Frontiers in Immunology | T Cell Biology

Mini Review

Published on 30 Sep 2025

Mechanisms and therapeutic strategies to reveal and overcome T-cell dysfunction in gastric cancer: translation from basic research to clinical application

in T Cell Biology

Huanyu Luo
Jianxi Wu
Yalan Yan
Danqi Xu
Jieying Zhang
Xuancheng Zhou
Guanhu Yang
Xiaolin Zhong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681539

4,094 views

Original Research

Published on 30 Sep 2025

Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response

in T Cell Biology

Yimo Sun
Yitao Tang
Priscilla Ortiz
Barbara Nassif Rausseo
Barbara Pazdrak
Lama Elzohary
Arjun Katailiha
Amjad Talukder
Cassian Yee
Richard Eric Davis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572342

2,603 views

Original Research

Published on 26 Sep 2025

Essential roles of CTCF binding sites at TAD boundaries in modulating chromatin interactions and transcriptional regulation at the Ifng locus

in T Cell Biology

Kazuya Muto
Daiki Yoshida
Toshiyuki Suzuki
Natsuo Yamamoto
Naokazu Inoue
Akiko Murakami-Sekimata
Ken Iseki
Masayuki Sekimata

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667851

4,117 views

Review

Published on 26 Sep 2025

CD3+CD4−CD8− T cells: a new potential therapeutic target in treating autoimmune diseases

in T Cell Biology

Xin Li
Di Guo
Isabelle Xinyue Zou
Lingyan Zhao
Na Yang
Yang Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683418

4,041 views
3 citations

Editorial

Published on 24 Sep 2025

Editorial: Exploring lymphocyte signaling: from health to disease

in T Cell Biology

Rosa Molfetta
Luca Simeoni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703096

2,576 views

Original Research

Published on 19 Sep 2025

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selection

in T Cell Biology

Daniil V. Luppov
Elizaveta K. Vlasova
Dmitry M. Chudakov
Mikhail Shugay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1605170

3,410 views
1 citation

Original Research

Published on 19 Sep 2025

Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells

in T Cell Biology

Anna K. Ehret
Sara Hartmann
Pavel Salavei
Virginia Andreani
Nicole Gensch
Laura Gámez-Díaz
Wolfgang W. Schamel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646135

2,609 views

Mini Review

Published on 19 Sep 2025

Regulatory T cell therapy for xenotransplantation, what perspectives?

in T Cell Biology

Raphaël Porret
Erica Lana
Antonio Mancarella
Philippe Guillaume
Manuel Pascual
Raphael P. H. Meier
Jonathan S. Bromberg
Muhammad M. Mohiuddin
Leo H. Buhler
Qizhi Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685682

4,681 views
1 citation

Original Research

Published on 19 Sep 2025

Focal adhesion kinase plays an essential role in Th17 cell differentiation by stimulating NF-κB signaling

in T Cell Biology

Hyeong Su Kim
Ji Hyeon Lee
Hyogon Sohn
Woo Ho Lee
Ga Eul Kim
Wonyong Lee
Hang-Rae Kim
Gap Ryol Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596802

3,188 views
1 citation

Original Research

Published on 16 Sep 2025

Th17-associated cytokine gene hypomethylation reflects epigenetic dysregulation in graves’ disease

in T Cell Biology

Yanfei Jiang
Kaida Mu
Zhaowei Huang
Xinwei Zhang
Yalin Wang
Wenyu Xu
Ronghua Song
Jinan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635883

2,766 views
2 citations

Review

Published on 10 Sep 2025

Innate iNKT cells: from biological insight to clinical impact

in T Cell Biology

Antonia Rotolo
Nicola J. Mason
Mark A. Exley

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653183

4,811 views

Original Research

Published on 09 Sep 2025

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis

in T Cell Biology

Fan Yang
Alexis Yanes
Miao Li
Patrick Heizer
Ivan Linatoc
Michael E. Stephens
Yang Song
Tatiana Ort
Kyle J. Bednar
Yasuhiro Ikeda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636434

3,564 views

Correction

Published on 08 Sep 2025

Correction: Mathematical models and computational approaches in CAR-T therapeutics

in T Cell Biology

Guido Putignano
Samuel Ruipérez-Campillo
Zhou Yuan
José Millet
Sara Guerrero-Aspizua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694607

1,311 views

Original Research

Published on 08 Sep 2025

Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery

in T Cell Biology

Vanesa Garrido-Rodríguez
Ángel Bulnes-Ramos
Israel Olivas-Martínez
María del Mar Pozo-Balado
Francisco Tejerina-Picado
Félix Gutiérrez
Cristina Marco-Sánchez
Juan Manuel Tiraboschi
Antonia Castillo-Navarro
Enrique Bernal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617674

2,711 views

Review

Published on 05 Sep 2025

Regulatory mechanisms of Th9 cell differentiation

in T Cell Biology

Xingyue Liu
Ya Li
Wenwen Wu
Han Huang
Yanmei Hao
Chuanwang Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650972

