Frontiers in Immunology | Primary Immunodeficiencies

Case Report

Published on 13 Nov 2025

GATA2 deficiency in an adult with alveolar proteinosis, infections, lymphadenopathy with granulomatosis, and immune deficiency: case report

in Primary Immunodeficiencies

Štefan Raffáč
Juliana Gabzdilová
Gabriela Krasňanská
Michal Konečný

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608392

551 views

Brief Research Report

Accepted on 12 Nov 2025

Do CVID patients on SCIG have more autoimmune (thrombo)cytopenic events than CVID patients on IVIG?

in Primary Immunodeficiencies

Nadezhda Camacho-Ordonez
Aleksandra Hirsch
Luiza Campos
Sigune Goldacker
Siobhan Oisin Burns
Fernando Moreira
Klaus Warnatz
Bodo Grimbacher

Frontiers in Immunology

Case Report

Accepted on 12 Nov 2025

A Novel De Novo SPI1 Mutation Identified in a Chinese Patient with Agammaglobulinemia

in Primary Immunodeficiencies

Qi Peng
Ming Deng
Xiaomei Zeng
Qingqiu Cheng
Mingyu Xie
Siping Li
Xiaomei Lu

Frontiers in Immunology

130 views

Original Research

Accepted on 10 Nov 2025

Dupilumab for Atopic Manifestations in Pediatric Patients with Inborn Errors of Immunity: Efficacy and Safety in a Genetically Diverse Cohort

in Primary Immunodeficiencies

Najla Alsediq
Thekra Algholaiqa
Ghadah Alnami
Abdulrahman N. Aljaber

Frontiers in Immunology

132 views

Case Report

Published on 10 Nov 2025

Case Report: A simple case of drug-induced secondary antibody deficiency or a rare primary immune deficiency?

in Primary Immunodeficiencies

Sarah L. Johnston
Julie C. Evans
Ian R. Berry
Oliver T. Watkinson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629876

320 views

Case Report

Accepted on 07 Nov 2025

A Novel CIITA Mutation Causing MHC Class II Deficiency: First Reported Case in Morocco

in Primary Immunodeficiencies

Aziza Bachir KATTRA
Ailal Fatima
Ibtihal Benhsaien
Fahi Mohammed
Drissi Bourhanbour Asmaa
Elamine Ahamada
Aadam Zahra
Errami Abderrahmane
Ahmed Aziz BOUSFIHA
Jalila El Bakkouri

Frontiers in Immunology

126 views

Original Research

Published on 07 Nov 2025

Long-term outcome of bone marrow transplantation in NIK deficiency: non-redundant role of non-canonical NF-κB signaling in thymic reconstitution and secondary lymphoid organ development

in Primary Immunodeficiencies

Sevgi Köstel Bal
Şule Haskoloğlu
Bernhard Ransmayr
Selin Sevinç
Candan İslamoğlu
Kübra Baskın
Nazlı Deveci
Berna Savaş
Suat Fitoz
Alphan Küpesiz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682642

529 views

Original Research

Accepted on 06 Nov 2025

Mapping the landscape of autoimmunity and autoinflammation in inborn errors of immunity: Broad distribution with distinct clustering patterns

in Primary Immunodeficiencies

Azzeddine Tahiat
Souad Touri
Amina Saad-Djaballah
Saliha Hakem
Faiza Fernini
Samira Aggoune
Hayet Belhadj
Chafa Bendahmane
Linda Mokrane
Tahar Bencharif Madani

Frontiers in Immunology

149 views

Brief Research Report

Accepted on 04 Nov 2025

From DGCR8 expression analysis to diseased pathways in 22q11.2 deletion syndrome

in Primary Immunodeficiencies

Valentina Boz
Marianna Di Rosa
Alessia Pin
Eleonora De Martino
Flavio Faletra
Francesco Baldo
Andrea Magnolato
Erica Valencic

Frontiers in Immunology

110 views

Original Research

Accepted on 03 Nov 2025

The genetic landscape of congenital neutropenia in Poland – summary of the nationwide screening campaign

in Primary Immunodeficiencies

Katarzyna Bąbol-Pokora
Weronika Dobrewa
Marta Bielska
Szymon Janczar
Joanna Madzio
Aleksandra Jaworowska
Sylwia Koltan
Marcin Hennig
Joanna Renke
Iwona Dachowska-Kałwak

Frontiers in Immunology

Original Research

Published on 03 Nov 2025

Is there an alternative to the indirect immunofluorescence ANA HEp-2 assay for the diagnosis of connective tissue diseases?

in Primary Immunodeficiencies

Tamazouzt Hadjout
Lydia Lamara Mahammed
Meriem Saad
Amel Zemmour
Nadia Tamechmacht
Ghalya Bousbia
Halima Ismail
Nawel Dahmani
Ines Allam
Reda Djidjik

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669124

465 views

Case Report

Accepted on 30 Oct 2025

Case report: Novel CYBB missense mutation causing X-linked chronic granulomatous disease in a boy with recurrent pneumonia and testicular abscesses misdiagnosed as tuberculosis

in Primary Immunodeficiencies

Weiqi Jiang
Ping Ren
Tian Tian

Frontiers in Immunology

106 views

Mini Review

Published on 30 Oct 2025

The unveiled face of IEI: Children Cancer Hospital—Egypt (CCHE-57357) experience

in Primary Immunodeficiencies

Nesrine Radwan
Youssef Medany
Hanaa Rashad
Ahmed Elhemaly
Mahmoud Hammad
Hany Abdel Rahman
Mona Fakhry
Nora Mahmmoud Marouf
Ahmed Mahdy
Mariam Elsherif

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570328

884 views

Case Report

Published on 30 Oct 2025

Case Report: Novel IRF2BP2 variant in a Japanese patient with impaired B-cell differentiation, Th1 polarization, and systemic immune dysregulation

in Primary Immunodeficiencies

Yushiro Endo
Tomohiro Koga
Shota Kurushima
Takuya Tomokawa
Hiroyuki Mishima
Koh-ichiro Yoshiura
Tadashi Matsumoto
Atsushi Kawakami

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662899

506 views

Case Report

Published on 28 Oct 2025

Case Report: A patient with a novel heterozygous IRF8 variant with repeated infection and immune-mediated organ disease, but without disseminated mycobacterial disease despite BCG immunization

in Primary Immunodeficiencies

Samuel C. C. Chiang
Erika Owsley
Ammar Husami
Nagako Akeno
Cristina M. Cobb
Li Yang
Rebecca A. Marsh
Kenneth A. Myers
Tamar S. Rubin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654617

831 views

Original Research

Published on 28 Oct 2025

Genotypic and phenotypic characterization of rare globin variants in Northern Guangxi, China

in Primary Immunodeficiencies

Wei-Jia Yang
Qing-Ping Kang
Li-Ming Liang
Qian Zhou
Xiao-Min Gong
Min Dou
Cui-Juan Huang
Ying Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695120

684 views