Frontiers in Immunology | Mucosal Immunity

Original Research

Published on 04 Jul 2025

Vaginal microbiome dysbiosis and sexually transmitted infections correlate with concentrations of immunoglobulin isotypes in human cervicovaginal mucus: insights into HIV-1 transmission

in Mucosal Immunity

Matrona M. Akiso
Israel Abook
Marianne W. Mureithi
Janet Kombo
Print Koi
Joel Musando
Ruth J. Chirchir
Michael D. McRaven
Ann M. Carias
Sarah Joseph

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627807

774 views

Original Research

Accepted on 03 Jul 2025

Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling

in Mucosal Immunity

Liang Hu
Zi Yang
Ying Zhang
Conglin Du
Yang Yang
Zhichao Chang
Xiangchun Li
Zhaochen Shan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622094

109 views

Original Research

Published on 01 Jul 2025

Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs

in Mucosal Immunity

Ranmali Kavishna
Thorunn Asta Olafsdottir
Siggeir F. Brynjólfsson
Dennis Christensen
Tobias Gustafsson-Hedberg
Peter Andersen
Manuela Terrinoni
Jan Holmgren
Ali M. Harandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599713

447 views

Original Research

Published on 01 Jul 2025

Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization

in Mucosal Immunity

Guanyuan Wang
Fan Yang
Guodong Zang
Ning Shen
Lina Huang
Zhaotian Ma
Ming Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1551892

482 views

Original Research

Published on 27 Jun 2025

Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis

in Mucosal Immunity

Kim M. Heuer
Michael Boettcher
Laia Pagerols Raluy
Johanna Hagens
Jan P. Kolman
Madeleine J. Bunders
Jasmin Wesche
Jasmin Knopf
Martin Herrmann
Konrad Reinshagen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582526

730 views

Original Research

Published on 18 Jun 2025

Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis

in Mucosal Immunity

Soo-In Kim
Min-Seok Rha
Jinsun Kim
Sang Hyeon Ahn
Ji-Hwan Ryu
Hyung-Ju Cho
Chang-Hoon Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596746

1,641 views

Correction

Published on 12 Jun 2025

Correction: Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity

in Mucosal Immunity

Kaiyu Shang
Xinxin Qi
Tingting Tian
Huidong Shi
Yuejie Zhu
Fengbo Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636022

415 views

Original Research

Published on 05 Jun 2025

LKB1 regulates ILC3 postnatal development and effector function through metabolic programming

in Mucosal Immunity

Huasheng Zhang
Linfeng Zhao
Qingbing Zhang
Lin Hu
Xiaohui Su
Jiping Sun
Lei Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587256

1,061 views

Original Research

Accepted on 02 Jun 2025

Intranasal Monoclonal Antibodies to Mugwort Pollen Reduce Allergic Inflammation in a Mouse Model of Allergic Rhinitis and Asthma

in Mucosal Immunity

Kairat Tabynov
Igor Nedushenko
Elmira Tailakova
Akbota Sergazina
Turlan Bolatbekov
Gleb Fomin
Tair Nurpeissov
Anton Demyanov
Yuri Lebedin
Kaissar Tabynov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595659

413 views

Editorial

Published on 02 Jun 2025

Editorial: Immune responses at barrier tissues: insights from synthetic biology in therapeutics, diagnostics, mechanisms, and beyond

in Mucosal Immunity

Siheng Chao
Naoki Iwanaga
Hernan Felipe Peñaloza
Nicola Ivan Lorè
Kong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621688

790 views

Original Research

Published on 22 May 2025

Remarkable increase in Interleukin-5 receptor expression beyond tissue eosinophils in inflammatory bowel disease

in Mucosal Immunity

You Ie Kim
Hyeon Jeong Oh
Hye Ran Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589421

1,211 views

Original Research

Published on 20 May 2025

Exploring the standardized detection and sampling methods of human nasal SARS-CoV-2 RBD IgA

in Mucosal Immunity

Xuanxuan Zhang
Jizong Jia
Chaoying Hu
Yulong Fu
Guanxing Liu
Yajing Li
Qian He
Fan Gao
Na Li
Lina Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571418

1,506 views

Original Research

Published on 15 May 2025

Persistent reduction of Bifidobacterium longum in the infant gut microbiome in the first year of age following intrapartum penicillin prophylaxis for maternal GBS colonization

in Mucosal Immunity

Jana Lucia Teuscher
Mariia Lupatsii
Simon Graspeuntner
Sinje Jonassen
Arne Bringewatt
Egbert Herting
Guido Stichtenoth
Verena Bossung
Jan Rupp
Christoph Härtel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540979

1,562 views

Original Research

Published on 12 May 2025

Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes

in Mucosal Immunity

Shahrokh Paktinat
Michael G. Gravett
Cara Tobey
Anna Kirby
Whitney Horner
Rebecca Shaffer
Michael Fialkow
Nam Phuong Nguyen
Germán G. Gornalusse
Maryam Kalatehjari

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564002

1,889 views

Original Research

Published on 09 May 2025

Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis

in Mucosal Immunity

Ziyi Zheng
Lin Lin
Huifang Lin
Jie Zhou
Zhe Wang
Yang Wang
Jianxin Chen
Caimin Lai
Renfu Li
Zhiyong Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1559966

1,970 views

Original Research

Published on 09 May 2025

Secretor and non-secretor human milk oligosaccharides differentially modulate immune response in the presence of cow’s milk allergen β-lactoglobulin in an in vitro sensitization model

in Mucosal Immunity

Anneke H. Hellinga
Marit Zuurveld
Marko Mank
Aletta D. Kraneveld
Johan Garssen
Kennedy Spann
Lars Bode
Linette E. M. Willemsen
Belinda van’t Land

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575656

1,649 views