Frontiers in Immunology | T Cell Biology

Original Research

Published on 23 Jun 2025

Co-expression of IL-15/IL-15Ra complex enhances NKG2D-CAR T cell-mediated anti-pancreatic cancer immunity by activating the JAK/STAT5 signaling pathway

in T Cell Biology

Yiran Chen
Chenxu Jin
Dandan Guo
Xinhui Hui
Yuzhou Ji
Yunhe Huang
Min Xue
Yaoxin Gao
Yaojun Ren
Haizhen Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1498706

455 views

Review

Published on 23 Jun 2025

Thymic B cells in aging and autoimmune disease

in T Cell Biology

Sarah A. Wedemeyer
Ann V. Griffith

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595805

449 views

Review

Accepted on 20 Jun 2025

Mathematical models and computational approaches in CAR-T therapeutics

in T Cell Biology

Guido Putignano
Samuel Ruiperez-Campillo
Zhou Yuan
Jose Millet
Sara Guerrero-Aspizua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581210

292 views

Original Research

Accepted on 19 Jun 2025

The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival

in T Cell Biology

Caitlyn Guldenpfennig
Yue Guan
Bela Cersi
Elida Lopez
Emma Teixeiro
Mark Daniels

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630599

119 views

Review

Accepted on 18 Jun 2025

CD1-restricted T cells: Are unconventional allies the key to future TB vaccines?

in T Cell Biology

Salah Mansour
Matthew A Milton

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629466

188 views

Review

Published on 18 Jun 2025

The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes

in T Cell Biology

Devin R. Fraser
Andrew W. Stadnyk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602934

791 views

Original Research

Published on 18 Jun 2025

Single-cell analysis of peripheral blood and pleural effusion reveals functional diversity of γδ T cells in tuberculosis infection

in T Cell Biology

Yanjun Feng
Yu Chen
Wanying Zhang
Xinghua Shen
Jinyu Yan
Lin Yao
Lijuan Zhang
Yayan Niu
Jianping Zhang
Peijun Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1605827

416 views

Brief Research Report

Published on 18 Jun 2025

P-glycoprotein expression skews mitochondrial dye measurements in T cells

in T Cell Biology

Sophia P. M. Sok
Jianan Cheng
Klaudia Strucinska
Narcis I. Popescu
Lihua Wu
Qiuqing Ke
William B. Kiosses
David Stanford
Willard M. Freeman
Satoshi Matsuzaki

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560104

368 views

Original Research

Published on 18 Jun 2025

Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia

in T Cell Biology

Freya Sibbertsen
Regine J. Dress
Sören Alexander Weidemann
Katharina Möller
Uta Herden
Lutz Fischer
Kevin Paul
Jun Oh
Eva Tolosa
Sebastian Schulz-Jürgensen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567645

433 views

Original Research

Published on 17 Jun 2025

Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns

in T Cell Biology

Ziran Bai
Siwen Yang
Jinyi Ren
Cheng Zhang
Xianmei Chen
Huina Huang
Guan Wang
Yawei Tang
Jingjing Qi
Xia Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608675

468 views

Editorial

Published on 17 Jun 2025

Editorial: Mechanisms of early intracellular signaling in T lymphocytes

in T Cell Biology

Enrique Aguado
Mikel M. Arbulo-Echevarria
Ewoud B. Compeer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638330

528 views

Mini Review

Accepted on 16 Jun 2025

Influences of Metabolism and Lipid Homeostasis on Regulatory vs. Conventional T Cells and Implications for Autoimmunity

in T Cell Biology

Madison Nguyen
Sarah Soobin Lee
Craig Michael Walsh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613230

157 views

Original Research

Published on 16 Jun 2025

Transcriptional fingerprinting of regulatory T cells: ensuring quality in cell therapy applications

in T Cell Biology

Zhang Cheng
Li-Jie Wang
Yuchi Honaker
Steven A. Cincotta
Claire E. Page
Sydney Vollhardt
Victor Yuan
S. Alice Long
Yuanyuan Xiao
Joshua N. Beilke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602172

1,214 views

Review

Published on 16 Jun 2025

The reprogramming factor KLF4 in normal and malignant blood cells

in T Cell Biology

H. Daniel Lacorazza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584181

345 views

Review

Published on 12 Jun 2025

Role of human antigen-specific T cells in tolerance and IgE-mediated allergic reactions to food

in T Cell Biology

Rosina López-Fandiño

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595696

693 views

Original Research

Accepted on 11 Jun 2025

Ex vivo-generated lymphoid progenitors encompass both T cell and innate lymphoid cell fates

in T Cell Biology

Juliette Paillet
Pierre GAUDEAUX
Monah Abou Alezz
Ranjita Devi Moirangthem
Sara Cascione
Marta Martin Corredera
Anne-Catherine Dolens
Katrien De Mulder
Imke Velghe
Marieke Lavaert

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617707

252 views