Frontiers in Immunology | T Cell Biology

Correction

Published on 02 Jan 2026

Correction: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

in T Cell Biology

Karina M. Berschneider
Bernhard Wetterauer
Carsten Sticht
Christian Orlik
Beate Jahraus
Henning Kirchgessner
Anastasiia Zuieva
Stefan Wölfl
Divya Lairikyengbam
Verena Beier

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761559

325 views

Original Research

Published on 02 Jan 2026

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models

in T Cell Biology

Ying Xing
Gangqiang Shi
Zhengli Li
Xiancheng Liu
Linghu Nie
Yu Zhang
Yiqin Song
Shilin Sun
Mike K. S. Chan
Michelle B. F. Wong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638585

575 views

Original Research

Accepted on 31 Dec 2025

Detection of Human Papillomavirus (HPV)-specific T cell response in women with low-grade cervical intraepithelial lesion and HPV vaccinated subjects

in T Cell Biology

Paola Zelini
Federica Zavaglio
Mattia Dominioni
Marta Valsecchi
Lucrezia Lo Grasso
Piera d'Angelo
Federica Giardina
Stefania Paolucci
Daniele Lilleri
Irene Cassaniti

Frontiers in Immunology

359 views

Review

Accepted on 30 Dec 2025

Metabolic Reprogramming Tailors T cell immunity in Sepsis

in T Cell Biology

Di Xian
Feng Chen
Bing Liu
Lei Wang

Frontiers in Immunology

164 views

Editorial

Accepted on 29 Dec 2025

Epigenetic Regulation of T Cell Function in Type 1 Diabetes

in T Cell Biology

Ubaid Ullah Kalim
Giuseppina Emanuela Grieco

Frontiers in Immunology

Original Research

Accepted on 24 Dec 2025

Differential composition of lymphocyte subpopulations and activation between the hypertensive Bph/2 and normotensive Bpn/3 mouse strains

in T Cell Biology

Devon Dattmore
Paiton O Mcdonald
Afrin Chowdhury
Saamera Awali
Allison P Boss
Yining Jin
Lisa Sather
D Adam Lauver
Cheryl Rockwell

Frontiers in Immunology

Original Research

Accepted on 22 Dec 2025

Moving for optimal immunity: The effect of acute high-intensity interval training on phenotype, virus specificity and chemokine receptor expression in human CD8+ T cells

in T Cell Biology

Katharina Leuchte
Thy Viet Luu
Sara Fresnillo
Kasper Madsen
Lise Heide-Ottosen
Signe Koggersbøl Skadborg
Janine Sophie Kemming
Morten Orebo Holmström
Hongjin Chen
Lars Rønn Olsen

Frontiers in Immunology

158 views

Original Research

Published on 19 Dec 2025

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

in T Cell Biology

Valerie Plajer
Adrián Madrigal-Avilés
Maria Dzamukova
Nayar Durán-Hernández
Philippe Saikali
Vivien Holecska
Isabel Panse
Katrin Lehmann
Jinfang Zhu
Mir-Farzin Mashreghi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716422

786 views

Review

Published on 19 Dec 2025

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond

in T Cell Biology

Xiang Fang
Shixuan Yan
Long He
Changwen Deng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735763

636 views

Original Research

Published on 19 Dec 2025

Longitudinal immune profiling uncovers regulatory T cell signatures associated with the progression of COVID-19

in T Cell Biology

Camila Kossack
Felipe Bravo
Francisco Fuentes-Villalobos
Claudio Quevedo
Matías A. Medina
Raúl Riquelme
María Luisa Rioseco
Mario Calvo
Karina Pino-Lagos
Felipe Aguilera

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697788

703 views

Review

Accepted on 18 Dec 2025

The TCR and LCK: Foundations for T-Cell Activation and Therapeutic Innovation

in T Cell Biology

Susana Minguet
Nadine M Wössner
Valeria Uleri
Ondrej Stepanek

Frontiers in Immunology

257 views

Original Research

Published on 18 Dec 2025

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

in T Cell Biology

Maria A. Salnikova
Ksenia K. Tuchynskaya
Anastasia A. Minervina
Mikhail V. Pogorelyy
Egor V. Okhezin
Galina G. Karganova
Ilgar Z. Mamedov
Yuri B. Lebedev

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663781

629 views

Review

Published on 16 Dec 2025

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

in T Cell Biology

Yuehong Hu
Qihan Zhao
Haoran Dai
Yadi Wu
Xinyue Tang
Naiqian Zhang
Hanxue Jiang
Hongliang Rui
Baoli Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687755

872 views

Original Research

Accepted on 15 Dec 2025

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

in T Cell Biology

Emily Reed
Tatlock H. Lauten
Tamara Natour
Lauren Jane Pitts
Caroline N. Jojo
Brooke L. Griffin
Sreeram Pasupuleti
Adam J Case

