Frontiers in Immunology | Systems Immunology

Original Research

Published on 27 Aug 2025

CEACAM6 as a machine learning derived immune biomarker for predicting neoadjuvant chemotherapy response in HR+/HER2− breast cancer

in Systems Immunology

Dalang Fang
Jie Lin
Jin Wang
Qingxiao Nong
Shouwen Tao
Bimin Lu
Yanrong Yu
Hao Peng
Yingying Tian
Qunying Su

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662004

3,704 views
1 citation

Correction

Published on 22 Aug 2025

Correction: Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis

in Systems Immunology

Shuaiwei Wang
Hao Fu
Xiaoqing Li
Hongrui Xu
Yu Bai
Wenjun Jiang
Xiaozhe Cheng
Na Chen
Yijie Zhang
Wei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678276

957 views

Original Research

Published on 21 Aug 2025

Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways

in Systems Immunology

Mengke Chen
Lujie Zhou
Yidan Gao
Yao Zhong
Cheng Chen
Zhicheng Wang
Xiaoning Wang
Rong Xia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656442

2,626 views

Mini Review

Published on 18 Aug 2025

The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

in Systems Immunology

Shuangyu Chen
Wenqian Chen
Tinghui Xu
Jiayang Li
Jianghao Yu
Yibo He
Shengliang Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639823

5,067 views
1 citation

Original Research

Published on 15 Aug 2025

Silencing RPL11 attenuates acute kidney injury by suppressing tubular apoptosis and macrophage-driven inflammation

in Systems Immunology

Qian Dong
Huan Xu
Pengjie Xu
Jiang Liu
Zhouji Shen
Yabin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642446

2,981 views

Review

Published on 13 Aug 2025

Ocular-cerebral immune dialogue: a new perspective and therapeutic potential of regional lymphatic systems

in Systems Immunology

Yiran Wang
Pei Guo
Weihong Li
Tong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595275

2,911 views

Original Research

Published on 12 Aug 2025

Antimicrobial and immunomodulatory activity of natural bioactive compounds – an in vitro investigation with potential applications in managing Hidradenitis Suppurativa

in Systems Immunology

Valentina-Alexandra Badaluta
Adrian Ionascu
Lia-Mara Ditu
Carmen Curutiu
Alina-Maria Holban
Eliza Oprea
Yiannis Kourkoutas
Mara Madalina Mihai
Corina Ioana Cucu
Ariana Hudita

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608269

3,187 views

Original Research

Published on 08 Aug 2025

An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation

in Systems Immunology

Sebastian Benjamin
GW McElfresh
Maanasa Kaza
Gregory J. Boggy
Benjamin Varco-Merth
Sohita Ojha
Shana Feltham
William Goodwin
Candice Nkoy
Derick Duell

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596760

3,132 views

Original Research

Published on 08 Aug 2025

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies

in Systems Immunology

Alexander Mazein
Oxana Lopata
Kristin Reiche
Katherina Sewald
Miriam Alb
Christina Sakellariou
Patricia Gogesch
Hannah Morgan
Vanessa Neuhaus
Nhu-Nguyen Pham

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601670

2,979 views
1 citation

Review

Published on 07 Aug 2025

Considering local immunity for innovative immunomodulatory approaches: pulmonary sepsis as a use case

in Systems Immunology

Emilie Vernay
Elisabeth Cerrato
François Santinon
Céline Monard
Pauline Perez
Florence Allantaz
Anne-Claire Lukaszewicz
Jean-François Llitjos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627313

2,082 views

Original Research

Published on 01 Aug 2025

Immune composition of the mononuclear cell fraction of human umbilical cord blood

in Systems Immunology

Karen Kikuta
Esmond Lee
Talia Menezes
Hannah Fung
Alvaro Amorin
Aditi Agrawal
Theodore L. Roth
Matthew Porteus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614230

2,791 views

Original Research

Published on 30 Jul 2025

Experimental validation of cuproptosis-associated molecular signatures and their immunological implications in pulmonary tuberculosis

in Systems Immunology

Xiaofang Liu
Qianqian Ma
Zhiming Li
Yong Xue
Jie Mi
Yuxi Li
Chunfeng Bai
Donglin Guo
Yinping Liu
Yan Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570992

2,366 views

Original Research

Published on 29 Jul 2025

Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential

in Systems Immunology

Kai Zhou
Jiaxiang Zhou
XianJin Luo
Yan Chen
Jian Ao
Wei Wu
Bo Yang
Zhongyuan He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606905

3,849 views
1 citation

Original Research

Published on 25 Jul 2025

A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease

in Systems Immunology

Tingting Hu
Xiaomei Duan
Jiale Gao
Zheng Li
Dan Xu
Jing Jing
Fengsen Li
Jianbing Ding
Li Ma
Min Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536551

