Frontiers in Immunology | Mucosal Immunity

Original Research

Published on 08 Aug 2025

Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury

in Mucosal Immunity

Min Hou
Yanshun Wang
Suheng Chen
Zhiguo Tan
Jie Liu
Xiaoxi Li
Xiaoxia Han
Zaiqi Yang
Yufang Leng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623080

2,661 views
1 citation

Original Research

Published on 05 Aug 2025

Heterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages

in Mucosal Immunity

Kaito A. Hioki
Xueting Liang
Adam C. Lynch
Ravi Ranjan
Elena L. Pobezinskaya
Leonid A. Pobezinsky

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637209

2,503 views

Original Research

Published on 04 Aug 2025

Characterization of bronchus-associated lymphoid tissue induced by co-exposure to Asian sand dust and ovalbumin: a study using 3D serial section imaging

in Mucosal Immunity

Yoshikazu Mikami
Manabu Hayatsu
Etsushi Kuroda
Hiromasa Tsuda
Taku Toriumi
Yusuke Mizutani
Takamichi Ichinose
Akiko Honda
Hirohisa Takano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578255

2,291 views
1 citation

Original Research

Published on 31 Jul 2025

Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7 through the AMPK-mTOR-NF-κB pathway

in Mucosal Immunity

Chunmei Ren
Kento Tazawa
Nobuyuki Kawashima
Risa Ohshima
Yamato Okada
Shihan Wang
Ziniu Yu
Peifeng Han
Yujin Ohsugi
Sayaka Katagiri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643676

3,763 views

Review

Published on 30 Jul 2025

Chronic obstructive pulmonary disease: in-depth analysis of microbiota association and innovative prevention and treatment approaches from the gut-lung axis perspective

in Mucosal Immunity

Yubo Wang
Xinyu Li
Feng Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1549865

3,882 views

Original Research

Published on 21 Jul 2025

Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling

in Mucosal Immunity

Liang Hu
Zi Yang
Ying Zhang
Conglin Du
Yang Yang
Zhichao Chang
Xiangchun Li
Zhaochen Shan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622094

2,855 views

Original Research

Published on 11 Jul 2025

Intranasal monoclonal antibodies to mugwort pollen reduce allergic inflammation in a mouse model of allergic rhinitis and asthma

in Mucosal Immunity

Kairat Tabynov
Igor Nedushenko
Elmira Tailakova
Akbota Sergazina
Turlan Bolatbekov
Gleb Fomin
Tair Nurpeissov
Utsav Vaghasiya
Nikolai Petrovsky
Anton Demyanov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595659

6,644 views

Original Research

Published on 04 Jul 2025

Vaginal microbiome dysbiosis and sexually transmitted infections correlate with concentrations of immunoglobulin isotypes in human cervicovaginal mucus: insights into HIV-1 transmission

in Mucosal Immunity

Matrona M. Akiso
Israel Abook
Marianne W. Mureithi
Janet Kombo
Print Koi
Joel Musando
Ruth J. Chirchir
Michael D. McRaven
Ann M. Carias
Sarah Joseph

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627807

3,241 views

Original Research

Published on 01 Jul 2025

Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs

in Mucosal Immunity

Ranmali Kavishna
Thorunn Asta Olafsdottir
Siggeir F. Brynjólfsson
Dennis Christensen
Tobias Gustafsson-Hedberg
Peter Andersen
Manuela Terrinoni
Jan Holmgren
Ali M. Harandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599713

2,236 views

Original Research

Published on 01 Jul 2025

Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization

in Mucosal Immunity

Guanyuan Wang
Fan Yang
Guodong Zang
Ning Shen
Lina Huang
Zhaotian Ma
Ming Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1551892

3,103 views

Original Research

Published on 27 Jun 2025

Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis

in Mucosal Immunity

Kim M. Heuer
Michael Boettcher
Laia Pagerols Raluy
Johanna Hagens
Jan P. Kolman
Madeleine J. Bunders
Jasmin Wesche
Jasmin Knopf
Martin Herrmann
Konrad Reinshagen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582526

3,592 views
2 citations

Original Research

Published on 18 Jun 2025

Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis

in Mucosal Immunity

Soo-In Kim
Min-Seok Rha
Jinsun Kim
Sang Hyeon Ahn
Ji-Hwan Ryu
Hyung-Ju Cho
Chang-Hoon Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596746

3,692 views

Correction

Published on 12 Jun 2025

Correction: Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity

in Mucosal Immunity

Kaiyu Shang
Xinxin Qi
Tingting Tian
Huidong Shi
Yuejie Zhu
Fengbo Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636022

1,174 views

Original Research

Published on 05 Jun 2025

LKB1 regulates ILC3 postnatal development and effector function through metabolic programming

in Mucosal Immunity

Huasheng Zhang
Linfeng Zhao
Qingbing Zhang
Lin Hu
Xiaohui Su
Jiping Sun
Lei Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1587256

2,571 views
1 citation

Editorial

Published on 02 Jun 2025

Editorial: Immune responses at barrier tissues: insights from synthetic biology in therapeutics, diagnostics, mechanisms, and beyond

in Mucosal Immunity

Siheng Chao
Naoki Iwanaga
Hernan Felipe Peñaloza
Nicola Ivan Lorè
Kong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621688

