Frontiers in Immunology | T Cell Biology

Original Research

Published on 20 Feb 2026

Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cells

in T Cell Biology

Alexandros Nianias
Afroditi Katsarou
Henk Jan Prins
Aida Shahrabi
Cindy van Velzen
Linda Henneman
Ruud Ruiter
Tuna Mutis
Richard Groen
Maria Themeli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1757174

365 views

Original Research

Accepted on 19 Feb 2026

The transcription factor ZNF683 marks an exhaustion-like GZMB⁺ CD8⁺ T cell in sepsis

in T Cell Biology

Mingtong Hou
Zhao Mi
Shiyu Ouyang
Guiquan Zhao
Wenbo Wang
Shengbao Wang

Frontiers in Immunology

Original Research

Published on 19 Feb 2026

Integrating pleural PD-1+CD8+ T cell as a complement variable into LENT score to assess patients with lung adenocarcinoma complicated with MPE

in T Cell Biology

Weizhen Jiang
Leilei Lv
Yaoxin Zhang
Qiuxia Qu
Cheng Chen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1630590

156 views

Original Research

Accepted on 16 Feb 2026

T Cell-Specific HIF-2α Attenuates Colitis by Antagonizing Notch-Driven Th2 Differentiations

in T Cell Biology

Ting Gao
Liangfeng Gao
Hui Zhang
Zaizhi Liu
Qing Zhu
Chunyan Wang
Song Zhang
Nan Feng

Frontiers in Immunology

Review

Accepted on 16 Feb 2026

Advancing immunotherapy via multiple immune cells co-engagement

in T Cell Biology

Han Li
Yuxuan Zhang
Qiuyang Wei
Qimeng Sun
Feng Lin
Peng R. Chen

Frontiers in Immunology

Review

Accepted on 13 Feb 2026

CAR T for Fighting IPF: Perspectives on a Living Drug

in T Cell Biology

Wei Sun
Sirui Lu
Tao Chen
Yanrui He
Zuojun Xu
Zhigang Cai

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

Dual-omics analysis of key biomarkers in T cell ubiquitination of rheumatoid arthritis blood and synovial tissue, validated by two-sample Mendelian randomization and qPCR

in T Cell Biology

Danting He
Haitao ZHAO
Jinghong MENG

Frontiers in Immunology

Original Research

Published on 12 Feb 2026

Detection of human papillomavirus (HPV)-specific T cell response in women with low-grade cervical intraepithelial lesion and HPV vaccinated subjects

in T Cell Biology

Paola Zelini
Federica Zavaglio
Mattia Dominioni
Marta Valsecchi
Lucrezia Lo Grasso
Piera d’Angelo
Federica Giardina
Greta Romano
Stefania Paolucci
Daniele Lilleri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733404

899 views

Editorial

Published on 11 Feb 2026

Editorial: The transcriptional and metabolic role of Foxp3 in regulatory T cells

in T Cell Biology

Mehdi Benamar

Frontiers in Immunology

doi 10.3389/fimmu.2026.1796661

388 views

Hypothesis and Theory

Published on 10 Feb 2026

The relativity of regulatory T cell suppression modes

in T Cell Biology

Lu Bai
Vivek Choudhary
Yongqiang Feng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1771099

619 views

Original Research

Published on 09 Feb 2026

Follicular helper-like γδ T cells promote plasma cell differentiation in Behçet’s disease

in T Cell Biology

Sahar Shaaban Mohammed
Abdullah Khalifah S. Alkhalifah
Rahilah Mirza
Sarah-Pristine Omoefe Okinedo
Rani Aishwarya Inampudi
Azimoon Bibi
Amal Senusi
Claire Pardieu
Neil E. McCarthy
Farida Fortune

Frontiers in Immunology

doi 10.3389/fimmu.2026.1763174

865 views

Editorial

Published on 09 Feb 2026

Editorial: Follicular helper T cells in immunity and autoimmunity, volume II

in T Cell Biology

Shahram Salek-Ardakani
Georgia Fousteri
Maria Pia Cicalese

Frontiers in Immunology

doi 10.3389/fimmu.2026.1790802

422 views

Review

Published on 06 Feb 2026

The tumor microenvironment in leukemia: molecular pathways of immune evasion

in T Cell Biology

Ying Zhu
Jinying Liu
Fang Qiu
Zhongjian You
Zhirui Liu
Jiqiang Zeng
Jinqiong Zhong
Ziling Song
Shanrong Zhang
Jiawei Lu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743920

1,099 views

Hypothesis and Theory

Accepted on 05 Feb 2026

Radioresistant intrathymic stem cells: Retrospective analysis and concept of the role in thymic oncogenesis and post-irradiation regeneration

in T Cell Biology

Valentin P. Shichkin

Frontiers in Immunology

143 views

Original Research

Published on 05 Feb 2026

Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion

in T Cell Biology

Mélanie Charmoy
Julia M. Maier
Tania Wyss
Vijaykumar Chennupati
Catherine Sabatel
Laurie Bonneaux
Alexandre Dumez
Romain Veber
Greta Guarda
Werner Held

