Frontiers in Immunology | Primary Immunodeficiencies

Original Research

Accepted on 18 Apr 2025

The effects of postponing BCG vaccination on the risk of BCGrelated complications among patients with severe combined immunodeficiency disease in Saudi Arabia

in Primary Immunodeficiencies

Amal Aldhaheri
Ohoud Alyabes
Suliman Aljumaah
Raghad Alhuthil
Raghad Alonazi
Shefa Alamoudi
Mohammed Alsuhaibani
Salem Alghamdi
Esam A Albanyan
Sami Al-Hajjar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596963

Original Research

Published on 17 Apr 2025

Reappraisal of IgG subclass deficiencies: a retrospective comparative cohort study

in Primary Immunodeficiencies

Damla Dogru
Yagmur Dogru
Faranaz Atschekzei
Abdulwahab Elsayed
Natalia Dubrowinskaja
Diana Ernst
Torsten Witte
Vega Gödecke
Georgios Sogkas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552513

258 views

Original Research

Accepted on 16 Apr 2025

Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) in Common Variable Immune Deficiency (CVID): an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection

in Primary Immunodeficiencies

Mattia Moratti
Gioacchino Schifino
Francesco Baccelli
Simona Ferrari
Elisabetta Magrini
Mirna Bassi
Aldo Guerrieri
Maurizio Zompatori
Marcello Lanari
Francesca Conti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589052

Case Report

Accepted on 11 Apr 2025

EBV-positive Diffuse Large B Cell Lymphoma Secondary to Activated Phosphoinositide 3 Kinase δ Syndrome Type 1 (APDS1): A Case Report and Literature Review

in Primary Immunodeficiencies

Qiu-Yuan Xiang
Min Zuo
Ji-Hao Zhou
Chun Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583405

Original Research

Accepted on 10 Apr 2025

Real-world Evidence of the Effectiveness and Utilization of Subcutaneous C1INH Long-term Prophylaxis in Patients With HAE in Spain and Germany

in Primary Immunodeficiencies

Marcus Maurer
Stefan Cimbollek
Maebh Kelly
Kyle Rodney
John Elliott
Eduardo Loboguerrero
Markus Magerl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576235

105 views

Case Report

Accepted on 07 Apr 2025

Activated PI3-kinase-δ syndrome and ovarian malignancies: a case series from the European ESID-APDS registry. Authors

in Primary Immunodeficiencies

Maria Pia Esposto
Nizar MAHLAOUI
Hassan Abolhassani
Koen Van Aerde
Simone Cesaro
Anita Chandra
Stephan R Ehl
Sven Kracker
Felipe Suarez
Vincent Barlogis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572194

Brief Research Report

Published on 28 Mar 2025

Genome and transcriptome sequencing for inborn errors of immunity: a feasible multi-omics diagnostic approach

in Primary Immunodeficiencies

Marija Rozevska
Katrina Daila Neiburga-Vigante
Inga Nartisa
Zane Lucane
Lota Ozola
Livija Bardina
Inta Jaunalksne
Natalija Gerula
Petra Krike
Gita Taurina

Frontiers in Immunology

doi 10.3389/fimmu.2025.1510365

869 views

Case Report

Accepted on 27 Mar 2025

Case Report: CD40LG Arg203Ile Variant Underlies Atypical Phenotype of X-Linked Hyper IgM Syndrome

in Primary Immunodeficiencies

Takuro Nishikawa
Dan Tomomasa
Atsushi Hijikata
Hiroshi Kasabata
Yasuhiro Okamoto
Hans Dieter Ochs
Hirokazu Kanegane

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572791

104 views

Case Report

Published on 21 Mar 2025

Case Report: Hydroa vacciniforme-like lymphoproliferative disorder, an EBV-associated disease, successfully treated with hematopoietic stem cell transplantation

in Primary Immunodeficiencies

Eduardo Liquidano-Perez
Gibert Maza-Ramos
Marco Yamazaki-Nakashimada
Rodolfo Rodríguez-Jurado
Alfonso G. Ramírez Ristori
Juan Carlos Bustamante-Ogando
Mario Ernesto Cruz-Munoz
Arturo Gutierrez-Guerrero
Marimar Saez-de-Ocariz
Sara Espinosa-Padilla

Frontiers in Immunology

doi 10.3389/fimmu.2025.1511385

728 views

Mini Review

Published on 20 Mar 2025

Patient-reported outcomes with subcutaneous immunoglobulin in secondary immunodeficiency

in Primary Immunodeficiencies

Juthaporn Cowan
Il-Kang Na
André Gladiator
Marta Kamieniak
S. Shahzad Mustafa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528414

1,261 views

Case Report

Published on 18 Mar 2025

Case Report: Infection with Streptococcus constellatus manifesting as gelatinous pleural effusion in an HIV-positive patient

in Primary Immunodeficiencies

Zhongxia Yang
Wanyuan Xiong
Zibing Qian
Xiaorong Mao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545165

541 views

Case Report

Published on 07 Mar 2025

Case Report: A novel IKBKB variant (c.1705G>T) is associated with immune dysregulation and disseminated tuberculosis

in Primary Immunodeficiencies

Gabriel Emmanuel Arce-Estrada
Miguel Rodríguez-Morales
Selma Cecilia Scheffler-Mendoza
Marimar Sáez-de-Ocariz
Laura Berrón-Ruiz
Sara Elva Espinosa-Padilla
Francisco Alberto Contreras-Verduzco

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541899

796 views

Review

Published on 07 Mar 2025

Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation

in Primary Immunodeficiencies

Lauren A. Henderson
Roshini S. Abraham
Aisha Ahmed
Lindsey Blount
Scott W. Canna
Natalia S. Chaimowitz
Shanmuganathan Chandrakasan
Bria Coates
James A. Connelly
Megan A. Cooper

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519955

1,031 views
1 citation

Case Report

Published on 28 Feb 2025

Case Report: Hypomorphic Ligase 4 deficiency – a paradigm of immunodysregulation

in Primary Immunodeficiencies

Catarina Andrade
Ana Isabel Cordeiro
Marta Valente Pinto
Conceição Neves
Catarina Martins
Jean-Pierre Villartay
João Farela Neves

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545630

903 views

Case Report

Published on 27 Feb 2025

Case report and literature review: clinical manifestations and treatment of human RelA deficiency

in Primary Immunodeficiencies

Chenghao Wang
Wenjie Wang
Xiaoying Hui
Jia Hou
Qinhua Zhou
Qifan Li
Qi Wu
Qi Ni
Bingbing Wu
Jinqiao Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1529654

841 views

Original Research

Published on 21 Feb 2025

Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome

in Primary Immunodeficiencies

Tamar Rubin
Stéphane Bernier
Lily Siok Hoon Lim
Michael S. Salman
Edward Leung
Aziz Mhanni
Sandra Marles
Cheryl Greenberg
Anna Perez
Yichun Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557632

1,170 views