Frontiers in Immunology | T Cell Biology

Review

Published on 16 Jul 2025

Navigating the manufacturing, testing and regulatory complexities of regulatory T cells for adoptive cell therapy

in T Cell Biology

Larissa A. Pikor
Sindhu Arivazhagan
Michael Mendicino
Sarmitha Sathiamoorthy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626085

2,998 views
2 citations

Original Research

Published on 10 Jul 2025

Temporal TCR dynamics and epitope diversity mark recovery in severe COVID-19 patients

in T Cell Biology

Kriti Khare
Sunita Yadav
Sayanti Halder
Yogiraj Ray
Dipyaman Ganguly
Rajesh Pandey

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582949

2,516 views

Review

Published on 10 Jul 2025

CD1-restricted T cells: are unconventional allies the key to future TB vaccines?

in T Cell Biology

Matthew Milton
Salah Mansour

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629466

2,652 views

Original Research

Published on 09 Jul 2025

Natural microbial exposure populates the maternal fetal interface with diverse T cells

in T Cell Biology

Amy Whillock
Perianne Smith
Sarah Burger
Adhvaith Sridhar
Alex Lindgren
James Berg
Sayaka Tsuda
Shweta Mahajan
Tamara Tilburgs
Nathaniel J. Schuldt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616491

2,684 views

Original Research

Published on 08 Jul 2025

Global trends and frontiers in iNKT cells: a bibliometric and visualized analysis

in T Cell Biology

Dan Zhang
Jun Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618254

2,538 views
1 citation

Original Research

Published on 07 Jul 2025

Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

in T Cell Biology

Meaghan M. Broman
Nadia A. Lanman
Renee E. Vickman
Gregory M. Cresswell
Harish Kothandaraman
Andree Kolliegbo
Juan Sebastian Paez Paez
Alexander P. Glaser
Brian T. Helfand
Gervaise Henry

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585446

4,402 views
3 citations

Mini Review

Published on 07 Jul 2025

Influences of metabolism and lipid homeostasis on regulatory vs. conventional T cells and implications for autoimmunity

in T Cell Biology

Madison A. Nguyen
Sarah S. Lee
Craig M. Walsh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613230

2,383 views
1 citation

Original Research

Published on 02 Jul 2025

The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival

in T Cell Biology

Caitlyn Guldenpfennig
Yue Guan
Bela Cseri
Elida Lopez
Emma Teixeiro
Mark Daniels

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630599

2,232 views

Case Report

Published on 01 Jul 2025

Effective venetoclax treatment for indolent T-cell lymphoma of the gastrointestinal tract: a case report and literature review

in T Cell Biology

Ji-Mo Jian
Hong-Yuan Hao
Cheng-Lu Yuan
Shu-Qi Zhang
Zou-Fang Huang
Jun Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593343

2,403 views

Original Research

Published on 27 Jun 2025

Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells

in T Cell Biology

Aida López Ruiz
Eric Slaughter
Kartik Bomb
Samantha L. Swedzinski
Paige J. LeValley
Zaining Yun
Jacob McCoskey
Kara Levine
Jonathan Steen
Joseph Almasian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1513148

3,096 views

Original Research

Published on 26 Jun 2025

Essential cell-intrinsic requirement for GMDS in T cell development

in T Cell Biology

Mehmet Yabas
Carla M. Roots
T. Daniel Andrews
Matt A. Field
Christopher C. Goodnow
Anselm Enders

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598923

1,962 views

Original Research

Published on 26 Jun 2025

The OT-II model reveals dual in vitro and in vivo immunomodulatory properties of CD6 in T cell activation

in T Cell Biology

Alejandra Leyton-Pereira
Irene Fernández-Delgado
María José Rodríguez-Lagunas
Cristina Català
Sergi Casadó-Llombart
Noa Beatriz Martin-Cofreces
Eugenio Bustos-Morán
Natalia Díaz-Garrido
Marta Consuegra-Fernández
Ana Cristina Calpena

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571590

3,048 views

Review

Published on 26 Jun 2025

Unlocking the therapeutic potential of thymus-isolated regulatory T cells

in T Cell Biology

Yueyuan Hu
Hugo Cruz
Samikshya Santosh Nirmala
Anke Fuchs

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612360

3,034 views

Original Research

Published on 23 Jun 2025

Co-expression of IL-15/IL-15Ra complex enhances NKG2D-CAR T cell-mediated anti-pancreatic cancer immunity by activating the JAK/STAT5 signaling pathway

in T Cell Biology

Yiran Chen
Chenxu Jin
Dandan Guo
Xinhui Hui
Yuzhou Ji
Yunhe Huang
Min Xue
Yaoxin Gao
Yaojun Ren
Haizhen Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1498706

