Frontiers in Immunology | Systems Immunology

Original Research

Accepted on 18 Apr 2025

Multi-omics Integration Identifies NK Cell-Mediated Cytotoxicity as a Therapeutic Target in Systemic Lupus Erythematosus

in Systems Immunology

Jingjing Zhang
Ling Ma
Hanyin Deng
Wenqian Yi
Alim Tohtihan
Xiaojun Tang
Xiudi Wu
Xuebing Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580540

Original Research

Accepted on 17 Apr 2025

Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing

in Systems Immunology

Hua Huang
Jiaze Ma
An Kang
Tianwei Guo
Wei Sun
Yan Xu
Lijiang Ji

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534768

243 views

Original Research

Published on 17 Apr 2025

Comprehensive molecular analyses of an autoimmune-related gene predictive model and immune infiltrations using machine learning methods in intracranial aneurysma

in Systems Immunology

Minxue Zhang
Lin Zhou
Yuying Zhao
Yanling Wang
Zhuobo Zhang
Zhan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1531930

117 views

Original Research

Accepted on 15 Apr 2025

Clinical and mechanistic relevance of high dimensionality analysis of the paediatric sepsis immunome

in Systems Immunology

Dandan Pi
Judith Ju Ming Wong
Katherine Nay Yaung
Nicholas Khoo
Su Li Poh
Martin Wasser
Pavanish Kumar
Thaschawee Arkachaisri
Feng Xu
Herng Lee Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569096

123 views

Review

Accepted on 15 Apr 2025

Anti-Ro/SSA Antibodies in Adult Arrhythmias: Pathogenesis, Clinical Implications, and Therapeutic Strategies

in Systems Immunology

Ruotong Cao
Huasheng Lv
Baopeng Tang
Yanmei Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561061

Mini Review

Accepted on 15 Apr 2025

Comprehending Toll-like Receptors: Pivotal Element in the Pathogenesis of Sepsis and Its Complications

in Systems Immunology

Wei Wang
Shengtian Mu
Dongli Yan
Huan Qin
Zhen Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591011

Original Research

Published on 10 Apr 2025

Development and validation of identification algorithms for five autoimmune diseases using electronic health records: a retrospective cohort study in China

in Systems Immunology

Junting Yang
Yunxiao Wu
Jinxin Guo
Xiaoxuan Wang
Xin Gao
Xin Chen
Mengdi Zhang
Jin Yang
Zuojing Liu
Yan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541203

311 views

Original Research

Published on 09 Apr 2025

Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis

in Systems Immunology

Danielle Dias Munhoz
Dennyson Leandro M. Fonseca
Igor Salerno Filgueiras
Haroldo Dutra Dias
Helder I. Nakaya
Igor Jurisica
Hans D. Ochs
Lena F. Schimke
Luiz Vicente Rizzo
Otavio Cabral-Marques

Frontiers in Immunology

doi 10.3389/fimmu.2025.1509805

411 views

Original Research

Accepted on 08 Apr 2025

Independent and temporally separated dynamics for RORγt and Foxp3 during Th17 differentiation

in Systems Immunology

Stav Miller
Inbal Eizenberg-Magar
Shlomit Reich-Zeliger
Jacob Rimer
Irina Zaretsky
Dan Reshef
Ekaterina Kopitman
Nir Friedman
Yaron E Antebi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1462045

Original Research

Published on 08 Apr 2025

Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings

in Systems Immunology

Tianmeng Chen
Julia Hughes
Alyssa Gregory
Julia Conroy
Patricia Loughran
Jinming Song
Wei Chen
Timothy Billiar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565211

312 views

Original Research

Accepted on 07 Apr 2025

Interpretable Machine Learning Algorithms Reveals Gut Microbiome Features Associated with Atopic Dermatitis

in Systems Immunology

Jingtai Ma
yiting fang
shiqi li
Lilian Zeng
Siyi Chen
Zhifeng Li
Guiyuan Ji
Xing-Fen Yang
wei wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528046

Review

Published on 02 Apr 2025

TREM2+ macrophages: a key role in disease development

in Systems Immunology

Xinxin Wang
Yunhan Wang
Lei Yang
Yi Zhang
Li Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550893

871 views

Original Research

Accepted on 01 Apr 2025

A computational account of joint SSRI and anti-inflammatory treatment

in Systems Immunology

Melissa Reneaux
Helen S. Mayberg
Karl Friston
Dimitris Pinotsis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1472732

124 views

Review

Published on 31 Mar 2025

Oral and transdermal administration of lipopolysaccharide safely enhances self-healing ability through the macrophage network

in Systems Immunology

Gen-Ichiro Soma
Masataka Oda
Vindy Tjendana Tjhin
Chie Kohchi
Hiroyuki Inagawa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563484

722 views

Review

Published on 31 Mar 2025

Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review

in Systems Immunology

Siyu He
Ziyue Wang
Yinan Zhu
Mingfang Sun
Xuyong Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1473817

712 views

Systematic Review

Accepted on 27 Mar 2025

Artificial intelligence in autoimmune diseases: a bibliometric exploration of the past two decades

in Systems Immunology

Sidi Liu
Yang Liu
Ming Li
Shuangshuang Shang
Yunxiang Cao
Xi Shen
Chuanbing Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1525462

127 views