Frontiers in Immunology | Systems Immunology

Original Research

Published on 03 Jan 2025

Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing

in Systems Immunology

Yafeng Jiang
Zhaolan Hu
Roujie Huang
Kaying Ho
Pengfei Wang
Jin Kang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1512483

1,510 views

Original Research

Published on 23 Dec 2024

Geny: a genotyping tool for allelic decomposition of killer cell immunoglobulin-like receptor genes

in Systems Immunology

Qinghui Zhou
Mazyar Ghezelji
Ananth Hari
Michael K. B. Ford
Connor Holley
S. Cenk Sahinalp
Ibrahim Numanagić

Frontiers in Immunology

doi 10.3389/fimmu.2024.1494995

494 views

Original Research

Published on 11 Dec 2024

Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice

in Systems Immunology

Chenlin Wang
Yanan Wu
Chao Liu
Yang Li
Song Mi
Xiaofan Yang
Tong Liu
Yuanjing Tian
YingYing Zhang
Pingping Hu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1405020

930 views
1 citation

Editorial

Published on 09 Dec 2024

Editorial: Systems immunology to advance vaccine development

in Systems Immunology

Jue Hou
Helder I. Nakaya

Frontiers in Immunology

doi 10.3389/fimmu.2024.1527238

679 views

Original Research

Published on 06 Dec 2024

Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis

in Systems Immunology

Yu Liu
Weijie Li
Lei Lei
Yaoliang Zhou
Mingcheng Huang
Yide Li
Xiaoying Zhang
Yingyu Jiang
Haiqi Wu
Zhihua Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2024.1449975

1,529 views

Original Research

Published on 06 Dec 2024

Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19

in Systems Immunology

Vasiliy E. Akimov
Dmitriy I. Tychinin
Olga A. Antonova
Abusaid M. Shaymardanov
Maria D. Voronina
Kseniia A. Deinichenko
Oleg D. Fateev
Vladimir S. Yudin
Sergey M. Yudin
Vladimir E. Mukhin

Frontiers in Immunology

doi 10.3389/fimmu.2024.1415317

1,183 views

Original Research

Published on 05 Dec 2024

Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity

in Systems Immunology

Hope A. Townsend
Kaylee J. Rosenberger
Lauren A. Vanderlinden
Jun Inamo
Fan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1454263

2,446 views
1 citation

Original Research

Published on 05 Dec 2024

Comprehensive analysis of skin growth-related hub genes and microenvironment characterization in a mouse expanded skin model

in Systems Immunology

Yinmin Wang
Wenxiao Qi
Shun Yu
Xianyu Zhou
Xiuxia Wang
Fei Liu
Rui Jin
Xusong Luo
Qiangliang Ma
Lin Lu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1306353

1,162 views

Original Research

Published on 04 Dec 2024

Machine learning-based diagnostic model of lymphatics-associated genes for new therapeutic target analysis in intervertebral disc degeneration

in Systems Immunology

Maoqiang Lin
Shaolong Li
Yabin Wang
Guan Zheng
Fukang Hu
Qiang Zhang
Pengjie Song
Haiyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2024.1441028

1,179 views

Original Research

Published on 27 Nov 2024

Computational analysis of the functional impact of MHC-II-expressing triple-negative breast cancer

in Systems Immunology

Yang Cui
Weihang Zhang
Xin Zeng
Yitao Yang
Sung-Joon Park
Kenta Nakai

Frontiers in Immunology

doi 10.3389/fimmu.2024.1497251

1,962 views

Original Research

Published on 22 Nov 2024

Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes

in Systems Immunology

Wenxu Wang
Jincheng Lu
Ningyun Pan
Huiying Zhang
Jingcen Dai
Jie Li
Cheng Chi
Liumei Zhang
Liang Wang
Mengying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1462003

2,143 views

Review

Published on 12 Nov 2024

Navigating the nano-bio immune interface: advancements and challenges in CNS nanotherapeutics

in Systems Immunology

Chantalle Moulton
Anna Baroni
Erica Quagliarini
Lucia Leone
Luca Digiacomo
Marta Morotti
Giulio Caracciolo
Maria Vittoria Podda
Ennio Tasciotti

Frontiers in Immunology

doi 10.3389/fimmu.2024.1447567

1,607 views

Brief Research Report

Published on 11 Nov 2024

Periodontal ligament tissues support neutrophil differentiation and maturation processes

in Systems Immunology

Guillermo Villagómez-Olea
Eileen Uribe-Querol
Francisco Javier Marichi-Rodríguez
Jorge Meléndez-Zajgla
Marco Antonio Alvaréz-Pérez
Carlos Rosales

Frontiers in Immunology

doi 10.3389/fimmu.2024.1446541

1,403 views

Original Research

Published on 11 Nov 2024

Molecular hybridization modification improves the stability and immunomodulatory activity of TP5 peptide

in Systems Immunology

Junyong Wang
Yuan Tang
Xuelian Zhao
Zetao Ding
Marhaba Ahmat
Dayong Si
Rijun Zhang
Xubiao Wei

Frontiers in Immunology

doi 10.3389/fimmu.2024.1472839

697 views
1 citation

Original Research

Published on 07 Nov 2024

Ensemble modeling of SARS-CoV-2 immune dynamics in immunologically naïve rhesus macaques predicts that potent, early innate immune responses drive viral elimination

in Systems Immunology

Catherine Byrne
Joshua T. Schiffer

Frontiers in Immunology

doi 10.3389/fimmu.2024.1426016

976 views

Review

Published on 04 Nov 2024

Gut microbiome and metabolomics in systemic sclerosis: feature, link and mechanisms

in Systems Immunology

Qicen Yao
Wenfeng Tan
Feihu Bai

Frontiers in Immunology

doi 10.3389/fimmu.2024.1475528

1,889 views
1 citation

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Articles

Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing

Geny: a genotyping tool for allelic decomposition of killer cell immunoglobulin-like receptor genes

Nervonic acid alleviates radiation-induced early phase lung inflammation by targeting macrophages activation in mice

Editorial: Systems immunology to advance vaccine development

Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis

Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19

Evaluating methods for integrating single-cell data and genetics to understand inflammatory disease complexity

Comprehensive analysis of skin growth-related hub genes and microenvironment characterization in a mouse expanded skin model

Machine learning-based diagnostic model of lymphatics-associated genes for new therapeutic target analysis in intervertebral disc degeneration

Computational analysis of the functional impact of MHC-II-expressing triple-negative breast cancer

Identification of early Alzheimer’s disease subclass and signature genes based on PANoptosis genes

Navigating the nano-bio immune interface: advancements and challenges in CNS nanotherapeutics

Periodontal ligament tissues support neutrophil differentiation and maturation processes

Molecular hybridization modification improves the stability and immunomodulatory activity of TP5 peptide

Ensemble modeling of SARS-CoV-2 immune dynamics in immunologically naïve rhesus macaques predicts that potent, early innate immune responses drive viral elimination

Gut microbiome and metabolomics in systemic sclerosis: feature, link and mechanisms