Frontiers in Immunology | Systems Immunology

Original Research

Published on 16 Dec 2021

Prostate Cancer: Early Detection and Assessing Clinical Risk Using Deep Machine Learning of High Dimensional Peripheral Blood Flow Cytometric Phenotyping Data

in Systems Immunology

Georgina Cosma
Stéphanie E. McArdle
Gemma A. Foulds
Simon P. Hood
Stephen Reeder
Catherine Johnson
Masood A. Khan
A. Graham Pockley

Frontiers in Immunology

doi 10.3389/fimmu.2021.786828

5,836 views
13 citations

Original Research

Published on 15 Dec 2021

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic

in Systems Immunology

Aliakbar Hasankhani
Abolfazl Bahrami
Negin Sheybani
Behzad Aria
Behzad Hemati
Farhang Fatehi
Hamid Ghaem Maghami Farahani
Ghazaleh Javanmard
Mahsa Rezaee
John P. Kastelic

Frontiers in Immunology

doi 10.3389/fimmu.2021.789317

20,125 views
54 citations

Original Research

Published on 15 Dec 2021

Integrative Transcriptomics Reveals Activation of Innate Immune Responses and Inhibition of Inflammation During Oral Immunotherapy for Egg Allergy in Children

in Systems Immunology

Piia Karisola
Kati Palosuo
Victoria Hinkkanen
Lukas Wisgrill
Terhi Savinko
Nanna Fyhrquist
Harri Alenius
Mika J. Mäkelä

Frontiers in Immunology

doi 10.3389/fimmu.2021.704633

6,037 views
12 citations

Original Research

Published on 06 Dec 2021

A Direct MS-Based Approach to Profile Human Milk Secretory Immunoglobulin A (IgA1) Reveals Donor-Specific Clonal Repertoires With High Longitudinal Stability

in Systems Immunology

Albert Bondt
Kelly A. Dingess
Max Hoek
Danique M. H. van Rijswijck
Albert J. R. Heck

Frontiers in Immunology

doi 10.3389/fimmu.2021.789748

5,867 views
16 citations

Original Research

Published on 01 Dec 2021

Identification and Validation of a Novel Six-Gene Expression Signature for Predicting Hepatocellular Carcinoma Prognosis

in Systems Immunology

Zongcai Yan
Meiling He
Lifeng He
Liuxia Wei
Yumei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2021.723271

6,655 views
8 citations

Original Research

Published on 30 Nov 2021

Increased B Cell Selection Stringency In Germinal Centers Can Explain Improved COVID-19 Vaccine Efficacies With Low Dose Prime or Delayed Boost

in Systems Immunology

Amar K. Garg
Soumya Mittal
Pranesh Padmanabhan
Rajat Desikan
Narendra M. Dixit

Frontiers in Immunology

doi 10.3389/fimmu.2021.776933

7,319 views
31 citations

Review

Published on 29 Nov 2021

Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities

in Systems Immunology

Modjtaba Emadi-Baygi
Mahsa Ehsanifard
Najmeh Afrashtehpour
Mahnaz Norouzi
Zahra Joz-Abbasalian

Frontiers in Immunology

doi 10.3389/fimmu.2021.778913

8,646 views
6 citations

Hypothesis and Theory

Published on 29 Nov 2021

Single-Cell and Bulk RNA-Sequencing Reveal Differences in Monocyte Susceptibility to Influenza A Virus Infection Between Africans and Europeans

in Systems Immunology

Mary B. O’Neill
Hélène Quach
Julien Pothlichet
Yann Aquino
Aurélie Bisiaux
Nora Zidane
Matthieu Deschamps
Valentina Libri
Milena Hasan
Shen-Ying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2021.768189

15,231 views
22 citations

Original Research

Published on 23 Nov 2021

Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma

in Systems Immunology

Na Li
Jiahong Wang
Xianquan Zhan

Frontiers in Immunology

doi 10.3389/fimmu.2021.752643

9,547 views
30 citations

Methods

Published on 19 Nov 2021

How to Prepare Spectral Flow Cytometry Datasets for High Dimensional Data Analysis: A Practical Workflow

in Systems Immunology

Hannah den Braanker
Margot Bongenaar
Erik Lubberts

Frontiers in Immunology

doi 10.3389/fimmu.2021.768113

43,720 views
31 citations

Perspective

Published on 16 Nov 2021

Systems Biology to Understand and Regulate Human Retroviral Proinflammatory Response

in Systems Immunology

Mohamed Helmy
Kumar Selvarajoo

Frontiers in Immunology

doi 10.3389/fimmu.2021.736349

5,424 views
9 citations

Technology and Code

Published on 05 Nov 2021

FlowKit: A Python Toolkit for Integrated Manual and Automated Cytometry Analysis Workflows

in Systems Immunology

Scott White
John Quinn
Jennifer Enzor
Janet Staats
Sarah M. Mosier
James Almarode
Thomas N. Denny
Kent J. Weinhold
Guido Ferrari
Cliburn Chan

Frontiers in Immunology

doi 10.3389/fimmu.2021.768541

24,691 views
29 citations

Original Research

Published on 05 Nov 2021

Continuous Modeling of T CD4 Lymphocyte Activation and Function

in Systems Immunology

David Martínez-Méndez
Luis Mendoza
Carlos Villarreal
Leonor Huerta

Frontiers in Immunology

doi 10.3389/fimmu.2021.743559

8,214 views
12 citations

Original Research

Published on 20 Oct 2021

Ductal Macrophages Predominate in the Immune Landscape of the Lactating Mammary Gland

in Systems Immunology

Chervin Hassel
Blandine Gausserès
Laurence Guzylack-Piriou
Gilles Foucras

Frontiers in Immunology

doi 10.3389/fimmu.2021.754661

6,668 views
22 citations

Original Research

Published on 20 Oct 2021

FUCA2 Is a Prognostic Biomarker and Correlated With an Immunosuppressive Microenvironment in Pan-Cancer

in Systems Immunology

Anyuan Zhong
Ting Chen
Yufei Xing
Xue Pan
Minhua Shi

Frontiers in Immunology

doi 10.3389/fimmu.2021.758648

12,830 views
18 citations

Original Research

Published on 19 Oct 2021

N6-Methyladenosine Methylomic Landscape of Lung Tissues in Murine Acute Allergic Asthma

in Systems Immunology

Fangzhou Teng
Weifeng Tang
Tulake Wuniqiemu
Jingjing Qin
Yaolong Zhou
Xi Huang
Shiyuan Wang
Xueyi Zhu
Zhao Tang
La Yi

Frontiers in Immunology

doi 10.3389/fimmu.2021.740571

6,441 views
19 citations