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743170

508 views

Review

Published on 04 Feb 2026

The role of miRNAs in the development of Super-Tregs as a potential therapy for neurodegenerative diseases

in T Cell Biology

Kamalika Mukherjee
Suvendra N. Bhattacharyya

Frontiers in Immunology

doi 10.3389/fimmu.2026.1708031

567 views

Original Research

Published on 04 Feb 2026

TCR β CDR3 repertoire remodeling in pediatric myocarditis reveals clonal expansion and disease-associated public clonotypes

in T Cell Biology

Xixiong Lin
Xing Zhang
Liping Zhang
Linhu Hui
Zhongjian Su
Xingzhu Liu
Bin Li
Jun Li
Yanfei Chen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1711681

475 views

Mini Review

Accepted on 03 Feb 2026

Regulatory T Cells in Hypoxic Environments

in T Cell Biology

Lourdes Gonzalez-Rivera
Rodrigo Luna-Gutierrez
Stephanie Cardenas
Consuelo Merino
Alex Handy
Ines Pepper
Mercedes Natalia Lopez

Frontiers in Immunology

Review

Accepted on 02 Feb 2026

Tumor-infiltrating Lymphocyte Therapy in Triple-negative Breast Cancer: From Mechanistic Exploration to Clinical Translation

in T Cell Biology

Yongxi Wang
Zhe Zhang
Zhuo Chen
Xiaoyun Xie
Fang Wang

Frontiers in Immunology

127 views

Review

Accepted on 27 Jan 2026

Immunomodulatory Roles of Regulatory T Cells in Cutaneous Wound Healing: Mechanisms and Therapeutic Opportunities

in T Cell Biology

Peter Samuel Emeka
Farooq Riaz
Yikui Li
Xiaoli Zhao
Fan Pan

Frontiers in Immunology

204 views

Review

Accepted on 27 Jan 2026

Smart Control of CAR-T Cells: Emerging Strategies for Safer and More Effective Cancer Immunotherapy

in T Cell Biology

Guokai Zhang
Hai-mei Wang
Fang Zhou

Frontiers in Immunology

112 views

Original Research

Published on 27 Jan 2026

Transcriptional and epigenetic control of human naïve CD8+ T cell activation

in T Cell Biology

Yaqiu Hu
Yuxia Du
Xuenuo Chen
Yongguo Li
Cheng Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1749526

784 views

Editorial

Published on 26 Jan 2026

Editorial: Community series in the role of CD1- and MR1-restricted T cells in immunity and disease: volume III

in T Cell Biology

Kazuya Iwabuchi
Luc Van Kaer

Frontiers in Immunology

doi 10.3389/fimmu.2026.1783936

545 views

Original Research

Published on 23 Jan 2026

Differential composition of lymphocyte subpopulations and activation between the hypertensive Bph/2 and normotensive Bpn/3 mouse strains

in T Cell Biology

Devon Dattmore
Paiton O. McDonald
Afrin Chowdhury
Saamera Awali
Allison P. Boss
Yining Jin
Lisa Sather
D. Adam Lauver
Cheryl E. Rockwell

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598843

853 views

2,232 articles

articles

Engineering of induced pluripotent stem cells for the efficient development of non-alloreactive, hypoimmunogenic CD8αβ CAR-T cells

The transcription factor ZNF683 marks an exhaustion-like GZMB⁺ CD8⁺ T cell in sepsis

Integrating pleural PD-1+CD8+ T cell as a complement variable into LENT score to assess patients with lung adenocarcinoma complicated with MPE

T Cell-Specific HIF-2α Attenuates Colitis by Antagonizing Notch-Driven Th2 Differentiations

Advancing immunotherapy via multiple immune cells co-engagement

CAR T for Fighting IPF: Perspectives on a Living Drug

Dual-omics analysis of key biomarkers in T cell ubiquitination of rheumatoid arthritis blood and synovial tissue, validated by two-sample Mendelian randomization and qPCR

Detection of human papillomavirus (HPV)-specific T cell response in women with low-grade cervical intraepithelial lesion and HPV vaccinated subjects

Editorial: The transcriptional and metabolic role of Foxp3 in regulatory T cells

The relativity of regulatory T cell suppression modes

Follicular helper-like γδ T cells promote plasma cell differentiation in Behçet’s disease

Editorial: Follicular helper T cells in immunity and autoimmunity, volume II

The tumor microenvironment in leukemia: molecular pathways of immune evasion

Radioresistant intrathymic stem cells: Retrospective analysis and concept of the role in thymic oncogenesis and post-irradiation regeneration

Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion

The role of miRNAs in the development of Super-Tregs as a potential therapy for neurodegenerative diseases

TCR β CDR3 repertoire remodeling in pediatric myocarditis reveals clonal expansion and disease-associated public clonotypes

Regulatory T Cells in Hypoxic Environments

Tumor-infiltrating Lymphocyte Therapy in Triple-negative Breast Cancer: From Mechanistic Exploration to Clinical Translation

Immunomodulatory Roles of Regulatory T Cells in Cutaneous Wound Healing: Mechanisms and Therapeutic Opportunities

Smart Control of CAR-T Cells: Emerging Strategies for Safer and More Effective Cancer Immunotherapy

Transcriptional and epigenetic control of human naïve CD8+ T cell activation

Editorial: Community series in the role of CD1- and MR1-restricted T cells in immunity and disease: volume III

Differential composition of lymphocyte subpopulations and activation between the hypertensive Bph/2 and normotensive Bpn/3 mouse strains