Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 23 Jun 2025

MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis

in Molecular Innate Immunity

Nirmal Parajuli
Yi Yao
Namir Khalasawi
Congcong Yin
Qiong Zhang
Indra Adrianto
Aakash Hans
Li Zhou
Qing-Sheng Mi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598306

3,239 views
1 citation

Original Research

Published on 20 Jun 2025

C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients

in Molecular Innate Immunity

Valeria Guaschino
Donata Santarsiero
Sara Gastoldi
Joshua M. Thurman
V. Michael Holers
Shelia M. Violette
Fei Liu
Kelly C. Fahnoe
Chiara Guarinoni
Ariela Benigni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620996

3,162 views

Original Research

Published on 19 Jun 2025

Bridging aging, immunity, and atherosclerosis: novel insights into senescence-related genes

in Molecular Innate Immunity

Yan Lu
Rong Yuan
Qiqi Xin
Keji Chen
Weihong Cong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557266

4,197 views

Review

Published on 19 Jun 2025

Impact of smoking on the complement system: a narrative review

in Molecular Innate Immunity

Ahmed B. Alarabi
Fatima Z. Alshbool
Fadi T. Khasawneh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619835

2,689 views
1 citation

Editorial

Published on 18 Jun 2025

Editorial: A new perspective in immune polymorphism (the HLA, KIR, and LILR genes)

in Molecular Innate Immunity

Seik-Soon Khor
Martin Maiers
Jason Krawic
Danillo G. Augusto
Aisha Souquette

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640672

1,504 views

Original Research

Published on 18 Jun 2025

Identification and validation of NETs-related biomarkers in active tuberculosis through bioinformatics analysis and machine learning algorithms

in Molecular Innate Immunity

Shengfang Xia
Qi An
Rui Lin
Yalan Tu
Zhu Chen
Dongmei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599667

3,942 views
1 citation

Mini Review

Published on 18 Jun 2025

Pro-inflammatory granzyme K contributes extracellularly to disease

in Molecular Innate Immunity

Christopher T. Turner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620670

5,681 views
3 citations

Original Research

Published on 18 Jun 2025

Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis

in Molecular Innate Immunity

Mahdi Eskandarian Boroujeni
Natalia Lopacinska
Aleksandra Antonczyk
Katarzyna Kluzek
Joanna Wesoly
Hans A. R. Bluyssen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590953

9,348 views
3 citations

Original Research

Published on 18 Jun 2025

In evolution’s unending race: ancestral STING sensors in Salmo salar mediate intracellular bacterial detection and programmed cell death through evolutionarily conserved pathways

in Molecular Innate Immunity

Alejandro J. Yañez
Jorge F. Beltrán
Claudia A. Barrientos
Genaro Soto-Rauch
Marcelo Aguilar
Adolfo Isla
Sandra N. Flores-Martin
Francisco T. Yañez
Yassef Yuivar
Adriana Ojeda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570871

2,652 views

Correction

Published on 13 Jun 2025

Corrigendum: 17β-Estradiol promotes trained immunity in female against sepsis via regulating nucleus translocation of RelB

in Molecular Innate Immunity

Zhiheng Sun
Yuchen Pan
Junxing Qu
Yujun Xu
Huan Dou
Yayi Hou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629629

1,019 views

Editorial

Published on 10 Jun 2025

Editorial: Cell death in innate immunity and inflammatory diseases

in Molecular Innate Immunity

Malvina Pizzuto
Chiara Cipollina

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635279

1,647 views

Editorial

Published on 09 Jun 2025

Editorial: Innate immune dysregulation: a driving force of autoimmunity and chronic inflammation

in Molecular Innate Immunity

Reza Akbarzadeh
Jens Y. Humrich
Tamás Németh
Kyle T. Amber

Frontiers in Immunology

doi 10.3389/fimmu.2025.1632416

2,951 views
3 citations

Original Research

Published on 06 Jun 2025

Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung

in Molecular Innate Immunity

Tao Wang
Jianfeng Hao
Bing Li
Ahjol Hyraht
Jialing Wang
Henglei Xia
Qingbin Wu
Wei Gao
Congxia Chen
Chuanqing Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609616

4,398 views
2 citations

Original Research

Published on 05 Jun 2025

Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis

in Molecular Innate Immunity

Shigeru Matsuda
Yoshimitsu Kuwabara
Yoshitaka Taketomi
Yuki Nagasaki
Yosuke Sugita
Shunji Suzuki
Ichiro Manabe
Makoto Murakami
Yumiko Oishi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547949

3,300 views

Review

Published on 04 Jun 2025

C-reactive protein: the nexus between inflammation and protein misfolding diseases

in Molecular Innate Immunity

Abhishek Roy
Johannes Zeller
Tracy L. Nero
Johanna Klepetko
Steffen U. Eisenhardt
Michael W. Parker
James D. McFadyen
Karlheinz Peter

