Frontiers in Immunology | T Cell Biology

Original Research

Published on 08 Apr 2025

T cells in ARAP-deficient mice present defective T cell receptor signaling and reduced severity in an experimentally-induced autoimmune disease

in T Cell Biology

Jee-Hae Kim
Seung Hee Jung
Chohee Park
Jong Ran Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556616

2,213 views

Review

Published on 07 Apr 2025

Regulatory T cells: a promising new therapeutic target in ventricular remodeling after myocardial infarction

in T Cell Biology

Yiran Qin
Mingxuan Li
Haibo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1514335

3,714 views
5 citations

Original Research

Published on 04 Apr 2025

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

in T Cell Biology

Daniil K. Lukyanov
Valeriia V. Kriukova
Kristin Ladell
Irina A. Shagina
Dmitry B. Staroverov
Bella E. Minasian
Anna S. Fedosova
Pavel Shelyakin
Oleg N. Suchalko
Alexander Y. Komkov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536302

7,083 views
3 citations

Original Research

Published on 01 Apr 2025

Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses

in T Cell Biology

Xiaokang Ruan
Linwei Wu
Zijian Tang
Yao Li
Jin Wang
Haolin Jiang
Li Zhang
Shengjia Wang
Zhaoqiang Chen
Chenlei Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533857

4,532 views
3 citations

Original Research

Published on 27 Mar 2025

Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment

in T Cell Biology

Zhaoyi Wang
Zhongqi Diao
Yiyan Zhang
Jiangying Liu
Yeshan Li
Zijin Sun
Huimin Zhen
Haojia Wang
Siyun Yang
Tieshan Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1537398

4,175 views

Original Research

Published on 26 Mar 2025

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

in T Cell Biology

Richard J. Suckling
Cevriye Pamukcu
Robert Alan Simmons
Daniel Fonseca
Emma Grant
Rory Harrison
Saher A. Shaikh
Rahul C. Khanolkar
Hemza Ghadbane
Andrew Creese

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547664

3,952 views
2 citations

Brief Research Report

Published on 26 Mar 2025

The distinctive signature of regulatory CD4 T cells committed in the human thymus

in T Cell Biology

Alexandre A. S. F. Raposo
Susana Paço
Miguel Ângelo-Dias
Pedro Rosmaninho
Afonso R. M. Almeida
Ana E. Sousa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553554

4,169 views
4 citations

Original Research

Published on 26 Mar 2025

Anoctamin 9 determines Ca2+ signals during activation of T-lymphocytes

in T Cell Biology

Rainer Schreiber
Jiraporn Ousingsawat
Karl Kunzelmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1562871

2,676 views
2 citations

Original Research

Published on 24 Mar 2025

Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients

in T Cell Biology

Tobias Jooss
Katharina Maier
Lena-Marie Reichardt
Bianca Hindelang
Lönna Süberkrüb
Kim Lena Hamberger
Jasmin Maria Bülow
Konrad Schuetze
Florian Gebhard
Marco Mannes

Frontiers in Immunology

doi 10.3389/fimmu.2025.1538516

2,248 views

Review

Published on 24 Mar 2025

RNA modification: a promising code to unravel the puzzle of autoimmune diseases and CD4+ T cell differentiation

in T Cell Biology

Hui Yu
Zhanchuan Ma
Sensen Su
Zheng Xu
Huanfa Yi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563150

2,857 views

Original Research

Published on 18 Mar 2025

Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia

in T Cell Biology

Andrea González-Torbay
Keren Reche-Yebra
Álvaro Clemente-Bernal
Yolanda Soto Serrano
Luz Yadira Bravo-Gallego
Almudena Fernández López
Rebeca Rodríguez-Pena
María Bravo García-Morato
Eduardo López-Granados
Lucía del Pino-Molina

Frontiers in Immunology

doi 10.3389/fimmu.2025.1544863

3,022 views
1 citation

Original Research

Published on 18 Mar 2025

Increased long-term central memory T cells in patients with retreatment pulmonary tuberculosis

in T Cell Biology

Xin Yao
Haomin Cai
Jianxia Chen
Fangyong Yu
Xiaocui Wu
Yarong Shi
Yang Hu
Yuyan Xu
Qinghua Xu
Zhonghua Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1545537

2,423 views
2 citations

Original Research

Published on 18 Mar 2025

Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients

in T Cell Biology

Chanchan Xiao
Jian Xiang
Haoyun Wang
Wen Gao
Tianchan Peng
Shumin Li
Jun Su
Xi Chen
Lijuan Gao
Ruohu Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1534530

