Frontiers in Immunology | T Cell Biology

Original Research

Published on 17 Feb 2025

Use of a universal targeting CAR T cell to simultaneously kill cancer cells and cancer-associated fibroblasts

in T Cell Biology

Bo Huang
Suilan Zheng
Kasireddy Sudarshan
Ramesh Mukkamala
Madduri Srinivasarao
Tushar Sardesai
Xiaofei Yang
Haiyan Chu
Philip S. Low

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539265

6,838 views
10 citations

Brief Research Report

Published on 17 Feb 2025

A large-scale database of T-cell receptor beta sequences and binding associations from natural and synthetic exposure to SARS-CoV-2

in T Cell Biology

Sean Nolan
Marissa Vignali
Mark Klinger
Jennifer N. Dines
Ian M. Kaplan
Emily Svejnoha
Tracy Craft
Katie Boland
Mitchell W. Pesesky
Rachel M. Gittelman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1488851

5,162 views
39 citations

Original Research

Published on 13 Feb 2025

Modulation of double-negative T cells by Huang-Lian-Jie-Du Decoction attenuates neuroinflammation in ischemic stroke: insights from single-cell transcriptomics

in T Cell Biology

Kai Wang
Zijin Sun
Qi Shao
Zhaoyi Wang
Haojia Zhang
Yuanhua Li
Jingmei Ming
Wenjing Zhang
Tieshan Wang
Yan Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1537277

4,007 views
4 citations

Original Research

Published on 11 Feb 2025

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer

in T Cell Biology

Lulu Zhang
Xiyuan Guo
Xiaoke Sun
Jue Liao
Qin Liu
Yingchun Ye
Zhihui Yang
Ratchada Cressey
Qing He
Qing Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1486329

6,071 views
8 citations

Original Research

Published on 07 Feb 2025

Commensal bacteria education history calibrates the naivety and activation threshold of adaptive antiviral immune system

in T Cell Biology

Baohua Li
Zhou Sha
Li Mou
Feng Zhang
Lifeng Jia
Yan Zhu
Yan Guo
Guohong Deng
Haibo Wu
Hong Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519023

3,000 views

Original Research

Published on 07 Feb 2025

Effects of neutrophil granule proteins on sepsis-associated lymphopenia and their relationship with CD4+ T-cell pyroptosis

in T Cell Biology

Jia-yu Mao
Ya-wen Xie
Xian-li Lei
Jia-hui Zhang
Wei Cheng
Na Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1507800

2,698 views

Original Research

Published on 06 Feb 2025

Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy

in T Cell Biology

Jianyao Zeng
Yan Sun
Yuan Fang
Xiaodie Wang
Qian Huang
Pingjing Zhang
Meiqi Shao
Pei Wang
Jingbo Cheng
Meng Di

Frontiers in Immunology

doi 10.3389/fimmu.2025.1541653

3,800 views
1 citation

Review

Published on 06 Feb 2025

A comprehensive review of the roles of T-cell immunity in preeclampsia

in T Cell Biology

Xu Peng
Ibeh Chinwe Oluchi-Amaka
Joanne Kwak-Kim
Xiuhua Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1476123

4,822 views
11 citations

Original Research

Published on 28 Jan 2025

Age influences the circulating immune profile in pediatric sepsis

in T Cell Biology

Grace Fisler
Mariana R. Brewer
Omar Yaipen
Clifford S. Deutschman
Matthew D. Taylor

Frontiers in Immunology

doi 10.3389/fimmu.2025.1527142

2,894 views
2 citations

Systematic Review

Published on 27 Jan 2025

Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis

in T Cell Biology

Victoria Kulesh
Kirill Peskov
Gabriel Helmlinger
Gennady Bocharov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1475871

5,955 views
3 citations

Mini Review

Published on 24 Jan 2025

Thymus ad astra, or spaceflight-induced thymic involution

in T Cell Biology

Wataru Muramatsu
Maria Maryanovich
Taishin Akiyama
George S. Karagiannis

Frontiers in Immunology

doi 10.3389/fimmu.2024.1534444

6,217 views
3 citations

Review

Published on 22 Jan 2025

Tumor cells escape immunosurveillance by hampering LFA-1

in T Cell Biology

Shishir Upadhyay
Lewis Murugu
Lena Svensson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1519841

3,807 views

Original Research

Published on 22 Jan 2025

Identification of circulating Tfh/Th subsets as a biomarker of developed hospital-acquired pneumonia

in T Cell Biology

Yuan Peng
Tao Tao
Ni-Wen Yu
Chenyang Xu
Cheng Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1513939

2,018 views

Original Research

Published on 20 Jan 2025

Annotation and characterization of immunoglobulin loci and CDR3 polymorphism in water buffalo (Bubalus bubalis)

in T Cell Biology

Yunlan Deng
Fengli Wu
Qianqian Li
Lidie Yao
Chengzhi Yang
Long Ma
Xinsheng Yao
Jun Li

Frontiers in Immunology

doi 10.3389/fimmu.2024.1503788

2,794 views
3 citations

Original Research

Published on 17 Jan 2025

A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells

in T Cell Biology

Zhao Zhang
Lianfeng Zhao
Tinghui Huang
Zhengliang Chen
Yaoyao Zhao
Junqing Liang
Xudong Ao
Xiaoqiong Jia
Lei Kang
Linghui Kong

Frontiers in Immunology

doi 10.3389/fimmu.2024.1531294

6,042 views
6 citations

Original Research

Published on 17 Jan 2025

Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19

in T Cell Biology

Aurelie Guironnet-Paquet
Hind Hamzeh-Cognasse
Frederic Berard
Fabrice Cognasse
Jean Christophe Richard
Hodane Yonis
Mehdi Mezidi
Olivier Desebbe
Bertrand Delannoy
Sophie Demeret

Frontiers in Immunology

doi 10.3389/fimmu.2024.1492672

5,903 views
4 citations

Original Research

Published on 15 Jan 2025

A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent lineage choice error

in T Cell Biology

Gregory A. Swan
Chika Fujii
Mia E. Guzynski
Sheridan M. Page
Isabelle V. Meyers
Yordan P. Penev
Sejiro Littleton
Adinda Azzahra
Christine Richardson
Sophia D. Sarafova

Frontiers in Immunology

doi 10.3389/fimmu.2024.1469402

3,076 views

Perspective

Published on 15 Jan 2025

Elusive modes of Foxp3 activity in versatile regulatory T cells

in T Cell Biology

Minghong He
Yongqiang Feng

Frontiers in Immunology

doi 10.3389/fimmu.2024.1533823

7,108 views
4 citations

Original Research

Published on 14 Jan 2025

Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11

in T Cell Biology

Ling Li
Manzhi Zhao
Marjan van Meurs
Inge Brouwers-Haspels
Renske J. H. den Dekker
Merel E. P. Wilmsen
Dwin G. B. Grashof
Harmen J. G. van de Werken
Shringar Rao
Casper Rokx

Frontiers in Immunology

doi 10.3389/fimmu.2024.1509874

4,615 views
3 citations

Original Research

Published on 10 Jan 2025

Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes

in T Cell Biology

Ayaka Sato
Hodaka Nagai
Ayano Suzuki
Aya Ito
Shimpei Matsuyama
Nagito Shibui
Masashi Morita
Mari Hikosaka-Kuniishi
Naoto Ishii
Takanori So

Frontiers in Immunology

doi 10.3389/fimmu.2024.1473815

5,489 views
2 citations

Mini Review

Published on 08 Jan 2025

Unfolded protein responses in T cell immunity

in T Cell Biology

Wencan Zhang
Xu Cao

Frontiers in Immunology

doi 10.3389/fimmu.2024.1515715

4,863 views
5 citations

Original Research

Published on 07 Jan 2025

Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels

in T Cell Biology

Thomas M. Snyder
Rachel M. Gittelman
Mark Klinger
Damon H. May
Edward J. Osborne
Ruth Taniguchi
H. Jabran Zahid
Ian M. Kaplan
Jennifer N. Dines
Matthew T. Noakes

Frontiers in Immunology

doi 10.3389/fimmu.2024.1488860

5,773 views
17 citations

Original Research

Published on 07 Jan 2025

VACCIMEL, an allogeneic melanoma vaccine, efficiently triggers T cell immune responses against neoantigens and alloantigens, as well as against tumor-associated antigens

in T Cell Biology

Ibel Carri
Erika Schwab
Juan Carlos Trivino
Erika M. von Euw
Morten Nielsen
José Mordoh
María Marcela Barrio

Frontiers in Immunology

doi 10.3389/fimmu.2024.1496204

7,565 views
10 citations

Editorial

Published on 06 Jan 2025

Editorial: Specific targeting of MHC antigens for T-cells and immune cells in human disease

in T Cell Biology

Ali Afzal
Muhammad Babar Khawar
Weijuan Gong
Brian M. Baker
Haibo Sun

Frontiers in Immunology

doi 10.3389/fimmu.2024.1540449

3,142 views
1 citation

2,227 articles

articles

Use of a universal targeting CAR T cell to simultaneously kill cancer cells and cancer-associated fibroblasts

A large-scale database of T-cell receptor beta sequences and binding associations from natural and synthetic exposure to SARS-CoV-2

Modulation of double-negative T cells by Huang-Lian-Jie-Du Decoction attenuates neuroinflammation in ischemic stroke: insights from single-cell transcriptomics

Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer

Commensal bacteria education history calibrates the naivety and activation threshold of adaptive antiviral immune system

Effects of neutrophil granule proteins on sepsis-associated lymphopenia and their relationship with CD4+ T-cell pyroptosis

Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy

A comprehensive review of the roles of T-cell immunity in preeclampsia

Age influences the circulating immune profile in pediatric sepsis

Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis

Thymus ad astra, or spaceflight-induced thymic involution

Tumor cells escape immunosurveillance by hampering LFA-1

Identification of circulating Tfh/Th subsets as a biomarker of developed hospital-acquired pneumonia

Annotation and characterization of immunoglobulin loci and CDR3 polymorphism in water buffalo (Bubalus bubalis)

A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells

Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19

A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent lineage choice error

Elusive modes of Foxp3 activity in versatile regulatory T cells

Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11

Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes

Unfolded protein responses in T cell immunity

Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels

VACCIMEL, an allogeneic melanoma vaccine, efficiently triggers T cell immune responses against neoantigens and alloantigens, as well as against tumor-associated antigens

Editorial: Specific targeting of MHC antigens for T-cells and immune cells in human disease