4,897 views
1 citation

Original Research

Published on 24 Jul 2025

Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults

in Systems Immunology

Ting Ge
Guixin He
Qian Cui
Shuangcui Wang
Zekun Wang
Yingying Xie
Yuanyuan Tian
Juyue Zhou
Wentao Li
Baohui Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599515

2,848 views

Review

Published on 24 Jul 2025

Emerging IO checkpoints in gastrointestinal oncology

in Systems Immunology

Alireza Tojjari
Anwaar Saeed
Ludimila Cavalcante

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575713

2,989 views
1 citation

Review

Published on 24 Jul 2025

Exercise workload: a key determinant of immune health – a narrative review

in Systems Immunology

Xinxin Shi
Lunuo Hu
David C. Nieman
Fei Li
Peijie Chen
Hui Shi
Yue Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617261

8,533 views
2 citations

Original Research

Published on 21 Jul 2025

Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis

in Systems Immunology

Jun Liu
Tong Li
Li Xin
Xingyu Li
Jianbo Zhang
Peng Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597676

3,720 views
1 citation

Review

Published on 21 Jul 2025

Multiscale information processing in the immune system

in Systems Immunology

Roberto Navarro Quiroz
Jose Villarreal Camacho
Eloina Zarate Peñata
Yesit Bello Lemus
Claudio López-Fernández
Lorena Gomez Escorcia
Cecilia Fernández-Ponce
Martha Rebolledo Cobos
Jennifer Fandiño Moreno
Ornella Fiorillo-Moreno

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563992

3,859 views
1 citation

Original Research

Published on 17 Jul 2025

NetTCR-struc, a structure driven approach for prediction of TCR-pMHC interactions

in Systems Immunology

Sebastian N. Deleuran
Morten Nielsen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616328

3,500 views
4 citations

Original Research

Published on 17 Jul 2025

Multiple analytical perspectives of mitochondrial genes in the context of preeclampsia: potential diagnostic markers

in Systems Immunology

Can Li
Fang Liu
Chao Li
Xiangzhong Zhao
Qiulan Lv
Aiping Jiang
Shuping Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595706

2,547 views

Original Research

Published on 15 Jul 2025

Systemic inflammatory indices and age-dependent severity in acute appendicitis: a retrospective cohort study

in Systems Immunology

Catalin Vladut Ionut Feier
Andrei Motoc
Calin Muntean
Razvan Constantin Vonica
Vasile Gaborean
Sorin Olariu
Marius Sorin Murariu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620459

2,338 views
1 citation

Original Research

Published on 14 Jul 2025

Exploration of differential expression and biological significance of amino acid metabolism genes in osteoarthritis

in Systems Immunology

Zhenghuan Zhu
Jiaqing Meng
Junfeng Hu
Lingmin Hu
Wenge Ding
Wanchao Zhang
Chuang Zhao
Lin Feng
Kejie Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588072

3,734 views

Review

Published on 11 Jul 2025

Advanced omics approaches in liver transplant settings: current applications and future prospectives

in Systems Immunology

Huijuan Wang
Yifeng Zhou
Lu Yu
Zhengtao Liu
Shusen Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1564248

3,566 views

523 articles

articles

CEACAM6 as a machine learning derived immune biomarker for predicting neoadjuvant chemotherapy response in HR+/HER2− breast cancer

Correction: Plasma polymeric immunoglobulin receptor exacerbates lung injury in Klebsiella pneumoniae-induced pneumosepsis

Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways

The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

Silencing RPL11 attenuates acute kidney injury by suppressing tubular apoptosis and macrophage-driven inflammation

Ocular-cerebral immune dialogue: a new perspective and therapeutic potential of regional lymphatic systems

Antimicrobial and immunomodulatory activity of natural bioactive compounds – an in vitro investigation with potential applications in managing Hidradenitis Suppurativa

An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies

Considering local immunity for innovative immunomodulatory approaches: pulmonary sepsis as a use case

Immune composition of the mononuclear cell fraction of human umbilical cord blood

Experimental validation of cuproptosis-associated molecular signatures and their immunological implications in pulmonary tuberculosis

Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential

A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease

Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults

Emerging IO checkpoints in gastrointestinal oncology

Exercise workload: a key determinant of immune health – a narrative review

Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis

Multiscale information processing in the immune system

NetTCR-struc, a structure driven approach for prediction of TCR-pMHC interactions

Multiple analytical perspectives of mitochondrial genes in the context of preeclampsia: potential diagnostic markers

Systemic inflammatory indices and age-dependent severity in acute appendicitis: a retrospective cohort study

Exploration of differential expression and biological significance of amino acid metabolism genes in osteoarthritis

Advanced omics approaches in liver transplant settings: current applications and future prospectives