5,397 views
2 citations

Case Report

Published on 03 Sep 2025

Mesenchymal stromal cells as rescue therapy in biologic-refractory psoriasis: insights from a case series

in T Cell Biology

Su M. Lwin
Shane Solanky
Cristiano Scottà
Chiara Giacomini
Shir Azrielant
Isabella Tosi
Atheer Al-Haddabi
Emelia Duarte-Williamson
Hannah Dawe
Sarah Walsh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656724

4,323 views

Brief Research Report

Published on 02 Sep 2025

Substantial loss of T cells upon lymphocyte isolation from heparin-anticoagulated peripheral blood

in T Cell Biology

Victoria Berg
J. Alexander Ross
Maria Dampmann
Ralf Küppers
Bettina Budeus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665686

2,217 views

Review

Published on 29 Aug 2025

The emerging role of tissue regulatory T cells in tissue repair and regeneration

in T Cell Biology

Abdul Raheem
Ilyas Khan
Iqbal Ahmad
Abdul Wajid
Mohammad Y. Alshahrani
Fuad M. Alzahrani
Khalid J. Alzahrani
Abdul Qadeer
I-Chuang Liao
Chien-Chin Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640113

5,075 views
4 citations

Original Research

Published on 27 Aug 2025

Targeting IL-6 receptor mediated metabolic pathways to control Th17 cell differentiation and inflammatory responses

in T Cell Biology

Yazan Alwarawrah
Amanda G. Nichols
Isha Patel
Andréa B. Ball
Nancie J. MacIver

Frontiers in Immunology

doi 10.3389/fimmu.2025.1568514

2,974 views

Original Research

Published on 27 Aug 2025

Large-scale statistical mapping of T-cell receptor β sequences to human leukocyte antigens

in T Cell Biology

H. Jabran Zahid
Ruth Taniguchi
Peter Ebert
I-Ting Chow
Chris Gooley
Jinpeng Lv
Lorenzo Pisani
Mikaela Rusnak
Rebecca Elyanow
Hiroyuki Takamatsu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603730

2,275 views
7 citations

Review

Published on 26 Aug 2025

Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications

in T Cell Biology

Bat-Erdene Jugder
Eunchong Park
Lijuan Du
Chetan Jawale
Nikolay Popov
Zengli Guo
Kyle J. Bednar
Tatiana Ort

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650451

7,253 views
4 citations

Original Research

Published on 26 Aug 2025

Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization

in T Cell Biology

Yining Zhou
Xinyi Xie
Huiwen Chen
Lina Xu
Che Qiu
Hui Shen
Wei Zhou
Zhongchen Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1590665

3,371 views

Original Research

Published on 22 Aug 2025

Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

in T Cell Biology

Elżbieta Supruniuk
Kamil Grubczak
Anna Parfieniuk-Kowerda
Robert Flisiak
Marcin Moniuszko
Jerzy Jaroszewicz
Adrian Chabowski
Magdalena Świderska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597204

2,596 views

Original Research

Published on 22 Aug 2025

Cord blood innate-like T cell responses in neonates born to healthy women and women living with HIV

in T Cell Biology

David Rach
Hao-Ting Hsu
Nginache Nampota-Nkomba
Godfrey Mvula
Felix A. Mkandawire
Osward M. Nyirenda
Bernadette Hritzo
Francesca Boldrin
Giulia Degiacomi
Laura Cioetto Mazzabò

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628145

3,890 views

2,231 articles

articles

Mechanisms and therapeutic strategies to reveal and overcome T-cell dysfunction in gastric cancer: translation from basic research to clinical application

Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response

Essential roles of CTCF binding sites at TAD boundaries in modulating chromatin interactions and transcriptional regulation at the Ifng locus

CD3+CD4−CD8− T cells: a new potential therapeutic target in treating autoimmune diseases

Editorial: Exploring lymphocyte signaling: from health to disease

Comprehensive analysis of αβT-cell receptor repertoires reveals signatures of thymic selection

Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells

Regulatory T cell therapy for xenotransplantation, what perspectives?

Focal adhesion kinase plays an essential role in Th17 cell differentiation by stimulating NF-κB signaling

Th17-associated cytokine gene hypomethylation reflects epigenetic dysregulation in graves’ disease

Innate iNKT cells: from biological insight to clinical impact

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGFβ-signaling via ARKADIA-SKI axis

Correction: Mathematical models and computational approaches in CAR-T therapeutics

Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery

Regulatory mechanisms of Th9 cell differentiation

Mesenchymal stromal cells as rescue therapy in biologic-refractory psoriasis: insights from a case series

Substantial loss of T cells upon lymphocyte isolation from heparin-anticoagulated peripheral blood

The emerging role of tissue regulatory T cells in tissue repair and regeneration

Targeting IL-6 receptor mediated metabolic pathways to control Th17 cell differentiation and inflammatory responses

Large-scale statistical mapping of T-cell receptor β sequences to human leukocyte antigens

Tissue-specific roles of regulatory T cells: mechanisms of suppression and beyond along with emerging therapeutic insights in autoimmune indications

Stat3-mediated Th17 pathogenicity induced by periodontitis contributes to cognitive impairment by promoting microglial M1 polarization

Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

Cord blood innate-like T cell responses in neonates born to healthy women and women living with HIV