Frontiers in Immunology | Systems Immunology

Original Research

Published on 26 Mar 2025

Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke

in Systems Immunology

Tianzhi Li
Xiaojia Kang
Sijie Zhang
Yihan Wang
Jinshan He
Hongyan Li
Chen Shao
Jingsong Kang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561544

1,273 views

Original Research

Published on 24 Mar 2025

A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma

in Systems Immunology

Jiale Fang
Siyuan Yu
Wei Wang
Cheng Liu
Xiaojia Lv
Jiaqi Jin
Xiaomin Han
Fang Zhou
Yukun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524120

1,252 views

Original Research

Published on 21 Mar 2025

Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning

in Systems Immunology

Junyang Ma
Shufu Hou
Xinxin Gu
Peng Guo
Jiankang Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533959

1,084 views

Original Research

Published on 21 Mar 2025

Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

in Systems Immunology

Piia Karisola
Mari Kanerva
Aki Vuokko
Helena Liira
Shuyuan Wang
Kirsi Kvarnström
Mikko Varonen
Hille Suojalehto
Harri Alenius

Frontiers in Immunology

doi 10.3389/fimmu.2025.1500997

758 views

Editorial

Published on 18 Mar 2025

Editorial: Spatial immunology of tissue microenvironments

in Systems Immunology

Roslyn A. Kemp
Felix Marsh-Wakefield

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584850

590 views

Correction

Published on 13 Mar 2025

Corrigendum: Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

in Systems Immunology

Wenyu Fu
Qinqin Xie
Pengfei Yu
Shuang Liu
Lingyao Xu
Xiaowei Ye
Wei Zhao
Qishan Wang
Yuchun Pan
Zhe Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588642

404 views

Original Research

Published on 12 Mar 2025

Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer

in Systems Immunology

Teng Wang
Zhaoming Chen
Wang Wang
Heng Wang
Shenglong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556386

1,451 views

Correction

Published on 07 Mar 2025

Corrigendum: Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

in Systems Immunology

Aliakbar Hasankhani
Abolfazl Bahrami
Negin Sheybani
Behzad Aria
Behzad Hemati
Farhang Fatehi
Hamid Ghaem Maghami Farahani
Ghazaleh Javanmard
Mahsa Rezaee
John P. Kastelic

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572273

401 views

Methods

Published on 28 Feb 2025

OnmiMHC: a machine learning solution for UCEC tumor vaccine development through enhanced peptide-MHC binding prediction

in Systems Immunology

Fangfang Jian
Haihua Cai
Qushuo Chen
Xiaoyong Pan
Weiwei Feng
Ye Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550252

927 views

Original Research

Published on 28 Feb 2025

Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

in Systems Immunology

Wenyu Fu
Qinqin Xie
Pengfei Yu
Shuang Liu
Lingyao Xu
Xiaowei Ye
Wei Zhao
Qishan Wang
Yuchun Pan
Zhe Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1530214

1,032 views

Original Research

Published on 25 Feb 2025

In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay

in Systems Immunology

Ágnes Kovács
Zoltán Hérincs
Krisztián Papp
Jakub Zbigniew Kaczmarek
Daniel Nyberg Larsen
Pernille Stage
László Bereczki
Eszter Ujhelyi
Tamás Pfeil
József Prechl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1494624

704 views

Original Research

Published on 19 Feb 2025

Clinical application of Myxovirus resistance protein A as a diagnostic biomarker to differentiate viral and bacterial respiratory infections in pediatric patients

in Systems Immunology

Min Zhu
Lijin Chen
Jiali Cao
Jianguo Cai
Shuying Huang
Huibin Wang
Huanjuan He
Zimin Chen
Rongfu Huang
Huiming Ye

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540675

891 views

Systematic Review

Published on 14 Feb 2025

Research trends of inflammation in autism spectrum disorders: a bibliometric analysis

in Systems Immunology

Yajing Chen
Xiaohuan Du
Xianming Zhang
Fang Li
Shuwei Yuan
Wenjing Wang
Zengyan Zhu
Mei Wang
Chao Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534660

1,359 views

Hypothesis and Theory

Published on 12 Feb 2025

Unique gating strategy identifier based on the Prime Population System and Gödel Numbers

in Systems Immunology

Antonio Cosma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1481412

689 views

Original Research

Published on 04 Feb 2025

Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers

in Systems Immunology

Ruohua Li
Cuixia Zhou
Kejun Ye
Haihui Chen
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1496046

1,297 views

Original Research

Published on 23 Jan 2025

Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning

in Systems Immunology

Tao Zhou
Can Zhu
Wei Zhang
Qiongfang Wu
Mingqiang Deng
Zhiwei Jiang
Longfei Peng
Hao Geng
Zhouting Tuo
Ci Zou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1511529

1,583 views