Frontiers in Immunology | T Cell Biology

Original Research

Published on 22 Jan 2026

Delineating phenotypic heterogeneity in human regulatory T cells across developmental stages and therapeutic sources

in T Cell Biology

Samikshya Santosh Nirmala
Yueyuan Hu
Friederike Dorothea Floegel
Hugo Cruz
Johanna Morgenstern
Alexander Platz
Marcel Vollroth
Anke Fuchs

Frontiers in Immunology

doi 10.3389/fimmu.2026.1697723

930 views

Original Research

Published on 19 Jan 2026

Moving for optimal immunity: the effect of acute high-intensity interval training on phenotype, virus specificity and chemokine receptor expression in human CD8+ T cells

in T Cell Biology

Katharina Leuchte
Thy Viet Luu
Sara Fresnillo Saló
Kasper Madsen
Lise Heide-Ottosen
Signe Koggersbøl Skadborg
Janine Sophie Kemming
Morten Orebo Holmström
Hongjin Chen
Lars Rønn Olsen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739657

1,658 views
1 citation

Review

Published on 16 Jan 2026

Metabolic reprogramming tailors T cell immunity in sepsis

in T Cell Biology

Di Xian
Feng Chen
Bing Liu
Lei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679493

1,188 views

Review

Published on 12 Jan 2026

The TCR and LCK: foundations for T-cell activation and therapeutic innovation

in T Cell Biology

Nadine M. Woessner
Valeria Uleri
Ondrej Stepanek
Susana Minguet

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737013

2,039 views
1 citation

Editorial

Published on 09 Jan 2026

Editorial: Epigenetic regulation of T cell function in type 1 diabetes

in T Cell Biology

Ubaid Ullah Kalim
Giuseppina Emanuela Grieco

Frontiers in Immunology

doi 10.3389/fimmu.2025.1773432

667 views

Original Research

Published on 08 Jan 2026

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

in T Cell Biology

Emily C. Reed
Tatlock H. Lauten
Tamara Natour
Lauren J. Pitts
Caroline N. Jojo
Brooke L. Griffin
Sreeram Pasupuleti
Adam J. Case

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725904

879 views

Original Research

Published on 07 Jan 2026

NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function

in T Cell Biology

Oded Shamriz
Zahala Bar-On
Omri Yosef
Leonor Cohen-Daniel
Ayelet Sheer
Or Reuven
Wajeeh Salaymeh
Amijai Saragovi
Raz Somech
Atar Lev

Frontiers in Immunology

doi 10.3389/fimmu.2025.1734203

1,295 views

Correction

Published on 02 Jan 2026

Correction: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

in T Cell Biology

Karina M. Berschneider
Bernhard Wetterauer
Carsten Sticht
Christian Orlik
Beate Jahraus
Henning Kirchgessner
Anastasiia Zuieva
Stefan Wölfl
Divya Lairikyengbam
Verena Beier

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761559

583 views

Original Research

Published on 02 Jan 2026

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models

in T Cell Biology

Ying Xing
Gangqiang Shi
Zhengli Li
Xiancheng Liu
Linghu Nie
Yu Zhang
Yiqin Song
Shilin Sun
Mike K. S. Chan
Michelle B. F. Wong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638585

2,193 views

Original Research

Published on 19 Dec 2025

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

in T Cell Biology

Valerie Plajer
Adrián Madrigal-Avilés
Maria Dzamukova
Nayar Durán-Hernández
Philippe Saikali
Vivien Holecska
Isabel Panse
Katrin Lehmann
Jinfang Zhu
Mir-Farzin Mashreghi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716422

1,710 views

Review

Published on 19 Dec 2025

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond

in T Cell Biology

Xiang Fang
Shixuan Yan
Long He
Changwen Deng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735763

2,217 views

Original Research

Published on 19 Dec 2025

Longitudinal immune profiling uncovers regulatory T cell signatures associated with the progression of COVID-19

in T Cell Biology

Camila Kossack
Felipe Bravo
Francisco Fuentes-Villalobos
Claudio Quevedo
Matías A. Medina
Raúl Riquelme
María Luisa Rioseco
Mario Calvo
Karina Pino-Lagos
Felipe Aguilera

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697788

1,624 views

Original Research

Published on 18 Dec 2025

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

in T Cell Biology

Maria A. Salnikova
Ksenia K. Tuchynskaya
Anastasia A. Minervina
Mikhail V. Pogorelyy
Egor V. Okhezin
Galina G. Karganova
Ilgar Z. Mamedov
Yuri B. Lebedev

