Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 01 Sep 2025

Comparative evaluation of isolation techniques and characterization of red pulp macrophages from pig splenocytes

in Molecular Innate Immunity

Phu Chi Vu
Nhat Minh Dang
Jonghyeok Jung
Min Hyuk Kim
Min Guk Lee
Joohyun Shim
Thi Xoan Hoang
Jae Young Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617203

2,362 views

Original Research

Published on 01 Sep 2025

The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression

in Molecular Innate Immunity

Qihang Yan
Chendi Xu
Li Gong
Dachuan Liang
Jie Yang
Yuzhen Zheng
Junye Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612041

2,975 views
2 citations

Original Research

Published on 01 Sep 2025

Real-time monitoring with iTLR4 assay identifies ligand-dependent TLR4-TLR4 conformational dynamics

in Molecular Innate Immunity

Sanam Mustafa
Samuel G. Evans
Mark R. Hutchinson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580070

2,371 views

Mini Review

Published on 29 Aug 2025

Microbiome-macrophage crosstalk in the tumor microenvironment: implications for oral squamous cell carcinoma progression and therapy

in Molecular Innate Immunity

Xin Deng
Shaohong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651837

3,746 views
3 citations

Review

Published on 29 Aug 2025

HACE1 as a bridge between oxidative stress and autophagy

in Molecular Innate Immunity

Jiyue Xia
Youhong Jiang
Xiangjun Xin
Ting Li
Wenbo Liao
Zhijun Xin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595601

2,232 views

Review

Published on 29 Aug 2025

Small molecules as ligands in the tuning of immune regulatory receptors

in Molecular Innate Immunity

Laura Fioretto
Marcello Ziaco
Genoveffa Nuzzo
Federica Albiani
Marisa Saponaro
Dalila Carbone
Giusi Barra
Mario dell’Isola
Olimpia Follero
Nunzia Esercizio

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648691

2,148 views

Review

Published on 29 Aug 2025

Tug of war: innate immunity and herpes simplex keratitis

in Molecular Innate Immunity

Preston Nguyen
Betty Jacobs
Athul Mohanram
Caleb Hammons
Junji Xing

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658579

24,373 views
1 citation

Original Research

Published on 29 Aug 2025

MiRNA sequencing of platelet and exosome revealed platelet miR-199b-3p as a potential biomarker in lung adenocarcinoma

in Molecular Innate Immunity

Xiaoxia Wen
Sisi Yu
Ping Leng
Yu Liu
Huaichao Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619448

3,485 views

Mini Review

Published on 27 Aug 2025

Progress in targeting tumor-associated macrophages in cancer immunotherapy

in Molecular Innate Immunity

Wanqiu Xia
Xianghan Zhang
Yaru Wang
Zihan Huang
Xinyu Guo
Lei Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658795

6,149 views
5 citations

Original Research

Published on 27 Aug 2025

Shared immune-inflammatory mechanisms between ulcerative colitis and periodontitis: a multi-omics analysis

in Molecular Innate Immunity

Hongjiao Li
Peimin Li
Xiaofeng Guo
Yan Zhou
Shaowei Ma
Xin Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668277

3,670 views

Original Research

Published on 27 Aug 2025

Tubular epithelial cell-derived extracellular vesicles carrying serum amyloid A1 exacerbate sepsis-associated acute kidney injury by promoting NETs formation

in Molecular Innate Immunity

Yang Jiao
Mei Liu
Xin Xie
Mengying Pi
Luyang Zhou
Wei Zhu
Jia Song
Ti Zhang
Zhengliang Ma
Xiaoping Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654295

4,519 views

Original Research

Published on 27 Aug 2025

Innate immune dysfunction and persistent activation in South African HIV elite controllers

in Molecular Innate Immunity

Asisipo Mohamed
Yenzekile Zungu
Sharon Shalekoff
Osman Ebrahim
Ziyaad Waja
Neil Martinson
Caroline T. Tiemessen
Christina Thobakgale

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603436

2,355 views
2 citations

Methods

Published on 26 Aug 2025

A novel and rapid method to purify the human complement opsonin C3b from human plasma

in Molecular Innate Immunity

Jannik Sichau
Christoph Q. Schmidt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639735

2,878 views

Original Research

Published on 26 Aug 2025

Evaluating functional C1INH with multiple laboratory methods across Hereditary Angioedema types

in Molecular Innate Immunity

Maine Luellah Demaret Bardou
Rosemeire Navickas Constantino-Silva
Maria Luiza Oliva Alonso
Ana Júlia Ribeiro Teixeira
Pedro Francisco Giavina-Bianchi
Eli Mansour
João Bosco Pesquero
Solange Oliveira Rodrigues Valle
Anete Sevciovic Grumach

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654078

2,792 views

Original Research

Published on 22 Aug 2025

Exploring the biological functions and immune regulatory roles of IRAK3, TNFRSF1A, CX3CR1, and JUNB in T2DM combined with MAFLD: integrated bioinformatics and single-cell analysis

in Molecular Innate Immunity

Qin Wang
Xiaoqi Li
Kaidierdan Wushoulaji
Jinyang Wang
Li Wan
Ye Yang
Xueli Gong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587225

