Frontiers in Immunology | Systems Immunology

Editorial

Published on 30 May 2025

Editorial: Revolutionizing immunological disease understanding through single cell multi-omics technologies

in Systems Immunology

Ying Zhu
Veronica G. Anania
Jennie R. Lill
Zora Modrusan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628120

2,673 views

Perspective

Published on 29 May 2025

Multi-physiology modeling of the immune system in the era of precision immunotherapy

in Systems Immunology

Sunghyun Hong
Kyemyung Park

Frontiers in Immunology

doi 10.3389/fimmu.2025.1548768

3,127 views

Original Research

Published on 29 May 2025

Transcriptional regulatory logic orchestrating lymphoid and myeloid cell fate decisions

in Systems Immunology

Rasoul Godini
Jingjing Yan
Michaël Chopin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544483

2,979 views
2 citations

Original Research

Published on 27 May 2025

Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation

in Systems Immunology

Jingyi Hou
Lihan Wang
Naiqiang Zhu
Xueli Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1543584

3,818 views
1 citation

Original Research

Published on 21 May 2025

Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma

in Systems Immunology

Maria Eduarda de Castro
Gustavo Forlin de Siqueira
Jean Ferrante Mariano
Marina Malta Letro Kizys
Lucieli Ceolin
Fernando Augusto Soares
Rodrigo Natal
Humberto Carneiro
Rodrigo Nalio Ramos
Laura Sterian Ward

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579205

3,126 views

Original Research

Published on 20 May 2025

Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2

in Systems Immunology

N. S. Suneesh
Kishore Dhotre
Pratik Mahajan
Debashree Dass
Anwesha Banerjee
Nikhat J. Siddiqi
Abdul Malik
Manali Joshi
Abdul Arif Khan
Vijay Nema

Frontiers in Immunology

doi 10.3389/fimmu.2025.1586271

6,806 views
2 citations

Original Research

Published on 16 May 2025

Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding

in Systems Immunology

Tingting Zhang
Laurie Baert
Neal W. Woodbury
Laimonas Kelbauskas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528524

3,360 views

Original Research

Published on 13 May 2025

Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing

in Systems Immunology

Hua Huang
Jiaze Ma
An Kang
Tianwei Guo
Wei Sun
Yan Xu
Lijiang Ji

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534768

5,994 views

Original Research

Published on 13 May 2025

Clinical and mechanistic relevance of high-dimensionality analysis of the paediatric sepsis immunome

in Systems Immunology

Dandan Pi
Judith Ju Ming Wong
Katherine Nay Yaung
Nicholas Kim Huat Khoo
Su Li Poh
Martin Wasser
Pavanish Kumar
Thaschawee Arkachaisri
Feng Xu
Herng Lee Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569096

2,444 views

Original Research

Published on 13 May 2025

Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

in Systems Immunology

Jingjing Zhang
Ling Ma
Hanyin Deng
Wenqian Yi
Alim Tohtihan
Xiaojun Tang
Xiudi Wu
Xuebing Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580540

4,430 views

Original Research

Published on 12 May 2025

Exploring shared pathogenic mechanisms and biomarkers in hepatic fibrosis and inflammatory bowel disease through bioinformatics and machine learning

in Systems Immunology

Shangkun Li
Haoyu Li
Mingran Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533246

5,060 views
2 citations

Original Research

Published on 08 May 2025

Single cell RNA-sequencing identified CCR7+/RELB+/IRF1+ T cell responding for juvenile idiopathic arthritis pathogenesis

in Systems Immunology

Lewei He
Xue Gong
Hui Guo
Kaiyu Zhou
Yue Lan
Mingyi Lv
Xiaoliang Liu
Sha Lin
Yimin Hua
Junling Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528446

3,589 views

Review

Published on 05 May 2025

Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies

in Systems Immunology

Ruotong Cao
Huasheng Lv
Baopeng Tang
Yanmei Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561061

4,067 views
1 citation

Mini Review

Published on 02 May 2025

Comprehending toll-like receptors: pivotal element in the pathogenesis of sepsis and its complications

in Systems Immunology

Wei Wang
Shengtian Mu
Dongli Yan
Huan Qin
Zhen Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591011

4,571 views
8 citations

Original Research

Published on 01 May 2025

Interpretable machine learning algorithms reveal gut microbiome features associated with atopic dermatitis

in Systems Immunology

Jingtai Ma
Yiting Fang
Shiqi Li
Lilian Zeng
Siyi Chen
Zhifeng Li
Guiyuan Ji
Xingfen Yang
Wei Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1528046