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663781

1,558 views

Review

Published on 16 Dec 2025

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

in T Cell Biology

Yuehong Hu
Qihan Zhao
Haoran Dai
Yadi Wu
Xinyue Tang
Naiqian Zhang
Hanxue Jiang
Hongliang Rui
Baoli Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687755

2,906 views

Mini Review

Published on 12 Dec 2025

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease

in T Cell Biology

Feven Getachew
Junhui Hu
Mehdi Benamar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729690

2,530 views

Review

Published on 12 Dec 2025

Immunomodulatory biomaterials for vascularized and innervated skeletal muscle repair

in T Cell Biology

Lauren G. Mottel
Brennagh R. Shields
Brian J. Kwee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657015

1,821 views

Review

Published on 11 Dec 2025

T cell heterogeneity in asthma pathogenesis: from immunological mechanisms to biological targeted therapies

in T Cell Biology

Qifeng Gan
Yuzhen Zhu
Yuxin Guo
Guo Fu
Xiao-Bin Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658774

1,448 views

Original Research

Published on 11 Dec 2025

Development of a humanized mouse model of graft-versus-host disease to assess human regulatory T cell function

in T Cell Biology

Charline Beguin
Oswin Kwan
Grégory Ehx
Stéphanie Humblet-Baron
Murat Cem Köse
Sophie Dubois
Lorenzo Canti
Justine Courtois
Coline Daulne
Jo Caers

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717133

2,031 views

Original Research

Published on 10 Dec 2025

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

in T Cell Biology

Akihiro Shimba
Satoru Munakata
Shinya Abe
Guangwei Cui
Ryoma Kato
Masaki Miyazaki
Atsuhiro Ichihara
Koichi Ikuta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566935

1,144 views

Brief Research Report

Published on 03 Dec 2025

T-cell receptors that are k-binding have defined sequence features

in T Cell Biology

Hyunjin Park
Jonathan Krog
Brandon Carter
Pallavi A. Balivada
Emily M. Pogue
Samyuktha Anand
Michael E. Birnbaum
David K. Gifford

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621201

2,644 views

Original Research

Published on 01 Dec 2025

SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing

in T Cell Biology

Chenxin Gan
Qian Wu
Jorg J. Goronzy
Yongchun Zhang
Lingjie Li
Huiming Sheng
Fengqin Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679064

1,282 views

Original Research

Published on 28 Nov 2025

Synergistic anti-tumor activity of the mTOR inhibitor everolimus and gemcitabine for relapsed/refractory peripheral T cell lymphoma

in T Cell Biology

Ling Huang
Hanguo Guo
Yan Teng
Diwen Pang
Fen Zhang
Yichen Sun
Choon Kiat Ong
Jing Tan
Wenyu Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683550

1,082 views
1 citation

Original Research

Published on 28 Nov 2025

Flow cytometric analysis of the immune cell subsets in adult hemophagocytic lymphohistiocytosis

in T Cell Biology

Yao Qin
Jianying Zhou
Pengpeng Liu
Yang Dai
Yun Tang
Xushu Zhong
Xinchuan Chen
Huanling Zhu
Ting Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678233

1,500 views

Original Research

Published on 26 Nov 2025

Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire

in T Cell Biology

Gautier Lhomme
Rémi Giraudet
Valéria Porcheddu
Evelyne Correia
Robert Olaso
Stephane Hua
Bernard Maillere

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713225

1,323 views

2,231 articles

articles

Delineating phenotypic heterogeneity in human regulatory T cells across developmental stages and therapeutic sources

Moving for optimal immunity: the effect of acute high-intensity interval training on phenotype, virus specificity and chemokine receptor expression in human CD8+ T cells

Metabolic reprogramming tailors T cell immunity in sepsis

The TCR and LCK: foundations for T-cell activation and therapeutic innovation

Editorial: Epigenetic regulation of T cell function in type 1 diabetes

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function

Correction: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond

Longitudinal immune profiling uncovers regulatory T cell signatures associated with the progression of COVID-19

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

Metabolic regulation of regulatory T cells: mechanisms, heterogeneity, and implications in disease

Immunomodulatory biomaterials for vascularized and innervated skeletal muscle repair

T cell heterogeneity in asthma pathogenesis: from immunological mechanisms to biological targeted therapies

Development of a humanized mouse model of graft-versus-host disease to assess human regulatory T cell function

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

T-cell receptors that are k-binding have defined sequence features

SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing

Synergistic anti-tumor activity of the mTOR inhibitor everolimus and gemcitabine for relapsed/refractory peripheral T cell lymphoma

Flow cytometric analysis of the immune cell subsets in adult hemophagocytic lymphohistiocytosis

Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire