Frontiers in Immunology | Multiple Sclerosis and Neuroimmunology

Original Research

Published on 16 Apr 2025

The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm

in Multiple Sclerosis and Neuroimmunology

Robert Hoffrogge
Anna Karachunskaya
Neele Heitmann
Xiomara Pedreiturria
Katharina Klöster
Verian Bader
Konstanze F. Winklhofer
Michael Hamacher
Bert Klebl
Ralf Gold

Frontiers in Immunology

doi 10.3389/fimmu.2025.1554999

2,102 views

Original Research

Published on 15 Apr 2025

Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study

in Multiple Sclerosis and Neuroimmunology

David Goncalves
Marie Benaiteau
Véronique Rogemond
Sterenn Closs
Anne-Laurie Pinto
Maroua Dhairi
Marine Villard
Géraldine Picard
Nicole Fabien
Jérôme Honnorat

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563877

1,295 views

Original Research

Published on 11 Apr 2025

Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)

in Multiple Sclerosis and Neuroimmunology

Julian Reza Kretschmer
Daria Tkachenko
Tania Kümpfel
Joachim Havla
Daniel Engels
Friedemann Paul
Patrick Schindler
Judith Bellmann-Strobl
Achim Berthele
Katrin Giglhuber

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575613

2,791 views

Case Report

Published on 04 Apr 2025

Switching to ublituximab from prior anti-CD20 monoclonal antibody therapy: a case report series

in Multiple Sclerosis and Neuroimmunology

Regina Berkovich
Jonathan Calkwood
Heidi Crayton
April Erwin
Simon Faissner
Ralf Gold
Joshua Katz
Mark Leekoff

Frontiers in Immunology

doi 10.3389/fimmu.2025.1527102

4,046 views

Mini Review

Published on 02 Apr 2025

The role of NLRP3 inflammasome in multiple sclerosis: pathogenesis and pharmacological application

in Multiple Sclerosis and Neuroimmunology

Wen-Gang Zhang
Xiao-Rui Zheng
Yi Yao
Wei-Jia Sun
Bo-Zong Shao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572140

1,909 views

Review

Published on 01 Apr 2025

Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI

in Multiple Sclerosis and Neuroimmunology

Xiaoqing Guan
Fengyi Zhang
Ning Zhang
Guangchun Li
Fei Yin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552704

1,859 views

Mini Review

Published on 25 Mar 2025

Advocating the role of trained immunity in the pathogenesis of ME/CFS: a mini review

in Multiple Sclerosis and Neuroimmunology

Bart Humer
Willem A. Dik
Marjan A. Versnel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1483764

3,458 views

Original Research

Published on 24 Mar 2025

Integrated bioinformatics analysis and biological experiments to identify key immune genes in vascular dementia

in Multiple Sclerosis and Neuroimmunology

Yilong Zhao
Wen Xing
Weiqi Chen
Yilong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560438

2,516 views

Review

Published on 21 Mar 2025

Current challenges in secondary progressive multiple sclerosis: diagnosis, activity detection and treatment

in Multiple Sclerosis and Neuroimmunology

Luis Brieva
Carmen Calles
Lamberto Landete
Celia Oreja-Guevara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543649

3,427 views

Original Research

Published on 14 Mar 2025

Comparison of the clinical and laboratory characteristics of neuromyelitis optica spectrum disorder with or without cerebrospinal fluid oligoclonal bands: a cohort with 36-month follow-up

in Multiple Sclerosis and Neuroimmunology

Wenbo Yang
Xiaoni Liu
Jie Wei
Hai Yu
Wanqing Wu
Jingguo Wang
Bo Deng
Xiaoqin Wu
Xiangjun Chen
Xiang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536853

1,397 views

Case Report

Published on 14 Mar 2025

Case Report: CASPR2-associated autoimmune encephalitis with NF155 Antibody-positive autoimmune nodopathies: a rare case with hyponatremia onset

in Multiple Sclerosis and Neuroimmunology

Wen-Ya Wang
Jing-Ying Huang
Ying Xue
An-Ran Zhang
Ruo-Yi Guo
Zhen Jia
Ya-Fei Sun
Bin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519878

1,060 views

Case Report

Published on 11 Mar 2025

Case Report: Ofatumumab treatment for concomitant multiple sclerosis and idiopathic thrombocytopenic purpura

in Multiple Sclerosis and Neuroimmunology

Yuki Yokota
Makoto Hara
Hideto Nakajima

Frontiers in Immunology

doi 10.3389/fimmu.2025.1515776

2,575 views

Original Research

Published on 05 Mar 2025

Positive allosteric modulation of AMPA receptors via PF4778574 leads to reduced demyelination and clinical disability in experimental models of multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Mustafa Sindi
Michael Dietrich
Diana Klees
Joel Gruchot
Christina Hecker
John Silbereis
Andrea Issberner
Hans-Peter Hartung
Tobias Ruck
Holger Stark

Frontiers in Immunology

doi 10.3389/fimmu.2025.1532877

2,050 views

Correction

Published on 05 Mar 2025

Corrigendum: Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study

in Multiple Sclerosis and Neuroimmunology

Heinz Wiendl
Frederik Barkhof
Xavier Montalban
Anat Achiron
Tobias Derfuss
Andrew Chan
Suzanne Hodgkinson
Alexandre Prat
Letizia Leocani
Klaus Schmierer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571978

1,151 views

Original Research

Published on 03 Mar 2025

The nomogram model predicts relapse risk in myelin oligodendrocyte glycoprotein antibody-associated disease: a single-center study

in Multiple Sclerosis and Neuroimmunology

Jiafei Cheng
Zhuoran Wang
Jing Wang
Xiaomin Pang
Jianli Wang
Meini Zhang
Junhong Guo
Huaxing Meng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1527057

1,998 views
1 citation

Review

Published on 28 Feb 2025

Digital remote monitoring of people with multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Michelangelo Dini
Giancarlo Comi
Letizia Leocani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1514813

2,904 views