5,042 views
4 citations

Original Research

Published on 28 Apr 2025

Independent and temporally separated dynamics for RORγt and Foxp3 during Th17 differentiation

in Systems Immunology

Stav Miller
Inbal Eizenberg-Magar
Shlomit Reich-Zeliger
Jacob Rimer
Irina Zaretsky
Dan Reshef
Ekaterina Kopitman
Nir Friedman
Yaron E Antebi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1462045

3,152 views
1 citation

Original Research

Published on 25 Apr 2025

A computational account of joint SSRI and anti-inflammatory treatment

in Systems Immunology

Melissa Reneaux
Helen Mayberg
Karl Friston
Dimitris A. Pinotsis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1472732

2,873 views
2 citations

Systematic Review

Published on 22 Apr 2025

Artificial intelligence in autoimmune diseases: a bibliometric exploration of the past two decades

in Systems Immunology

Sidi Liu
Yang Liu
Ming Li
Shuangshuang Shang
Yunxiang Cao
Xi Shen
Chuanbing Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1525462

6,818 views
6 citations

Original Research

Published on 17 Apr 2025

Comprehensive molecular analyses of an autoimmune-related gene predictive model and immune infiltrations using machine learning methods in intracranial aneurysma

in Systems Immunology

Minxue Zhang
Lin Zhou
Yuying Zhao
Yanling Wang
Zhuobo Zhang
Zhan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1531930

2,742 views

Original Research

Published on 10 Apr 2025

Development and validation of identification algorithms for five autoimmune diseases using electronic health records: a retrospective cohort study in China

in Systems Immunology

Junting Yang
Yunxiao Wu
Jinxin Guo
Xiaoxuan Wang
Xin Gao
Xin Chen
Mengdi Zhang
Jin Yang
Zuojing Liu
Yan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541203

4,631 views

Original Research

Published on 09 Apr 2025

Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis

in Systems Immunology

Danielle Dias Munhoz
Dennyson Leandro M. Fonseca
Igor Salerno Filgueiras
Haroldo Dutra Dias
Helder I. Nakaya
Igor Jurisica
Hans D. Ochs
Lena F. Schimke
Luiz Vicente Rizzo
Otavio Cabral-Marques

Frontiers in Immunology

doi 10.3389/fimmu.2025.1509805

5,768 views
1 citation

Original Research

Published on 08 Apr 2025

Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings

in Systems Immunology

Tianmeng Chen
Julia Hughes
Alyssa Gregory
Julia Conroy
Patricia Loughran
Jinming Song
Wei Chen
Timothy Billiar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565211

3,560 views

Review

Published on 02 Apr 2025

TREM2+ macrophages: a key role in disease development

in Systems Immunology

Xinxin Wang
Yunhan Wang
Lei Yang
Yi Zhang
Li Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550893

11,022 views
5 citations

Review

Published on 31 Mar 2025

Oral and transdermal administration of lipopolysaccharide safely enhances self-healing ability through the macrophage network

in Systems Immunology

Gen-Ichiro Soma
Masataka Oda
Vindy Tjendana Tjhin
Chie Kohchi
Hiroyuki Inagawa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563484

4,330 views
1 citation

523 articles

articles

Editorial: Revolutionizing immunological disease understanding through single cell multi-omics technologies

Multi-physiology modeling of the immune system in the era of precision immunotherapy

Transcriptional regulatory logic orchestrating lymphoid and myeloid cell fate decisions

Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation

Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma

Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2

Serologic biomarker discovery for differentiating Lyme disease from diseases with similar clinical symptoms using broad profiling of antibody binding

Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing

Clinical and mechanistic relevance of high-dimensionality analysis of the paediatric sepsis immunome

Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

Exploring shared pathogenic mechanisms and biomarkers in hepatic fibrosis and inflammatory bowel disease through bioinformatics and machine learning

Single cell RNA-sequencing identified CCR7+/RELB+/IRF1+ T cell responding for juvenile idiopathic arthritis pathogenesis

Anti-Ro/SSA antibodies in adult arrhythmias: pathogenesis, clinical implications, and therapeutic strategies

Comprehending toll-like receptors: pivotal element in the pathogenesis of sepsis and its complications

Interpretable machine learning algorithms reveal gut microbiome features associated with atopic dermatitis

Independent and temporally separated dynamics for RORγt and Foxp3 during Th17 differentiation

A computational account of joint SSRI and anti-inflammatory treatment

Artificial intelligence in autoimmune diseases: a bibliometric exploration of the past two decades

Comprehensive molecular analyses of an autoimmune-related gene predictive model and immune infiltrations using machine learning methods in intracranial aneurysma

Development and validation of identification algorithms for five autoimmune diseases using electronic health records: a retrospective cohort study in China

Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis

Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings

TREM2+ macrophages: a key role in disease development

Oral and transdermal administration of lipopolysaccharide safely enhances self-healing ability through the macrophage network