3,796 views

Brief Research Report

Published on 14 Mar 2025

A pooled CRISPR screen identifies the Tα2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes

in T Cell Biology

Pascal Y. Schönberg
Ángela Muñoz-Ovalle
Maciej Paszkowski-Rogacz
Eugenia Crespo
Duran Sürün
Anja Feldmann
Frank Buchholz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536003

3,342 views

Review

Published on 06 Mar 2025

The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis

in T Cell Biology

Peiyan Zhang
Jiawei Wang
Jinlin Miao
Ping Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560578

4,873 views
10 citations

Review

Published on 04 Mar 2025

Advance in chimeric antigen receptor T therapy in autoimmune diseases

in T Cell Biology

Xiaolan Ji
Yunfan Sun
Yuyang Xie
Jianling Gao
Ji Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533254

5,648 views
2 citations

Original Research

Published on 03 Mar 2025

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

in T Cell Biology

Beatriz Moleirinho
Margarida Paulo-Pedro
Nicole C. Martins
Emily Jelagat
Eller Conti
Tiago R. Velho
Miguel Abecasis
Rui Anjos
Afonso R. M. Almeida
Ana E. Sousa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553535

5,048 views
1 citation

Correction

Published on 27 Feb 2025

Corrigendum: State of play in the molecular presentation and recognition of anti-tumor lipid-based analogues

in T Cell Biology

T. Praveena
Jérôme Le Nours

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574591

1,078 views

Original Research

Published on 26 Feb 2025

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

in T Cell Biology

Vasileios Kyttaris
Daniel J. Wallace
Arezou Khosroshahi
Andrew Concoff
Nicole Wilson
Chau Ching Liu
Susan Manzi
Joseph Ahearn
Sepehr Taghavi
Touba Warsi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1518208

9,008 views
2 citations

Review

Published on 26 Feb 2025

The clinical significance of T-cell regulation in hypertension treatment

in T Cell Biology

Miaoxin Fu
Mingzhu Lv
Jinyue Guo
Aihua Mei
Hang Qian
Handong Yang
Wenwen Wu
Zhixin Liu
Jixin Zhong
Ying Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550206

4,242 views
5 citations

Brief Research Report

Published on 25 Feb 2025

Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

in T Cell Biology

Yumi Tamura
Shun Ohki
Haruna Nagai
Rin Yoshizato
Shizuki Nishi
Yuqi Jin
Yasuo Kitajima
Yun Guo
Tatsuo Ichinohe
Satoshi Okada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560383

4,132 views
1 citation

Review

Published on 19 Feb 2025

Neural regulation of the thymus: past, current, and future perspectives

in T Cell Biology

Randall S. Carpenter
Maria K. Lagou
George S. Karagiannis
Maria Maryanovich

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552979

7,348 views
2 citations

Editorial

Published on 18 Feb 2025

Editorial: Current insights in cancer metabolism and T cell based tumor immunity

in T Cell Biology

Takashi MaruYama
Takashi Tanikawa
Jian Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566491

1,455 views

Original Research

Published on 18 Feb 2025

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

in T Cell Biology

José Pedro Loureiro
Alessandro Vacchini
Giuliano Berloffa
Jan Devan
Verena Schaefer
Vladimir Nosi
Rodrigo Colombo
Aisha Beshirova
Giulia Montanelli
Benedikt Meyer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519128

3,908 views
1 citation

2,227 articles

articles

T cells in ARAP-deficient mice present defective T cell receptor signaling and reduced severity in an experimentally-induced autoimmune disease

Regulatory T cells: a promising new therapeutic target in ventricular remodeling after myocardial infarction

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses

Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

The distinctive signature of regulatory CD4 T cells committed in the human thymus

Anoctamin 9 determines Ca2+ signals during activation of T-lymphocytes

Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients

RNA modification: a promising code to unravel the puzzle of autoimmune diseases and CD4+ T cell differentiation

Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia

Increased long-term central memory T cells in patients with retreatment pulmonary tuberculosis

Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients

A pooled CRISPR screen identifies the Tα2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes

The dual role of tissue regulatory T cells in tissue repair: return to homeostasis or fibrosis

Advance in chimeric antigen receptor T therapy in autoimmune diseases

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

Corrigendum: State of play in the molecular presentation and recognition of anti-tumor lipid-based analogues

Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers

The clinical significance of T-cell regulation in hypertension treatment

Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans

Neural regulation of the thymus: past, current, and future perspectives

Editorial: Current insights in cancer metabolism and T cell based tumor immunity

Recognition of MR1-antigen complexes by TCR Vγ9Vδ2