Frontiers in Immunology | Systems Immunology

Original Research

Published on 13 Feb 2024

Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches

in Systems Immunology

Anna Niarakis
Marek Ostaszewski
Alexander Mazein
Inna Kuperstein
Martina Kutmon
Marc E. Gillespie
Akira Funahashi
Marcio Luis Acencio
Ahmed Hemedan
Michael Aichem

Frontiers in Immunology

doi 10.3389/fimmu.2023.1282859

11,429 views
9 citations

Technology and Code

Published on 08 Feb 2024

DiscoTope-3.0: improved B-cell epitope prediction using inverse folding latent representations

in Systems Immunology

Magnus Haraldson Høie
Frederik Steensgaard Gade
Julie Maria Johansen
Charlotte Würtzen
Ole Winther
Morten Nielsen
Paolo Marcatili

Frontiers in Immunology

doi 10.3389/fimmu.2024.1322712

11,258 views
50 citations

Original Research

Published on 02 Feb 2024

MIHIC: a multiplex IHC histopathological image classification dataset for lung cancer immune microenvironment quantification

in Systems Immunology

Ranran Wang
Yusong Qiu
Tong Wang
Mingkang Wang
Shan Jin
Fengyu Cong
Yong Zhang
Hongming Xu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1334348

6,124 views
6 citations

Original Research

Published on 01 Feb 2024

Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

in Systems Immunology

Julia Femel
Cameron Hill
Irineu Illa Bochaca
Jamie L. Booth
Tina G. Asnaashari
Maria M. Steele
Ata S. Moshiri
Hyungrok Do
Judy Zhong
Iman Osman

Frontiers in Immunology

doi 10.3389/fimmu.2024.1328602

5,333 views
2 citations

Original Research

Published on 29 Jan 2024

An in silico modeling approach to understanding the dynamics of the post-burn immune response

in Systems Immunology

H. Ibrahim Korkmaz
Vivek M. Sheraton
Roland V. Bumbuc
Meifang Li
Anouk Pijpe
Patrick P. G. Mulder
Bouke K. H. L. Boekema
Evelien de Jong
Stephan G. F. Papendorp
Ruud Brands

Frontiers in Immunology

doi 10.3389/fimmu.2024.1303776

3,126 views
1 citation

Original Research

Published on 25 Jan 2024

Elucidating common pathogenic transcriptional networks in infective endocarditis and sepsis: integrated insights from biomarker discovery and single-cell RNA sequencing

in Systems Immunology

Chen Yi
Haoxiang Zhang
Jun Yang
Dongjuan Chen
Shaofeng Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1298041

3,497 views
4 citations

Original Research

Published on 23 Jan 2024

Evidence of collective influence in innate sensing using fluidic force microscopy

in Systems Immunology

Elizabeth J. Mulder
Brittany Moser
Jennifer Delgado
Rachel C. Steinhardt
Aaron P. Esser-Kahn

Frontiers in Immunology

doi 10.3389/fimmu.2024.1340384

1,758 views
2 citations

Original Research

Published on 22 Jan 2024

Highly heterogenous humoral immune response in Lyme disease patients revealed by broad machine learning-assisted antibody binding profiling with random peptide arrays

in Systems Immunology

L. Kelbauskas
J. B. Legutki
N. W. Woodbury

Frontiers in Immunology

doi 10.3389/fimmu.2024.1335446

2,943 views
4 citations

Original Research

Published on 11 Jan 2024

Bioinformatic analysis of related immune cell infiltration and key genes in the progression of osteonecrosis of the femoral head

in Systems Immunology

Xudong Duan
Fangze Xing
Jiewen Zhang
Heng Li
Yang Chen
Yutian Lei
Yiwei Zhao
Ruomu Cao
Huanshuai Guan
Ning Kong

Frontiers in Immunology

doi 10.3389/fimmu.2023.1340446

5,158 views
7 citations

Review

Published on 11 Jan 2024

Ceramide on the road to insulin resistance and immunometabolic disorders in transition dairy cows: driver or passenger?

in Systems Immunology

Yuchao Zhao
Huiying Zhao
Liuxue Li
Shiqing Yu
Ming Liu
Linshu Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1321597

3,997 views
4 citations

Original Research

Published on 11 Jan 2024

Comprehensive analysis of an endoplasmic reticulum stress-related gene prediction model and immune infiltration in idiopathic pulmonary fibrosis

in Systems Immunology

Honglan Zhu
Aiming Zhou
Menglin Zhang
Lin Pan
Xiao Wu
Chenkun Fu
Ling Gong
Wenting Yang
Daishun Liu
Yiju Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2023.1305025

3,167 views
5 citations

Original Research

Published on 10 Jan 2024

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning

in Systems Immunology

Yifei Geng
Yuchen Liu
Min Wang
Xi Dong
Xiao Sun
Yun Luo
Xiaobo Sun

Frontiers in Immunology

doi 10.3389/fimmu.2023.1320475

4,757 views
1 citation

Original Research

Published on 08 Jan 2024

HOXA3 functions as the on-off switch to regulate the development of hESC-derived third pharyngeal pouch endoderm through EPHB2-mediated Wnt pathway

in Systems Immunology

Yingjie Fu
Xueyan Zhang
Haibin Wu
Pingping Zhang
Shoupei Liu
Tingting Guo
Huanhuan Shan
Yan Liang
Honglin Chen
Jinghe Xie

Frontiers in Immunology

doi 10.3389/fimmu.2023.1258074

3,401 views
3 citations

Original Research

Published on 08 Jan 2024

Integrative analysis of potential diagnostic markers and therapeutic targets for glomerulus-associated diabetic nephropathy based on cellular senescence

in Systems Immunology

Donglin Sun
Shuqi Wei
Dandan Wang
Min Zeng
Yihao Mo
Huafeng Li
Caixing Liang
Lu Li
Jun Wei Zhang
Li Wang

Frontiers in Immunology

doi 10.3389/fimmu.2023.1328757

5,988 views
4 citations

Original Research

Published on 04 Jan 2024

Prediction of six macrophage phenotypes and their IL-10 content based on single-cell morphology using artificial intelligence

in Systems Immunology

Mischa Selig
Logan Poehlman
Nils C. Lang
Marita Völker
Bernd Rolauffs
Melanie L. Hart

Frontiers in Immunology

doi 10.3389/fimmu.2023.1336393

5,726 views
16 citations

Original Research

Published on 02 Jan 2024

A comprehensive battery of flow cytometric immunoassays for the in vitro testing of chemical effects in human blood cells

in Systems Immunology

Arkadiusz Pierzchalski
Ana C. Zenclussen
Gunda Herberth

Frontiers in Immunology

doi 10.3389/fimmu.2023.1327960

5,105 views
6 citations