Frontiers in Immunology | Molecular Innate Immunity

Mini Review

Published on 04 Nov 2025

From chronic inflammation to immune escape: mapping the tumor microenvironment evolution in renal cell carcinoma

in Molecular Innate Immunity

Hanjun Xu
Baojun Tu
Hui Li
Yong Shan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683844

2,234 views

Review

Published on 03 Nov 2025

Regulation of the innate immune response in rheumatoid arthritis

in Molecular Innate Immunity

Aikeremujiang Muheremu
Shalayiding Aierxiding
Jian Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545625

2,702 views

Mini Review

Published on 03 Nov 2025

Immune snapshots along the inflammation-to-cancer road in bladder urothelium

in Molecular Innate Immunity

Lingxiang Lu
Fei Wang
Zhenfan Wang
Shuai Guo
Minjun Jiang
Zheng Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685237

1,878 views
1 citation

Mini Review

Published on 31 Oct 2025

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring

in Molecular Innate Immunity

Ilja L. Kruglikov
Katarzyna Walendzik
Philipp E. Scherer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701998

1,688 views
1 citation

Original Research

Published on 31 Oct 2025

Global research hotspots and trends in microglia in ischemic stroke

in Molecular Innate Immunity

Yingquan Liu
Yu Ye
Fan Dai
Lin Bai
Hongjie Ji
Xingxing Su
Peijia Hu
Hongliang Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622499

2,357 views

Original Research

Published on 31 Oct 2025

Single-cell and spatial transcriptomics integration reveals FAM49B promotes tumor-associated macrophages polarization in colorectal cancer via the MK pathway

in Molecular Innate Immunity

Tianyu Liu
Quchen Ding
Jin Gou
Chen Lu
Xingming Lu
Jiatong Chen
Yiming E.
Lianhong Li
Chongguo Zhang
Xiaojuan Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682637

4,057 views

Original Research

Published on 30 Oct 2025

Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

in Molecular Innate Immunity

Zichen Shao
Qinqin Deng
Ling Cheng
Jianfeng Wu
Weikang Sun
Weidong Liang
Huanan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680305

3,331 views
1 citation

Original Research

Published on 30 Oct 2025

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

in Molecular Innate Immunity

Zhen Yang
Xiao Zhang
Chaoqun Liu
Ning Huang
Yan Teng
Junming Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621440

1,570 views

Original Research

Published on 29 Oct 2025

Necrosis by sodium overload-associated genes TRPM4 and SLC9A1: biological roles and clinical implications in breast cancer progression

in Molecular Innate Immunity

Yingze Zhu
Yaxin Guo
Yanlin Su
Zhuoqi Zhang
Yige Lu
Xianghan Zhang
Hui Pang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623511

2,232 views

Original Research

Published on 28 Oct 2025

The peptide genomic therapy increases antibacterial immunity and survival in sepsis by reprograming the gene orthologs of human immunodeficiencies in the spleen and lungs

in Molecular Innate Immunity

Huan Qiao
Jozef Zienkiewicz
Yan Liu
Jacek Hawiger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635081

2,219 views
1 citation

Mini Review

Published on 24 Oct 2025

Endoplasmic reticulum stress and unfolded protein response in immune cell function

in Molecular Innate Immunity

Goshi Matsushima
Yuhki Yanase
Tadashi Nakagawa
Mitsuhiro Goda
Koichiro Ozawa
Toru Hosoi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694102

2,940 views
1 citation

Original Research

Published on 23 Oct 2025

Expression of NEAT1 induced by influenza virus infection is regulated by activated STAT3 and contributes to STAT3-mediated antiviral immunity

in Molecular Innate Immunity

Rongrong Gu
Erying Xu
Jingjie Hong
Liqing Fan
Shasha Liu
Ji-Long Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693884

2,157 views

Brief Research Report

Published on 23 Oct 2025

Dual-functional cerium oxide nanoparticles with antioxidant and DNase I activities to prevent and degrade neutrophil extracellular traps

in Molecular Innate Immunity

Hachem Dich
Ramy Abou Rjeily
Gabriela Rath
Mathéo Berthet
Bénédicte Dayde-Cazals
Jean-François Berret
Eduardo Angles-Cano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693809

