Frontiers in Immunology | Systems Immunology

Original Research

Published on 13 Jan 2025

Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases

in Systems Immunology

Cheng-Cheng Deng
Xue-Yan Xu
Yan Zhang
Long-Can Liu
Xuan Wang
Jun-Yi Chen
Liu-Yi Yao
Ding-Heng Zhu
Bin Yang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1522076

749 views

Mini Review

Published on 10 Jan 2025

Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways

in Systems Immunology

Fangbo Lin

Frontiers in Immunology

doi 10.3389/fimmu.2024.1543009

637 views

Review

Published on 09 Jan 2025

Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy

in Systems Immunology

Jay Chadokiya
Kai Chang
Saurabh Sharma
Jack Hu
Jennie R. Lill
Jennifer Dionne
Amanda Kirane

Frontiers in Immunology

doi 10.3389/fimmu.2024.1520860

974 views

Original Research

Published on 08 Jan 2025

Drp1–associated genes implicated in sepsis survival

in Systems Immunology

Marissa D. Pokharel
Anlin Feng
Ying Liang
Wenli Ma
Saurabh Aggarwal
Hoshang Unwalla
Stephen M. Black
Ting Wang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1516145

472 views

Original Research

Published on 06 Jan 2025

Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma

in Systems Immunology

Zhengyan Li
Wei Chen
Shu Yao
Zuxiang Peng
Hongming Liu
Yongliang Tang
Yi Feng

Frontiers in Immunology

doi 10.3389/fimmu.2024.1448878

663 views

Original Research

Published on 03 Jan 2025

Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing

in Systems Immunology

Yafeng Jiang
Zhaolan Hu
Roujie Huang
Kaying Ho
Pengfei Wang
Jin Kang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1512483

878 views

Original Research

Published on 23 Dec 2024

Geny: a genotyping tool for allelic decomposition of killer cell immunoglobulin-like receptor genes

in Systems Immunology

Qinghui Zhou
Mazyar Ghezelji
Ananth Hari
Michael K. B. Ford
Connor Holley
S. Cenk Sahinalp
Ibrahim Numanagić

Frontiers in Immunology

doi 10.3389/fimmu.2024.1494995

342 views

Original Research

Published on 11 Dec 2024

Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice

in Systems Immunology

Chenlin Wang
Yanan Wu
Chao Liu
Yang Li
Song Mi
Xiaofan Yang
Tong Liu
Yuanjing Tian
YingYing Zhang
Pingping Hu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1405020

677 views

Editorial

Published on 09 Dec 2024

Editorial: Systems immunology to advance vaccine development

in Systems Immunology

Jue Hou
Helder I. Nakaya

Frontiers in Immunology

doi 10.3389/fimmu.2024.1527238

480 views

Original Research

Published on 06 Dec 2024

Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis

in Systems Immunology

Yu Liu
Weijie Li
Lei Lei
Yaoliang Zhou
Mingcheng Huang
Yide Li
Xiaoying Zhang
Yingyu Jiang
Haiqi Wu
Zhihua Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2024.1449975

1,110 views

Original Research

Published on 06 Dec 2024

Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19

in Systems Immunology

Vasiliy E. Akimov
Dmitriy I. Tychinin
Olga A. Antonova
Abusaid M. Shaymardanov
Maria D. Voronina
Kseniia A. Deinichenko
Oleg D. Fateev
Vladimir S. Yudin
Sergey M. Yudin
Vladimir E. Mukhin

Frontiers in Immunology

doi 10.3389/fimmu.2024.1415317

931 views

Original Research

Published on 05 Dec 2024

Comprehensive analysis of skin growth-related hub genes and microenvironment characterization in a mouse expanded skin model

in Systems Immunology

Yinmin Wang
Wenxiao Qi
Shun Yu
Xianyu Zhou
Xiuxia Wang
Fei Liu
Rui Jin
Xusong Luo
Qiangliang Ma
Lin Lu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1306353

913 views

Original Research

Published on 05 Dec 2024

Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity

in Systems Immunology

Hope A. Townsend
Kaylee J. Rosenberger
Lauren A. Vanderlinden
Jun Inamo
Fan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1454263

1,732 views

Original Research

Published on 04 Dec 2024

Machine learning-based diagnostic model of lymphatics-associated genes for new therapeutic target analysis in intervertebral disc degeneration

in Systems Immunology

Maoqiang Lin
Shaolong Li
Yabin Wang
Guan Zheng
Fukang Hu
Qiang Zhang
Pengjie Song
Haiyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2024.1441028

891 views

Original Research

Published on 27 Nov 2024

Computational analysis of the functional impact of MHC-II-expressing triple-negative breast cancer

in Systems Immunology

Yang Cui
Weihang Zhang
Xin Zeng
Yitao Yang
Sung-Joon Park
Kenta Nakai

Frontiers in Immunology

doi 10.3389/fimmu.2024.1497251

1,503 views

Original Research

Published on 22 Nov 2024

Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes

in Systems Immunology

Wenxu Wang
Jincheng Lu
Ningyun Pan
Huiying Zhang
Jingcen Dai
Jie Li
Cheng Chi
Liumei Zhang
Liang Wang
Mengying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1462003

1,605 views

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Articles

Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases

Tuberculous meningitis diagnosis and treatment: classic approaches and high-throughput pathways

Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy

Drp1–associated genes implicated in sepsis survival

Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma

Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing

Geny: a genotyping tool for allelic decomposition of killer cell immunoglobulin-like receptor genes

Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice

Editorial: Systems immunology to advance vaccine development

Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis

Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19

Comprehensive analysis of skin growth-related hub genes and microenvironment characterization in a mouse expanded skin model

Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity

Machine learning-based diagnostic model of lymphatics-associated genes for new therapeutic target analysis in intervertebral disc degeneration

Computational analysis of the functional impact of MHC-II-expressing triple-negative breast cancer

Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes