Frontiers in Immunology | Systems Immunology

Review

Published on 16 Feb 2026

From mechanosensing to immune regulation: mechanisms of acupuncture signal initiation and amplification mediated by macrophages

in Systems Immunology

Wenru Sheng
Rui Wang
Xiqing Xue
Pan Zhao
Jingwen Zhang
Yiider Tseng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1744045

448 views

Original Research

Accepted on 13 Feb 2026

A Multicenter Explainable Machine Learning Analysis of Autoimmune Disease Comorbidity in Ankylosing Spondylitis

in Systems Immunology

Jichong Zhu
Chengqian Huang
Yang Lin
Tianyou Chen
Lei Ren
Jiarui Chen
Jiang Xue
Hao Li
Hong Cheng
Xinli Zhan

Frontiers in Immunology

Original Research

Published on 13 Feb 2026

Integrative omics and experimental validation reveal METTL17 and SLC27A1 as biomarkers and potential therapeutic targets in chronic kidney disease

in Systems Immunology

Shiyun Ling
Kaifeng Xie
Penghui Chen
Lichang Liang
Xinyu Shi
Renfa Huang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1724740

365 views

Original Research

Published on 13 Feb 2026

Carnosine protects human microglia against Aβ oligomers through a multimodal mechanism of action: inhibition of oxidative stress, rescue of cellular energy status, and enhancement of phagocytosis

in Systems Immunology

Anna Privitera
Vincenzo Cardaci
Matthew C. Zupan
Lucia Di Pietro
Giuseppe Carota
Jay Sibbitts
Renata Mangione
Andrea Graziani
Lucia Buccarello
Francesco Bellia

Frontiers in Immunology

doi 10.3389/fimmu.2026.1768094

369 views

Original Research

Published on 12 Feb 2026

Multi-omics signatures of chronic inflammation across immune-related disease states

in Systems Immunology

Hui Li
Xiaolin Xie
Lirui Tang
Chuanben Chen
Jinluan Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753156

356 views

Review

Accepted on 10 Feb 2026

Immune dysregulation in Mycoplasma pneumoniae pneumonia: Mechanistic controversies and clinical translation from inflammatory dysregulation and immune evasion to chronic injury

in Systems Immunology

Xuejun Li
Yudong Wang
Qiuyan Wang
Hongji Wu
Yong-bin YAN
Yibai Xiong
Ying Ding

Frontiers in Immunology

Review

Accepted on 09 Feb 2026

Immune Modulation by Sex Hormones: Unveiling the Complex Interplay and Regulatory Networks

in Systems Immunology

Bohan Wan
Wanquan Chen
Mengmeng Shan
Liang Chi

Frontiers in Immunology

163 views

Review

Accepted on 09 Feb 2026

The gene regulatory networks shaping macrophage plasticity and altered function in fibrosis

in Systems Immunology

Zsuzsanna Kolostyak
Laszlo Nagy

Frontiers in Immunology

Original Research

Published on 06 Feb 2026

Integrated multi-omics analysis of dampness-heat gout reveals diagnostic biomarkers and therapeutic targets

in Systems Immunology

Le Yang
Ye Sun
Chuanning Li
Hui Sun
Shuyun Wei
Fangjie Zhu
Wenkai Wang
Runyue Huang
Xin Sun
Maojie Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1677920

498 views

Original Research

Accepted on 05 Feb 2026

Cross-Species Hepatic Transcriptomics Identify Conserved Immune-Metabolic Reprogramming in Acute-on-Chronic Liver Failure Progression

in Systems Immunology

Panyu Chen
Yun Song
Xiao Lin
Zhaokai Zeng
Wenxi Su
Yunyun Ren
Chen Wang
Kang He
Min Shi
Yugang Wang

Frontiers in Immunology

292 views

Original Research

Published on 05 Feb 2026

Systemic immune dysregulation in hypertensive disorders of pregnancy persists years after delivery

in Systems Immunology

Maximilian Sabayev
Edward A. Ganio
Ina A. Stelzer
Masaki Sato
Amélie Cambriel
Thomas A. Bonham
Zala N. Juvan
Maïgane Diop
Purnima Iyer
Oshra Sedan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1716809

620 views

Editorial

Accepted on 04 Feb 2026

Editorial: Modeling the Immune System: from PK/PD to Systems Immunology

in Systems Immunology

Lucía Alfonso-González
Francisco J. Fernández
M. Cristina Vega

Frontiers in Immunology

236 views

Mini Review

Accepted on 04 Feb 2026

MiRNAs: a Call to Arms That Shapes the Plasticity of Tumor Associated Macrophages in Breast Cancer

in Systems Immunology

Valentina Fogazzi
GIULIA COSENTINO
Michele Sommariva
Angela Galardi
Elisa Dell'Orto
Serenella Pupa
Cristian Taccioli
Marilena Valeria Iorio

Frontiers in Immunology

Original Research

Published on 04 Feb 2026

Enhancing Named Entity Recognition for immunology and immune-mediated disorders

in Systems Immunology

Songyue Chen
Jinshan Che
Mingming Sun
Yuhong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613479

630 views

Original Research

Published on 04 Feb 2026

Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis

in Systems Immunology

Victoria Kulesh
Kirill Peskov
Gabriel Helmlinger
Gennady Bocharov

Frontiers in Immunology

doi 10.3389/fimmu.2026.1742817

692 views

Original Research

Accepted on 03 Feb 2026

Granzyme B from Mast Cells Contributes to Choroidal Neovascularization in a Model of Wet Age-Related Macular Degeneration

in Systems Immunology

Manjosh Uppal
Amir Hosseini
Khola Bilal
Nielan Tan
Zhengyuan Ai
Wania Khan
Isa Samad
Gurmohit Gill
Hyung-Suk Yoo
Harshini Chakravarthy

Frontiers in Immunology

143 views

Review

Accepted on 31 Jan 2026

Decoding Lung-Kidney Interactions in Sepsis: An Integrated View of Molecular Mechanisms, Pathophysiology, and Therapeutic Interventions

in Systems Immunology

Chenye Ma
Hongyi Li
Zirong Chen
Heng Song
Yuze Wang
Zhihui Liu
Xuefan Bu
Xianfei Ding
Hanfang Si
Jing-Hua Yang

Frontiers in Immunology

130 views

Original Research

Accepted on 30 Jan 2026

Heterogeneous immune recovery after viral response through a dynamical model of feedback-driven persistence and clearance

in Systems Immunology

Xiaoxin Wang
Kai Kang
Leyi Zhang
Changjing Zhuge

Frontiers in Immunology

122 views

Original Research

Accepted on 30 Jan 2026

Identification of Predictive Biomarkers and Dose Optimization for Camrelizumab Combined with Apatinib in the Treatment of Advanced Hepatocellular Carcinoma: A Quantitative Systems Pharmacology Approach

in Systems Immunology

Weikun Huang
Guihui Tu
Dandan Li
Chenyu Wang
Jianxing Zhou
Zheng Jiao
Lin Yang

Frontiers in Immunology

176 views

Case Report

Published on 30 Jan 2026

Severe DRESS syndrome with hemophagocytic lymphohistiocytosis and cryptococcal meningitis: a case report and diagnostic challenge

in Systems Immunology

Shi Yan
Yu-ting Gan
Jia-jia Li
Yu Sheng
Bing-jun Shi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1703040

445 views

Original Research

Published on 29 Jan 2026

Immunoproteomic mediators of diabetic peripheral neuropathy: causal insights from Mendelian randomization and single-cell validation

in Systems Immunology

Chenhao Hu
Shengqiao Sun
Dezhi Li
Lebao Yu
Chao Guo
Song Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1681223

734 views

Original Research

Published on 29 Jan 2026

Mendelian randomization and transcriptome analysis reveal depression-driven regulatory patterns of the immune microenvironment in myocardial infarction and heart failure

in Systems Immunology

Zihao Zhou
Xiaotongning Yu
Yani Jin
Ziyi Liu
Guoqiang Liang
Ben Ma
Anqi Hou
Tongfei Gu
Na Xu
Shuo Sun

Frontiers in Immunology

doi 10.3389/fimmu.2026.1727699

397 views

Editorial

Published on 28 Jan 2026

Editorial: Systems Immunology and Translational Research in Infectious Diseases

in Systems Immunology

Mariana Araújo-Pereira
Caian L. Vinhaes
Artur T. L. Queiroz
Bruno B. Andrade

Frontiers in Immunology

doi 10.3389/fimmu.2026.1791482

554 views

Original Research

Accepted on 27 Jan 2026

Integrated Spatial Transcriptomics and Single-Cell RNA Sequencing Reveal Lars2-Mediated Spatiotemporal Dynamics of Myocardial Remodeling in a Mouse Model of Transverse Aortic Constriction (TAC)

in Systems Immunology

Hanwen Ni
Feng Liang
Huanhuan Huo
Xuechao Feng
He Ben

Frontiers in Immunology

179 views

546 articles

articles

From mechanosensing to immune regulation: mechanisms of acupuncture signal initiation and amplification mediated by macrophages

A Multicenter Explainable Machine Learning Analysis of Autoimmune Disease Comorbidity in Ankylosing Spondylitis

Integrative omics and experimental validation reveal METTL17 and SLC27A1 as biomarkers and potential therapeutic targets in chronic kidney disease

Carnosine protects human microglia against Aβ oligomers through a multimodal mechanism of action: inhibition of oxidative stress, rescue of cellular energy status, and enhancement of phagocytosis

Multi-omics signatures of chronic inflammation across immune-related disease states

Immune dysregulation in Mycoplasma pneumoniae pneumonia: Mechanistic controversies and clinical translation from inflammatory dysregulation and immune evasion to chronic injury

Immune Modulation by Sex Hormones: Unveiling the Complex Interplay and Regulatory Networks

The gene regulatory networks shaping macrophage plasticity and altered function in fibrosis

Integrated multi-omics analysis of dampness-heat gout reveals diagnostic biomarkers and therapeutic targets

Cross-Species Hepatic Transcriptomics Identify Conserved Immune-Metabolic Reprogramming in Acute-on-Chronic Liver Failure Progression

Systemic immune dysregulation in hypertensive disorders of pregnancy persists years after delivery

Editorial: Modeling the Immune System: from PK/PD to Systems Immunology

MiRNAs: a Call to Arms That Shapes the Plasticity of Tumor Associated Macrophages in Breast Cancer

Enhancing Named Entity Recognition for immunology and immune-mediated disorders

Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis

Granzyme B from Mast Cells Contributes to Choroidal Neovascularization in a Model of Wet Age-Related Macular Degeneration

Decoding Lung-Kidney Interactions in Sepsis: An Integrated View of Molecular Mechanisms, Pathophysiology, and Therapeutic Interventions

Heterogeneous immune recovery after viral response through a dynamical model of feedback-driven persistence and clearance

Identification of Predictive Biomarkers and Dose Optimization for Camrelizumab Combined with Apatinib in the Treatment of Advanced Hepatocellular Carcinoma: A Quantitative Systems Pharmacology Approach

Severe DRESS syndrome with hemophagocytic lymphohistiocytosis and cryptococcal meningitis: a case report and diagnostic challenge

Immunoproteomic mediators of diabetic peripheral neuropathy: causal insights from Mendelian randomization and single-cell validation

Mendelian randomization and transcriptome analysis reveal depression-driven regulatory patterns of the immune microenvironment in myocardial infarction and heart failure

Editorial: Systems Immunology and Translational Research in Infectious Diseases

Integrated Spatial Transcriptomics and Single-Cell RNA Sequencing Reveal Lars2-Mediated Spatiotemporal Dynamics of Myocardial Remodeling in a Mouse Model of Transverse Aortic Constriction (TAC)