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612703

4,352 views
2 citations

Original Research

Published on 04 Jun 2025

Pro-dermcidin and derivatives as potential therapeutics for lethal experimental sepsis

in Molecular Innate Immunity

Weiqiang Chen
Xiaoling Qiang
Cassie Shu Zhu
Jianhua Li
Li Lou
Ping Wang
Kevin J. Tracey
Haichao Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621633

2,782 views
1 citation

Original Research

Published on 03 Jun 2025

Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells

in Molecular Innate Immunity

Akiko Sugimoto-Ishige
Aya Jodo
Takashi Tanaka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524110

2,432 views
2 citations

Original Research

Published on 29 May 2025

Outer membrane vesicles derived from probiotic Escherichia coli Nissle 1917 promote metabolic remodeling and M1 polarization of RAW264.7 macrophages

in Molecular Innate Immunity

DongXue Ma
YuXin Zhang
Jia Zhang
Jun Shi
ShanHu Gao
Fei Long
Xin Wang
XingYu Pu
Jiayao Sun
Shuang Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1501174

4,892 views
4 citations

Original Research

Published on 29 May 2025

Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis

in Molecular Innate Immunity

Anna Herminghaus
Mykola Totskyi
Christian Vollmer
Thomas Dimski
Timo Brandenburger
Anne Kuebart
Helen Rinderknecht
Christian B. Bergmann
Ina Vernikouskaya
Jasmin Maria Bülow

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591262

1,813 views
1 citation

Original Research

Published on 28 May 2025

H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases

in Molecular Innate Immunity

Lingli Han
Lin Li
Liangjiao Yao
Huaqin Bu
Yajie Tian
Qifan Li
Ke Zhu
Haili Yao
Xiaochuan Wang
Maoxiang Qian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572796

2,937 views
1 citation

Original Research

Published on 27 May 2025

Phosphatidylglucoside regulates apoptosis of human neutrophilic lineage cells

in Molecular Innate Immunity

Noriko Yokoyama
Roudy Chiminch Ekyalongo
Madoka Kage
Kei Hanafusa
Hitoshi Nakayama
Yoshio Hirabayashi
Kenji Takamori
Kazuhisa Iwabuchi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597423

2,262 views

Review

Published on 26 May 2025

The role of CXCL16 in atherosclerosis: from mechanisms to therapy

in Molecular Innate Immunity

Yue Liu
Xintao Tian
Chunyan Jia
Xinrui Cheng
Changxing Cui
Cuiping Li
Shaonan Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1555438

2,763 views

Review

Published on 22 May 2025

Coordination of innate immune responses by connexins

in Molecular Innate Immunity

Qirou Wu
Tiejun Zhao
Pinglong Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594015

3,631 views

Original Research

Published on 21 May 2025

Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts

in Molecular Innate Immunity

Halldór Bjarki Einarsson
Anders Frisk Mortensen
Morten Schallburg Nielsen
Menglin Chen
Søren Roesgaard Nielsen
David Christian Evar Kraft
Jonas Jensen
Mette Bjerre
Morten Nørregaard Andersen
Jens Vinge Nygaard

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572238

3,009 views

3,542 articles

articles

MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis

C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients

Bridging aging, immunity, and atherosclerosis: novel insights into senescence-related genes

Impact of smoking on the complement system: a narrative review

Editorial: A new perspective in immune polymorphism (the HLA, KIR, and LILR genes)

Identification and validation of NETs-related biomarkers in active tuberculosis through bioinformatics analysis and machine learning algorithms

Pro-inflammatory granzyme K contributes extracellularly to disease

Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosis

In evolution’s unending race: ancestral STING sensors in Salmo salar mediate intracellular bacterial detection and programmed cell death through evolutionarily conserved pathways

Corrigendum: 17β-Estradiol promotes trained immunity in female against sepsis via regulating nucleus translocation of RelB

Editorial: Cell death in innate immunity and inflammatory diseases

Editorial: Innate immune dysregulation: a driving force of autoimmunity and chronic inflammation

Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung

Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis

C-reactive protein: the nexus between inflammation and protein misfolding diseases

Pro-dermcidin and derivatives as potential therapeutics for lethal experimental sepsis

Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells

Outer membrane vesicles derived from probiotic Escherichia coli Nissle 1917 promote metabolic remodeling and M1 polarization of RAW264.7 macrophages

Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis

H3K27me3 modulates trained immunity of monocytes in HDM-allergic diseases

Phosphatidylglucoside regulates apoptosis of human neutrophilic lineage cells

The role of CXCL16 in atherosclerosis: from mechanisms to therapy

Coordination of innate immune responses by connexins

Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts