promotes immune escape and disease progression in endometriosis

in Molecular Innate Immunity

Weiyu Jiang
Wen Xu
Feng Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657605

3,074 views
1 citation

Original Research

Published on 04 Sep 2025

Francisella tularensis-infected human neutrophils are trojan horses for infection of macrophages

in Molecular Innate Immunity

Sydney M. Escobar
Jenna McCracken
Justin T. Schwartz
Ann M. Miller
Lee-Ann H. Allen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1632942

1,936 views

Original Research

Published on 02 Sep 2025

Experimental conditions shape in vitro formation of murine platelet-leukocyte aggregates

in Molecular Innate Immunity

Silvia Maria Grazia Trivigno
Alice Assinger
Waltraud Cornelia Schrottmaier

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637038

1,640 views

Original Research

Published on 01 Sep 2025

Comparative evaluation of isolation techniques and characterization of red pulp macrophages from pig splenocytes

in Molecular Innate Immunity

Phu Chi Vu
Nhat Minh Dang
Jonghyeok Jung
Min Hyuk Kim
Min Guk Lee
Joohyun Shim
Thi Xoan Hoang
Jae Young Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617203

1,876 views

Original Research

Published on 01 Sep 2025

The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression

in Molecular Innate Immunity

Qihang Yan
Chendi Xu
Li Gong
Dachuan Liang
Jie Yang
Yuzhen Zheng
Junye Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612041

2,383 views
1 citation

Original Research

Published on 01 Sep 2025

Real-time monitoring with iTLR4 assay identifies ligand-dependent TLR4-TLR4 conformational dynamics

in Molecular Innate Immunity

Sanam Mustafa
Samuel G. Evans
Mark R. Hutchinson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580070

1,935 views

Mini Review

Published on 29 Aug 2025

Microbiome-macrophage crosstalk in the tumor microenvironment: implications for oral squamous cell carcinoma progression and therapy

in Molecular Innate Immunity

Xin Deng
Shaohong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651837

3,016 views

Review

Published on 29 Aug 2025

HACE1 as a bridge between oxidative stress and autophagy

in Molecular Innate Immunity

Jiyue Xia
Youhong Jiang
Xiangjun Xin
Ting Li
Wenbo Liao
Zhijun Xin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595601

1,672 views

Review

Published on 29 Aug 2025

Small molecules as ligands in the tuning of immune regulatory receptors

in Molecular Innate Immunity

Laura Fioretto
Marcello Ziaco
Genoveffa Nuzzo
Federica Albiani
Marisa Saponaro
Dalila Carbone
Giusi Barra
Mario dell’Isola
Olimpia Follero
Nunzia Esercizio

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648691

1,584 views

Review

Published on 29 Aug 2025

Tug of war: innate immunity and herpes simplex keratitis

in Molecular Innate Immunity

Preston Nguyen
Betty Jacobs
Athul Mohanram
Caleb Hammons
Junji Xing

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658579

23,611 views

Original Research

Published on 29 Aug 2025

MiRNA sequencing of platelet and exosome revealed platelet miR-199b-3p as a potential biomarker in lung adenocarcinoma

in Molecular Innate Immunity

Xiaoxia Wen
Sisi Yu
Ping Leng
Yu Liu
Huaichao Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619448

2,709 views

Original Research

Published on 27 Aug 2025

Tubular epithelial cell-derived extracellular vesicles carrying serum amyloid A1 exacerbate sepsis-associated acute kidney injury by promoting NETs formation

in Molecular Innate Immunity

Yang Jiao
Mei Liu
Xin Xie
Mengying Pi
Luyang Zhou
Wei Zhu
Jia Song
Ti Zhang
Zhengliang Ma
Xiaoping Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654295

3,674 views

Mini Review

Published on 27 Aug 2025

Progress in targeting tumor-associated macrophages in cancer immunotherapy

in Molecular Innate Immunity

Wanqiu Xia
Xianghan Zhang
Yaru Wang
Zihan Huang
Xinyu Guo
Lei Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658795

4,672 views

3,544 articles

articles

Immunotherapy strategies targeting tumor-associated macrophages and their mechanisms of action in tumor progression

The role of cGAS-STING signaling in the liver and gastrointestinal system: from signaling networks to target intervention

Clinical laboratory analytes and platelet-associated parameters as surrogate markers of subclinical inflammation in latent tuberculosis infection

The innate immune axis drives aortic dissection pathogenesis through inflammation and presents novel therapeutic targets

SIFD-associated TRNT1 deficiency unveils importance of TSPO during macrophage antibacterial and antiviral responses

Advance in therapies targeting tumor-associated macrophages in ovarian cancer

The role of IL-2 in type 2 immunity

Large extracellular vesicles derived from LPS-preconditioned cardiomyocytes alleviate myocarditis via mediating macrophage polarization and modulating p38 MAPK pathway

The feasibility of targeting macrophage for disease treatment: roles of CEBPD

Prognostic model of ubiquitination-related genes in ovarian cancer based on transcriptomic analysis and experimental validation

Impact of ERAP1 downregulation on the pathogenesis of DSS-induced colitis and therapeutic response to sulfasalazine

Dysfunction of natural killer cells promotes immune escape and disease progression in endometriosis

Francisella tularensis-infected human neutrophils are trojan horses for infection of macrophages

Experimental conditions shape in vitro formation of murine platelet-leukocyte aggregates

Comparative evaluation of isolation techniques and characterization of red pulp macrophages from pig splenocytes

The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression

Real-time monitoring with iTLR4 assay identifies ligand-dependent TLR4-TLR4 conformational dynamics

Microbiome-macrophage crosstalk in the tumor microenvironment: implications for oral squamous cell carcinoma progression and therapy

HACE1 as a bridge between oxidative stress and autophagy

Small molecules as ligands in the tuning of immune regulatory receptors

Tug of war: innate immunity and herpes simplex keratitis

MiRNA sequencing of platelet and exosome revealed platelet miR-199b-3p as a potential biomarker in lung adenocarcinoma

Tubular epithelial cell-derived extracellular vesicles carrying serum amyloid A1 exacerbate sepsis-associated acute kidney injury by promoting NETs formation

Progress in targeting tumor-associated macrophages in cancer immunotherapy