Frontiers in Immunology | Systems Immunology

Original Research

Published on 01 May 2025

Interpretable machine learning algorithms reveal gut microbiome features associated with atopic dermatitis

in Systems Immunology

Jingtai Ma
Yiting Fang
Shiqi Li
Lilian Zeng
Siyi Chen
Zhifeng Li
Guiyuan Ji
Xingfen Yang
Wei Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528046

1,979 views

Original Research

Published on 28 Apr 2025

Independent and temporally separated dynamics for RORγt and Foxp3 during Th17 differentiation

in Systems Immunology

Stav Miller
Inbal Eizenberg-Magar
Shlomit Reich-Zeliger
Jacob Rimer
Irina Zaretsky
Dan Reshef
Ekaterina Kopitman
Nir Friedman
Yaron E Antebi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1462045

1,296 views

Original Research

Published on 25 Apr 2025

A computational account of joint SSRI and anti-inflammatory treatment

in Systems Immunology

Melissa Reneaux
Helen Mayberg
Karl Friston
Dimitris A. Pinotsis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1472732

1,426 views

Systematic Review

Published on 22 Apr 2025

Artificial intelligence in autoimmune diseases: a bibliometric exploration of the past two decades

in Systems Immunology

Sidi Liu
Yang Liu
Ming Li
Shuangshuang Shang
Yunxiang Cao
Xi Shen
Chuanbing Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1525462

2,605 views

Original Research

Published on 17 Apr 2025

Comprehensive molecular analyses of an autoimmune-related gene predictive model and immune infiltrations using machine learning methods in intracranial aneurysma

in Systems Immunology

Minxue Zhang
Lin Zhou
Yuying Zhao
Yanling Wang
Zhuobo Zhang
Zhan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1531930

1,394 views

Original Research

Published on 10 Apr 2025

Development and validation of identification algorithms for five autoimmune diseases using electronic health records: a retrospective cohort study in China

in Systems Immunology

Junting Yang
Yunxiao Wu
Jinxin Guo
Xiaoxuan Wang
Xin Gao
Xin Chen
Mengdi Zhang
Jin Yang
Zuojing Liu
Yan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541203

2,268 views

Original Research

Published on 09 Apr 2025

Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis

in Systems Immunology

Danielle Dias Munhoz
Dennyson Leandro M. Fonseca
Igor Salerno Filgueiras
Haroldo Dutra Dias
Helder I. Nakaya
Igor Jurisica
Hans D. Ochs
Lena F. Schimke
Luiz Vicente Rizzo
Otavio Cabral-Marques

Frontiers in Immunology

doi 10.3389/fimmu.2025.1509805

2,509 views

Original Research

Published on 08 Apr 2025

Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings

in Systems Immunology

Tianmeng Chen
Julia Hughes
Alyssa Gregory
Julia Conroy
Patricia Loughran
Jinming Song
Wei Chen
Timothy Billiar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565211

1,882 views

Review

Published on 02 Apr 2025

TREM2+ macrophages: a key role in disease development

in Systems Immunology

Xinxin Wang
Yunhan Wang
Lei Yang
Yi Zhang
Li Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550893

3,946 views
1 citation

Review

Published on 31 Mar 2025

Oral and transdermal administration of lipopolysaccharide safely enhances self-healing ability through the macrophage network

in Systems Immunology

Gen-Ichiro Soma
Masataka Oda
Vindy Tjendana Tjhin
Chie Kohchi
Hiroyuki Inagawa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563484

2,068 views

Review

Published on 31 Mar 2025

Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review

in Systems Immunology

Siyu He
Ziyue Wang
Yinan Zhu
Mingfang Sun
Xuyong Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1473817

2,373 views

Original Research

Published on 26 Mar 2025

Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke

in Systems Immunology

Tianzhi Li
Xiaojia Kang
Sijie Zhang
Yihan Wang
Jinshan He
Hongyan Li
Chen Shao
Jingsong Kang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561544

3,052 views

Original Research

Published on 24 Mar 2025

A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma

in Systems Immunology

Jiale Fang
Siyuan Yu
Wei Wang
Cheng Liu
Xiaojia Lv
Jiaqi Jin
Xiaomin Han
Fang Zhou
Yukun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524120

2,291 views

Original Research

Published on 21 Mar 2025

Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning

in Systems Immunology

Junyang Ma
Shufu Hou
Xinxin Gu
Peng Guo
Jiankang Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533959

2,301 views

Original Research

Published on 21 Mar 2025

Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

in Systems Immunology

Piia Karisola
Mari Kanerva
Aki Vuokko
Helena Liira
Shuyuan Wang
Kirsi Kvarnström
Mikko Varonen
Hille Suojalehto
Harri Alenius

Frontiers in Immunology

doi 10.3389/fimmu.2025.1500997

1,262 views

Editorial

Published on 18 Mar 2025

Editorial: Spatial immunology of tissue microenvironments

in Systems Immunology

Roslyn A. Kemp
Felix Marsh-Wakefield

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584850

1,019 views