Frontiers in Immunology | Systems Immunology

Review

Published on 31 Mar 2025

Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review

in Systems Immunology

Siyu He
Ziyue Wang
Yinan Zhu
Mingfang Sun
Xuyong Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1473817

4,265 views
1 citation

Original Research

Published on 26 Mar 2025

Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke

in Systems Immunology

Tianzhi Li
Xiaojia Kang
Sijie Zhang
Yihan Wang
Jinshan He
Hongyan Li
Chen Shao
Jingsong Kang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561544

8,560 views
1 citation

Original Research

Published on 24 Mar 2025

A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma

in Systems Immunology

Jiale Fang
Siyuan Yu
Wei Wang
Cheng Liu
Xiaojia Lv
Jiaqi Jin
Xiaomin Han
Fang Zhou
Yukun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524120

4,174 views

Original Research

Published on 21 Mar 2025

Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning

in Systems Immunology

Junyang Ma
Shufu Hou
Xinxin Gu
Peng Guo
Jiankang Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533959

4,439 views
1 citation

Original Research

Published on 21 Mar 2025

Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

in Systems Immunology

Piia Karisola
Mari Kanerva
Aki Vuokko
Helena Liira
Shuyuan Wang
Kirsi Kvarnström
Mikko Varonen
Hille Suojalehto
Harri Alenius

Frontiers in Immunology

doi 10.3389/fimmu.2025.1500997

2,264 views
1 citation

Editorial

Published on 18 Mar 2025

Editorial: Spatial immunology of tissue microenvironments

in Systems Immunology

Roslyn A. Kemp
Felix Marsh-Wakefield

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584850

1,982 views

Correction

Published on 13 Mar 2025

Corrigendum: Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

in Systems Immunology

Wenyu Fu
Qinqin Xie
Pengfei Yu
Shuang Liu
Lingyao Xu
Xiaowei Ye
Wei Zhao
Qishan Wang
Yuchun Pan
Zhe Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588642

1,104 views

Original Research

Published on 12 Mar 2025

Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer

in Systems Immunology

Teng Wang
Zhaoming Chen
Wang Wang
Heng Wang
Shenglong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556386

7,997 views
4 citations

Correction

Published on 07 Mar 2025

Corrigendum: Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

in Systems Immunology

Aliakbar Hasankhani
Abolfazl Bahrami
Negin Sheybani
Behzad Aria
Behzad Hemati
Farhang Fatehi
Hamid Ghaem Maghami Farahani
Ghazaleh Javanmard
Mahsa Rezaee
John P. Kastelic

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572273

1,127 views

Methods

Published on 28 Feb 2025

OnmiMHC: a machine learning solution for UCEC tumor vaccine development through enhanced peptide-MHC binding prediction

in Systems Immunology

Fangfang Jian
Haihua Cai
Qushuo Chen
Xiaoyong Pan
Weiwei Feng
Ye Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550252

3,323 views
1 citation

Original Research

Published on 28 Feb 2025

Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

in Systems Immunology

Wenyu Fu
Qinqin Xie
Pengfei Yu
Shuang Liu
Lingyao Xu
Xiaowei Ye
Wei Zhao
Qishan Wang
Yuchun Pan
Zhe Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1530214

4,296 views
1 citation

Original Research

Published on 25 Feb 2025

In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay

in Systems Immunology

Ágnes Kovács
Zoltán Hérincs
Krisztián Papp
Jakub Zbigniew Kaczmarek
Daniel Nyberg Larsen
Pernille Stage
László Bereczki
Eszter Ujhelyi
Tamás Pfeil
József Prechl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1494624

2,030 views
3 citations

Original Research

Published on 19 Feb 2025

Clinical application of Myxovirus resistance protein A as a diagnostic biomarker to differentiate viral and bacterial respiratory infections in pediatric patients

in Systems Immunology

Min Zhu
Lijin Chen
Jiali Cao
Jianguo Cai
Shuying Huang
Huibin Wang
Huanjuan He
Zimin Chen
Rongfu Huang
Huiming Ye

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540675

3,809 views
2 citations

Systematic Review

Published on 14 Feb 2025

Research trends of inflammation in autism spectrum disorders: a bibliometric analysis

in Systems Immunology

Yajing Chen
Xiaohuan Du
Xianming Zhang
Fang Li
Shuwei Yuan
Wenjing Wang
Zengyan Zhu
Mei Wang
Chao Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534660

6,017 views
5 citations

Hypothesis and Theory

Published on 12 Feb 2025

Unique gating strategy identifier based on the Prime Population System and Gödel Numbers

in Systems Immunology

Antonio Cosma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1481412

1,888 views

Original Research

Published on 04 Feb 2025

Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers

in Systems Immunology

Ruohua Li
Cuixia Zhou
Kejun Ye
Haihui Chen
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1496046

3,762 views
3 citations

Original Research

Published on 23 Jan 2025

Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning

in Systems Immunology

Tao Zhou
Can Zhu
Wei Zhang
Qiongfang Wu
Mingqiang Deng
Zhiwei Jiang
Longfei Peng
Hao Geng
Zhouting Tuo
Ci Zou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1511529

5,189 views
3 citations

Original Research

Published on 23 Jan 2025

Feature selection enhances peptide binding predictions for TCR-specific interactions

in Systems Immunology

Hamid Teimouri
Zahra S. Ghoreyshi
Anatoly B. Kolomeisky
Jason T. George

Frontiers in Immunology

doi 10.3389/fimmu.2024.1510435

3,998 views
3 citations

Original Research

Published on 23 Jan 2025

Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia

in Systems Immunology

Rong Lin
XiaoYing Weng
Liang Lin
XuYang Hu
ZhiYan Liu
Jing Zheng
FenFang Shen
Rui Li

Frontiers in Immunology

doi 10.3389/fimmu.2024.1453633

3,799 views
2 citations

Original Research

Published on 20 Jan 2025

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space

in Systems Immunology

Maria Moreno-Villanueva
Luis E. Jimenez-Chavez
Stephanie Krieger
Liang-Hao Ding
Ye Zhang
Adriana Babiak-Vazquez
Mark Berres
Sandra Splinter
Kristen E. Pauken
Brian C. Schaefer

Frontiers in Immunology

doi 10.3389/fimmu.2024.1512578

5,627 views
9 citations

Original Research

Published on 20 Jan 2025

Heightened expression of type I interferon signaling genes in CD4+ T cells from acutely HIV-1–infected women is associated with lower viral loads

in Systems Immunology

Elina El-Badry
Luxiao Chen
Khader Ghneim
Ziyi Li
Kelsie Brooks
Jake Rhodes
Rafick Sekaly
William Kilembe
Susan Allen
Hao Wu

Frontiers in Immunology

doi 10.3389/fimmu.2024.1507530

3,139 views

Original Research

Published on 14 Jan 2025

Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis

in Systems Immunology

Bong-Ki Hong
Sungyong You
Jung Gon Kim
Minhyung Kim
Naeun Lee
Kijun Lee
In-Pyo Baek
Ji Hyeon Ju
Wan-Uk Kim
Ho-Youn Kim

Frontiers in Immunology

doi 10.3389/fimmu.2024.1439082

4,936 views
3 citations

Original Research

Published on 14 Jan 2025

Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets

in Systems Immunology

Huahua Li
Lingling Zou
Zhaowei Long
Junkun Zhan

Frontiers in Immunology

doi 10.3389/fimmu.2024.1537909

6,661 views
13 citations

Original Research

Published on 14 Jan 2025

Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease

in Systems Immunology

Yuyan Li
Yueming Luo
Yilan Hu
Siting Li
Guandong Li
Wanyangchuan Zhang
Xiufen Gu
Jianting Wang
Shunmin Li
Hong Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2024.1512519

5,395 views
2 citations

523 articles

articles

Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review

Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke

A tumor-infiltrating B lymphocytes -related index based on machine-learning predicts prognosis and immunotherapy response in lung adenocarcinoma

Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning

Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup

Editorial: Spatial immunology of tissue microenvironments

Corrigendum: Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer

Corrigendum: Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

OnmiMHC: a machine learning solution for UCEC tumor vaccine development through enhanced peptide-MHC binding prediction

Pig jejunal single-cell RNA landscapes revealing breed-specific immunology differentiation at various domestication stages

In-depth immunochemical characterization of the serum antibody response using a dual-titration microspot assay

Clinical application of Myxovirus resistance protein A as a diagnostic biomarker to differentiate viral and bacterial respiratory infections in pediatric patients

Research trends of inflammation in autism spectrum disorders: a bibliometric analysis

Unique gating strategy identifier based on the Prime Population System and Gödel Numbers

Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers

Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning

Feature selection enhances peptide binding predictions for TCR-specific interactions

Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space

Heightened expression of type I interferon signaling genes in CD4+ T cells from acutely HIV-1–infected women is associated with lower viral loads

Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis

Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets

Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease