Frontiers in Immunology | Systems Immunology

Original Research

Published on 22 Oct 2025

Differential gene expression profiling and machine learning-based discovery of key genetic markers in VTE and CKD

in Systems Immunology

Hui Li
Cai Lin
Junjie Kuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654673

2,225 views

Original Research

Published on 20 Oct 2025

Identification of genes associated with disulfidptosis in the subacute phase of spinal cord injury and analysis of potential therapeutic targets

in Systems Immunology

Shenglong Wang
Xiaochen Su
Wenting Xu
Yonghui Zhao
Yulong Zhang
Yingang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642757

2,766 views

Original Research

Published on 20 Oct 2025

Membraneless organelles-based integrative analysis constructs an immune-related prognostic signature and identifies NRG1 as a novel methylation biomarker in colorectal cancer

in Systems Immunology

Jingsong Cheng
Nanting Chen
Qingyao Yin
Ziheng Zheng
Xue Chen
Xinyi Zhu
Yuanyuan Wan
Ningxi Wang
Siqi Luo
Chengxi Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678096

2,688 views

Systematic Review

Published on 17 Oct 2025

Global research trends on macrophage polarization in osteoarthritis: a bibliometric analysis

in Systems Immunology

Abdulaziz S. Bamahel
Jia Liu
Zhuoyu Zhang
Yizhuo Deng
Chaoyou Xue
Xun Sun
Wei Wu
Sheng Bi
Nadeem Zubair
Guangchen Nie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659938

3,486 views

Original Research

Published on 17 Oct 2025

Sulfotransferase SULT2B1 contributes to the epithelial–immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis

in Systems Immunology

Kenji Morino
Sayaka Akiyoshi
Keisuke Matsubara
Yuki Sugiura
Yoshihiro Izumi
Shu Yotsumoto
Kazuhiko Yamamura
Rae Maeda
Masatomo Takahashi
Keisuke Nakata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1632426

2,430 views

Original Research

Published on 15 Oct 2025

Identification of hub genes in congenital hypothyroidism and construction of the associated immune regulatory network

in Systems Immunology

Mingliang Shan
Li Xu
Wenzhe Yang
Shiguo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608098

3,074 views

Original Research

Published on 02 Oct 2025

Artificial intelligence–driven analysis of antibody and nucleic acid biomarkers for enhanced disease diagnostics

in Systems Immunology

Zihan Liu
Feng Zhu
Mei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633989

2,114 views

Review

Published on 30 Sep 2025

AI-based hardware and software tools in microscopy to boost research in immunology and virology

in Systems Immunology

Diego Morone
Rocco D’Antuono

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610345

4,870 views
2 citations

Original Research

Published on 30 Sep 2025

Integrated transcriptomic and single-cell RNA-seq analysis identifies CLCNKB, KLK1 and PLEKHA4 as key gene of AKI-to-CKD progression

in Systems Immunology

Fanhua Zeng
Zhenhua Yang
Zufeng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628962

4,391 views
1 citation

Methods

Published on 29 Sep 2025

A flexible systems analysis pipeline for elucidating spatial relationships in the tumor microenvironment linked with cellular phenotypes and patient-level features

in Systems Immunology

Gabriel F. Hanson
Kate A. Goundry
Remziye E. Wessel
Michael G. Brown
Timothy N. J. Bullock
Sepideh Dolatshahi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642527

3,290 views
1 citation

Original Research

Published on 26 Sep 2025

Protein phosphorylation regulation of key genes in oral squamous cell carcinoma and their role in the immune microenvironment

in Systems Immunology

Yu Zeng
Chunyang Wang
Wenli Zhao
Ye Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677807

2,753 views

Original Research

Published on 26 Sep 2025

Integration of multi-omics and machine learning strategies identifies immune related candidate biomarkers in inflammation-associated hypertrophic cardiomyopathy

in Systems Immunology

Qingzhu Liang
Jin Wang
Qingxiao Nong
Shouwen Tao
Dalang Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645382

6,593 views
1 citation

Original Research

Published on 19 Sep 2025

The role of eosinophils and their activation state in hypereosinophilia-associated heart disease

in Systems Immunology

Usman Sunusi
Immaculeta Osuji
Benjamin Ziegelmeyer
Mario Medvedovic
Haley Todd
Joe Abou-Khalil
Nives Zimmermann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635483

4,738 views

Original Research

Published on 16 Sep 2025

Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality

in Systems Immunology

Suzanne K. Shoffner-Beck
Robert M. Theisen
Kade E. Wong
Supachai Rerks-Ngarm
Punnee Pitisuttithum
Sorachai Nitayaphan
Stephen Kent
Amy W. Chung
Kelly B. Arnold

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578500

3,437 views

Opinion

Published on 15 Sep 2025

Opinion on “Artificial intelligence in sepsis early prediction and diagnosis using unstructured data in healthcare”

in Systems Immunology

Aifeng He
Leiming Xu
Shengkai Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629766

3,432 views

Original Research

Published on 12 Sep 2025

AI-assisted design of ligands for lipocalin-2

in Systems Immunology

Jacopo Sgrignani
Sara Buscarini
Patrizia Locatelli
Concetta Guerra
Alberto Furlan
Yingyi Chen
Giada Zoppi
Andrea Cavalli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631868

3,886 views
1 citation

Original Research

Published on 11 Sep 2025

PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome

in Systems Immunology

Hua Ma
Dahe Qi
Yating Xu
Tingting Shang
Yu Si
Wenyue Chen
Hongting Zhao
Qingling Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610713

4,336 views
2 citations

Mini Review

Published on 05 Sep 2025

Systems immunology: When systems biology meets immunology

in Systems Immunology

Lucía Alfonso-González
Francisco J. Fernández
M. Cristina Vega

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630488

5,043 views
5 citations

Opinion

Published on 04 Sep 2025

Reconciling specificity and non-specificity in antibody binding: an energy landscape framework for immunology education

in Systems Immunology

Zhiyong Wang
Jiaqi Li
Min Wang
Yan Yu
Yanxin Lu
Qiang Xia
Pei Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650722

2,630 views
1 citation

Review

Published on 02 Sep 2025

Topological data analysis in single cell biology

in Systems Immunology

Enrique Hernández-Lemus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1615278

4,851 views
1 citation

Original Research

Published on 01 Sep 2025

Single-cell RNA-seq reveals a repair pattern in cystic lesions in steroid induced osteonecrosis of the femoral head

in Systems Immunology

Peng Peng
Jiaqing Tian
Kun Lin
Weihua Fang
Fangming Yao
Xiaoqiang Yang
Wenyuan Hou
Fangjun Xiao
Shun Lu
Wei He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626337

3,425 views

Review

Published on 29 Aug 2025

Skin immune microenvironment in psoriasis: from bench to bedside

in Systems Immunology

Yi Yao
Li-Qing Chen
Yi-Bo Lv
Shun-Li Tang
Wei Shen
Hui Sun
Hua-Jie Zhong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643418

6,362 views
3 citations

Review

Published on 29 Aug 2025

Diagnosis of cancer, autoimmune and infectious diseases and prediction of the therapy effectiveness based on the individual’s immunotype

in Systems Immunology

Dmitry V. Tabakov
Anna A. Maznina
Ekaterina A. Astakhova
Anastasia E. Egorova
Elena N. Zakharova
Olga V. Glushkova
Ekaterina S. Petriaikina
Dmitry V. Svetlichnyy
Julia A. Krupinova
Viktor P. Bogdanov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658970

3,048 views
2 citations

Original Research

Published on 27 Aug 2025

CEACAM6 as a machine learning derived immune biomarker for predicting neoadjuvant chemotherapy response in HR+/HER2− breast cancer

in Systems Immunology

Dalang Fang
Jie Lin
Jin Wang
Qingxiao Nong
Shouwen Tao
Bimin Lu
Yanrong Yu
Hao Peng
Yingying Tian
Qunying Su

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662004

4,254 views
2 citations

546 articles

articles

Differential gene expression profiling and machine learning-based discovery of key genetic markers in VTE and CKD

Identification of genes associated with disulfidptosis in the subacute phase of spinal cord injury and analysis of potential therapeutic targets

Membraneless organelles-based integrative analysis constructs an immune-related prognostic signature and identifies NRG1 as a novel methylation biomarker in colorectal cancer

Global research trends on macrophage polarization in osteoarthritis: a bibliometric analysis

Sulfotransferase SULT2B1 contributes to the epithelial–immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis

Identification of hub genes in congenital hypothyroidism and construction of the associated immune regulatory network

Artificial intelligence–driven analysis of antibody and nucleic acid biomarkers for enhanced disease diagnostics

AI-based hardware and software tools in microscopy to boost research in immunology and virology

Integrated transcriptomic and single-cell RNA-seq analysis identifies CLCNKB, KLK1 and PLEKHA4 as key gene of AKI-to-CKD progression

A flexible systems analysis pipeline for elucidating spatial relationships in the tumor microenvironment linked with cellular phenotypes and patient-level features

Protein phosphorylation regulation of key genes in oral squamous cell carcinoma and their role in the immune microenvironment

Integration of multi-omics and machine learning strategies identifies immune related candidate biomarkers in inflammation-associated hypertrophic cardiomyopathy

The role of eosinophils and their activation state in hypereosinophilia-associated heart disease

Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality

Opinion on “Artificial intelligence in sepsis early prediction and diagnosis using unstructured data in healthcare”

AI-assisted design of ligands for lipocalin-2

PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome

Systems immunology: When systems biology meets immunology

Reconciling specificity and non-specificity in antibody binding: an energy landscape framework for immunology education

Topological data analysis in single cell biology

Single-cell RNA-seq reveals a repair pattern in cystic lesions in steroid induced osteonecrosis of the femoral head

Skin immune microenvironment in psoriasis: from bench to bedside

Diagnosis of cancer, autoimmune and infectious diseases and prediction of the therapy effectiveness based on the individual’s immunotype

CEACAM6 as a machine learning derived immune biomarker for predicting neoadjuvant chemotherapy response in HR+/HER2− breast cancer