Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Accepted on 15 Aug 2025

Upper respiratory tract immunization with Pam2Cys-adjuvanted spike protein vaccine achieves sterilizing protection against SARS-CoV-2

in Vaccines and Molecular Therapeutics

Erica L Stewart
Skye Stockdale
Matt Johansen
Lachlan Smith
Sibel Alca
Joshua WC Maxwell
Duc H Nguyen
Stefan Miemczyk
Guanshu Zhao
Stuart Turville

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654126

317 views

Brief Research Report

Published on 15 Aug 2025

Orally administered extracellular vesicles from Salmonella-infected macrophages confer protective immunity in vivo

in Vaccines and Molecular Therapeutics

Saloni Bhimani
Jorge J. Canas
Samantha M. Enslow
Ryan Mulcare
Mariola J. Ferraro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628756

612 views

Correction

Accepted on 14 Aug 2025

BCG and beyond: unlocking new frontiers in TB vaccine development

in Vaccines and Molecular Therapeutics

AISHWARYA SHAJI
Akanksha Verma
Ashima Bhaskar
Ved Prakash Dwivedi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677868

Clinical Trial

Accepted on 14 Aug 2025

Immunogenicity and Safety of Co-administration with the Sabin-Strain-Based Inactivated Poliovirus Vaccine (Vero Cell) and the Diphtheria-Tetanus-acellular Pertussis Vaccine in Eligible Children in China: A randomized, controlled, multicenter, non-inferiority trial

in Vaccines and Molecular Therapeutics

Xiaoyu Liu
ShaSha Han
Xiao Chen
Li Sun
Ruize Wang
Xuanwen Shi
Yu Guo
Hui Wang
Haiping Chen
Shaoying Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633170

118 views

Original Research

Published on 14 Aug 2025

Impact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey

in Vaccines and Molecular Therapeutics

Zhixin Geng
Wen Wang
Yuanyuan Zhu
Yan Xu
Qiang Chen
Lei Zhang
Jing Yu
Xiang Sun
Zhiguo Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630442

630 views

Original Research

Published on 14 Aug 2025

Therapeutic vaccination with the Ag85B-Rv2660c-MPT70 fusion protein enhances Mycobacterium tuberculosis H37Ra clearance in post-exposure mice

in Vaccines and Molecular Therapeutics

Zhiming Hu
Shaohua Guo
Wenlong Chen
Jiangshan Ouyang
Chunxu Huang
Ting Cao
Jun Mou
Xinxia Gu
Jie Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624923

599 views

Editorial

Published on 14 Aug 2025

Editorial: Basic and applied research toward the development of vaccines against African swine fever virus

in Vaccines and Molecular Therapeutics

Daniel Pérez-Núñez
Sandra Blome
Linda K. Dixon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658984

328 views

Review

Accepted on 13 Aug 2025

Antigen-presenting cell internalization is key for understanding and evaluating therapeutic antibodies' immunogenicity

in Vaccines and Molecular Therapeutics

Maria Lteif
Marc Pallardy
Isabelle TURBICA

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617395

106 views

Original Research

Published on 13 Aug 2025

BIDpred: unraveling B cell Immunodominance hierarchical pattern using statistical feature discovery and deep learning prediction

in Vaccines and Molecular Therapeutics

Sungjin Choi
Dongsup Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646946

569 views

Review

Published on 13 Aug 2025

Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies

in Vaccines and Molecular Therapeutics

Keda Chen
Jutao Hu
Jiaxuan Li
Guangshang Wu
Xiaotian Tie
Hao Wu
Hongyu Li
Jianhua Li
Yanjun Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618406

1,956 views

Original Research

Accepted on 12 Aug 2025

Reduced Spike specific T-cell responses in COVID-19 vaccinated subjects undergoing SARS-CoV-2 breakthrough infection

in Vaccines and Molecular Therapeutics

Stefania Varchetta
Federica Sole Golfetto
Patrizia Bono
Annapaola Callegaro
Tanya Fabbris
ANDREA FAVALLI
MARIACRISTINA CROSTI
Tullia Maria De Feo
Nathalie Iannotti
Giorgio Bozzi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657082

320 views

Original Research

Accepted on 12 Aug 2025

Effects of Sex but not Race and geographic origin on vaccine-induced HIVspecific Antibody Responses

in Vaccines and Molecular Therapeutics

Wilbert Mbuya
Augusta Horvath
Kathrin Held
Lucas Maganga
Michael Hoelscher
Linda-Gail Bekker
Ann Duerr
Zoe Moodie
Gavin Churchyard
Michael Keefer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601865

156 views

Original Research

Accepted on 12 Aug 2025

Evaluation of a Multi-Epitope Vaccine PME for Pasteurella multocida in Mouse Model

in Vaccines and Molecular Therapeutics

Rui Zhang
璐戴
Yizhen Jia
Haoran Qi
Junfeng He
Jiaxin Chen
Xuejun Gao
Liancheng Lei
Feng Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652907

Original Research

Published on 12 Aug 2025

Circulating SARS-CoV-2 spike IgG antibody responses in cancer patients following multiple COVID-19 vaccination boosters

in Vaccines and Molecular Therapeutics

Huijing Xue
Troy J. Kemp
Hayley North
Nancy V. Roche
Thomas E. Hickey
Ligia A. Pinto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629473

643 views

General Commentary

Published on 12 Aug 2025

Commentary: Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa

in Vaccines and Molecular Therapeutics

Artur Słomka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651751

514 views

Original Research

Accepted on 11 Aug 2025

Effect of co-vaccination of cattle with RB51 and BCG on vaccine-specific CD4+ T cell responses

in Vaccines and Molecular Therapeutics

Haley M Sterle
Ellie Jordan Putz
Steven Olsen
Mitchell Palmer
Paola M Boggiatto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664398

162 views