Frontiers in Immunology | Systems Immunology

Original Research

Published on 14 Jan 2026

Multimodal analysis of TAAD pathogenesis: SHAP-enhanced interpretable models and single-cell sequencing analysis reveal immune microenvironment alterations

in Systems Immunology

Zhong Wang
Yixian Wang
Dianjun Tang
Qingwei Gang
Shikai Shen
Hongming Wei
Dongwen Zhao
Jian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630404

943 views

Review

Published on 12 Jan 2026

From disruption to remodeling: the evolution and therapeutic prospects of Neuroimmune Regulatory Circuitry after ischemic stroke

in Systems Immunology

Yikun Gao
Qing Chen
Rui Tao
Wenrui Han
Zhanyong Zhu
Lijuan Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702245

1,201 views

Original Research

Published on 12 Jan 2026

Classification of angioedema types using decision tree modeling

in Systems Immunology

Felix Aulenbacher
Annika Gutsche
Henriette Farkas
Kinga Viktória Kőhalmi
Emek Kocatürk
Emel Aygören-Pürsün
Ludovic Martin
Hilary Longhurst
Petra Staubach
Andrea Zanichelli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697143

1,083 views

Original Research

Published on 09 Jan 2026

The role of 5-methylcytosine regulator-related genes in diagnostic and immune regulatory functions in atherosclerosis

in Systems Immunology

Hui Zhao
Ying Kong
Pengfei Ding
Luqun Yang
Ning Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636323

1,073 views

Original Research

Published on 09 Jan 2026

Cuproptosis-driven reprogramming of fibroblast communication by GK is associated with the immune microenvironment in diabetic foot ulcers

in Systems Immunology

Tianbo Li
Jiangning Wang
Lei Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687806

1,130 views

Methods

Published on 09 Jan 2026

Making deep immunophenotyping accessible: the successful application of a guided 23-parameter mouse immunophenotyping panel package provided through a shared resource

in Systems Immunology

Madison G. Isbell
Alex Wendling
Xinyan Pei
Amit Kumar
Padmanabhan Mannangatti
Bradley A. Krisanits
Stanley Cheatham
Marie Michenkova
Kirill Shumilov
Rachel G. Mendoza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668405

1,235 views

Original Research

Published on 09 Jan 2026

ULMnet: inferring physical cell-cell communication networks from scRNAseq data using univariate linear models

in Systems Immunology

Sodiq A. Hameed
Luis Fernando Iglesias-Martinez
Walter Kolch
Vadim Zhernovkov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722504

1,780 views

Original Research

Published on 08 Jan 2026

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

in Systems Immunology

Hyunsu Bong
Joonhong Min
Songhyeon Kim
Wootaek Lim
Dongyoung Lim
Hyunjeong Eom
Young Her
Minji Jeon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670993

1,247 views

Original Research

Published on 08 Jan 2026

A fundamental relationship between TCR diversity, repertoire size and systemic clonal expansion: insights from 30,000 TCRβ repertoires

in Systems Immunology

H. Jabran Zahid
Damon May
Harlan Robins
Julia Greissl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707727

1,094 views

Correction

Published on 05 Jan 2026

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

in Systems Immunology

Robert J. Petrella

Frontiers in Immunology

doi 10.3389/fimmu.2025.1756946

741 views

Original Research

Published on 02 Jan 2026

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

in Systems Immunology

HongLi Yu
YingLi Cao
Jiebo Wang
Xianfeng Weng
Weituan Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695979

1,192 views

Original Research

Published on 02 Jan 2026

An integrative model of pro- and anti-inflammatory signaling pathways in macrophage differentiation: the role of NF-κB and CREB

in Systems Immunology

David Martínez-Méndez
Ilean Z. Aguilar-Elguea
Lilian S. Castelán-Pacheco
Luis Armando Jiménez-Alvarez
Alfredo Cruz-Lagunas
Joaquín Zúñiga
Carlos Villarreal
Leonor Huerta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639005

1,603 views

Original Research

Published on 19 Dec 2025

Immunomodulation by bacterial products promotes innate signatures favorable to macrophage responses in tuberculosis infection

in Systems Immunology

Dámaris P. Romero-Rodríguez
Eduardo Montes
Héctor Isaac Rocha-González
Martha Torres
Joaquín Zúñiga
Esmeralda Juárez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664444

2,274 views

Original Research

Published on 19 Dec 2025

Systemic immune classification related to immune exhaustion evaluates the clinical response of patients with HBV-HCC after transarterial chemoembolization

in Systems Immunology

Lihua Yu
Xiaoli Liu
Ying Hu
Huiwen Yan
Yuqing Xie
Zimeng Shang
Yuling Liang
Wanxin Shi
Juan Du
Yuyong Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629052

