Frontiers in Immunology | T Cell Biology

Original Research

Published on 26 Nov 2025

Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire

in T Cell Biology

Gautier Lhomme
Rémi Giraudet
Valéria Porcheddu
Evelyne Correia
Robert Olaso
Stephane Hua
Bernard Maillere

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713225

904 views

Systematic Review

Published on 25 Nov 2025

The role of microRNAs and long non-coding RNAs in epigenetic regulation of T cells: implications for autoimmunity

in T Cell Biology

Soumil Prasad
Harini Adivikolanu
Abhinav Banerjee
Mannat Mittal
Joana R. N. Lemos
Rahul Mittal
Khemraj Hirani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695894

1,481 views

Opinion

Published on 24 Nov 2025

Towards a sustainable, comprehensive and community-accepted nomenclature and naming standard of antibody and T cell receptor germline genes and alleles

in T Cell Biology

Ayelet Peres
Mats Ohlin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689673

839 views

Original Research

Published on 21 Nov 2025

Enhancement of activation-induced T cell proliferation by SIRPG in a CD47-independent manner

in T Cell Biology

Flavien Marguerie
Mohammad A. Saifi
Benjamin Geary
David Barnes
Laura Lim
Anna Helena Jonsson
I-Cheng Ho

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668361

1,311 views

Original Research

Published on 21 Nov 2025

Disruption of Notch signaling by KGF induces a developmental pause in thymocytes

in T Cell Biology

Ruifeng Teng
Francis A. Flomerfelt
Ping Xue
Anjali Chandroth
Constance Tom Noguchi
Nikolaos Svoronos
Ronald E. Gress
Naomi Taylor

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675823

765 views

Review

Published on 21 Nov 2025

Imbalance of T cell subsets: a core event that mediates the progression of T2DM and its complications

in T Cell Biology

Xiang Xie
Fan Li
Qian Wu
Chunlan Zeng
Xi Chen
Wenwen Wang
Chunxiang Zhang
Huan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688392

1,058 views

Review

Published on 18 Nov 2025

Beyond the genome: epigenetic regulation of immune responses and T cells in brain tumors

in T Cell Biology

Shuo Sun
Yu Han
Haiying Li
Chengyan Wang
Shu Zhou
Xiaowei Zhang
Shuhong Dai
Yao Peng
Zhuoqun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690552

1,886 views

Original Research

Published on 18 Nov 2025

CGRP restrains CD4+ T cell responses and allergic sensitization

in T Cell Biology

Xiaoshi Li
Ying Zhang
Wenlong Chen
Qingren Meng
Ai Huang
Jiayi Pan
Duan Chen
Yue Xiao
Jialin Wei
Heng Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671269

942 views

Original Research

Published on 11 Nov 2025

CHASERR-CHD2 dynamics in T cell quiescence and its modulation by cyclosporine

in T Cell Biology

Anna Budkina
Anatoliy Zubritskiy
Daria Marakulina
Marina Yu. Loguinova
Nikita A. Sergeev
Yulia A. Medvedeva

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652359

1,148 views

Original Research

Published on 06 Nov 2025

Defined metabolic states shape T cell fate and function across culture conditions

in T Cell Biology

Kayla Sylvester
Natasha Karassina
Anthony C. Lauer
Gediminas Vidugiris
Jolanta Vidugiriene

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703095

1,112 views

Mini Review

Published on 31 Oct 2025

Regulatory T cell therapies: from patient data to biological insights

in T Cell Biology

Kameron B. Rodrigues
Peter J. Eggenhuizen
Rosa Bacchetta
Zinaida Good

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675114

4,451 views

Review

Published on 29 Oct 2025

Linking epigenetic mechanisms of T cell dysfunction with pathophysiology of type 1 diabetes mellitus

in T Cell Biology

Abdullah Jabri
Abdulrahman Elsalti
Mohamed Alsharif
Raghad Alsharif
Tasnim Abbad
Dania Sibai
Bader Taftafa
Abdulaziz Mhannayeh
Mohammad Imran Khan
Ahmed Yaqinuddin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664255

1,927 views

Editorial

Published on 28 Oct 2025

Editorial: Role of tissue-localized regulatory T cells in health and disease

in T Cell Biology

Bevin Smith
Diane Mathis
Ali A. Zarrin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718891

2,048 views

Original Research

Published on 24 Oct 2025

Assessment of antigen-specific T cell recall responses in non-human primates using a composite AIM assay

in T Cell Biology

Jan M. Schmidt
Mayuri Prasad
Kenna Degner
Rebecca Schiavo
Allison Repic
Lauren Little
Laura Israel
Feng Chen
Regine Hansen
Anette C. Karle

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661480

1,602 views

Original Research

Published on 23 Oct 2025

Distinct characteristics of T cell receptor repertoire associated with the SARS-CoV-2 reinfection

in T Cell Biology

Liling Zeng
Li Liu
Baolin Ren
Bing Feng
Xudong Lai
Xunxi Lai
Zhimin Chen
Yihui Huang
Wenxin Hong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680089

11,519 views

Original Research

Published on 17 Oct 2025

Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis

in T Cell Biology

Min Lin
Jianbo Lin
Quan Du
Yuanrong Tu
Jianfeng Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656632

2,094 views

Review

Published on 16 Oct 2025

Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics

in T Cell Biology

Caifeng Shen
Qiong Fu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686687

2,264 views

Hypothesis and Theory

Published on 15 Oct 2025

The role of ubiquitin ligases in regulating immune cell functions

in T Cell Biology

Saci-Elodie Marty
Linda Yip
Fangyuan Wang
Manoj Kumar
C. Garrison Fathman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625419

1,713 views

Original Research

Published on 15 Oct 2025

Comparative immunophenotyping of peripheral blood lymphocyte subsets in pulmonary tuberculosis and nontuberculous mycobacterial pulmonary disease: a retrospective study

in T Cell Biology

Shuai Ren
Ruifang Chen
Ping Xu
Zhangyan Zhao
Haicheng Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682099

1,157 views

Original Research

Published on 15 Oct 2025

Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

in T Cell Biology

Karina M. Berschneider
Bernhard Wetterauer
Carsten Sticht
Christian Orlik
Beate Jahraus
Henning Kirchgessner
Anastasiia Zuieva
Stefan Wölfl
Divya Lairikyengbam
Verena Beier

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655212

1,715 views
1 citation

Review

Published on 14 Oct 2025

Thymus research in relation to myasthenia gravis: a new perspective on cell subpopulations and future directions

in T Cell Biology

Naoko Matsui
Izumi Ohigashi
Alexander Marx

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649171

3,091 views

Original Research

Published on 14 Oct 2025

Elevated Th1 and terminally differentiated cytotoxic T cells with suppressed Tc17 lymphocytes in lung tissue of advanced COPD and IPF patients undergoing lung transplantation

in T Cell Biology

Irena Šarc
Matija Rijavec
Luka Dejanović
Ana Koren
Matthias Zimmermann
Hendrik J. Ankersmit
Peter Korošec

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646711

3,296 views

Review

Published on 13 Oct 2025

Next-generation T cell immunotherapy: overcoming exhaustion, senescence, and suppression

in T Cell Biology

Guangmei Li
Dengju Li
Xiaojian Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662145

3,679 views
1 citation

Review

Published on 08 Oct 2025

Th17/Treg imbalance in inflammatory bowel disease: immunological mechanisms and microbiota-driven regulation

in T Cell Biology

Yuyuan Hu
Yuhang Yang
Yan Li
Qiang Zhang
Wei Zhang
Jinghan Jia
Zhuoyi Han
Jinxi Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651063

5,801 views
1 citation

2,208 articles

articles

Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire

The role of microRNAs and long non-coding RNAs in epigenetic regulation of T cells: implications for autoimmunity

Towards a sustainable, comprehensive and community-accepted nomenclature and naming standard of antibody and T cell receptor germline genes and alleles

Enhancement of activation-induced T cell proliferation by SIRPG in a CD47-independent manner

Disruption of Notch signaling by KGF induces a developmental pause in thymocytes

Imbalance of T cell subsets: a core event that mediates the progression of T2DM and its complications

Beyond the genome: epigenetic regulation of immune responses and T cells in brain tumors

CGRP restrains CD4+ T cell responses and allergic sensitization

CHASERR-CHD2 dynamics in T cell quiescence and its modulation by cyclosporine

Defined metabolic states shape T cell fate and function across culture conditions

Regulatory T cell therapies: from patient data to biological insights

Linking epigenetic mechanisms of T cell dysfunction with pathophysiology of type 1 diabetes mellitus

Editorial: Role of tissue-localized regulatory T cells in health and disease

Assessment of antigen-specific T cell recall responses in non-human primates using a composite AIM assay

Distinct characteristics of T cell receptor repertoire associated with the SARS-CoV-2 reinfection

Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis

Follicular helper T cells (Tfh): heterogeneity in spatial distribution and phenotypic characteristics

The role of ubiquitin ligases in regulating immune cell functions

Comparative immunophenotyping of peripheral blood lymphocyte subsets in pulmonary tuberculosis and nontuberculous mycobacterial pulmonary disease: a retrospective study

Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

Thymus research in relation to myasthenia gravis: a new perspective on cell subpopulations and future directions

Elevated Th1 and terminally differentiated cytotoxic T cells with suppressed Tc17 lymphocytes in lung tissue of advanced COPD and IPF patients undergoing lung transplantation

Next-generation T cell immunotherapy: overcoming exhaustion, senescence, and suppression

Th17/Treg imbalance in inflammatory bowel disease: immunological mechanisms and microbiota-driven regulation