Frontiers in Immunology | Primary Immunodeficiencies

Original Research

Published on 23 Aug 2021

Serum Protein Electrophoresis May Be Used as a Screening Tool for Antibody Deficiency in Children and Adolescents

in Primary Immunodeficiencies

Cristina Frias Sartorelli de Toledo Piza
Carolina Sanchez Aranda
Dirceu Solé
Stephen Jolles
Antonio Condino-Neto

Frontiers in Immunology

doi 10.3389/fimmu.2021.712637

7,821 views
8 citations

Review

Published on 17 Aug 2021

Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity

in Primary Immunodeficiencies

Hassan Abolhassani
Yating Wang
Lennart Hammarström
Qiang Pan-Hammarström

Frontiers in Immunology

doi 10.3389/fimmu.2021.720025

9,133 views
36 citations

Original Research

Published on 13 Aug 2021

Clinical Application of Metagenomic Next-Generation Sequencing for Suspected Infections in Patients With Primary Immunodeficiency Disease

in Primary Immunodeficiencies

Wenjing Tang
Yu Zhang
Chong Luo
Lina Zhou
Zhiyong Zhang
Xuemei Tang
Xiaodong Zhao
Yunfei An

Frontiers in Immunology

doi 10.3389/fimmu.2021.696403

8,155 views
45 citations

Original Research

Published on 12 Aug 2021

Needs for Increased Awareness of Gastrointestinal Manifestations in Patients With Human Inborn Errors of Immunity

in Primary Immunodeficiencies

Eun Sil Kim
Dongsub Kim
Yoonsun Yoon
Yiyoung Kwon
Sangwoo Park
Jihyun Kim
Kang Mo Ahn
Soomin Ahn
Yon Ho Choe
Yae-Jean Kim

Frontiers in Immunology

doi 10.3389/fimmu.2021.698721

5,908 views
7 citations

Original Research

Published on 10 Aug 2021

Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management

in Primary Immunodeficiencies

Marta López-Nevado
Luis I. González-Granado
Raquel Ruiz-García
Daniel Pleguezuelo
Oscar Cabrera-Marante
Nerea Salmón
Pilar Blanco-Lobo
Nerea Domínguez-Pinilla
Rebeca Rodríguez-Pena
Elena Sebastián

Frontiers in Immunology

doi 10.3389/fimmu.2021.671755

28,817 views
74 citations

Original Research

Published on 05 Aug 2021

One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency

in Primary Immunodeficiencies

Julia Körholz
Anastasia Gabrielyan
John M. Sowerby
Felix Boschann
Lan-Sun Chen
Diana Paul
David Brandt
Janina Kleymann
Martin Kolditz
Nicole Toepfner

Frontiers in Immunology

doi 10.3389/fimmu.2021.680334

11,802 views
27 citations

Case Report

Published on 03 Aug 2021

Case Report: Acquired Disseminated BCG in the Context of a Delayed Immune Reconstitution After Hematological Malignancy

in Primary Immunodeficiencies

Vincent Gies
Yannick Dieudonné
Florence Morel
Wladimir Sougakoff
Raphaël Carapito
Aurélie Martin
Noëlle Weingertner
Léa Jacquel
Fabrice Hubele
Cornelia Kuhnert

Frontiers in Immunology

doi 10.3389/fimmu.2021.696268

4,830 views
6 citations

Original Research

Published on 23 Jul 2021

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

in Primary Immunodeficiencies

Xavier Solanich
Gardenia Vargas-Parra
Caspar I. van der Made
Annet Simons
Janneke Schuurs-Hoeijmakers
Arnau Antolí
Jesús del Valle
Gemma Rocamora-Blanch
Fernando Setién
Manel Esteller

Frontiers in Immunology

doi 10.3389/fimmu.2021.719115

15,680 views
107 citations

Opinion

Published on 21 Jul 2021

Are All Primary Immunodeficiency Disorders Inborn Errors of Immunity?

in Primary Immunodeficiencies

Rohan Ameratunga
Hilary Longhurst
Klaus Lehnert
Richard Steele
Emily S. J. Edwards
See-Tarn Woon

Frontiers in Immunology

doi 10.3389/fimmu.2021.706796

10,250 views
13 citations

Case Report

Published on 15 Jul 2021

Cryptococcal Meningitis and Post-Infectious Inflammatory Response Syndrome in a Patient With X-Linked Hyper IgM Syndrome: A Case Report and Review of the Literature

in Primary Immunodeficiencies

Lorenza Romani
Peter Richard Williamson
Silvia Di Cesare
Gigliola Di Matteo
Maia De Luca
Rita Carsetti
Lorenzo Figà-Talamanca
Caterina Cancrini
Paolo Rossi
Andrea Finocchi

Frontiers in Immunology

doi 10.3389/fimmu.2021.708837

7,148 views
13 citations

Case Report

Published on 12 Jul 2021

Hemophagocytic Lymphohistiocytosis Associated to Klebsiella pneumoniae Infection: A Case Report

in Primary Immunodeficiencies

Zhiyu Zhang
Junqian Liu
Jingyue Wang
Yushi Wang

Frontiers in Immunology

doi 10.3389/fimmu.2021.684805

4,601 views
1 citation

Original Research

Published on 12 Jul 2021

Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology

in Primary Immunodeficiencies

Sophie Steiner
Tatjana Schwarz
Victor M. Corman
Franziska Sotzny
Sandra Bauer
Christian Drosten
Hans-Dieter Volk
Carmen Scheibenbogen
Leif G. Hanitsch

Frontiers in Immunology

doi 10.3389/fimmu.2021.687449

11,326 views
31 citations

Original Research

Published on 08 Jul 2021

Efficacy, Safety and Tolerability of a New 10% Intravenous Immunoglobulin for the Treatment of Primary Immunodeficiencies

in Primary Immunodeficiencies

Elena E. Perez
Jacques Hébert
Anne K. Ellis
Oral Alpan
William R. Lumry
Ralph Shapiro
Daniel Suez
J. Fernando Mandujano
Richard L. Wasserman

Frontiers in Immunology

doi 10.3389/fimmu.2021.707463

8,069 views
4 citations

Original Research

Published on 08 Jul 2021

Altered Functions of Neutrophils in Two Chinese Patients With Severe Congenital Neutropenia Type 4 Caused by G6PC3 Mutations

in Primary Immunodeficiencies

Rongxin Dai
Ge Lv
Wenyan Li
Wenjing Tang
Junjie Chen
Qiao Liu
Lu Yang
Min Zhang
Zhirui Tian
Lina Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2021.699743

4,746 views
12 citations

Editorial

Published on 08 Jul 2021

Editorial: Interstitial Lung Disease in Primary Immunodeficiencies

in Primary Immunodeficiencies

Børre Fevang
Klaus Warnatz
John R. Hurst

Frontiers in Immunology

doi 10.3389/fimmu.2021.699126

5,299 views
2 citations

Original Research

Published on 05 Jul 2021

Common Variable Immunodeficiency and Autoimmune Diseases: A Retrospective Study of 95 Adult Patients in a Single Tertiary Care Center

in Primary Immunodeficiencies

Ilaria Mormile
Alessandra Punziano
Carlo Alberto Riolo
Francescopaolo Granata
Michela Williams
Amato de Paulis
Giuseppe Spadaro
Francesca Wanda Rossi

Frontiers in Immunology

doi 10.3389/fimmu.2021.652487

21,769 views
51 citations

Original Research

Published on 29 Jun 2021

Survival and Functional Immune Reconstitution After Haploidentical Stem Cell Transplantation in Atm-Deficient Mice

in Primary Immunodeficiencies

Ruth Pia Duecker
Lucia Gronau
Patrick C. Baer
Stefan Zielen
Ralf Schubert

Frontiers in Immunology

doi 10.3389/fimmu.2021.693897

4,197 views
5 citations

Editorial

Published on 24 Jun 2021

Editorial: Advances in Primary Immunodeficiencies in India

in Primary Immunodeficiencies

Sudhir Gupta
Shobha Sehgal

Frontiers in Immunology

doi 10.3389/fimmu.2021.701335

5,928 views
6 citations

Review

Published on 24 Jun 2021

The Use of Biologic Modifiers as a Bridge to Hematopoietic Cell Transplantation in Primary Immune Regulatory Disorders

in Primary Immunodeficiencies

Danielle E. Arnold
Deepak Chellapandian
Jennifer W. Leiding

Frontiers in Immunology

doi 10.3389/fimmu.2021.692219

4,887 views
15 citations

Case Report

Published on 24 Jun 2021

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome

in Primary Immunodeficiencies

Brahim Belaid
Lydia Lamara Mahammed
Aida Mohand Oussaid
Melanie Migaud
Yasmine Khadri
Jean Laurent Casanova
Anne Puel
Nafissa Ben Halla
Reda Djidjik

Frontiers in Immunology

doi 10.3389/fimmu.2021.696350

12,912 views
10 citations

Original Research

Published on 24 Jun 2021

Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

in Primary Immunodeficiencies

Thomas J. Weitering
Janine E. Melsen
Monique M. van Ostaijen-ten Dam
Corry M. R. Weemaes
Marco W. Schilham
Mirjam van der Burg

Frontiers in Immunology

doi 10.3389/fimmu.2021.686333

6,586 views
10 citations

Original Research

Published on 23 Jun 2021

A Novel Mutation in the NBD Domain of NLRC4 Causes Mild Autoinflammation With Recurrent Urticaria

in Primary Immunodeficiencies

Li Wang
Wen Wen
Mengyue Deng
Yue Li
Gan Sun
Xiaodong Zhao
Xuemei Tang
Huawei Mao

Frontiers in Immunology

doi 10.3389/fimmu.2021.674808

7,954 views
23 citations

Original Research

Published on 17 Jun 2021

A Novel Non-Coding Variant in DCLRE1C Results in Deregulated Splicing and Induces SCID Through the Generation of a Truncated ARTEMIS Protein That Fails to Support V(D)J Recombination and DNA Damage Repair

in Primary Immunodeficiencies

Steven Strubbe
Marieke De Bruyne
Ulrich Pannicke
Elien Beyls
Bart Vandekerckhove
Georges Leclercq
Elfride De Baere
Victoria Bordon
Anne Vral
Klaus Schwarz

Frontiers in Immunology

doi 10.3389/fimmu.2021.674226

7,543 views
7 citations

Case Report

Published on 28 May 2021

AIRE Gene Mutation Presenting at Age 2 Years With Autoimmune Retinopathy and Steroid-Responsive Acute Liver Failure: A Case Report and Literature Review

in Primary Immunodeficiencies

Hirotaka Sakaguchi
Tatsuki Mizuochi
Masatoshi Haruta
Ryuta Takase
Shigeo Yoshida
Yushiro Yamashita
Ryuta Nishikomori

Frontiers in Immunology

doi 10.3389/fimmu.2021.687280

6,052 views
8 citations

1,017 articles

articles

Serum Protein Electrophoresis May Be Used as a Screening Tool for Antibody Deficiency in Children and Adolescents

Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity

Clinical Application of Metagenomic Next-Generation Sequencing for Suspected Infections in Patients With Primary Immunodeficiency Disease

Needs for Increased Awareness of Gastrointestinal Manifestations in Patients With Human Inborn Errors of Immunity

Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management

One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency

Case Report: Acquired Disseminated BCG in the Context of a Delayed Immune Reconstitution After Hematological Malignancy

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

Are All Primary Immunodeficiency Disorders Inborn Errors of Immunity?

Cryptococcal Meningitis and Post-Infectious Inflammatory Response Syndrome in a Patient With X-Linked Hyper IgM Syndrome: A Case Report and Review of the Literature

Hemophagocytic Lymphohistiocytosis Associated to Klebsiella pneumoniae Infection: A Case Report

Reactive T Cells in Convalescent COVID-19 Patients With Negative SARS-CoV-2 Antibody Serology

Efficacy, Safety and Tolerability of a New 10% Intravenous Immunoglobulin for the Treatment of Primary Immunodeficiencies

Altered Functions of Neutrophils in Two Chinese Patients With Severe Congenital Neutropenia Type 4 Caused by G6PC3 Mutations

Editorial: Interstitial Lung Disease in Primary Immunodeficiencies

Common Variable Immunodeficiency and Autoimmune Diseases: A Retrospective Study of 95 Adult Patients in a Single Tertiary Care Center

Survival and Functional Immune Reconstitution After Haploidentical Stem Cell Transplantation in Atm-Deficient Mice

Editorial: Advances in Primary Immunodeficiencies in India

The Use of Biologic Modifiers as a Bridge to Hematopoietic Cell Transplantation in Primary Immune Regulatory Disorders

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome

Normal Numbers of Stem Cell Memory T Cells Despite Strongly Reduced Naive T Cells Support Intact Memory T Cell Compartment in Ataxia Telangiectasia

A Novel Mutation in the NBD Domain of NLRC4 Causes Mild Autoinflammation With Recurrent Urticaria

A Novel Non-Coding Variant in DCLRE1C Results in Deregulated Splicing and Induces SCID Through the Generation of a Truncated ARTEMIS Protein That Fails to Support V(D)J Recombination and DNA Damage Repair

AIRE Gene Mutation Presenting at Age 2 Years With Autoimmune Retinopathy and Steroid-Responsive Acute Liver Failure: A Case Report and Literature Review