4,475 views
2 citations

Review

Published on 23 Jun 2025

Thymic B cells in aging and autoimmune disease

in T Cell Biology

Sarah A. Wedemeyer
Ann V. Griffith

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595805

3,783 views

Review

Published on 18 Jun 2025

The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes

in T Cell Biology

Devin R. Fraser
Andrew W. Stadnyk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602934

3,628 views
1 citation

Original Research

Published on 18 Jun 2025

Single-cell analysis of peripheral blood and pleural effusion reveals functional diversity of γδ T cells in tuberculosis infection

in T Cell Biology

Yanjun Feng
Yu Chen
Wanying Zhang
Xinghua Shen
Jinyu Yan
Lin Yao
Lijuan Zhang
Yayan Niu
Jianping Zhang
Peijun Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1605827

2,457 views
3 citations

Brief Research Report

Published on 18 Jun 2025

P-glycoprotein expression skews mitochondrial dye measurements in T cells

in T Cell Biology

Sophia P. M. Sok
Jianan Cheng
Klaudia Strucinska
Narcis I. Popescu
Lihua Wu
Qiuqing Ke
William B. Kiosses
David Stanford
Willard M. Freeman
Satoshi Matsuzaki

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560104

2,402 views

Original Research

Published on 18 Jun 2025

Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia

in T Cell Biology

Freya Sibbertsen
Regine J. Dress
Sören Alexander Weidemann
Katharina Möller
Uta Herden
Lutz Fischer
Kevin Paul
Jun Oh
Eva Tolosa
Sebastian Schulz-Jürgensen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567645

2,861 views

Original Research

Published on 17 Jun 2025

Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns

in T Cell Biology

Ziran Bai
Siwen Yang
Jinyi Ren
Cheng Zhang
Xianmei Chen
Huina Huang
Guan Wang
Yawei Tang
Jingjing Qi
Xia Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608675

3,940 views
1 citation

Editorial

Published on 17 Jun 2025

Editorial: Mechanisms of early intracellular signaling in T lymphocytes

in T Cell Biology

Enrique Aguado
Mikel M. Arbulo-Echevarria
Ewoud B. Compeer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638330

1,603 views

Original Research

Published on 16 Jun 2025

Transcriptional fingerprinting of regulatory T cells: ensuring quality in cell therapy applications

in T Cell Biology

Zhang Cheng
Li-Jie Wang
Yuchi Honaker
Steven A. Cincotta
Claire E. Page
Sydney Vollhardt
Victor Yuan
S. Alice Long
Yuanyuan Xiao
Joshua N. Beilke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602172

4,410 views

Review

Published on 16 Jun 2025

The reprogramming factor KLF4 in normal and malignant blood cells

in T Cell Biology

H. Daniel Lacorazza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584181

2,963 views
3 citations

Review

Published on 12 Jun 2025

Role of human antigen-specific T cells in tolerance and IgE-mediated allergic reactions to food

in T Cell Biology

Rosina López-Fandiño

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595696

2,971 views
1 citation

2,208 articles

articles

Navigating the manufacturing, testing and regulatory complexities of regulatory T cells for adoptive cell therapy

Temporal TCR dynamics and epitope diversity mark recovery in severe COVID-19 patients

CD1-restricted T cells: are unconventional allies the key to future TB vaccines?

Natural microbial exposure populates the maternal fetal interface with diverse T cells

Global trends and frontiers in iNKT cells: a bibliometric and visualized analysis

Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

Influences of metabolism and lipid homeostasis on regulatory vs. conventional T cells and implications for autoimmunity

The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival

Effective venetoclax treatment for indolent T-cell lymphoma of the gastrointestinal tract: a case report and literature review

Bio-functional hydrogel coated membranes to decrease T-cell exhaustion in manufacturing of CAR T-cells

Essential cell-intrinsic requirement for GMDS in T cell development

The OT-II model reveals dual in vitro and in vivo immunomodulatory properties of CD6 in T cell activation

Unlocking the therapeutic potential of thymus-isolated regulatory T cells

Co-expression of IL-15/IL-15Ra complex enhances NKG2D-CAR T cell-mediated anti-pancreatic cancer immunity by activating the JAK/STAT5 signaling pathway

Thymic B cells in aging and autoimmune disease

The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes

Single-cell analysis of peripheral blood and pleural effusion reveals functional diversity of γδ T cells in tuberculosis infection

P-glycoprotein expression skews mitochondrial dye measurements in T cells

Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia

Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns

Editorial: Mechanisms of early intracellular signaling in T lymphocytes

Transcriptional fingerprinting of regulatory T cells: ensuring quality in cell therapy applications

The reprogramming factor KLF4 in normal and malignant blood cells

Role of human antigen-specific T cells in tolerance and IgE-mediated allergic reactions to food