6,606 views
2 citations

Original Research

Published on 21 Aug 2025

Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome

in Molecular Innate Immunity

Laura M. Baas
Kioa L. Wijnsma
Fokje Zijlstra
Nicole C. A. J. van de Kar
Lieke ter Steeg
Antonia H. M. Bouts
Marloes A. H. M. Michels
Jeroen D. Langereis
Dirk Lefeber
Hans J. C. T. Wessels

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645196

3,302 views
1 citation

Review

Published on 21 Aug 2025

Kaempferol as a multifaceted immunomodulator: implications for inflammation, autoimmunity, and cancer

in Molecular Innate Immunity

Han Dong
Ge Song
Zhe Wang
Xue Wu
Qi Wang
Yue-Hui Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671519

4,848 views
4 citations

Mini Review

Published on 20 Aug 2025

Dual roles of innate immune cells and cytokines in shaping the breast cancer microenvironment

in Molecular Innate Immunity

Chen Zhang
Wei Liu
Ping Yang
Rubing Lin
Lulan Pu
Hongying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654947

4,532 views
6 citations

Review

Published on 20 Aug 2025

Oxidative stress, DAMPs, and immune cells in acute pancreatitis: molecular mechanisms and therapeutic prospects

in Molecular Innate Immunity

Hanwen Chen
Yanhong Wang
Maddalena Zippi
Sirio Fiorino
Wandong Hong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608618

4,771 views
5 citations

Mini Review

Published on 19 Aug 2025

Evolving insights on the role of microglia in neuroinflammation, plasticity, and regeneration of the injured spinal cord

in Molecular Innate Immunity

Emily A. Swarts
Faith H. Brennan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621789

3,593 views
2 citations

Original Research

Published on 15 Aug 2025

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin

in Molecular Innate Immunity

Uday Kishore
Praveen M. Varghese
Chandan Kumar
Susan Idicula-Thomas
Martin Mayora Neto
Anthony G. Tsolaki
Pretty Ponnachan
Khaled Masmoudi
Basel Al-Ramadi
Manu Vatish

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620229

3,320 views

Original Research

Published on 14 Aug 2025

Collectin-11 promotes fibroblast proliferation and modulates their activation status and extracellular matrix synthesis

in Molecular Innate Immunity

Wan-Bing Chen
Bo Cao
Gang Li
Gang Wang
Kun-Yi Wu
Ting Zhang
Ning Ma
Wuding Zhou
Ke Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592921

2,918 views

Original Research

Published on 14 Aug 2025

Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics

in Molecular Innate Immunity

Jordan C. Langston
Dan Liu
Qingliang Yang
Salim Merali
Carmen Merali
Narender Singh
Jennifer L. Fisher
Balabhaskar Prabhakarpandian
Laurie E. Kilpatrick
Mohammad F. Kiani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646141

2,468 views

Brief Research Report

Published on 13 Aug 2025

Elevated C-reactive protein and D-dimer to predict venous thromboembolism in patients with bladder cancer

in Molecular Innate Immunity

Bo Chen
Tonghe Zhang
Yisong Wang
Zhaoyang Li
Haoyu Liu
Zhan Jiang
Huitang Yang
Yandong Cai
Guoju Fan
Kaiqiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652139

2,511 views

3,602 articles

articles

Comparative evaluation of isolation techniques and characterization of red pulp macrophages from pig splenocytes

The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression

Real-time monitoring with iTLR4 assay identifies ligand-dependent TLR4-TLR4 conformational dynamics

Microbiome-macrophage crosstalk in the tumor microenvironment: implications for oral squamous cell carcinoma progression and therapy

HACE1 as a bridge between oxidative stress and autophagy

Small molecules as ligands in the tuning of immune regulatory receptors

Tug of war: innate immunity and herpes simplex keratitis

MiRNA sequencing of platelet and exosome revealed platelet miR-199b-3p as a potential biomarker in lung adenocarcinoma

Progress in targeting tumor-associated macrophages in cancer immunotherapy

Shared immune-inflammatory mechanisms between ulcerative colitis and periodontitis: a multi-omics analysis

Tubular epithelial cell-derived extracellular vesicles carrying serum amyloid A1 exacerbate sepsis-associated acute kidney injury by promoting NETs formation

Innate immune dysfunction and persistent activation in South African HIV elite controllers

A novel and rapid method to purify the human complement opsonin C3b from human plasma

Evaluating functional C1INH with multiple laboratory methods across Hereditary Angioedema types

Exploring the biological functions and immune regulatory roles of IRAK3, TNFRSF1A, CX3CR1, and JUNB in T2DM combined with MAFLD: integrated bioinformatics and single-cell analysis

Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome

Kaempferol as a multifaceted immunomodulator: implications for inflammation, autoimmunity, and cancer

Dual roles of innate immune cells and cytokines in shaping the breast cancer microenvironment

Oxidative stress, DAMPs, and immune cells in acute pancreatitis: molecular mechanisms and therapeutic prospects

Evolving insights on the role of microglia in neuroinflammation, plasticity, and regeneration of the injured spinal cord

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin

Collectin-11 promotes fibroblast proliferation and modulates their activation status and extracellular matrix synthesis

Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics

Elevated C-reactive protein and D-dimer to predict venous thromboembolism in patients with bladder cancer