Frontiers in Immunology | Systems Immunology

Original Research

Accepted on 14 Jun 2025

Prediction and immune landscape study of potentially key autophagyrelated biomarkers in preeclampsia with gestational diabetes mellitus

in Systems Immunology

Qin Wang
Xiaoqi Li
Wen Ye
Lin Lin
Kejun Ye
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571795

607 views

Original Research

Published on 12 Jun 2025

Hematopoietic effects of Fufang E’jiao Jiang revealed by microbiome, metabolome and transcriptome analyses: a multi-omics strategy

in Systems Immunology

Yueting Mo
Xiyuan He
Peixin Shi
Yifei Ning
Mingmei Zhou
Hao Cui
Ting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561477

878 views

Original Research

Accepted on 11 Jun 2025

Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors -a network metaanalysis

in Systems Immunology

Monika Golinska
Aleksander Rycerz
Matylda Sobczak
Jedrzej Chrzanowski
Konrad Stawiski
Wojciech Fendler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619434

116 views

Original Research

Published on 10 Jun 2025

Construction of a novel inflammatory-related prognostic signature of acute myelocytic leukemia based on conjoint analysis of single-cell and bulk RNA sequencing

in Systems Immunology

Yongfen Huang
Ping Yi
Yixuan Wang
Lingling Wang
Yongqin Cao
Jingbo Lu
Kun Fang
Yuexin Cheng
Yuqing Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565954

932 views

Original Research

Published on 10 Jun 2025

Distinct metabolomic signatures in allergic rhinitis with concurrent chronic spontaneous urticaria: an untargeted metabolomics analysis reveals novel biomarkers and pathway alterations

in Systems Immunology

Xiaohong Lyu
Yi Liu
Huaijun Zheng
Hongna Li
Zhoujie Wu
Yi Sun
Shanhong Wu
Xuehan Jiang
Shandong Wu
Rui Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1555664

1,052 views

Original Research

Accepted on 09 Jun 2025

Systemic Inflammatory Indices and Age-Dependent Severity in Acute Appendicitis: A Retrospective Cohort Study

in Systems Immunology

Catalin Vladut Ionut Feier
Andrei Motoc
Muntean C
Razvan Constantin Vonica
Vasile Gaborean
Sorin Olariu
Marius-Sorin Murariu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620459

131 views

Original Research

Accepted on 09 Jun 2025

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma

in Systems Immunology

Yuxiang Chi
Guoyuan Ma
Qiang Liu
Yz X
Defeng Liu
Jiajun Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608407

177 views

Original Research

Accepted on 09 Jun 2025

CD79A and GADD45A as Novel Immune-Related Biomarkers for Respiratory Syncytial Virus Severity in Children: An Integrated Machine Learning Analysis and Clinical Validation

in Systems Immunology

Juan Juan Chen
Zhang Ze Lu
Yuxin Jing
Na Lin
Mei Xing Nong
Yan Qin
Jie Wei
Jin Yang Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609183

263 views

Original Research

Published on 09 Jun 2025

Inflammatory markers in pregnancy – identifying drivers in four large cohorts

in Systems Immunology

Frederieke A. J. Gigase
Anna Suleri
Elena Isaevska
Anna-Sophie Rommel
Myrthe G. B. M. Boekhorst
Olga Dmitrichenko
Hanan El Marroun
Eric A. P. Steegers
Manon H. J. Hillegers
Ryan L. Muetzel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561798

1,157 views

Original Research

Published on 09 Jun 2025

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction

in Systems Immunology

Jingjing Chen
Dan Zhang
Chengxiu Zhu
Lin Lin
Kejun Ye
Ying Hua
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595222

1,283 views

Original Research

Published on 05 Jun 2025

Axl inhibitor-mediated reprogramming of the myeloid compartment of the in vitro tumor microenvironment is influenced by prior targeted therapy treatment

in Systems Immunology

Anisha Datta
Laura C. Bahlmann
Diana N. Gong
Erin N. Tevonian
James B. Lorens
Douglas A. Lauffenburger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601420

1,587 views

Original Research

Published on 05 Jun 2025

Targeting inflammatory macrophages with hyaluronan tetrasaccharide: effects on fibroblast collagen degradation and synthesis

in Systems Immunology

Eiko Uno
Florence Kim
Mihoko Yoshino
Yasunari Sato
Masao Hashimoto
Kenji Watanabe
Yoichi Mizukami
Jun Muto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1592751

1,526 views

Original Research

Published on 05 Jun 2025

Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation

in Systems Immunology

Huan Ma
Xiayan Qian
Xiaodong Song
Rongjie Jiang
Jialin Li
Fang Xiao
Ruoxu Dou
Xiangdong Guan
Ka Yin Lui
Shuhe Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610519

1,133 views

Original Research

Published on 03 Jun 2025

Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections

in Systems Immunology

Hao Xing
Junlin Pan
Huan Liu
Yanan Wang
Zhengqi Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600194

1,094 views

Systematic Review

Published on 02 Jun 2025

Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review

in Systems Immunology

Xianghui Zhao
Peiying Lv
Zixing Cai
Jun Dong
Wenxiang Chen
Liang Sun
Ruiyue Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579924

1,618 views

Original Research

Published on 30 May 2025

KDDC: a new framework that integrates kmers, dataset filtering, dimension reduction and classification algorithms to achieve immune cell heterogeneity classification

in Systems Immunology

Nan Zhang
Shishun Zhao
Runze Wu
Xizi Luo
Ming Yang
Zecheng Chang
Jianting Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602907

901 views