1,967 views
1 citation

Review

Published on 22 Oct 2025

Innate immunity in tumors: roles and therapeutic targets

in Molecular Innate Immunity

Songze Leng
Yuyue Ren
Yaoyao Tian
Weiwei Zhao
Yue Mou
Xingyu Chen
Hong Zhou
Wei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689714

2,463 views

Original Research

Published on 21 Oct 2025

Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis

in Molecular Innate Immunity

Ryosuke Aihara
Masatomo Takahashi
Kenji Morino
Keisuke Matsubara
Kazufumi Kunimura
Akihiko Nishikimi
Yoshihiro Izumi
Takeshi Bamba
Yoshinori Fukui
Takehito Uruno

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666184

2,215 views

Original Research

Published on 16 Oct 2025

TNF-α-mediated downregulation of CD36 and phagocytic impairment of alveolar macrophages via upregulation of ADAM17 in asthma

in Molecular Innate Immunity

Xingyue Liu
Ya Li
Feifei Shang
Minzhu Niu
Jiaqi Yan
Minyu Xie
Xiangnan Tao
Han Huang
Wenwen Wu
Shu Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663513

1,819 views

Review

Published on 16 Oct 2025

From mechanisms to therapies: the multifaceted roles of guanylate-binding protein 2 in immunity, cancer, and beyond

in Molecular Innate Immunity

Wenqi Cui
Tianlu Wang
Juan Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708319

2,119 views
1 citation

Review

Published on 16 Oct 2025

Immune cell regulatory networks in chronic obstructive pulmonary disease: mechanistic analysis from innate to adaptive immunity

in Molecular Innate Immunity

Hui Li
Yingqi Wang
Hongxia Duan
Yidie Bao
Xinliao Deng
Yucheng He
Qian Gao
Peijun Li
Xiaodan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651808

5,516 views
2 citations

Original Research

Published on 15 Oct 2025

Human colon stem cells are the predominant epithelial responders to bacterial antigens

in Molecular Innate Immunity

Maaike H. De Vries
Claartje A. Meddens
Hemme J. Hijma
Anne-Claire Berrens
Suze A. Jansen
Berend A. P. Kooiman
Scott Snapper
Hans Clevers
Michal Mokry
Ewart W. Kuijk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677943

2,736 views
1 citation

Original Research

Published on 14 Oct 2025

Integrative modeling of malignant epithelial programs in EGFR-mutant LUAD via single-cell transcriptomics and multi-algorithm machine learning

in Molecular Innate Immunity

Weiran Zhang
Lin Tan
Qiuqiao Mu
Han Zhang
Daqiang Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661679

2,753 views
1 citation

Review

Published on 14 Oct 2025

Luteolin as a multifaceted immunomodulator: insights into its effects on diverse immune cell populations and therapeutic implications

in Molecular Innate Immunity

Xiaolan Wang
Junbo Zhao
Ying Li
Sujun Gao
Long Su

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621367

3,965 views
3 citations

Original Research

Published on 13 Oct 2025

Fibroblast heterogeneity and FN1-mediated signaling in endometriosis revealed by single-cell and spatial transcriptomics

in Molecular Innate Immunity

Wenwen Shao
Hongmei Ju
Zhikai Xiahou
Sheng Fang
Rugen Yan
Chunyan Li
Yuan Xu
Pingping Cai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680849

4,505 views

Mini Review

Published on 09 Oct 2025

Roles of tumor-associated macrophages in triple-negative breast cancer progression

in Molecular Innate Immunity

Tianhai Wu
Yuling Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677363

4,229 views

Review

Published on 09 Oct 2025

Unveiling CD177: a key player in tumors, autoimmune diseases, and inflammatory disorders

in Molecular Innate Immunity

Dongmei Yang
Xiaobin Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653587

4,491 views
1 citation