1,429 views

Original Research

Published on 22 May 2025

Remarkable increase in Interleukin-5 receptor expression beyond tissue eosinophils in inflammatory bowel disease

in Mucosal Immunity

You Ie Kim
Hyeon Jeong Oh
Hye Ran Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589421

2,471 views
1 citation

Original Research

Published on 20 May 2025

Exploring the standardized detection and sampling methods of human nasal SARS-CoV-2 RBD IgA

in Mucosal Immunity

Xuanxuan Zhang
Jizong Jia
Chaoying Hu
Yulong Fu
Guanxing Liu
Yajing Li
Qian He
Fan Gao
Na Li
Lina Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571418

3,257 views
1 citation

Original Research

Published on 15 May 2025

Persistent reduction of Bifidobacterium longum in the infant gut microbiome in the first year of age following intrapartum penicillin prophylaxis for maternal GBS colonization

in Mucosal Immunity

Jana Lucia Teuscher
Mariia Lupatsii
Simon Graspeuntner
Sinje Jonassen
Arne Bringewatt
Egbert Herting
Guido Stichtenoth
Verena Bossung
Jan Rupp
Christoph Härtel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540979

3,184 views
2 citations

Original Research

Published on 12 May 2025

Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes

in Mucosal Immunity

Shahrokh Paktinat
Michael G. Gravett
Cara Tobey
Anna Kirby
Whitney Horner
Rebecca Shaffer
Michael Fialkow
Nam Phuong Nguyen
Germán G. Gornalusse
Maryam Kalatehjari

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564002

3,811 views
1 citation

Original Research

Published on 09 May 2025

Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis

in Mucosal Immunity

Ziyi Zheng
Lin Lin
Huifang Lin
Jie Zhou
Zhe Wang
Yang Wang
Jianxin Chen
Caimin Lai
Renfu Li
Zhiyong Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1559966

4,625 views
5 citations

Original Research

Published on 09 May 2025

Secretor and non-secretor human milk oligosaccharides differentially modulate immune response in the presence of cow’s milk allergen β-lactoglobulin in an in vitro sensitization model

in Mucosal Immunity

Anneke H. Hellinga
Marit Zuurveld
Marko Mank
Aletta D. Kraneveld
Johan Garssen
Kennedy Spann
Lars Bode
Linette E. M. Willemsen
Belinda van’t Land

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575656

3,095 views
1 citation

Review

Published on 08 May 2025

Glycemic control and vaccine response: the role of mucosal immunity after vaccination in diabetic patients

in Mucosal Immunity

Moaz A. Mojaddidi
Moutasem Aboonq
Saeed A. Alqahtani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577523

3,725 views
1 citation

Original Research

Published on 08 May 2025

Baicalin enhances respiratory mucosal immunity by modulating antiviral protein expression and T-cell homeostasis during H9N2 infection

in Mucosal Immunity

Zhenyi Liu
Haotong Guo
Yan Zhi
Xiaorui Jiang
Qian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593691

2,795 views
2 citations

Review

Published on 08 May 2025

Intraepithelial lymphocytes in human oral diseases

in Mucosal Immunity

Dong-Yang Zhou
Chao-Fan Bao
Gang Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597088

3,369 views

997 articles

articles

Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury

Heterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages

Characterization of bronchus-associated lymphoid tissue induced by co-exposure to Asian sand dust and ovalbumin: a study using 3D serial section imaging

Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7 through the AMPK-mTOR-NF-κB pathway

Chronic obstructive pulmonary disease: in-depth analysis of microbiota association and innovative prevention and treatment approaches from the gut-lung axis perspective

Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling

Intranasal monoclonal antibodies to mugwort pollen reduce allergic inflammation in a mouse model of allergic rhinitis and asthma

Vaginal microbiome dysbiosis and sexually transmitted infections correlate with concentrations of immunoglobulin isotypes in human cervicovaginal mucus: insights into HIV-1 transmission

Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs

Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization

Neutrophils aggravate inflammatory lesions in intestinal organoids from necrotizing enterocolitis

Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis

Correction: Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity

LKB1 regulates ILC3 postnatal development and effector function through metabolic programming

Editorial: Immune responses at barrier tissues: insights from synthetic biology in therapeutics, diagnostics, mechanisms, and beyond

Remarkable increase in Interleukin-5 receptor expression beyond tissue eosinophils in inflammatory bowel disease

Exploring the standardized detection and sampling methods of human nasal SARS-CoV-2 RBD IgA

Persistent reduction of Bifidobacterium longum in the infant gut microbiome in the first year of age following intrapartum penicillin prophylaxis for maternal GBS colonization

Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes

Acetylcholine from tuft cells promotes M2 macrophages polarization in Hirschsprung-associated enterocolitis

Secretor and non-secretor human milk oligosaccharides differentially modulate immune response in the presence of cow’s milk allergen β-lactoglobulin in an in vitro sensitization model

Glycemic control and vaccine response: the role of mucosal immunity after vaccination in diabetic patients

Baicalin enhances respiratory mucosal immunity by modulating antiviral protein expression and T-cell homeostasis during H9N2 infection

Intraepithelial lymphocytes in human oral diseases