Frontiers in Immunology | Vaccines and Molecular Therapeutics

Clinical Trial

Published on 14 Nov 2025

Safety, tolerability, and immunogenicity of a DNA-based vaccine (INO-4700) against Middle East respiratory syndrome coronavirus: phase 2a study in healthy volunteers

in Vaccines and Molecular Therapeutics

Joseph T. Agnes
Sarah A. Marcus
Sahem S. Al-Ghraibeh
Suleimman Ahmad Al-Sweedan
Josphat Kosgei
Bernhards Ogutu
ShuPing Yang
Kathleen A. Walker
Bonaventure Orizu
Kate E. Broderick

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662923

1,067 views

Clinical Trial

Published on 14 Nov 2025

Immunogenicity and safety of an Escherichia coli-produced 9-valent human papillomavirus vaccine (types 6/11/16/18/31/33/45/52/58) in healthy Chinese women aged 20–45 years: a single-center, randomized, observer-blinded, positive controlled phase 2 clinical trial

in Vaccines and Molecular Therapeutics

Mingwei Wei
Hongyan Liu
Hongyang Yu
Hongxing Pan
Hong Tao
Jing Zhang
Weiwei Han
Dan Wu
Wenjuan Wang
Jingxin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706662

432 views

Mini Review

Accepted on 13 Nov 2025

Marine-Derived L-Asparaginase: Unlocking Marine Power in Anti-tumor Therapeutics

in Vaccines and Molecular Therapeutics

Ritika Gopalakrishnan
Kamala Kannan
Ragul G
Priya Ram
Dhanraj Ganapathy
Pitchiah Sivaperumal

Frontiers in Immunology

Original Research

Accepted on 13 Nov 2025

Cross-Species Analysis of FcγRIIa/b (CD32a/b) Polymorphisms at Position 131: Structural and Functional Insights into the Mechanism of IgG-Mediated Phagocytosis in Human and Macaque

in Vaccines and Molecular Therapeutics

William Tolbert
Paula B. Nhan
Haleigh E Conley
XIAOXUAN GE
Monika Chandravanshi
Madeleine Lee
Julianna Veilleux
Marek Korzeniowski
Suneetha Gottumukkala
Margaret E Ackerman

Frontiers in Immunology

Mini Review

Accepted on 13 Nov 2025

Next-Generation Vaccines Against Bacterial Pathogens: mRNA and Beyond

in Vaccines and Molecular Therapeutics

Huimin Chen
Ye Gu
Lei Song
Lihui Si

Frontiers in Immunology

Correction

Accepted on 12 Nov 2025

Correction: An oral M-cell targeted Lactococcus lactis vaccine against Echinococcus multilocularis infection

in Vaccines and Molecular Therapeutics

Feng Tang
Yang Xiao
Zhao-Hui Luo
Shun-Juan Wang
Yao Dai
Jia-Yu Chen
Jia-Yong Cui
Runle Li

Frontiers in Immunology

Original Research

Accepted on 11 Nov 2025

Antibodies directed against extracellular loops of FadL orthologs disrupt outer membrane integrity and neutralize infectivity of Treponema pallidum, the syphilis spirochete

in Vaccines and Molecular Therapeutics

Kristina Nicole Delgado
Crystal F. Vicente
Carson J. La Vake
Melissa Jo Caimano
Justin David Radolf
Kelly Lynn Hawley

Frontiers in Immunology

210 views

Editorial

Published on 11 Nov 2025

Editorial: Vaccines and therapeutics utilizing new adjuvants and potential inhibitors to target emerging infectious diseases

in Vaccines and Molecular Therapeutics

Jiae Kim
Ousman Jobe
Mara Jana Broadhurst

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716739

526 views

Original Research

Published on 11 Nov 2025

Immunization with outer membrane vesicles drived Proteus mirabilis protects mice against bacteria-induced lethality

in Vaccines and Molecular Therapeutics

Wei Fan
Yilu Zhai
Xinyu Zhang
Fuliang Sun
Lin Kong
Wei Wang
Dazhuo Zhao
Jiaqi Fu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688837

525 views

Original Research

Published on 11 Nov 2025

Multi-antigen MVA-vectored SARS-CoV-2 vaccine, GEO-CM04S1, induces cross-protective immune responses to ancestral and Omicron variants

in Vaccines and Molecular Therapeutics

Amany Elsharkawy
Shannon Stone
Anchala Guglani
Felix Wussow
JD Burleson
Mary Hauser
Arban Domi
Pratima Kumari
Todd R. Albrecht
Chinonye Dim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694699

773 views

Original Research

Published on 11 Nov 2025

Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses

in Vaccines and Molecular Therapeutics

Naomi Krickeberg
Hans-Georg Rammensee
Karin Schilbach

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676455

703 views

Original Research

Published on 11 Nov 2025

Influence of heparin-based anticoagulants on antibiotic therapy

in Vaccines and Molecular Therapeutics

Denisa Cont
Claudia Schildböck
Claudia Kolm
Alexander K. T. Kirschner
Andreas H. Farnleitner
Jens Hartmann
Viktoria Weber
Stephan Harm

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708169

349 views

Original Research

Accepted on 10 Nov 2025

Establishment of rapid saturation mutagenesis and screening methods for improving the neutralizing activity of monoclonal antibodies

in Vaccines and Molecular Therapeutics

Xi Wu
Lijie Wang
Chenchen He
Yanru Shen
Youchun Wang
Weijin Huang

Frontiers in Immunology

116 views

Original Research

Accepted on 10 Nov 2025

In Silico Design of Novel Precision Vaccine Targeting Sclerostin Epitopes for Osteoporosis Prevention and Treatment

in Vaccines and Molecular Therapeutics

Jianzhou Luo
Tailin Wu
Bin Guan
Lin Li
Zili Yang
Huiren Tao

Frontiers in Immunology

Original Research

Published on 10 Nov 2025

Assessment of immune responses to Brucella abortus S19 vaccination in cattle and buffaloes

in Vaccines and Molecular Therapeutics

Rajeswari Shome
Prabhakar Yallanur Konda
Somy Skariah
Gandu Shanmugam
Praveen Kumar Attiganahalli Muninarayanaswamy
Pavan Kalyan Nagaraja
Kirti Megha
Nanditha Thimmappa Rajeshwari
Nagalingam Mohandoss

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663259

684 views

Correction

Accepted on 07 Nov 2025

Synergistic nano-vaccine strategy for comprehensive activation of adaptive and innate immunity against Staphylococcus aureus infection

in Vaccines and Molecular Therapeutics

Jiayue Xi
Minxuan Cui
Zhuoyue Shi
zhuo Wan
Yufei Hou
Nan Sun
Muqiong Li
Zhengjun Ma
Yupu Zhu
Xin He

Frontiers in Immunology