Frontiers in Immunology

178 views

Review

Published on 12 Dec 2025

Immunomodulatory biomaterials for vascularized and innervated skeletal muscle repair

in T Cell Biology

Lauren G. Mottel
Brennagh R. Shields
Brian J. Kwee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657015

1,232 views

Mini Review

Published on 12 Dec 2025

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease

in T Cell Biology

Feven Getachew
Junhui Hu
Mehdi Benamar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729690

950 views

Review

Published on 11 Dec 2025

T cell heterogeneity in asthma pathogenesis: from immunological mechanisms to biological targeted therapies

in T Cell Biology

Qifeng Gan
Yuzhen Zhu
Yuxin Guo
Guo Fu
Xiao-Bin Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658774

530 views

Original Research

Published on 11 Dec 2025

Development of a humanized mouse model of graft-versus-host disease to assess human regulatory T cell function

in T Cell Biology

Charline Beguin
Oswin Kwan
Grégory Ehx
Stéphanie Humblet-Baron
Murat Cem Köse
Sophie Dubois
Lorenzo Canti
Justine Courtois
Coline Daulne
Jo Caers

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717133

1,077 views

Original Research

Published on 10 Dec 2025

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

in T Cell Biology

Akihiro Shimba
Satoru Munakata
Shinya Abe
Guangwei Cui
Ryoma Kato
Masaki Miyazaki
Atsuhiro Ichihara
Koichi Ikuta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566935

708 views

Original Research

Accepted on 09 Dec 2025

NDUFS4, a Mitochondrial Complex I Subunit, is Essential for T-Cell Metabolic Fitness and Immune Function

in T Cell Biology

Oded Shamriz
Zahala Bar-On
Omri Yosef
Leonor Cohen-Daniel
Ayelet Sheer
Or Reuven
Wajeeh Salaymeh
Amijai Saragovi
Raz Somech
Atar Lev

Frontiers in Immunology

302 views

Brief Research Report

Published on 03 Dec 2025

T-cell receptors that are k-binding have defined sequence features

in T Cell Biology

Hyunjin Park
Jonathan Krog
Brandon Carter
Pallavi A. Balivada
Emily M. Pogue
Samyuktha Anand
Michael E. Birnbaum
David K. Gifford

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621201

2,258 views

Original Research

Published on 01 Dec 2025

SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing

in T Cell Biology

Chenxin Gan
Qian Wu
Jorg J. Goronzy
Yongchun Zhang
Lingjie Li
Huiming Sheng
Fengqin Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679064

873 views

Original Research

Published on 28 Nov 2025

Synergistic anti-tumor activity of the mTOR inhibitor everolimus and gemcitabine for relapsed/refractory peripheral T cell lymphoma

in T Cell Biology

Ling Huang
Hanguo Guo
Yan Teng
Diwen Pang
Fen Zhang
Yichen Sun
Choon Kiat Ong
Jing Tan
Wenyu Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683550

745 views

Original Research

Published on 28 Nov 2025

Flow cytometric analysis of the immune cell subsets in adult hemophagocytic lymphohistiocytosis

in T Cell Biology

Yao Qin
Jianying Zhou
Pengpeng Liu
Yang Dai
Yun Tang
Xushu Zhong
Xinchuan Chen
Huanling Zhu
Ting Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678233

931 views

2,208 articles

articles

Correction: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models

Detection of Human Papillomavirus (HPV)-specific T cell response in women with low-grade cervical intraepithelial lesion and HPV vaccinated subjects

Metabolic Reprogramming Tailors T cell immunity in Sepsis

Epigenetic Regulation of T Cell Function in Type 1 Diabetes

Differential composition of lymphocyte subpopulations and activation between the hypertensive Bph/2 and normotensive Bpn/3 mouse strains

Moving for optimal immunity: The effect of acute high-intensity interval training on phenotype, virus specificity and chemokine receptor expression in human CD8+ T cells

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond

Longitudinal immune profiling uncovers regulatory T cell signatures associated with the progression of COVID-19

The TCR and LCK: Foundations for T-Cell Activation and Therapeutic Innovation

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

Immunomodulatory biomaterials for vascularized and innervated skeletal muscle repair

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease

T cell heterogeneity in asthma pathogenesis: from immunological mechanisms to biological targeted therapies

Development of a humanized mouse model of graft-versus-host disease to assess human regulatory T cell function

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

NDUFS4, a Mitochondrial Complex I Subunit, is Essential for T-Cell Metabolic Fitness and Immune Function

T-cell receptors that are k-binding have defined sequence features

SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing

Synergistic anti-tumor activity of the mTOR inhibitor everolimus and gemcitabine for relapsed/refractory peripheral T cell lymphoma

Flow cytometric analysis of the immune cell subsets in adult hemophagocytic lymphohistiocytosis