Frontiers in Immunology | Systems Immunology

Editorial

Published on 30 May 2025

Editorial: Revolutionizing immunological disease understanding through single cell multi-omics technologies

in Systems Immunology

Ying Zhu
Veronica G. Anania
Jennie R. Lill
Zora Modrusan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628120

1,199 views

Perspective

Published on 29 May 2025

Multi-physiology modeling of the immune system in the era of precision immunotherapy

in Systems Immunology

Sunghyun Hong
Kyemyung Park

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548768

950 views

Original Research

Published on 29 May 2025

Transcriptional regulatory logic orchestrating lymphoid and myeloid cell fate decisions

in Systems Immunology

Rasoul Godini
Jingjing Yan
Michaël Chopin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544483

1,302 views

Original Research

Published on 27 May 2025

Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation

in Systems Immunology

Jingyi Hou
Lihan Wang
Naiqiang Zhu
Xueli Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543584

1,349 views

Review

Accepted on 23 May 2025

Advanced Omics Approaches in Liver Transplant Settings: Current Applications and Future Prospectives

in Systems Immunology

Huijuan Wang
Yifeng Zhou
Lu Yu
Zhengtao Liu
Shusen Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564248

203 views

Original Research

Published on 21 May 2025

Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma

in Systems Immunology

Maria Eduarda de Castro
Gustavo Forlin de Siqueira
Jean Ferrante Mariano
Marina Malta Letro Kizys
Lucieli Ceolin
Fernando Augusto Soares
Rodrigo Natal
Humberto Carneiro
Rodrigo Nalio Ramos
Laura Sterian Ward

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579205

1,438 views

Original Research

Published on 20 May 2025

Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2

in Systems Immunology

N. S. Suneesh
Kishore Dhotre
Pratik Mahajan
Debashree Dass
Anwesha Banerjee
Nikhat J. Siddiqi
Abdul Malik
Manali Joshi
Abdul Arif Khan
Vijay Nema

Frontiers in Immunology

doi 10.3389/fimmu.2025.1586271

2,923 views

Original Research

Published on 16 May 2025

Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding

in Systems Immunology

Tingting Zhang
Laurie Baert
Neal W. Woodbury
Laimonas Kelbauskas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528524

1,529 views

Original Research

Published on 13 May 2025

Clinical and mechanistic relevance of high-dimensionality analysis of the paediatric sepsis immunome

in Systems Immunology

Dandan Pi
Judith Ju Ming Wong
Katherine Nay Yaung
Nicholas Kim Huat Khoo
Su Li Poh
Martin Wasser
Pavanish Kumar
Thaschawee Arkachaisri
Feng Xu
Herng Lee Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569096

1,253 views

Original Research

Published on 13 May 2025

Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing

in Systems Immunology

Hua Huang
Jiaze Ma
An Kang
Tianwei Guo
Wei Sun
Yan Xu
Lijiang Ji

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534768

2,030 views

Original Research

Published on 13 May 2025

Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

in Systems Immunology

Jingjing Zhang
Ling Ma
Hanyin Deng
Wenqian Yi
Alim Tohtihan
Xiaojun Tang
Xiudi Wu
Xuebing Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580540

1,679 views

Original Research

Published on 12 May 2025

Exploring shared pathogenic mechanisms and biomarkers in hepatic fibrosis and inflammatory bowel disease through bioinformatics and machine learning

in Systems Immunology

Shangkun Li
Haoyu Li
Mingran Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533246

1,718 views

Original Research

Published on 08 May 2025

Single cell RNA-sequencing identified CCR7+/RELB+/IRF1+ T cell responding for juvenile idiopathic arthritis pathogenesis

in Systems Immunology

Lewei He
Xue Gong
Hui Guo
Kaiyu Zhou
Yue Lan
Mingyi Lv
Xiaoliang Liu
Sha Lin
Yimin Hua
Junling Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528446

1,649 views

Review

Published on 05 May 2025

Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies

in Systems Immunology

Ruotong Cao
Huasheng Lv
Baopeng Tang
Yanmei Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561061

1,518 views

Mini Review

Published on 02 May 2025

Comprehending toll-like receptors: pivotal element in the pathogenesis of sepsis and its complications

in Systems Immunology

Wei Wang
Shengtian Mu
Dongli Yan
Huan Qin
Zhen Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591011

1,698 views
1 citation

Original Research

Published on 01 May 2025

Interpretable machine learning algorithms reveal gut microbiome features associated with atopic dermatitis

in Systems Immunology

Jingtai Ma
Yiting Fang
Shiqi Li
Lilian Zeng
Siyi Chen
Zhifeng Li
Guiyuan Ji
Xingfen Yang
Wei Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528046

1,945 views