1,391 views

Original Research

Published on 17 Dec 2025

Dynamic genetic regulation of CD4+ T cells in obstructive sleep apnea: integrating context-specific eQTL, Mendelian randomization, single-cell sequencing, and experimental validation

in Systems Immunology

Xinyue Zhang
Lingfei Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691347

1,692 views

Review

Published on 15 Dec 2025

Acoustic immune reprogramming: a novel paradigm for spatiotemporally controlled immune regulation using ultrasound-responsive nanoplatforms

in Systems Immunology

Tianyi Chen
Junli Chen
Mingkai Chen
Ruixiao Song
Mingsi Wang
Xiaolong Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715455

1,594 views

Original Research

Published on 12 Dec 2025

Deep learning-aided inter-species-comparison reveals shared and distinct molecular patterns in cynomolgus monkey and humans following non-specific T cell activation

in Systems Immunology

Vincent D. Friedrich
Kari Neier
Kristina Müller
Birgit Fogal
Zuzana Loncova
Michael Rade
Muhammad Shoaib
Ulrike Köhl
Kathleen Hoyt
Parimal Pande

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603716

3,089 views

Original Research

Published on 12 Dec 2025

SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population

in Systems Immunology

Nasima Sultana
Himani Adhikari
Achintya Mohan Goswami
Amalesh Mondal
Indranil Ganai
Himani Biswas
Asif Iqbal
Aratrika Das
Saibal Moitra
Sanjoy Podder

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689340

1,550 views

Correction

Published on 12 Dec 2025

Correction: The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

in Systems Immunology

Shuangyu Chen
Wenqian Chen
Tinghui Xu
Jiayang Li
Jianghao Yu
Yibo He
Shengliang Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761409

535 views
1 citation

Original Research

Published on 12 Dec 2025

Application of the Richards function to serum antibody titration

in Systems Immunology

Ágnes Kovács
Krisztián Papp
József Prechl
Tamás Pfeil

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657633

1,276 views

Original Research

Published on 10 Dec 2025

Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn’s disease: insights from a systems biology and artificial intelligence-based approach

in Systems Immunology

Ignacio Marín-Jiménez
Mónica Sierra-Ausín
Teresa Letosa-Abián
Jesús Aparicio
Carmen Montoto-Otero
Silvia Sánchez-Ramón

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699203

1,702 views

Correction

Published on 10 Dec 2025

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

in Systems Immunology

Dan Chen
Xiyi Huang
Chun Wang
Cheng Zheng
Yunhao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746347

617 views

Original Research

Published on 08 Dec 2025

Concentration monitoring and dose optimization for infliximab in Crohn’s disease patients: a machine learning-based covariate ensemble model

in Systems Immunology

Yuewen Chen
Shoutian Zhang
Si Chen
Shaojun Jiang
Shuifang Zhou
Jing Liu
Zhoujie Liu
Rongfang Lin
Jianwen Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715241

1,496 views

Editorial

Published on 03 Dec 2025

Editorial: Systems immunology and computational omics for transformative medicine

in Systems Immunology

Aaron S. Meyer
Chuangqi Wang
Fan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746667

1,276 views

546 articles

articles

Multimodal analysis of TAAD pathogenesis: SHAP-enhanced interpretable models and single-cell sequencing analysis reveal immune microenvironment alterations

From disruption to remodeling: the evolution and therapeutic prospects of Neuroimmune Regulatory Circuitry after ischemic stroke

Classification of angioedema types using decision tree modeling

The role of 5-methylcytosine regulator-related genes in diagnostic and immune regulatory functions in atherosclerosis

Cuproptosis-driven reprogramming of fibroblast communication by GK is associated with the immune microenvironment in diabetic foot ulcers

Making deep immunophenotyping accessible: the successful application of a guided 23-parameter mouse immunophenotyping panel package provided through a shared resource

ULMnet: inferring physical cell-cell communication networks from scRNAseq data using univariate linear models

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

A fundamental relationship between TCR diversity, repertoire size and systemic clonal expansion: insights from 30,000 TCRβ repertoires

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

An integrative model of pro- and anti-inflammatory signaling pathways in macrophage differentiation: the role of NF-κB and CREB

Immunomodulation by bacterial products promotes innate signatures favorable to macrophage responses in tuberculosis infection

Systemic immune classification related to immune exhaustion evaluates the clinical response of patients with HBV-HCC after transarterial chemoembolization

Dynamic genetic regulation of CD4+ T cells in obstructive sleep apnea: integrating context-specific eQTL, Mendelian randomization, single-cell sequencing, and experimental validation

Acoustic immune reprogramming: a novel paradigm for spatiotemporally controlled immune regulation using ultrasound-responsive nanoplatforms

Deep learning-aided inter-species-comparison reveals shared and distinct molecular patterns in cynomolgus monkey and humans following non-specific T cell activation

SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population

Correction: The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

Application of the Richards function to serum antibody titration

Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn’s disease: insights from a systems biology and artificial intelligence-based approach

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

Concentration monitoring and dose optimization for infliximab in Crohn’s disease patients: a machine learning-based covariate ensemble model

Editorial: Systems immunology and computational omics for transformative medicine